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1. Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab–bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study

Author

Allende, Daniela S, Amaddeo, Giuliana, Argemi, Josepmaria, Baulande, Sylvain, Beaufrère, Aurélie, Bermúdez-Ramos, María, Boulagnon-Rombi, Camille, Boursier, Jérôme, Bruges, Léa, Calderaro, Julien, Campani, Claudia, Caruso, Stefano, Casadei-Gardini, Andrea, Castano Garcia, Andres, Chan, Stephen Lam, D'Alessio, Antonio, Di Tommaso, Luca, Diaz, Alba, Digklia, Antonia, Dufour, Jean-François, Garcia-Porrero, Guillermo, Ghaffari Laleh, Narmin, Gnemmi, Viviane, Gopal, Purva, Graham, Rondell P., Heurgué, Alexandra, Iavarone, Massimo, Iñarrairaegui, Mercedes, Kather, Jakob Nikolas, Klein, Christophe, Labgaa, Ismail, Lameiras, Sonia, Legoix, Patricia, Lequoy, Marie, Leung, Howard Ho-Wai, Loménie, Nicolas, Maggioni, Marco, Maille, Pascale, Marín-Zuluaga, Juan Ignacio, Mendoza-Pacas, Guillermo, Michalak, Sophie, Mínguez, Beatriz, El Nahhas, Omar S M, Nault, Jean-Charles, Navale, Pooja, Ningarhari, Massih, Paradis, Valérie, Park, Young Nyun, Pawlotsky, Jean-Michel, Pedica, Federica, Perbellini, Riccardo, Peter, Simon, Pinato, David James, Pinter, Matthias, Radu, Pompilia, Regnault, Hélène, Reig, Maria, Rela, Mohamed, Rhee, Hyungjin, Rimassa, Lorenza, Rimini, Margherita, Salcedo, María Teresa, Sangro, Bruno, Scheiner, Bernhard, Sempoux, Christine, Su, Tung-Hung, Torres, Callie, Tran, Nguyen H, Trépo, Eric, Varela, Maria, Verset, Gontran, Vij, Mukul, Vogel, Arndt, Wendum, Dominique, Zeng, Qinghe, and Ziol, Marianne

Published
2023
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3. Enhanced Artificial Intelligence Methods for Liver Steatosis Assessment Using Machine Learning and Color Image Processing: Liver Color Project.

Author

Gómez‐Gavara, Concepción, Bilbao, Itxarone, Piella, Gemma, Vazquez‐Corral, Javier, Benet‐Cugat, Berta, Pando, Elizabeth, Molino, José Andrés, Salcedo, María Teresa, Dalmau, Mar, Vidal, Laura, Esono, Daniel, Cordobés, Miguel Ángel, Bilbao, Ángela, Prats, Josa, Moya, Mar, Dopazo, Cristina, Mazo, Christopher, Caralt, Mireia, Hidalgo, Ernest, and Charco, Ramon

Subjects
COLOR image processing, ANALYSIS of colors, TEXTURE analysis (Image processing), FEATURE extraction, BRAIN death
Abstract

Background: The use of livers with significant steatosis is associated with worse transplantation outcomes. Brain death donor liver acceptance is mostly based on subjective surgeon assessment of liver appearance, since steatotic livers acquire a yellowish tone. The aim of this study was to develop a rapid, robust, accurate, and cost‐effective method to assess liver steatosis. Methods: From June 1, 2018, to November 30, 2023, photographs and tru‐cut needle biopsies were taken from adult brain death donor livers at a single university hospital for the study. All the liver photographs were taken by smartphones then color calibrated, segmented, and divided into patches. Color and texture features were then extracted and used as input, and the machine learning method was applied. This is a collaborative project between Vall d'Hebron University Hospital and Barcelona MedTech, Pompeu Fabra University, and is referred to as LiverColor. Results: A total of 192 livers (362 photographs and 7240 patches) were included. When setting a macrosteatosis threshold of 30%, the best results were obtained using the random forest classifier, achieving an AUROC = 0.74, with 85% accuracy. Conclusion: Machine learning coupled with liver texture and color analysis of photographs taken with smartphones provides excellent accuracy for determining liver steatosis. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab–bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study

