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4. COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS

Author

de Souza Xavier Costa, Natália, Ribeiro Júnior, Gabriel, do Nascimento, Ellen Caroline Toledo, de Brito, Jôse Mara, Antonangelo, Leila, Faria, Caroline Silvério, Monteiro, Jhonatas Sirino, Setubal, João Carlos, Pinho, João Renato Rebello, Pereira, Roberta Verciano, Seelaender, Marilia, de Castro, Gabriela Salim, Lima, Joanna D. C. C., de Almeida Monteiro, Renata Aparecida, Duarte-Neto, Amaro Nunes, Saldiva, Paulo Hilário Nascimento, Ferraz da Silva, Luiz Fernando, Dolhnikoff, Marisa, and Mauad, Thais

Published
2023
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5. Comparison for the effects of different components of temperature variability on mortality: A multi-country time-series study

Author

Wen, Bo, Wu, Yao, Guo, Yuming, Gasparrini, Antonio, Tong, Shilu, Overcenco, Ala, Urban, Aleš, Schneider, Alexandra, Entezari, Alireza, Vicedo-Cabrera, Ana Maria, Zanobetti, Antonella, Analitis, Antonis, Zeka, Ariana, Tobias, Aurelio, Nunes, Baltazar, Alahmad, Barrak, Armstrong, Ben, Forsberg, Bertil, Pan, Shih-Chun, Íñiguez, Carmen, Ameling, Caroline, Valencia, César De la Cruz, Åström, Christofer, Houthuijs, Danny, Van Dung, Do, Royé, Dominic, Indermitte, Ene, Lavigne, Eric, Mayvaneh, Fatemeh, Acquaotta, Fiorella, de’Donato, Francesca, Rao, Shilpa, Sera, Francesco, Carrasco-Escobar, Gabriel, Kan, Haidong, Orru, Hans, Kim, Ho, Holobaca, Iulian-Horia, Kyselý, Jan, Madureira, Joana, Schwartz, Joel, Jaakkola, Jouni J.K., Katsouyanni, Klea, Diaz, Magali Hurtado, Ragettli, Martina S., Hashizume, Masahiro, Pascal, Mathilde, Coélho, Micheline de Sousa Zanotti Stagliorio, Ortega, Nicolás Valdés, Ryti, Niilo, Scovronick, Noah, Michelozzi, Paola, Matus Correa, Patricia, Goodman, Patrick, Saldiva, Paulo Hilario Nascimento, Raz, Raanan, Abrutzky, Rosana, Osorio, Samuel, Dang, Tran Ngoc, Colistro, Valentina, Huber, Veronika, Lee, Whanhee, Seposo, Xerxes, Honda, Yasushi, Kim, Yoonhee, Guo, Yue Leon, Bell, Michelle L., and Li, Shanshan

Published
2024
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13. The association of COVID-19 incidence with temperature, humidity, and UV radiation – A global multi-city analysis

Author

Nottmeyer, Luise, Armstrong, Ben, Lowe, Rachel, Abbott, Sam, Meakin, Sophie, O'Reilly, Kathleen M., von Borries, Rosa, Schneider, Rochelle, Royé, Dominic, Hashizume, Masahiro, Pascal, Mathilde, Tobias, Aurelio, Vicedo-Cabrera, Ana Maria, Lavigne, Eric, Correa, Patricia Matus, Ortega, Nicolás Valdés, Kynčl, Jan, Urban, Aleš, Orru, Hans, Ryti, Niilo, Jaakkola, Jouni, Dallavalle, Marco, Schneider, Alexandra, Honda, Yasushi, Ng, Chris Fook Sheng, Alahmad, Barrak, Carrasco-Escobar, Gabriel, Holobâc, Iulian Horia, Kim, Ho, Lee, Whanhee, Íñiguez, Carmen, Bell, Michelle L., Zanobetti, Antonella, Schwartz, Joel, Scovronick, Noah, Coélho, Micheline de Sousa Zanotti Stagliorio, Saldiva, Paulo Hilario Nascimento, Diaz, Magali Hurtado, Gasparrini, Antonio, and Sera, Francesco

