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Background & Objective: To evaluate fertility outcomes in infertile women with severe endometriosis who underwent Frozen embryo transfer (FET) after laparoscopic surgery and assess the optimal time interval between laparoscopy and FET. Materials & Methods: Number of 215 females with advanced-stage endometriosis were included in this retrospective cohort study. At first embryo were then laparoscopic surgery was performed. Patients received gonadotropin-releasing hormone agonist (GnRH agonist) for the next three months after the laparoscopic surgery. FET was scheduled during the next several time-points after the laparoscopic surgery. The results of treatment such as live birth, the interval between the operation and pregnancy, improved dysmenorrhea/dyspareunia, and post-operative complications were evaluated. Results: A total of 215 patients with a mean ± SD age of 34.33 ± 6.62 were included, among which, 143 cases (86.2%) had no past medical history. Ninety-three individuals (44%) were referred for the first IVF procedure. The mean ± SD of the infertility period was 4.71 ± 5.43 years. The mean ± SD number of frozen embryos was 2.53 ± 3.36 and the period between the laparoscopic intervention and IVF was 1.58 ± 2.65 months. Conclusion: Women with severe endometriosis may benefit from embryo freezing before laparoscopic surgery then FET. The optimal time between laparoscopy and embryo transfer is seemed to be between two and four months. [ABSTRACT FROM AUTHOR]

Toluene di-isocyanate (TDI) is extensively used in the manufacture of flexible polyurethane foams. The present study aimed to examine pulmonary function indices and respiratory symptoms in individuals exposed to isocyanates. Spirometric indices of 136 employees, 91 (66.91%) of whom were directly exposed to isocyanates and 45 (33.08%) were not exposed. These informations regarding demographic characteristics and respiratory symptoms, including coughs and dyspnea, were collected using a questionnaire from 2013 to 2016. The mean values of all respiratory indices decreased significantly in both groups over the 4 year period. There was a significant relationship between the decline in all indices and age, work experience and smoking. In the exposed group, a decrease in FEV1 and FEV1/FVC was significantly higher in smokers than in the non-exposed group. The exposed group, although younger and with a lower smoking rate, which has lower respiratory indices than the non-exposed group at the beginning and end of the measurement. [ABSTRACT FROM AUTHOR]

Introduction: According to WHO, 190 million reproductive-aged women are affected by endometriosis. Using self-care interventions has a significant impact on managing endometriosis-related pain. Despite the enormous potential of different endometriosis applications, the medical professionals’ role has been neglected in the process of app development. This study aimed to extract the requirements for developing a mobile-based app for self-care of endometriosis patients through an overview of the literature and validate them according to the expert gynecologists’ point of view. Material and Methods: This cross-sectional descriptive study was carried out in two steps. First, endometriosis-related articles were reviewed. Second, a researcher-made questionnaire (Cronbach’s alpha=0.98) was designed to validate the identified information elements. Elements that obtained at least an average score of 3.2 (60%) out of 5-point Likert scale, were considered as required data elements for designing an android-based mobile app for self-care of endometriosis patients. Results: Based on the literature review, 36 studies were retrieved and 126 data elements were extracted. The elements were classified into six categories including electronic health record, educational materials, followup, pain management, nutritional diet, and lifestyle. All data elements except “using traditional opioids/drugs” were verified. Conclusion: In this study, a minimum data set was achieved for designing an endometriosis mobile app. Since due to the lack of international standards for designing health apps, the results of this research can be beneficial for the design and development of endometriosis apps. In the current research, an effort has been made to study all related references carefully in order to provide a comprehensive data set for designing and developing an app. This data set could be useful not only for designing a mobile-based app but also for the design of any other systems which is related to endometriosis. [ABSTRACT FROM AUTHOR]

Purpose: Assessment of patients for temporal lobe epilepsy (TLE) surgery requires multimodality input, including EEG recordings to ensure optimal surgical planning. Often EEG demonstrates abnormal foci not detected on 1.5T MRI. Ultra-high field MRI at 7T provides improved resolution of the brain. We investigated the utility of 7T MRI to detect potential anatomical abnormalities associated with EEG changes. Methods: Ultra-high field data were acquired on a 7T MRI scanner for 13 patients with history of drug resistant TLE who had had EEG telemetry recordings. Qualitative evaluation of 7T imaging for presence of focal abnormalities detected on EEG was performed. Correlation of 7T MRI findings with EEG recordings of focal slowing or interictal epileptic spikes (IEDs), and seizures was performed. Results: Assessment of 7T MRI demonstrated concordance with TLE as determined by the multidisciplinary team in 61.5% of cases (n = 8). Among these, 3 patients exhibited supportive abnormal 7T MRI abnormalities not detected by 1.5T MRI. In patients who underwent surgery, 72.7% had concordant histopathology findings with 7T MRI findings (n = 8). However, qualitative assessment of 7T images revealed focal anatomical abnormalities to account for EEG findings in only 15.4% of patients (n = 2). Other regions that were found to have localized IEDs in addition to the lesional temporal lobe, included the contralateral temporal lobe (n = 5), frontal lobe (n = 3), and parieto-occipital lobe (n = 2). Conclusion: Ultra-high field 7T MRI findings show concordance with clinical data. However, 7T MRI did not reveal anatomical findings to account for abnormalities detected by EEG. [ABSTRACT FROM AUTHOR]

Introduction: Tobacco use plays an important role in the development of oral lesions. The aim of this study was to evaluate the relationship between tobacco use and the incidence of these lesions. Materials & Methods: This cross-sectional study was performed on 399 patients referred to Qom Dental School in four groups of non-tobacco users (n=146), cigarette smokers (n=98), water pipe smokers (hookah) (n=81), and cigarette and water pipe smokers (n=74) .Oral lesions, dental caries, halitosis and xerostomia were evaluated with the help of oral examination and the use of a questionnaire. Data were analyzed using the SPSS 24, ANOVA, Chi-square test (P<0.05). Results: The highest prevalence of oral mucosal lesions (98.6%) was noted in group 4 (cigarette and water pipe smokers). Gingivitis, periodontitis, and coated tongue had the highest frequency among all oral mucosal lesions. Xerostomia, halitosis, impaired sense of taste, hairy tongue, coated tongue, nicotinic stomatitis, leukoedema, smoker's melanosis, and non-keratotic white plaques had significant correlations with tobacco use (P<0.05). Decayed, Missing and Filled Teeth (DMFT) also had a significant correlation with tobacco use (P<0.05). Conclusion: A wide and varied range of oral mucosal lesions was observed in smokers. Due to its harmful influence on the oral mucosa and awareness of the prevalence of lesions and increase the risk of oral cancer, periodic examinations by specialists are emphasized. [ABSTRACT FROM AUTHOR]