Author

Zeng, Qinghe, primary, Klein, Christophe, additional, Caruso, Stefano, additional, Maille, Pascale, additional, Allende, Daniela S, additional, Mínguez, Beatriz, additional, Iavarone, Massimo, additional, Ningarhari, Massih, additional, Casadei-Gardini, Andrea, additional, Pedica, Federica, additional, Rimini, Margherita, additional, Perbellini, Riccardo, additional, Boulagnon-Rombi, Camille, additional, Heurgué, Alexandra, additional, Maggioni, Marco, additional, Rela, Mohamed, additional, Vij, Mukul, additional, Baulande, Sylvain, additional, Legoix, Patricia, additional, Lameiras, Sonia, additional, Amaddeo, Giuliana, additional, Argemi, Josepmaria, additional, Beaufrère, Aurélie, additional, Bermúdez-Ramos, María, additional, Boursier, Jérôme, additional, Bruges, Léa, additional, Calderaro, Julien, additional, Campani, Claudia, additional, Castano Garcia, Andres, additional, Chan, Stephen Lam, additional, D'Alessio, Antonio, additional, Di Tommaso, Luca, additional, Diaz, Alba, additional, Digklia, Antonia, additional, Dufour, Jean-François, additional, Garcia-Porrero, Guillermo, additional, Ghaffari Laleh, Narmin, additional, Gnemmi, Viviane, additional, Gopal, Purva, additional, Graham, Rondell P., additional, Iñarrairaegui, Mercedes, additional, Kather, Jakob Nikolas, additional, Labgaa, Ismail, additional, Lequoy, Marie, additional, Leung, Howard Ho-Wai, additional, Loménie, Nicolas, additional, Marín-Zuluaga, Juan Ignacio, additional, Mendoza-Pacas, Guillermo, additional, Michalak, Sophie, additional, El Nahhas, Omar S M, additional, Nault, Jean-Charles, additional, Navale, Pooja, additional, Paradis, Valérie, additional, Park, Young Nyun, additional, Pawlotsky, Jean-Michel, additional, Peter, Simon, additional, Pinato, David James, additional, Pinter, Matthias, additional, Radu, Pompilia, additional, Regnault, Hélène, additional, Reig, Maria, additional, Rhee, Hyungjin, additional, Rimassa, Lorenza, additional, Salcedo, María Teresa, additional, Sangro, Bruno, additional, Scheiner, Bernhard, additional, Sempoux, Christine, additional, Su, Tung-Hung, additional, Torres, Callie, additional, Tran, Nguyen H, additional, Trépo, Eric, additional, Varela, Maria, additional, Verset, Gontran, additional, Vogel, Arndt, additional, Wendum, Dominique, additional, Zeng, Qinghe, additional, and Ziol, Marianne, additional

Published
2023
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8. An algorithm based on immunotherapy discontinuation and liver biopsy spares corticosteroids in two thirds of cases of severe checkpoint inhibitor‐induced liver injury.

Author

Riveiro‐Barciela, Mar, Barreira‐Díaz, Ana, Salcedo, María‐Teresa, Callejo‐Pérez, Ana, Muñoz‐Couselo, Eva, Iranzo, Patricia, Ortiz‐Velez, Carolina, Cedrés, Susana, Díaz‐Mejía, Nely, Ruiz‐Cobo, Juan Carlos, Morales, Rafael, Aguilar‐Company, Juan, Zamora, Ester, Oliveira, Mafalda, Sanz‐Martínez, María‐Teresa, Viladomiu, Lluis, Martínez‐Gallo, Mónica, Felip, Enriqueta, and Buti, María

Subjects
LIVER biopsy, LIVER injuries, IMMUNOTHERAPY, CORTICOSTEROIDS, ALGORITHMS
Abstract