Published
2023
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14. Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19

Author

Erjefält, Jonas S., de Souza Xavier Costa, Natália, Jönsson, Jimmie, Cozzolino, Olga, Dantas, Katia Cristina, Clausson, Carl-Magnus, Siddhuraj, Premkumar, Lindö, Caroline, Alyamani, Manar, Lombardi, Suzete Cleusa Ferreira Spina, Mendroni Júnior, Alfredo, Antonangelo, Leila, Faria, Caroline Silvério, Duarte-Neto, Amaro Nunes, de Almeida Monteiro, Renata Aparecida, Rebello Pinho, João Renato, Gomes-Gouvêa, Michele Soares, Verciano Pereira, Roberta, Monteiro, Jhonatas Sirino, Setubal, João Carlos, de Oliveira, Ellen Pierre, Theodoro Filho, Jair, Sanden, Caroline, Orengo, Jamie M., Sleeman, Matthew A., da Silva, Luiz Fernando Ferraz, Saldiva, Paulo Hilário Nascimento, Dolhnikoff, Marisa, and Mauad, Thais

Published
2022
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15. Validation of physician certified verbal autopsy using conventional autopsy: a large study of adult non-external causes of death in a metropolitan area in Brazil

Author

de André, Carmen Diva Saldiva, Bierrenbach, Ana Luiza, Barroso, Lucia Pereira, de André, Paulo Afonso, Justo, Lisie Tocci, Pereira, Luiz Alberto Amador, Taniguchi, Mauro T., Minto, Cátia Martinez, Takecian, Pedro Losco, Kamaura, Leonardo Tadashi, Ferreira, João Eduardo, Hazard, Riley H., Mclaughlin, Deirdre, Riley, Ian, Lopez, Alan D., Ramos, Ana Maria de Oliveira, de Souza, Maria de Fatima Marinho, França, Elisabeth Barboza, Saldiva, Paulo Hilário Nascimento, and da Silva, Luiz Fernando Ferraz

Published
2022
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16. A New Method Proposed for the Estimation of Exposure to Atmospheric Pollution through the Analysis of Black Pigments on the Lung Surface.

Author

Waked, Dunia, Veras, Mariana Matera, Saldiva, Paulo Hilário Nascimento, and Takano, Ana Paula Cremasco

Subjects
AIR pollution, DUST diseases, PARTICULATE matter, HUMAN ecology, REMOTE sensing, INHALERS
Abstract

Megacities can be considered excellent laboratories for studying the effects of the urban environment on human health. Typically, exposure to pollution is estimated according to daily or annual averages of pollutant concentrations, collected at monitoring stations, using satellite data for remote sensing of pollutant levels, considering proximity to major roads, or through personal exposure monitoring with portable sensors. However, these approaches fall short in identifying individual exposure values over a lifetime. It is well established that individuals living in large urban areas inhale atmospheric particles containing carbonaceous components, resulting in the deposition of black pigments in lung tissue, known as black carbon or anthracosis. This study aims to detail the procedures for assessing the deposition of such pigments, which serve as an estimate of an individual's exposure to atmospheric pollution particles. Data collection involves administering detailed questionnaires and capturing lung images in the autopsy room. The analysis is based on macroscopic quantification of black pigments, supplemented by an evaluation of personal habits and the clinical histories of the individuals. This method of estimating lifetime exposure to inhaled particles provides a valuable tool for understanding the correlation between urban living and its potential health effects. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Validation of SmartVA using conventional autopsy: A study of adult deaths in Brazil

