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Medial pivot total knee arthroplasty (MP-TKA) is a relatively new design that simulates normal knee mechanics with the aim of enhancing postoperative recovery. Furthermore, it reduces postoperative complications in patients with end-stage osteoarthritis of the knee. No study has been done regarding this topic in Saudi Arabia yet, so we aimed to study the post-operative clinical and radiological outcomes of MP-TKA, as well as the postoperative complications. A retrospective cohort chart review study was conducted on 46 patients and 70 knees after applying our inclusion/exclusion criteria. The patients were followed up for an average period of two years. Clinical outcomes were assessed pre- and postoperatively by the validated Saudi Arabian version of the Knee Injury and Osteoarthritis Outcome Score (KOOS), as well as radiological outcomes and postoperative complications gathered from patients’ charts. The postoperative KOOS score showed a statistically significant improvement in pain, symptoms, and activities of daily living in comparison with the preoperative score (P-value < 0.0001). The mean time until ambulation and length of hospital stay were five and 14 days, respectively. Four patients (8.7%) showed radiological complications. Deep vein thrombosis was observed in only two knees (4.3%), and there were no revision cases. Thus, MP-TKA has been shown to improve pain, symptoms, and activities of daily living with a relatively short time until ambulation and length of hospital stay, in addition to a low incidence of postoperative and radiological complications.

Septic encephalopathy (SE) is the most common complication of sepsis and a major cause of mortality and morbidity worldwide. It occurs in around two third of patients admitted with sepsis in the intensive care units. The objective of this review is to discuss clinical symptoms, diagnosis and outcomes in patients with SE. Robust research was conducted from online databases such as Google Scholar and Cochrane. Studies from the last ten years were included in our review. The pathophysiology of SE is highly dynamic where a complex sequence of events occurs as a host response to an extracranial infection. SE presents a myriad of symptoms ranging from an altered mental state with confusion, disorientation to a more severe presentation with delirium and impaired consciousness. Arriving to a diagnosis of SE requires a rigorous systemic and neurological investigation. Modalities such as neuromonitoring, neuroimaging, clinical biomarkers and mental assessment scales offer limited diagnostic value but can be utilized to co-relate clinical symptoms. It is associated with adverse outcomes such as a high rate of 28-day and 180-day mortality. The quality of life is poor in surviving patients. There is a dearth of original research on SE in the Arab region and worldwide. Major research, both as prospective and retrospective studies is essential to achieve improved management of SE. Therapeutic approaches should be tailored towards modulating pathophysiological processes of sepsis. Follow up studies based on 180 day follow ups should be used to study patient quality of life and outcomes.

OBJECTIVE: To study the prevalence of various errors of refraction among the medical students studying at the college of medicine, Qassim University, Saudi Arabia.METHODS: This is a cross-sectional descriptive study conducted at Qassim University clinics over a period of two months. The study population comprised 162 male and female students from different academic years. The students were selected randomly so that around 35-40 students were taken from each academic class. The selected study population was explained the objectives of the study and a written consent form that stated the purpose, methods, risks, benefits, and the assurance of the confidentiality of the data was obtained from each student. After giving the consent, each subject was examined by auto refractometer. The examination was carried out by an optometrist without using cycloplegia. Both right and left eyes were thoroughly examined by auto refractometer and on the average three readings of the refraction measurements were taken. The readings were recorded on a data sheet of every individual, and the Statistical analysis was performed using Statistical Package for Social Sciences (SPSS).RESULTS: One hundred and sixty-two (162) students with a mean age of 22.44 years, Std 1.661 and a range of 8 (19-27) were included in the study. Of the total number, 111 (68.51%) were males and remaining 51 (31.48%) were females. Of the total sample, only 1 (0.617%) student had diabetes mellitus, and 6 (3.70%) students gave a history of previous ocular surgery. Myopia was found to be the commonest error of refraction 53.7% with hyperopia next to it.CONCLUSION: Myopia is found to be a common error of refraction in young adults. A regular checkup is essential to timely correct the error and to prevent deterioration of the vision.

Introduction: Antipsychotic agents are categorized usually as either “typical antipsychotics” or “atypical antipsychotics”. Typical antipsychotic pharmacological agents, which are also called first-generation antipsychotics or traditional antipsychotics, include chlorpromazine and haloperidol. On the other hand, atypical antipsychotic pharmacological agents, which are also called second generation antipsychotics, include risperidone, quetiapine, and olanzapine. Both typical and atypical antipsychotics work in similar mechanisms by inhibiting the activation of specific receptors in the dopamine pathway.Aim of work: In this review, we will discuss the antipsychotics- classification, uses, and adverse effects, Methodology: We did a systematic search for antipsychotics- classification, uses, and adverse effects using PubMed search engine (http://www.ncbi.nlm.nih.gov/) and Google Scholar search engine (https://scholar.google.com). All relevant studies were retrieved and discussed. We only included full articles.Conclusions: The prescription of atypical antipsychotic agents, like quetiapine and olanzapine, has been significantly increasing and in many conditions, they are sometimes prescribed “off-label” – which is a worrying trend due to their possible risk of developing harmful adverse events. Therefore, atypical antipsychotic agents must only be used in their specific indications and with caution, especially among older patients and young adults. Atypical antipsychotic agents can be indicated for schizophrenia treatment and other associated conditions and in some cases to treat the behavioral and psychological manifestations related to dementia (risperidone only). Antipsychotics are not first-line treatments for patients with anxiety and are not generally recommended for the use in patients with posttraumatic stress disorder or insomnia. Key words: antipsychotics, classification, uses, and adverse effects.