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8. Punicalagin’s Protective Effects on Parkinson’s Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway

Author

Salem, Hoda A., primary, Abu-Elfotuh, Karema, additional, Alzahrani, Sharifa, additional, Rizk, Nermin I., additional, Ali, Howaida S., additional, Elsherbiny, Nehal, additional, Aljohani, Alhanouf, additional, Hamdan, Ahmed M. E., additional, Chellasamy, Panneerselvam, additional, Abdou, Nada S., additional, Gowifel, Ayah M. H., additional, Darwish, Alshaymaa, additional, Ibrahim, Osama Mohamed, additional, and Abd Elmageed, Zakaria Y., additional

Published
2023
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13. Neuroprotective Effect of Morin Hydrate against Attention-Deficit/Hyperactivity Disorder (ADHD) Induced by MSG and/or Protein Malnutrition in Rat Pups: Effect on Oxidative/Monoamines/Inflammatory Balance and Apoptosis

Author

Salem, Hoda A., primary, Elsherbiny, Nehal, additional, Alzahrani, Sharifa, additional, Alshareef, Hanan M., additional, Abd Elmageed, Zakaria Y., additional, Ajwah, Sadeem M., additional, Hamdan, Ahmed M. E., additional, Abdou, Yahia S., additional, Galal, Omneya O., additional, El Azazy, Marwa K. A., additional, and Abu-Elfotuh, Karema, additional

Published
2022
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14. Neuroprotective Effects of Phytochemicals against Aluminum Chloride-Induced Alzheimer’s Disease through ApoE4/LRP1, Wnt3/β-Catenin/GSK3β, and TLR4/NLRP3 Pathways with Physical and Mental Activities in a Rat Model

Author

Hamdan, Ahmed Mohsen Elsaid, primary, Alharthi, Fatimah Hussain J., additional, Alanazi, Ahmed Hadi, additional, El-Emam, Soad Z., additional, Zaghlool, Sameh S., additional, Metwally, Kamel, additional, Albalawi, Sana Abdulaziz, additional, Abdu, Yahia S., additional, Mansour, Reda El-Sayed, additional, Salem, Hoda A., additional, Abd Elmageed, Zakaria Y., additional, and Abu-Elfotuh, Karema, additional

Published
2022
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15. Unique localization of disseminated pancreas in the oesophagus of catfish (clarias gariepinus) with reference to sexual dimorphism

Author

Karkit, Mayada W., Salem, Hoda F., Bareedy, Mohammad H., and Elewa, Yaser H. A.

Subjects
oesophagus, glucagon-secreting alpha cells, pancreas, islets of Langerhans, insulin-secreting beta cells
Abstract

Background The fish pancreas has been reported to be composed of two portions: compact and disseminated. However, little has been elucidated in catfish. The present study describes a unique localization of the disseminated pancreas in African catfish. Methods The sections were obtained and used for either routine histological examination following staining with haematoxylin and eosin (H & E), periodic acid-Schiff's, or were subjected to immunohistochemical staining for detection of both insulin-producing beta cells and glucagon-producing alpha cells. Results Our investigation showed that the pancreas of catfish consisted of both compact and disseminated portions. The compact pancreas was embedded in the mesenteric adipose tissue between the spleen, stomach and liver. However, the disseminated one showed unique localization in the tunica adventitia of the middle portion of the oesophagus. The pancreas consisted of two portions, exocrine and endocrine. Furthermore, in both types of pancreas, the female showed a significantly higher ratio for the endocrine islet area/pancreatic tissue area than that of the male and also a significantly higher ratio for both insulin- and glucagon-positive area/islet area in the female pancreas (compact and disseminated) than that of the male. In conclusion The present study provides evidence on a unique localization of the disseminated pancreas in the oesophagus of catfish. Furthermore, we revealed sex-related difference in the endocrine portion in both pancreatic tissues with more development in the female. The study suggests that sex hormones could be contributed to such sexual dimorphism. However, further investigation is required to compare the degree of development during the spawning and resting seasons.