Author

Hart, John D., de André, Paulo Afonso, de André, Carmen Diva Saldiva, Adair, Tim, Barroso, Lucia Pereira, Valongueiro, Sandra, Bierrenbach, Ana Luiza, de Carvalho, Patrícia Ismael, Antunes, Maria Bernadete de Cerqueira, de Oliveira, Conceição Maria, Pereira, Luiz Alberto Amador, Minto, Cátia Martinez, Bezerra, Tânia Maria da Silva, Costa, Sérgio Parente, de Azevedo, Bárbara Araújo, de Lima, José Ricardo Alves, Mota, Denise Souza de Meira, Ramos, Ana Maria de Oliveira, de Souza, Maria de Fátima Marinho, da Silva, Luiz Fernando Ferraz, França, Elisabeth Barboza, McLaughlin, Deirdre, Riley, Ian D., and Saldiva, Paulo Hilário Nascimento

Published
2022
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21. An autopsy study of the spectrum of severe COVID-19 in children: From SARS to different phenotypes of MIS-C

Author

Duarte-Neto, Amaro Nunes, Caldini, Elia Garcia, Gomes-Gouvêa, Michele Soares, Kanamura, Cristina Takami, de Almeida Monteiro, Renata Aparecida, Ferranti, Juliana Ferreira, Ventura, Andrea Maria Cordeiro, Regalio, Fabiane Aliotti, Fiorenzano, Daniela Matos, Gibelli, Maria Augusta Bento Cicaroni, Carvalho, Werther Brunow de, Leal, Gabriela Nunes, Pinho, João Renato Rebello, Delgado, Artur Figueiredo, Carneiro-Sampaio, Magda, Mauad, Thais, Ferraz da Silva, Luiz Fernando, Saldiva, Paulo Hilario Nascimento, and Dolhnikoff, Marisa

Published
2021
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25. Linha do tempo do 'tratamento precoce' para Covid-19 no Brasil: desinformação e comunicação do Ministério da Saúde/Timeline of Covid-19 'early treatment' in Brazil: disinformation and communications from the Ministry of Health/Línea del tiempo del 'tratamiento precoz' para Covid-19 en Brasil: desinformación y comunicación del Ministerio de la Salud

Author

Floss, Mayara, Tolotti, Gabrielle, dos Santos Rossetto, Andrei, de Camargo, Tatiana Souza, and Saldiva, Paulo Hilário Nascimento

Published
2023
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26. Air pollution aggravates renal ischaemia–reperfusion‐induced acute kidney injury.

Author

Sanches, Talita Rojas, Parra, Antonio Carlos, Sun, Peiqi, Graner, Mariana Pereira, Itto, Lucas Yuji Umesaki, Butter, Loes Maria, Claessen, Nike, Roelofs, Joris JTH, Florquin, Sandrine, Veras, Mariana Matera, Andrade, Maria de Fatima, Saldiva, Paulo Hilário Nascimento, Kers, Jesper, Andrade, Lucia, and Tammaro, Alessandra

Subjects
ACUTE kidney failure, AIR pollution, PARTICULATE matter, DISEASE risk factors, CHRONIC kidney failure, PASSIVE euthanasia
Abstract

Chronic kidney disease (CKD) has emerged as a significant global public health concern. Recent epidemiological studies have highlighted the link between exposure to fine particulate matter (PM2.5) and a decline in renal function. PM2.5 exerts harmful effects on various organs through oxidative stress and inflammation. Acute kidney injury (AKI) resulting from ischaemia–reperfusion injury (IRI) involves biological processes similar to those involved in PM2.5 toxicity and is a known risk factor for CKD. The objective of this study was to investigate the impact of PM2.5 exposure on IRI‐induced AKI. Through a unique environmentally controlled setup, mice were exposed to urban PM2.5 or filtered air for 12 weeks before IRI followed by euthanasia 48 h after surgery. Animals exposed to PM2.5 and IRI exhibited reduced glomerular filtration, impaired urine concentration ability, and significant tubular damage. Further, PM2.5 aggravated local innate immune responses and mitochondrial dysfunction, as well as enhancing cyclic GMP–AMP synthase‐stimulator of interferon genes (cGAS–STING) pathway activation. This increased renal senescence and suppressed the anti‐ageing protein klotho, leading to early fibrotic changes. In vitro studies using proximal tubular epithelial cells exposed to PM2.5 and hypoxia/reoxygenation revealed heightened activation of the STING pathway triggered by cytoplasmic mitochondrial DNA, resulting in increased tubular damage and a pro‐inflammatory phenotype. In summary, our findings imply a role for PM2.5 in sensitising proximal tubular epithelial cells to IRI‐induced damage, suggesting a plausible association between PM2.5 exposure and heightened susceptibility to CKD in individuals experiencing AKI. Strategies aimed at reducing PM2.5 concentrations and implementing preventive measures may improve outcomes for AKI patients and mitigate the progression from AKI to CKD. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Main autopsy findings of visceral involvement by fatal mpox in patients with AIDS: necrotising nodular pneumonia, nodular ulcerative colitis, and diffuse vasculopathy