Summary: Background: There are few data on corticosteroids (CS)‐sparing strategies for checkpoint inhibitor (ICI)‐induced liver injury (ChILI). Aim: We aimed to assess the performance of a 2‐step algorithm for severe ChILI, based on ICI temporary discontinuation (step‐1) and, if lack of biochemical improvement, CS based on the degree of necroinflammation at biopsy (step‐2). Methods: Prospective study that included all subjects with grade 3/4 ChILI. Peripheral extended immunophenotyping was performed. Indication for CS: severe necroinflammation; mild or moderate necroinflammation with later biochemical worsening. Results: From 111 subjects with increased transaminases (January 2020 to August 2023), 44 were diagnosed with grade 3 (N = 35) or grade 4 (N = 9) ChILI. Main reason for exclusion was alternative diagnosis. Lung cancer (13) and melanoma (12) were the most common malignancies. ICI: 23(52.3%) anti‐PD1, 8(18.2%) anti‐PD‐L1, 3(6.8%) anti‐CTLA‐4, 10(22.7%) combined ICI. Liver injury pattern: hepatocellular (23,52.3%) mixed (12,27.3%) and cholestatic (9,20.5%). 14(32%) presented bilirubin >1.2 mg/dL. Overall, 30(68.2%) patients did not require CS: 22(50.0%) due to ICI discontinuation (step‐1) and 8/22 (36.4%) based on the degree of necroinflammation (step‐2). Biopsy mainly impacted on grade 3 ChILI, sparing CS in 8 out of 15 (53.3%) non‐improvement patients after ICI discontinuation. CD8+ HLA‐DR expression (p = 0.028), central memory (p = 0.046) were lower in CS‐free managed subjects, but effector‐memory cells (p = 0.002) were higher. Time to transaminases normalisation was shorter in those CS‐free managed (overall: p < 0.001, grade 3: p < 0.001). Considering our results, a strategy based on ICI discontinuation and biopsy for grade 3 ChILI is proposed. Conclusions: An algorithm based on temporary immunotherapy discontinuation and biopsy allows CS avoidance in two thirds of cases of severe ChILI. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Optimization of Statin-Loaded Delivery Nanoparticles for Treating Chronic Liver Diseases by Targeting Liver Sinusoidal Endothelial Cells

Author

Gil, Mar, primary, Khouri, Lareen, additional, Raurell, Imma, additional, Rafael, Diana, additional, Andrade, Fernanda, additional, Abasolo, Ibane, additional, Schwartz, Simo, additional, Martínez-Gómez, María, additional, Salcedo, María Teresa, additional, Pericàs, Juan Manuel, additional, Hide, Diana, additional, Wei, Mingxing, additional, Metanis, Norman, additional, Genescà, Joan, additional, and Martell, María, additional

Published
2023
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10. A two-step algorithm avoids corticosteroids in two-thirds of cancer patients with severe immune-mediated hepatitis due to immune checkpoint inhibitors

Author

Barciela, Mar Riveiro, primary, Barreira, Ana, additional, Salcedo, María-Teresa, additional, Callejo-Pérez, Ana, additional, Muñoz-Couselo, Eva, additional, Iranzo, Patricia, additional, Ortiz-Velez, Carolina, additional, Cedrés, Susana, additional, Díaz-Mejía, Nely, additional, Ruíz-Cobo, Juan Carlos, additional, Morales, Rafael, additional, Aguilar-Company, Juan, additional, Zamora, Ester, additional, Oliveira, Mafalda, additional, Sanz-Martínez, María-Teresa, additional, Viladomiu, Lluís, additional, Martínez-Gallo, Mónica, additional, Felip, Enriqueta, additional, and Buti, Maria, additional

Published
2023
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11. Proyecto de ejecución de una central hortofrutícola destinada al procesado de apio, brócoli y coliflor en Caravaca de la Cruz (Murcia)

Author

Jódar Salcedo, María Teresa

Subjects
Food processing plants, Electric wiring, Celery, Broccoli, Brócoli, Estructuras (Construcción), Cauliflower, Coliflor, Industria de productos hortícolas, Apio, Máster Universitario en Ingeniería Agronómica-Master Universitari en Enginyeria Agronòmica, Pumping, Fontanería, Horticultural products industry, Structural design, INGENIERIA AGROFORESTAL, Instalaciones eléctricas, Plantas procesadoras de alimentos
Abstract

[ES] El presente proyecto trata sobre la ejecución de una central hortofrutícola destinada al procesado de apio, brócoli y coliflor en el municipio de Caravaca de la Cruz. El objeto del proyecto de ejecución es la descripción, el diseño y los cálculos, debidamente justificados, de la obra que va a ejecutarse (la nueva central hortofrutícola) en las mejores condiciones técnico-sanitarias posibles, de acuerdo con la legislación vigente. Se abordarán tanto los cálculos constructivos, como los cálculos de las instalaciones pertinentes. El alcance de este Trabajo fin de máster será el siguiente: memoria, donde se incluirán: la memoria descriptiva, la memoria constructiva, el cumplimiento del Código Técnico de la Edificación y los anejos a la memoria; planos; pliego de condiciones; mediciones y presupuesto y, finalmente, estudio de seguridad e higiene. Con este Trabajo fin de máster se pretende ampliar los conocimientos adquiridos durante el máster acerca de diferentes materias como proyectos, estructuras, instalaciones, etc., [EN] This project deals with the execution of a fruit and vegetable plant for the processing of celery, broccoli and cauliflower in the municipality of Caravaca de la Cruz. The purpose of the execution project is the description, design and calculations, duly justified of the work to be executed (new fruit and vegetable plant) in the best possible technical-sanitary conditions, in accordance with current legislation. Both the constructive calculations and the calculations of the relevant installations will be addressed. The scope of this Master's Thesis will be as follows: - Memory, which includes: o Descriptive Report o Construction Report o Compliance with the Technical Building Code. o Annexes to the report - Drawings - Specifications - Measurements and Budget - Program of Possible Development of the Works: A planning will be drawn up showing the execution deadlines by items or chapters. - Health and Safety Study This Master's Thesis is intended to expand the knowledge acquired during the Master's Degree on different subjects such as projects, structures, installations, etc.