Published
2021

20. Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis

Author

Tony,Fatma Ahmed, Soliman,Youssef Mohamed Amin, salem,Hoda Abdelaziz, Tony,Fatma Ahmed, Soliman,Youssef Mohamed Amin, and salem,Hoda Abdelaziz

Abstract

Fatma Ahmed Tony,1 Youssef Mohamed Amin Soliman,2 Hoda A Salem3 1Clinical Pharmacy Department, Faculty of Pharmacy, British University in Egypt (BUE), Cairo, Egypt; 2Chest Department, El-Kasr Al-Aini Hospital, Faculty of Medicine, Cairo University, Giza, Egypt; 3Pharmacy Practice Department, Faculty of Pharmacy, Tabuk University and Al-Azhar University, Nasr City, EgyptCorrespondence: Fatma Ahmed TonyClinical Pharmacy Department, Faculty of Pharmacy, British University in Egypt (BUE), Cairo, 11837, EgyptTel +20 1004339333Email Fatmatony242@gmail.comBackground: Hypersensitivity pneumonitis (HP) is an immune-mediated disorder that causes inflammation of interstitial lung, bronchioles, and alveoli. Although corticosteroids have been used as first line treatment for HP for many years, it does not provide satisfactory results in all patients. The aim of this study is to compare the effect of oral methylprednisolone on different radiological patterns of HP to identify the most adequate candidates for corticosteroids.Patients and Methods: Fifty-three patients with confirmed diagnosis of HP were divided into two groups according to their radiological patterns based on high resolution computed tomography (HRCT) findings. The first group included 21 patients with fibrotic HP (fHP), the second group included 32 patients without fibrosis; non-fibrotic HP patients (nfHP). The second group is divided into 3 subgroups: mosaic, attenuation, centrilobular nodules and finally, ground-glass opacities. All patients were administered methylprednisolone by dose 0.5mg/kg/day for eight consecutive weeks. HRCT was performed at the beginning of the study. Spirometry, six-minute walk and oximetry were performed periodically to assess the patients’ progress.Results: Upon finalizing the treatment process, a significant improvement was noticed in FEV1 (p < 0.001), FVC (p < 0.001), six-minute walk test (p =0.001) and oximetry (p < 0.05) in nfHP compared to the fHP p

Published
2021

26. A randomized controlled trial evaluating the effects of amlodipine on myocardial iron deposition in pediatric patients with thalassemia major

Author

Khaled,Arwa, Salem,Hoda A, Ezzat,Dina, Seif,Haddel M, and Rabee,Hoda

Subjects
Drug Design, Development and Therapy
Abstract

Arwa Khaled,1 Hoda A Salem,2 Dina A Ezzat,3 Hadeel M Seif,4 Hoda Rabee51Department of Clinical Pharmacy, Beni-Suef University Hospital, Beni-Suef University, Beni Suef, 62515, Egypt; 2Department of Clinical Pharmacy, Faculty of Pharmacy, Al–azhar University, Girl Branch, Cairo, 12655, Egypt; 3Department of Pediatrics and Pediatric Hematology, Faculty of Medicine, Beni-Suef University, Beni Suef, 12568, Egypt; 4Department of Radiology, Faculty of Medicine, Cairo University Cairo, Cairo 8582, Egypt; 5Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, EgyptBackground: Mortality rates increase due to iron deposition in the cardiac muscles of thalassemia major (TM) patients. Iron overload cardiomyopathy could be treated with a combination therapy of an iron chelator and an L-type calcium channel blocker. We designed a randomized controlled study to assess the potential of amlodipine, alongside chelation, in reducing myocardial iron concentration in TM patients compared with a placebo.Objectives: This study aims to estimate the change in myocardial iron concentration (MIC) determined by magnetic resonance imaging after 6months of treatment with amlodipine, as well as measuring the changes in the secondary outcomes (liver iron concentration (LIC), serum ferritin level (SF), and left ventricle ejection fraction (LVEF)) of study participants.Methods: A single, randomized, placebo-controlled trial was performed in 40 β-Thalassemia major patients aged between 6 and 20years old, who received either oral amlodipine 2.5–5mg/day or a placebo, in addition to a Deferasirox chelation regimen in a 1:1 allocation ratio.Results: After 6months, a significant reduction was noted in the MIC of patients receiving amlodipine (n=20), compared with the patients receiving the placebo (n=20). At baseline, the mean was 0.76±0.11mg/g dry weight, while at 6months, the mean was 0.51±0.07mg/g dry weight (p