Author

Duarte-Neto, Amaro Nunes, primary, Gonçalves, Ana Maria, additional, Eliodoro, Raissa Heloisa de Araujo, additional, Martins, Wilker Dias, additional, Claro, Ingra Morales, additional, Valença, Ian Nunes, additional, Paes, Vitor Ribeiro, additional, Teixeira, Ralcyon, additional, Sztajnbok, Jaques, additional, França e Silva, Ivan Leonardo Avelino, additional, Leite, Luiz Antônio Ferreira, additional, Malaque, Ceila Maria Sant'Ana, additional, Borges, Luciana Marques Sansão, additional, Gonzalez, Mario Peribanez, additional, Barra, Luiz Alberto Costa, additional, Junior, Luiz Carlos Pereira, additional, Mello, Claudia Figueiredo, additional, Queiroz, Wladimir, additional, Atomya, Angela Naomi, additional, Fernezlian, Sandra de Morais, additional, Alves, Venâncio Avancini Ferreira, additional, Leite, Katia Ramos Moreira, additional, Ferreira, Cristiane Rubia, additional, Saldiva, Paulo Hilário Nascimento, additional, Mauad, Thais, additional, da Silva, Luiz Fernando Ferraz, additional, Faria, Nuno R, additional, Mendes Corrêa, Maria Cássia Jacinto, additional, Sabino, Ester Cerdeira, additional, Sotto, Mirian Nacagami, additional, and Dolhnikoff, Marisa, additional

Published
2023
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31. Morphometric brain changes during aging: Results from a Brazilian necropsy sample

Author

de Lucena Ferretti, Renata Eloah, Jacob-Filho, Wilson, Grinberg, Lea Tenenholz, Leite, Renata Elaine Paraízo, Farfel, José Marcelo, Suemoto, Claudia Kimie, Saldiva, Paulo Hilário Nascimento, Rosemberg, Sérgio, Pasqualucci, Carlos Augusto, and Nitrini, Ricardo

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Aging, Clinical Research, aging, brain/anatomy, cephalometry, Biological psychology
Abstract

The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes.MethodsA cross-sectional study was conducted at the São Paulo Autopsy Service in Brazil where, after informed consent, data was gathered from next of kin interview with reference to clinical status prior to death. Brain weight, volume and density measurements were taken and then adjusted for head circumference. Descriptive statistics and tests of hypothesis and correlations were applied, considering a p-value of 0.05.Results414 subjects, mostly men (60.4%), with a mean age of 67.1 years, were included. The mean brain weight of the sample was 1219.2g±140.9and mean volume was 1217mL±152.3. The mean brain density of the sample was 1.0g/mL±0.09. Values differed between males and females in terms of weight and volume. Brain weight decreased during aging by about 45g per decade (r= -0.300; p

Published
2010

32. Morphometric brain changes during aging: Results from a Brazilian necropsy sample.

Author

Ferretti, Renata Eloah de Lucena, Jacob-Filho, Wilson, Grinberg, Lea Tenenholz, Leite, Renata Elaine Paraízo, Farfel, José Marcelo, Suemoto, Claudia Kimie, Saldiva, Paulo Hilário Nascimento, Rosemberg, Sérgio, Pasqualucci, Carlos Augusto, and Nitrini, Ricardo