Published
2022

13. Risk of infections in patients with NAFLD and Type 2 Diabetes under treatment with SGLT2 inhibitors and relationship with liver outcomes: A retrospective case-control study

Author

Bañares, Juan, primary, Manzano-Nuñez, Ramiro, additional, Prió, Alba, additional, Rivera-Esteban, Jesús, additional, Camps-Relats, Laura, additional, Villarejo, Ana, additional, Ruiz-Ortega, Lourdes, additional, Pons, Mònica, additional, Ciudin, Andreea, additional, Salcedo, María Teresa, additional, Vargas, Víctor, additional, Genescà, Joan, additional, and Pericàs, Juan M., additional

Published
2022
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14. Ultra Deep Sequencing of Circulating Cell-Free DNA as a Potential Tool for Hepatocellular Carcinoma Management

Author

Higuera, Mónica, primary, Vargas-Accarino, Elena, additional, Torrens, María, additional, Gregori, Josep, additional, Salcedo, María Teresa, additional, Martínez-Campreciós, Joan, additional, Torres, Gloria, additional, Bermúdez-Ramos, María, additional, Bilbao, Itxarone, additional, Guerrero-Murillo, Mercedes, additional, Serres-Créixams, Xavier, additional, Merino, Xavier, additional, Rodríguez-Frías, Francisco, additional, Quer, Josep, additional, and Mínguez, Beatriz, additional

Published
2022
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15. Análisis de la implementación de un sistema de gestión de energía basado en la norma ISO 50001 en organizaciones de Latinoamérica.

Author

Salas Orozco, Gustavo Adolfo, Unibio Salcedo, María Teresa, Salas Orozco, Gustavo Adolfo, and Unibio Salcedo, María Teresa

Abstract

Este documento tuvo como fin analizar la implementación de un Sistema de Gestión de Energía (SGEn), basado en los lineamientos que establece la norma internacional ISO 50001, a través de la exposición y análisis de una serie de casos de estudio de organizaciones latinoamericanas. Inicialmente se describen generalidades del estándar ISO 50001 y se destaca la estrategia de mejora continua que adopta y bajo la cual se rige todo el despliegue de un Sistema de Gestión de Energía. Asimismo, desde una perspectiva estratégica se describe la evolución de la normativa a través de los años a nivel global focalizando en el panorama latinoamericano, apuntando así aquellos países de Latinoamérica y los respectivos sectores industriales que lideran la implantación y certificación.

Published
2022

16. A Nine-Strain Bacterial Consortium Improves Portal Hypertension and Insulin Signaling and Delays NAFLD Progression In Vivo

Author

Pinheiro, Iris, primary, Barberá, Aurora, additional, Raurell, Imma, additional, Estrella, Federico, additional, Leeuw, Marcel de, additional, Bolca, Selin, additional, Gottardi, Davide, additional, Horscroft, Nigel, additional, Possemiers, Sam, additional, Salcedo, María Teresa, additional, Genescà, Joan, additional, Martell, María, additional, and Augustin, Salvador, additional

Published
2022
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17. ACE Score Identifies HBeAg-negative Inactive Carriers at a Single-point Evaluation, Regardless of HBV Genotype

Author

Roade, Luisa, primary, Riveiro-Barciela, Mar, additional, Palom, Adriana, additional, Rodríguez-Frías, Francisco, additional, Bes, Marta, additional, Rando, Ariadna, additional, Salcedo, María Teresa, additional, Casillas, Rosario, additional, Vargas-Accarino, Elena, additional, Tabernero, David, additional, Sauleda, Silvia, additional, Esteban, Rafael, additional, and Buti, María, additional

Published
2022
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18. ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity

Author

Mirra, Serena, Gavaldà-Navarro, Aleix, Manso, Yasmina, Higuera, Mónica, Serrat, Román, Salcedo, María Teresa, Burgaya, Ferran, Balibrea, José María, Santamaría Monasterio, Eva, Uriarte, Iker, Berasain, Carmen, Avila, Matias A., Mínguez Rosique, Beatriz, Soriano, Eduardo, Villarroya, Francesc, Universidad Autònoma de Barcelona, Mirra, Serena, Gavaldà-Navarro, Aleix, Manso, Yasmina, Higuera, Mónica, Serrat, Román, Salcedo, María Teresa, Burgaya, Ferran, Balibrea, José María, Santamaría Monasterio, Eva, Uriarte, Iker, Berasain, Carmen, Avila, Matias A., Mínguez Rosique, Beatriz, Soriano, Eduardo, Villarroya, Francesc, and Universidad Autònoma de Barcelona

Abstract

An excess fat in the liver enhances the susceptibility to hepatic cancer. We found that Armcx3, a protein only known to date to play a role in neural development, is strongly increased in mouse liver in response to lipid availability and proliferation-inducing insults. In patients, the levels of hepatic Armcx3 are also increased in conditions of high exposure of the liver to fat. We wanted to determine the role of Armcx3 in the hepatocarcinogenesis favored by a high-fat diet. We generated mice with genetically driven suppression of Armcx3, and we found that they were protected against experimentally induced hepatic cancer, especially in conditions of a high-fat diet. Armcx3 was also found to promote hepatic cell proliferation through the interaction with Sox9, a known proliferation factor in hepatocellular carcinoma. Armcx3 is identified as a novel factor in meditating propensity to liver cancer in conditions of high hepatic lipid insults. ARMCX3 is encoded by a member of the Armcx gene family and is known to be involved in nervous system development and function. We found that ARMCX3 is markedly upregulated in mouse liver in response to high lipid availability, and that hepatic ARMCX3 is upregulated in patients with NAFLD and hepatocellular carcinoma (HCC). Mice were subjected to ARMCX3 invalidation (inducible ARMCX3 knockout) and then exposed to a high-fat diet and diethylnitrosamine-induced hepatocarcinogenesis. The effects of experimental ARMCX3 knockdown or overexpression in HCC cell lines were also analyzed. ARMCX3 invalidation protected mice against high-fat-diet-induced NAFLD and chemically induced hepatocarcinogenesis. ARMCX3 invalidation promoted apoptotic cell death and macrophage infiltration in livers of diethylnitrosamine-treated mice maintained on a high-fat diet. ARMCX3 downregulation reduced the viability, clonality and migration of HCC cell lines, whereas ARMCX3 overexpression caused the reciprocal effects. SOX9 was found to mediate the effects of

Published
2021

20. ARMCX3 Mediates Susceptibility to Hepatic Tumorigenesis Promoted by Dietary Lipotoxicity

Author

Mirra, Serena, primary, Gavaldà-Navarro, Aleix, additional, Manso, Yasmina, additional, Higuera, Mónica, additional, Serrat, Román, additional, Salcedo, María Teresa, additional, Burgaya, Ferran, additional, Balibrea, José Maria, additional, Santamaría, Eva, additional, Uriarte, Iker, additional, Berasain, Carmen, additional, Avila, Matias A., additional, Mínguez, Beatriz, additional, Soriano, Eduardo, additional, and Villarroya, Francesc, additional

Published
2021
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21. WED-263 - A two-step algorithm avoids corticosteroids in two-thirds of cancer patients with severe immune-mediated hepatitis due to immune checkpoint inhibitors

Author

Barciela, Mar Riveiro, Barreira, Ana, Salcedo, María-Teresa, Callejo-Pérez, Ana, Muñoz-Couselo, Eva, Iranzo, Patricia, Ortiz-Velez, Carolina, Cedrés, Susana, Díaz-Mejía, Nely, Ruíz-Cobo, Juan Carlos, Morales, Rafael, Aguilar-Company, Juan, Zamora, Ester, Oliveira, Mafalda, Sanz-Martínez, María-Teresa, Viladomiu, Lluís, Martínez-Gallo, Mónica, Felip, Enriqueta, and Buti, Maria

Published
2023
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22. The influence and benefits of technology as a strategy in organizations

Author

Vargas-Hernánez, José G., Alcántara Salcedo, María Teresa, Vargas-Hernánez, José G., and Alcántara Salcedo, María Teresa

Abstract

[EN] The article presents a description of "The Influence and Benefits of Technology as a Strategy in Organizations." Technology is considered as a competitive advantage, which allows organizations to benefit, this technology means that these companies can maintain themselves and acquire a position interesting within the market, now organizations are interested in the acquisition of technology, this acquisition takes value because of the economic importance that can come from having the best technology within the organization. The document presents information about technology as a key strategy, which can help companies to create a competitive advantage within the market.

