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306 results on '"Salem, Ahmed M."'

6. Entropy Generation Analysis During Heat Transfer by Darcy-Forchheimer Flow of Water-Based Al2O3 Nanofluid over a Curved Stretchable Surface

Author

Mekheimer, Kh. S., Seddeek, M. A., Abo-Elkhair, R. E., Salem, Ahmed M., Gadelhak, Ayman A., Howlett, Robert J., Series Editor, Littlewood, John, Series Editor, Jain, Lakhmi C., Series Editor, Tripathi, Dharmendra, editor, Sharma, Ravi Kumar, editor, Oztop, Hakan F., editor, and Natarajan, Rajamohan, editor

Published
2023
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20. Developing the next generation of renewable energy technologies: an overview of low-TRL EU-funded research projects

Author

Pérez Caballero, Laura María, primary, Neira D'Angelo, Fernanda, additional, Tschentscher, Roman, additional, Gottschalk, Axel, additional, Salem, Ahmed M., additional, Carbonell, Daniel, additional, Dudita-Kauffeld, Mihaela, additional, Bruch, Arnaud, additional, Alamaro, Eleonora, additional, Pasquini, Luca, additional, Ceroni, Paola, additional, Grozdanova, Anastasia, additional, Privitera, Stefania, additional, Vermang, Bart, additional, Schulz, Philip, additional, Mencarelli, Davide, additional, Pierantoni, Luca, additional, Midrio, Michele, additional, Leithead, William, additional, Gurruchaga, Ignacio, additional, Haberl, Robert, additional, Vermaut, Jasper, additional, and Kauffeld, Michael, additional

Published
2023
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25. Pharmacokinetic Modeling Using Real‐World Data to Optimize Unfractionated Heparin Dosing in Pediatric Patients on Extracorporeal Membrane Oxygenation and Evaluate Target Achievement–Clinical Outcomes Relationship

Author

Salem, Ahmed M., primary, Smith, Trey, additional, Wilkes, Jacob, additional, Bailly, David K., additional, Heyrend, Caroline, additional, Profsky, Michael, additional, Yellepeddi, Venkata K., additional, and Gopalakrishnan, Mathangi, additional

Published
2023
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31. An empirical analysis of Libyan business environment and foreign direct investment

Author

Abdulla, Salem Ahmed M.

Subjects
337
Abstract

The economic development needs of developing countries require capital accumulation, which is no longer an easy task, even for industrialised countries. Although borrowing remains an important alternative, it has proved to be an expensive method in the long run. Consequently, to attract foreign direct investment (FDI), developing countries have been liberalising their economies, which is expected to contribute to job creation and income generation. At the beginning of the 21st century Libya declared its intention to liberalise its economy and to integrate into the global economy in order to achieve comprehensive development. This study investigates and explores the conditions of the Libyan business environment in relation to foreign and joint companies, particularly in the non-oil sectors. A questionnaire survey method was utilised to assemble the primary data. This was conducted with the representatives of both foreign and joint companies in order to establish their perceptions and opinions towards the Libyan business environment across various dimensions. In addition, a structured interview method was used with the Libyan senior officials to investigate the difficulties and challenges facing the General People’s Committees and bodies in improving the business environment. The questionnaire data were analysed using SPSS through descriptive and analytical statistics by employing frequency, factor analysis, chi-square of goodness of fit test and cross-tabulation tools, while interviews were analysed by using coding technique through interpretative analysis. To substantiate the results, the Porter model was utilised supported by a SWOT analysis with the objective of gauging how competitive the Libyan business environment is for attracting foreign direct investment. The study reveals that despite the numerous obstacles and shortcomings associated with the Libyan business environment, the country’s experiment for attracting FDI in the non-oil sectors can be described as successful. It also shows that despite this success, many foreign and joint projects have been cancelled as a result of difficulties associated with the Libyan business environment. The study also revealed that there are many challenges facing Libyan policy environment in order to reform the business environment to make it more attractive for FDI.

Published
2010

38. Pharmacokinetic Modeling Using Real‐World Data to Optimize Unfractionated Heparin Dosing in Pediatric Patients on Extracorporeal Membrane Oxygenation and Evaluate Target Achievement–Clinical Outcomes Relationship.

Author

Salem, Ahmed M., Smith, Trey, Wilkes, Jacob, Bailly, David K., Heyrend, Caroline, Profsky, Michael, Yellepeddi, Venkata K., and Gopalakrishnan, Mathangi

Subjects
*BIOLOGICAL models, *EXTRACORPOREAL membrane oxygenation, *PEDIATRICS, *RETROSPECTIVE studies, *TREATMENT duration, *TREATMENT effectiveness, *COMPARATIVE studies, *HEPARIN
Abstract