Subjects
aging, brain/anatomy, cephalometry
Abstract

The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes. Methods:A cross-sectional study was conducted at the São Paulo Autopsy Service in Brazil where, after informed consent, data was gathered from next of kin interview with reference to clinical status prior to death. Brain weight, volume and density measurements were taken and then adjusted for head circumference. Descriptive statistics and tests of hypothesis and correlations were applied, considering a p-value of 0.05. Results:414 subjects, mostly men (60.4%), with a mean age of 67.1 years, were included. The mean brain weight of the sample was 1219.2g±140.9and mean volume was 1217mL±152.3. The mean brain density of the sample was 1.0g/mL±0.09. Values differed between males and females in terms of weight and volume. Brain weight decreased during aging by about 45g per decade (r= -0.300; p

Published
2010

33. Post-Mortem diagnosis of dementia by informant interview.

Author

Ferretti, Renata Eloah de Lucena, Damin, Antonio Eduardo, Brucki, Sonia Maria Dozzi, Morillo, Lilian Schafirovits, Perroco, Tibor Rilho, Campora, Flávia, Moreira, Eliza Guccione, Balbino, Érika Silvério, Lima, Maria do Carmo de Ascenção, Battela, Camila, Ruiz, Lumena, Grinberg, Lea Tenenholz, Farfel, José Marcelo, Leite, Renata Elaine Paraiso, Suemoto, Claudia Kimie, Pasqualucci, Carlos Augusto, Rosemberg, Sérgio, Saldiva, Paulo Hilário Nascimento, Jacob-Filho, Wilson, and Nitrini, Ricardo

Subjects
aging, brain bank, dementia, informant-interview, postmortem diagnosis
Abstract

The diagnosis of normal cognition or dementia in the Brazilian Brain Bank of the Aging Brain Study Group (BBBABSG) has relied on postmortem interview with an informant. Objectives:To ascertain the sensitivity and specificity of postmortem diagnosis based on informant interview compared against the diagnosis established at a memory clinic. Methods:A prospective study was conducted at the BBBABSG and at the Reference Center for Cognitive Disorders (RCCD), a specialized memory clinic of the Hospital das Clínicas, University of São Paulo Medical School. Control subjects and cognitively impaired subjects were referred from the Hospital das Clínicas to the RCCD where subjects and their informants were assessed. The same informant was then interviewed at the BBBABSG. Specialists' panel consensus, in each group, determined the final diagnosis of the case, blind to other center's diagnosis. Data was compared for frequency of diagnostic equivalence. For this study, the diagnosis established at the RCCD was accepted as the gold standard. Sensitivity and specificity were computed. Results:Ninety individuals were included, 45 with dementia and 45 without dementia (26 cognitively normal and 19 cognitively impaired but non-demented). The informant interview at the BBBABSG had a sensitivity of 86.6% and specificity of 84.4% for the diagnosis of dementia, and a sensitivity of 65.3% and specificity of 93.7% for the diagnosis of normal cognition. Conclusions:The informant interview used at the BBBABSG has a high specificity and sensitivity for the diagnosis of dementia as well as a high specificity for the diagnosis of normal cognition.

Published
2010

35. Short-term exposure to air pollution (PM2.5) induces hypothalamic inflammation, and long-term leads to leptin resistance and obesity via Tlr4/Ikbke in mice

Author

Campolim, Clara Machado, Weissmann, Lais, Ferreira, Clílton Kraüss de Oliveira, Zordão, Olivia Pizetta, Dornellas, Ana Paula Segantine, de Castro, Gisele, Zanotto, Tamires Marques, Boico, Vitor Ferreira, Quaresma, Paula Gabriele Fernandes, Lima, Raquel Patrícia Ataíde, Donato, Jr, Jose, Veras, Mariana Matera, Saldiva, Paulo Hilário Nascimento, Kim, Young-Bum, and Prada, Patricia Oliveira