Published
2020

23. Steatosis as main determinant of portal hypertension through a restriction of hepatic sinusoidal area in a dietary rat nash model

Author

Barberá, Aurora, primary, Raurell, Imma, additional, García‐Lezana, Teresa, additional, Torres‐Arauz, Manuel, additional, Bravo, Miren, additional, Hide, Diana, additional, Gil, Mar, additional, Salcedo, María Teresa, additional, Genescà, Joan, additional, Martell, María, additional, and Augustin, Salvador, additional

Published
2020
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25. Evaluación de la remoción de grasas y aceites en suelo contaminado con diésel B10 y biodiésel aplicando la tecnología OSEII implementada por Eom Consulting SAS

Author

Rodríguez García, Marco Antonio, Cabrera Lobelo, Laura María, Unibio Salcedo, María Teresa, Rodríguez García, Marco Antonio, Cabrera Lobelo, Laura María, and Unibio Salcedo, María Teresa

Abstract

Esta investigación se realizó para demostrar la efectividad de la tecnología OSEII en la remoción de grasas y aceites en un suelo contaminado con diésel B10 y biodiésel en un periodo de tratamiento de 28 días. Para dar inicio a la evaluación, a partir de un reporte entregado por CENIT en el que se especifican los derrames de diésel ocurridos en suelo en Colombia durante el año 2018 e inicio de 2019 y un análisis de los tipos de suelo presente en estas zonas afectadas, se elige la clase textural del suelo que se va a trabajar en la fase experimental.

Published
2019

27. SAT-472-Massive sequencing of circulating DNA as a potential tool for diagnosis and follow-up in patients with hepatocellular carcinoma

Author

Higuera, Monica, primary, Vargas-Accarino, Elena, additional, Soria, María Eugenia, additional, Gregori, Josep, additional, Torrens, Maria, additional, Salcedo, María Teresa, additional, Bilbao, Itxarone, additional, Rodríguez-Frías, Francisco, additional, Quer, Josep, additional, and Minguez, Beatriz, additional

Published
2019
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30. Programa 'pequeños escritores' para alumnos del segundo grado de primaria de una institución educativa no estatal del distrito de SAN JUAN DE MIRAFLORES

Author

Bautista Salcedo, María Teresa and Escurra Mayaute, Luis Miguel

Subjects
cuentos, Distrito de San Juan de Miraflores, niños de siete años, producción de textos, institución educativa
Abstract

La presente investigación consistió en conocer cómo influye el Programa “Pequeños Escritores” en el desarrollo de la escritura de cuentos, en niños de siete años de una institución educativa no estatal del distrito de San Juan de Miraflores. El grupo experimental estuvo conformado por 31 alumnos y el grupo de control por 30 alumnos pertenecientes al segundo grado de educación primaria. Dicho programa de creación de cuentos fue validado por profesionales expertos en el tema, el programa propone actividades sistematizadas en 16 sesiones, integrando estrategias de escritura y creación literaria. Bajo una metodología lúdica, grupal, individual y metacognitiva, permitiendo así, un aprendizaje significativo. Luego de seleccionar los grupos de manera no probabilística intencional, se aplicó la Lista de Cotejo a los respectivos grupos de control y experimental. A continuación se aplicó el Programa “Pequeños Escritores” durante dos meses con el grupo experimental. Los resultados demostraron el efecto de la aplicación del Programa “Pequeños Escritores”, permitiendo el enriquecimiento de la producción de sus escritos en los cuentos de los alumnos del grupo experimental, evidenciando que se logra establecer diferencias estadísticamente significativas en el pre y post test del grupo experimental y en el post test entre el grupo experimental y control. Tesis

Published
2017

31. Thrombotic thrombocytopenic purpura relapse induced by acute hepatitis E transmitted by cryosupernatant plasma and successfully controlled with ribavirin

Author

Riveiro-Barciela, Mar, primary, Bes, Marta, additional, Quer, Josep, additional, Valcarcel, David, additional, Piriz, Sofia, additional, Gregori, Josep, additional, Llorens, Meritxell, additional, Salcedo, María-Teresa, additional, Piron, Maria, additional, Esteban, Rafael, additional, Buti, Maria, additional, and Sauleda, Silvia, additional