Unfractionated heparin (UFH) is a commonly used anticoagulant for pediatric patients undergoing extracorporeal membrane oxygenation (ECMO), but evidence is lacking on the ideal dosing. We aimed to (1) develop a population pharmacokinetic (PK) model for UFH, measured through anti–factor Xa assay; (2) optimize UFH starting infusions and dose titrations through simulations; and (3) explore UFH exposure–clinical outcomes relationship. Data from 218 patients admitted to Utah's Primary Children's Hospital were retrospectively collected. A 1‐compartment PK model with time‐varying clearance (CL) adequately described UFH PK. Weight on CL and volume of distribution and ECMO circuit change on CL were significant covariates. The typical estimates for initial CL and first‐order rate constant to reach steady‐state CL were 0.57 L/(h·10 kg) and 0.02/h. Comparable to non‐ECMO patients, the typical steady‐state CL was 0.81 L/(h·10 kg). Simulations showed that a 75 IU/kg UFH bolus dose followed by starting infusions of 25 and 20 IU/h/kg for patients aged younger than 6 years and 6 years or older, respectively, achieved the therapeutic target in 56.6% of all patients, whereas only 3.1% exceeded the target. The proposed UFH titration schemes achieved the target in more than 90% of patients while less than 0.63% were above the target after 24 and 48 hours of treatment. The median intensive care unit survival time in patients within and below the target at 24 hours was 136 and 66 hours, respectively. In conclusion, PK model of UFH was developed for pediatric patients on ECMO. The proposed UFH dosing scheme attained the anti–factor Xa target rapidly and safely. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Characteristics of conventional high-risk coronary plaques and a novel CT defined thin-cap fibroatheroma in patients undergoing CCTA with stable chest pain

Author

Salem, Ahmed M, Davis, Joel, Gopalan, Deepa, Rudd, James HF, Clarke, Sarah C, Schofield, Peter M, Bennett, Martin R, Brown, Adam J, Obaid, Daniel R, Rudd, James [0000-0003-2243-3117], and Apollo - University of Cambridge Repository

Subjects
Cardiac events, High-risk plaques, Atherosclerosis, Coronary computed tomography
Abstract

BACKGROUND: Coronary computed tomography angiography (CCTA) can identify high-risk coronary plaque types. However, the inter-observer variability for high-risk plaque features, including low attenuation plaque (LAP), positive remodelling (PR), and the Napkin-Ring sign (NRS), may reduce their utility, especially amongst less experienced readers. METHODOLOGY: In a prospective study, we compared the prevalence, location and inter-observer variability of both conventional CT-defined high-risk plaques with a novel index based on quantifying the ratio of necrotic core to fibrous plaque using individualised X-ray attenuation cut-offs (the CT-defined thin-cap fibroatheroma - CT-TCFA) in 100 patients followed-up for 7 years. RESULTS: In total, 346 plaques were identified in all patients. Seventy-two (21%) of all plaques were classified by conventional CT parameters as high-risk (either NRS or PR and LAP combined), and 43 (12%) of plaques were considered high-risk using the novel CT-TCFA definition of (Necrotic Core/fibrous plaque ratio of >0.9). The majority (80%) of the high-risk plaques (LAP&PR, NRS and CT-TCFA) were located in the proximal and mid-LAD and RCA. The kappa co-efficient of inter-observer variability (k) for NRS was 0.4 and for PR and LAP combined 0.4. While the kappa co-efficient of inter-observer variability (k) for the new CT-TCFA definition was 0.7. During follow-up, patients with either conventional high-risk plaques or CT-TCFAs were significantly more likely to have MACE (Major adverse cardiovascular events) compared to patients without coronary plaques (p value 0.03 & 0.03, respectively). CONCLUSION: The novel CT-TCFA is associated with MACE and has improved inter-observer variability compared with current CT-defined high-risk plaques.

Published
2023

41. Developing the next generation of renewable energy technologies: an overview of low-TRL EU-funded research projects

Author

Pérez Caballero, Laura María, Neira D'Angelo, Fernanda, Tschentscher, Roman, Gottschalk, Axel, Salem, Ahmed M., Carbonell, Daniel, Dudita-Kauffeld, Mihaela, Bruch, Arnaud, Alamaro, Eleonora, Pasquini, Luca, Ceroni, Paola, Grozdanova, Anastasia, Privitera, Stefania, Vermang, Bart, Schulz, Philip, Mencarelli, Davide, Pierantoni, Luca, Midrio, Michele, Leithead, William, Gurruchaga, Ignacio, Haberl, Robert, Vermaut, Jasper, Kauffeld, Michael, Pérez Caballero, Laura María, Neira D'Angelo, Fernanda, Tschentscher, Roman, Gottschalk, Axel, Salem, Ahmed M., Carbonell, Daniel, Dudita-Kauffeld, Mihaela, Bruch, Arnaud, Alamaro, Eleonora, Pasquini, Luca, Ceroni, Paola, Grozdanova, Anastasia, Privitera, Stefania, Vermang, Bart, Schulz, Philip, Mencarelli, Davide, Pierantoni, Luca, Midrio, Michele, Leithead, William, Gurruchaga, Ignacio, Haberl, Robert, Vermaut, Jasper, and Kauffeld, Michael

Abstract

A cluster of eleven research and innovation projects, funded under the same call of the EU’s H2020 programme, are developing breakthrough and game-changing renewable energy technologies that will form the backbone of the energy system by 2030 and 2050 are, at present, at an early stage of development. These projects have joined forces at a collaborative workshop, entitled ‘ Low-TRL Renewable Energy Technologies’, at the 10th Sustainable Places Conference (SP2022), to share their insights, present their projects’ progress and achievements to date, and expose their approach for exploitation and market uptake of their solutions.

Published
2023

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