Published
2020
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36. Nrf2 positively regulates autophagy antioxidant response in human bronchial epithelial cells exposed to diesel exhaust particles

Author

Frias, Daniela Perroni, Gomes, Raquel Labiapari Nunes, Yoshizaki, Kelly, Carvalho-Oliveira, Regiani, Matsuda, Monique, Junqueira, Mara de Souza, Teodoro, Walcy Rosolia, Vasconcellos, Pérola de Castro, Pereira, Daniela Cristina de Almeida, Conceição, Paulo Roberto da, Saldiva, Paulo Hilário Nascimento, Mauad, Thais, and Macchione, Mariangela

Published
2020
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37. Origin of the São Paulo Yellow Fever epidemic of 2017–2018 revealed through molecular epidemiological analysis of fatal cases

Author

Cunha, Marielton dos Passos, Duarte-Neto, Amaro Nunes, Pour, Shahab Zaki, Ortiz-Baez, Ayda Susana, Černý, Jiří, Pereira, Bárbara Brito de Souza, Braconi, Carla Torres, Ho, Yeh-Li, Perondi, Beatriz, Sztajnbok, Jaques, Alves, Venancio Avancini Ferreira, Dolhnikoff, Marisa, Holmes, Edward C., Saldiva, Paulo Hilário Nascimento, and Zanotto, Paolo Marinho de Andrade

Published
2019
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39. Maternal exposure to air pollution alters energy balance transiently according to gender and changes gut microbiota

Author

Zordão, Olivia Pizetta, primary, Campolim, Clara Machado, additional, Yariwake, Victor Yuji, additional, Castro, Gisele, additional, Ferreira, Clílton Kraüss de Oliveira, additional, Santos, Andrey, additional, Norberto, Sónia, additional, Veras, Mariana Matera, additional, Saad, Mario Jose Abdalla, additional, Saldiva, Paulo Hilário Nascimento, additional, Kim, Young-Bum, additional, and Prada, Patricia Oliveira, additional

Published
2023
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44. Association Between Hydrological Conditions and Dengue Fever Incidence in Coastal Southeastern China From 2013 to 2019

Author

Li, Chuanxi, primary, Wang, Zhendong, additional, Yan, Yu, additional, Qu, Yinan, additional, Hou, Liangyu, additional, Li, Yijie, additional, Chu, Cordia, additional, Woodward, Alistair, additional, Schikowski, Tamara, additional, Saldiva, Paulo Hilário Nascimento, additional, Liu, Qiyong, additional, Zhao, Qi, additional, and Ma, Wei, additional

Published
2023
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45. Mortality risk attributable to high and low ambient temperature: a multicountry observational study

Author

Gasparrini, Antonio, Guo, Yuming, Hashizume, Masahiro, Lavigne, Eric, Zanobetti, Antonella, Schwartz, Joel, Tobias, Aurelio, Tong, Shilu, Rocklöv, Joacim, Forsberg, Bertil, Leone, Michela, De Sario, Manuela, Bell, Michelle L, Guo, Yue-Liang Leon, Wu, Chang-fu, Kan, Haidong, Yi, Seung-Muk, de Sousa Zanotti Stagliorio Coelho, Micheline, Saldiva, Paulo Hilario Nascimento, Honda, Yasushi, Kim, Ho, and Armstrong, Ben

Published
2015
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46. Línea del tiempo del 'tratamiento precoz' para Covid-19 en Brasil: desinformación y comunicación del Ministerio de la Salud

Author

Floss, Mayara, Tolotti, Gabrielle, Rossetto, Andrei dos Santos, Camargo, Tatiana Souza de, and Saldiva, Paulo Hilário Nascimento

Subjects
Pandemia, Pandemic, Sobremedicalización, Communication, Desinformación, Sobremedicalização, Disinformation, Covid-19, Comunicación, Desinformação, Overmedicalization, Comunicação
Abstract