Published
2018
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32. Restoration of a healthy intestinal microbiota normalizes portal hypertension in a rat model of nonalcoholic steatohepatitis

Author

García‐Lezana, Teresa, primary, Raurell, Imma, additional, Bravo, Miren, additional, Torres‐Arauz, Manuel, additional, Salcedo, María Teresa, additional, Santiago, Alba, additional, Schoenenberger, Andreu, additional, Manichanh, Chaysavanh, additional, Genescà, Joan, additional, Martell, María, additional, and Augustin, Salvador, additional

Published
2018
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33. THE INFLUENCE AND BENEFITS OF TECHNOLOGY AS A STRATEGY IN ORGANIZATIONS.

Author

Vargas Hernández, José G. and Alcántara Salcedo, María Teresa

Subjects
COMPETITIVE advantage in business, VALUE (Economics), KNOWLEDGE management
Abstract

The article presents a description of "The Influence and Benefits of Technology as a Strategy in Organizations." Technology is considered as a competitive advantage, which allows organizations to benefit, this technology means that these companies can maintain themselves and acquire a position interesting within the market, now organizations are interested in the acquisition of technology, this acquisition takes value because of the economic importance that can come from having the best technology within the organization. The document presents information about technology as a key strategy, which can help companies to create a competitive advantage within the market. [ABSTRACT FROM AUTHOR]

Published
2019

34. La apariencia de la ley y las calles como metáforas: jóvenes y fuerza pública en Colombia

Author

Salcedo, María Teresa

Abstract

Este artículo analiza los modos en los que la ley en Colombia estructura la experiencia cotidiana de la gente joven con la policía y los militares en espacios urbanos. Primero argumento que las calles son metáforas de la apariencia física de los jóvenes tanto como de su sentido de pertenencia a lugares y espacios en las ciudades colombianas. Y segundo, abordo a la ley como un filtro desplegado en los espacios urbanos por las fuerzas públicas para excluir o aceptar a la gente como legal o ilegal, y que a la vez identifica a los jóvenes como “peligrosos” en determinados momentos y lugares. Palabras clave: ciudad, juventud, fuerza pública, Colombia, reconocimiento, antropología de las calles Abstract This article analyzes the ways in which the law in Colombia structures the everyday experience of young people with the police and the military in urban spaces. I first argue that streets are metaphors both of young people's physicalappearance and of their sense of belonging to place and space in Colombian cities.bSecond, I approach the law as a screening device deployed in urban spaces by the forces of public order to exclude or accept persons as legal or illegal, identifying young people as "dangerous" at certain times and in certain places. Key words: city, youth, police and military forces, Colombia, recognition, anthropology of the streets

Published
2014

36. EDITORIAL

Author

Salcedo, María Teresa

Published
2013

38. Sonidos y heteroglosas de la trangresión en Colombia: inversiones rituales en la cultura hip-hop y la música electrónica

Author

Salcedo, María Teresa

Abstract

Este artículo elabora un contraste entre lo oficial y lo no-oficial como se vive y se representa desde la producción de música en la cultura hip-hop y desde la música electrónica y sus respectivos escenarios subterráneos, en Colombia. Los argumentos que sustentan esta comparación son los siguientes: 1) la producción de música en los distintos ámbitos de estas subculturas juveniles tiene su contrapunto en procesos de socialización de jóvenes músicos y productores culturales colombianos, específicamente expresiones de socialidad colectiva e individual en tanto representaciones de transgresión con respecto a formas de hablar y de narrar cómo los afecta la violencia, y con respecto a formas de vivir discursos sobre el consumo, la apariencia, el bienestar promulgado por las reformas neoliberales y el statu quo en general. Y 2) la producción de diferentes clases de sonidos y narrativas transgresoras tiene como propósito la disposición de espacios urbanos no-oficiales, tales como las calles, en tanto nuevos códigos musicales.