Published
2019

27. Effective method of evaluating myocardial iron concentration in pediatric patients with thalassemia major

Author

Khaled,Arwa, Ezzat,Dina A., Salem,Hoda A, Seif,Hadeel M, and Rabee,Hoda

Subjects
Journal of Blood Medicine
Abstract

Arwa Khaled,1 Dina A Ezzat,2 Hoda A Salem,3 Hadeel M Seif,4 Hoda Rabee51Department Of Clinical Pharmacy, Beni-Suef University Hospital, Beni-Suef University, Beni Suef, Egypt; 2Department of Pediatrics and Pediatric Hematology, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt; 3Department of Clinical Pharmacy, Faculty of Pharmacy, Al – Azhar University, Girl Branch, Cairo, Egypt; 4Department of Radiology, Faculty of Medicine, Cairo University, Cairo, Egypt; 5Department of Clinical Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni Suef, EgyptBackground: The use of T2* magnetic resonance imaging (MRI) has been promoted by recent studies as a noninvasive method for the detection of iron overload in thalassemia major patients. This study aims to estimate the iron load in the heart and liver of thalassemia major patients using T2* MRI and to determine its correlation with the left ventricle ejection fraction and serum ferritin level.Methods: Forty β-Thalassemia major patients were included in the study. We evaluated the serum ferritin level, echocardiography, cardiac T2*, myocardial iron concentration (MIC), liver iron concentration (LIC) and hepatic T2* in all patients. CMR T2* findings were categorized as normal cardiac T2* (T2* >20ms) or abnormal cardiac T2* (T2*

Published
2019

28. STRUCTURAL STUDY ON THE HEART VENTRICLES OF THE DOMESTIC DOGS (Canis familiaris) WITH SPECIAL REFERENCES TO CARDIOMYOCYTE ULTRASTRUCTURE.

Author

Salem, Hoda F., Beheiry, Rasha R., Kilany, Maha S., and El Sayed, Shafika A.

Subjects
*HEART ventricles, *DOGS, *CANIS, *PERICARDIUM, *CONNECTIVE tissues
Abstract

Our study aimed to investigate the light microscopic structure of the dog’s ventricular wall in addition to the fine structure of the cardiomyocytes and the interstitial telocytes. For this purpose, tissue samples from the ventricles of 15 adult domestic dogs (Canis familiaris) were prepared and processed for histological, immunohistochemical, and ultrastructural analysis. The ventricular wall consisted of; epicardium, myocardium, and endocardium. The mesothelium and subepicardial connective tissue layer made up the epicardium. The myocardium was composed of bundles of cardiomyocytes separated by loose connective tissue. The endocardium was lined with endothelium located above the subendothelial connective tissue. Purkinje fibers were found only beneath the sub endothelium in the subendocardial layer. The intercalated disc reacted positively to anti-E-cadherin protein. Under the transmission electron microscope (TEM) the ventricular cardiomyocyte appeared enveloped with a scalloped sarcolemma and had a striated sarcoplasm. The nucleus was oval, euchromatic, and centrally located. The mitochondria were multiple and polymorphic located either under the sarcolemma, between the myofibrils, or at the perinuclear pole. At the perinuclear pole, small electron-dense granules were observed. The intercalated disc was made up of desmosomes, adherens junctions, and gap junctions and bound the adjacent cardiomyocytes. Interstitial telocytes with cellular prolongations was evidenced. These interested microscopic structures of the dog’s ventricular wall are expected to help researchers better understand the physiology of the heart ventricles, also provide a control picture that improves the differentiation of ventricular pathological conditions. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Comparative Study of Antimicrobial Activity and Cytotoxicity of Saponin Extracted from Six Egyptian Sea-cucumber Species, Licorice, and Ginseng

Author

Eissa, Samia H., Salem, Hoda K., Omran, Nahla E., Kabbash, Amal M., Amer, Wesam H., and Kandeil, Manar A.

Abstract

Background: The study aimed to compare the antimicrobial activity and cytotoxicity of saponin extracted from six sea-cucumber species, licorice, and ginseng to determine the most potent one. Methods: Antimicrobial activity assessed by well diffusion and agar dilution methods. The inhibitory effects of the tested extracts on cell growth of Liver (HePG-2) and breast (MCF-7) cell lines assessed by MTT [3- (4, 5- dimethyl thiazol-2yl) - 2, 5- diphenyl tetrazolium bromide] assay. Results: The results revealed that licorice extract presented higher antibacterial activity against Gram-positive bacterial strains than sea-cucumber extracts; but has comparable results for Gramnegative (Salmonella tyhimurium, Klebsiella spp, and Acinetobacter baumanii). Holothuria atra body wall and Bohadschia tubules have the highest antifungal effect against Candida albicans, Candida krusei, Candida famata, Candida glabrata, and Candida tropicalis. Sea-cucumbers are more potent against fungal strains than licorice and ginseng extract. Licorice and ginseng presented higher cytotoxicity against HePG2 and MCF-7 cell lines than sea-cucumbers. Conclusion: This study promotes the use of licorice extract as a better antibacterial substance than sea-cucumber extracts; however, the use of sea-cucumber extracts as antifungal agents than herbal extracts. Also, we support the utilization of licorice and ginseng as a cytotoxic agent instead of seacucumbers to stop the fishing of animals and consequently save it from extinction.