Em fevereiro de 2020, a Organização Mundial da Saúde alertou sobre a gravidade da epidemia de Covid-19 e enfatizou que as iniciativas relacionadas ao seu combate têm sido acompanhadas por uma infodemia. O Ministério da Saúde do Brasil publicou diretrizes em relação ao manejo da doença com o “tratamento precoce”. O objetivo deste artigo foi construir uma linha do tempo visual de janeiro de 2020 até abril de 2021 por meio de pesquisa bibliográfica, documental e análise de conteúdo. Sistematizaram-se as principais notícias veiculadas no website do Ministério da Saúde sobre o “tratamento precoce”, as evidências científicas sobre os medicamentos relacionados a este e os dados das mortes e fatos relacionados à doença que aconteceram no Brasil. A linha do tempo evidencia a insistência da promoção do “tratamento precoce”, no contexto da desinfodemia, pelo Ministério da Saúde na existência de evidências contrárias a essa intervenção. In February 2020, the World Health Organisation warned about the gravity of the Covid-19 epidemic, emphasizing that initiatives to combat the problem had been accompanied by an “infodemic”. Brazil’s ministry of health published guidelines on the management of the disease using "early treatment”. The aim of this study was to create a visual timeline from January 2020 to April 2021 based on the review of relevant literature and documents examined using document analysis. We synthesized the main items of news on early treatment published on the Ministry of Health website, scientific evidence on the medications used, and facts related to the disease in Brazil. The timeline evidenced the insistent promotion of early treatment by the Ministry of Health within the context of a “disinfodemic” despite the existence of evidence against this type of intervention. En febrero de 2020, la Organización Mundial de la Salud alertó sobre la gravedad de la epidemia de Covid-19 y enfatizó que las iniciativas relacionadas con su combate habían sido acompañadas por una infodemia. El Ministerio de la Salud de Brasil publicó directrices con relación al manejo de la enfermedad con el “tratamiento precoz”. El objetivo de este artículo fue construir una línea del tiempo visual desde enero de 2020 hasta abril de 2021 por medio de una investigación bibliográfica, documental y análisis de contenido. Se sistematizaron las principales noticias publicadas en la página web del Ministerio de la Salud sobre el “tratamiento precoz”, las evidencias científicas sobre estos medicamentos y los datos de las muertes y hechos relacionados a la enfermedad en Brasil. La línea de tiempo dejará clara la insistencia de la promoción del “tratamiento precoz”, en el contexto de la desinfodemia, por parte del Ministerio de la Salud con la existencia de evidencias contrarias a esta intervención.

Published
2022

48. Phylogeographic patterns of the yellow fever virus around the metropolitan region of São Paulo, Brazil, 2016–2019

Author

Cunha, Marielton dos Passos, primary, Duarte-Neto, Amaro Nunes, additional, Pour, Shahab Zaki, additional, Pereira, Bárbara Brito de Souza, additional, Ho, Yeh-Li, additional, Perondi, Beatriz, additional, Sztajnbok, Jaques, additional, Alves, Venancio Avancini Ferreira, additional, da Silva, Luiz Fernando Ferraz, additional, Dolhnikoff, Marisa, additional, Saldiva, Paulo Hilário Nascimento, additional, and Zanotto, Paolo Marinho de Andrade, additional

Published
2022
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50. Global Variation in the Effects of Ambient Temperature on Mortality: A Systematic Evaluation

Author

Guo, Yuming, Gasparrini, Antonio, Armstrong, Ben, Li, Shanshan, Tawatsupa, Benjawan, Tobias, Aurelio, Lavigne, Eric, de Sousa Zanotti Stagliorio Coelho, Micheline, Leone, Michela, Pan, Xiaochuan, Tong, Shilu, Tian, Linwei, Kim, Ho, Hashizume, Masahiro, Honda, Yasushi, Guo, Yue-Liang Leon, Wu, Chang-Fu, Punnasiri, Kornwipa, Yi, Seung-Muk, Michelozzi, Paola, Saldiva, Paulo Hilario Nascimento, and Williams, Gail

Published
2014

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