Published
2010

48. Rostros urbanos, espacios públicos, iluminaciones profanas en las calles de Bogotá.

Author

Salcedo, María Teresa

Subjects
*GUERRILLAS, *TEENAGERS & violence
Abstract

This article explores, through a teenager guerrilla member's life story, the problem of encounters and the migrant's face as representative expressions of the urban, and of cruelty in general. Using a narrative where alternative images of the war in the mountains appear, and a travel through Bogota streets, this images' meeting is analyzed as a face or as a profane illumination, using Walter Benjamin and Emmanuel Levinas' works. That which cannot be defined in an encounter, as in a face, and that which applies to the way we understand the problem of identity in the city, can only be compared with the surrealist experience of encounters and disencounters between Nadja and André Breton, similar also to the anthropological experience of facing object consumption and the look over things while we walk on the streets and descend from buses that bring us for the first time to the city. This essay is a shorter version of a paper I wrote for the Symposium "Cruel sceneries: esthetics and signs of trance and violence in Puerto Rico and Colombia" that took place in San Juan de Puerto Rico in April 2001. I thank Manuel Hernández Benavides for his reading and suggestions to a previous version of this article. [ABSTRACT FROM AUTHOR]

Published
2001
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49. A Nine-Strain Bacterial Consortium Improves Portal Hypertension and Insulin Signaling and Delays NAFLD Progression In Vivo

Author

Iris Pinheiro, Aurora Barberá, Imma Raurell, Federico Estrella, Marcel de Leeuw, Selin Bolca, Davide Gottardi, Nigel Horscroft, Sam Possemiers, María Teresa Salcedo, Joan Genescà, María Martell, Salvador Augustin, Pinheiro, Iri, Barberá, Aurora, Raurell, Imma, Estrella, Federico, de Leeuw, Marcel, Bolca, Selin, Gottardi, Davide, Horscroft, Nigel, Possemiers, Sam, Salcedo, María Teresa, Genescà, Joan, Martell, María, Augustin, Salvador, Institut Català de la Salut, [Pinheiro I, de Leeuw M, Bolca S] MRM Health NV, Ghent, Belgium. [Barberá A, Estrella F] Unitat Hepàtica, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Raurell I, Genescà J, Martell M, Augustin S] Unitat Hepàtica, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro De Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto De Salud Carlos III, Madrid, Spain. [Salcedo MT] Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
enfermedades del sistema digestivo::enfermedades hepáticas::hígado graso::esteatosis hepática no alcohólica [ENFERMEDADES], Esteatosi hepàtica - Prognosi, bacterial consortium, Medicine (miscellaneous), Digestive System Diseases::Liver Diseases::Fatty Liver::Non-alcoholic Fatty Liver Disease [DISEASES], Digestive System Diseases::Liver Diseases::Hypertension, Portal [DISEASES], gut microbiome, portal hypertension, Hipertensió portal, digestive system, General Biochemistry, Genetics and Molecular Biology, NAFLD, fibrosis, enfermedades del sistema digestivo::enfermedades hepáticas::hipertensión portal [ENFERMEDADES], fenómenos microbiológicos::microbiota::consorcios microbianos [FENÓMENOS Y PROCESOS], Intestins - Microbiologia, fibrosi, Microbiological Phenomena::Microbiota::Microbial Consortia [PHENOMENA AND PROCESSES]
Abstract

Bacterial consortium; Gut microbiome; Portal hypertension Consorcio bacteriano; Microbioma intestinal; Hipertensión portal Consorci bacterià; Microbioma intestinal; Hipertensió portal The gut microbiome has a recognized role in Non-alcoholic fatty liver disease (NAFLD) and associated comorbidities such as Type-2 diabetes and obesity. Stool transplantation has been shown to improve disease by restoring endothelial function and insulin signaling. However, more patient-friendly treatments are required. The present study aimed to test the effect of a defined bacterial consortium of nine gut commensal strains in two in vivo rodent models of Non-alcoholic steatohepatitis (NASH): a rat model of NASH and portal hypertension (PHT), and the Stelic animal (mouse) model (STAM™). In both studies the consortium was administered orally q.d. after disease induction. In the NASH rats, the consortium was administered for 2 weeks and compared to stool transplant. In the STAM™ study administration was performed for 4 weeks, and the effects compared to vehicle or Telmisartan at the stage of NASH/early fibrosis. A second group of animals was followed for another 3 weeks to assess later-stage fibrosis. In the NASH rats, an improvement in PHT and endothelial function was observed. Gut microbial compositional changes also revealed that the consortium achieved a more defined and richer replacement of the gut microbiome than stool transplantation. Moreover, liver transcriptomics suggested a beneficial modulation of pro-fibrogenic pathways. An improvement in liver fibrosis was then confirmed in the STAM™ study. In this study, the bacterial consortium improved the NAFLD activity score, consistent with a decrease in steatosis and ballooning. Serum cytokeratin-18 levels were also reduced. Therefore, administration of a specific bacterial consortium of defined composition can ameliorate NASH, PHT, and fibrosis, and delay disease progression.

Published
2022

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