Published
2021
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36. Histological and ultrastructural studies on the coronary artery of adult domestic dog (Canis familiaris).

Author

Kilany, Maha S., El Sayed, Shafika A., Salem, Hoda F., and Beheiry, Rasha R.

Subjects
DOGS, TRANSMISSION electron microscopes, CANIS, CORONARY arteries, CONNECTIVE tissues, LIGHT transmission
Abstract

The objective of this work was to study the histological structure of the dog's coronary artery by light and transmission electron microscope (TEM). The coronary artery consisted of three tunics: tunica intima, tunica media and tunica adventitia. The tunica intima consisted of endothelium rested directly on internal elastic lamina without the subendothelial connective tissue layer. The tunica media were composed of smooth muscle fibres interspersed with few elastic and collagen fibres. The tunica adventitia consisted of collagen and elastic fibres intermingled with fibroblast cells; it had vasa vasorum and nervi vasorum. Some histomorphometric measurements were performed and compared statistically. The ultrastructural study showed that the endothelial cells were communicated through complex junctions and characterised by filiform cytoplasmic processes passed through the opening of the underlying internal elastic membrane. The smooth muscle fibres of tunica media communicated with each other through cytoplasmic processes. The tunica adventitia showed minute non‐myelinated nerve. This work revealed that the dog's coronary arteries are typical muscular arteries, which show little structural variations from that of other mammals. [ABSTRACT FROM AUTHOR]

Published
2020
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39. Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study.

Author

El-Housiny, Shaimaa, Shams Eldeen, Maii Atef, El-Attar, Yasmina Ahmed, Salem, Hoda A., Attia, Dalia, Bendas, Ehab R., and El-Nabarawi, Mohamed A.

Subjects
TINEA versicolor, NANOPARTICLES, ANTIFUNGAL agents, FLUCONAZOLE, LIPIDS
Abstract

Solid lipid nanoparticles (SLNs) are very potential formulations for topical delivery of antifungal drugs. Hence, the purpose of this research was to formulate the well-known antifungal agent Fluconazole (FLZ)-loaded SLNs topical gel to improve its efficiency for treatment of Pityriasis Versicolor (PV). FLZ-SLNs were prepared by modified high shear homogenization and ultrasonication method using different concentration of solid lipid (Compritol 888 ATO, Precirol ATO5) and surfactant (Cremophor RH40, Poloxamer 407). The physicochemical properties and the in vitro release study for all FLZ-SLNs were investigated. Furthermore, the optimized FLZ-SLN formula was incorporated into gel using Carpobol 934. A randomized controlled clinical trial (RCT) of potential batches was carried out on 30 well diagnosed PV patients comparing to market product Candistan® 1% cream. Follow up was done for 4 weeks by clinical and KOH examinations. The results showed that FlZ-SLNs were almost spherical shape having colloidal sizes with no aggregation. The drug entrapment efficiency ranged from 55.49% to 83.04%. The zeta potential values lie between −21 and −33 mV presenting good stability. FLZ showed prolonged in vitro release from SLNs dispersion and its Carbapol gel following Higuchi order equation. Clinical studies registered significant improvement (p < .05) in therapeutic response (1.4-fold; healing%, 4-fold; complete eradication) in terms of clinical cure and mycological cure rate from PV against marketed cream. Findings of the study suggest that the developed FLZ loaded SLNs topical gels have superior significant fast therapeutic index in treatment of PV over commercially available Candistan® cream. [ABSTRACT FROM AUTHOR]

Published
2018
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40. Autologous transplantation of CD34+ bone marrow derived mononuclear cells in management of non-reconstructable critical lower limb ischemia

Author

Ismail, Ahmed M., primary, Abdou, Said M., additional, Aty, Hassan Abdel, additional, Kamhawy, Adel H., additional, Elhinedy, Mohammed, additional, Elwageh, Mohammed, additional, Taha, Atef, additional, Ezzat, Amal, additional, Salem, Hoda A., additional, Youssif, Said, additional, and Salem, Mohamed L., additional

Published
2014
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