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2. Rationale and Design of the Diet, CKD, and Apolipoprotein L1 Study in Low-Income and Middle-Income Countries

Author

Ilori, Titilayo O, Solarin, Adaobi, Manmak, Mamven, Raji, Yemi R, Braimoh, Rotimi, Kwakyi, Edward, Umeizudike, Theophilus, Ajepe, Titilope, Bolanle, Omotoso, Ripiye, Nanna, Eduful, Ernestina, Adebile, Temitayo, Ijeoma, Chinwuba, Mumuni, Amisu A, Chern, Jessica, Akinpelu, Morenikeji, Ulasi, Ifeoma, Arogundade, Fatiu, Salako, Babatunde L, Gbadegesin, Rasheed, Parekh, Rulan S, Dupuis, Josée, Amira, Christiana O, Adu, Dwomoa, Anderson, Cheryl AM, Ojo, Akinlolu, and Waikar, Sushrut S

Subjects
Clinical Research, Nutrition, Kidney Disease, Clinical Trials and Supportive Activities, Prevention, Good Health and Well Being, 24hr-urine potassium & sodium, Africa, engagement, retention
Abstract

IntroductionDiet, chronic kidney disease (CKD), and Apolipoprotein L1 (APOL1) (DCA) Study is examining the role of dietary factors in CKD progression and APOL1 nephropathy. We describe enrollment and retention efforts and highlight facilitators and barriers to enrollment and operational challenges, as well as accommodations made in the study protocol.MethodsThe DCA study is enrolling participants in 7 centers in West Africa. Participants who consented were invited to complete dietary recalls and 24-hour urine collections in year 1. We conducted focus groups and semistructured interviews among study personnel to identify facilitators and barriers to enrollment as well as retention and operational challenges in the execution of the study protocol. We analyzed emerging themes using content analyses.ResultsA total of 712 participants were enrolled in 18 months with 1256 24-hour urine and 1260 dietary recalls. Barriers to enrollment were the following: (i) a lack of understanding of research, (ii) the burden of research visits, and (iii) incorporating cultural and traditional nuances when designing research protocols. Factors facilitating enrollment were the following: (i) designing convenient research visits, (ii) building rapport and increased communication between the research team and participants, and (iii) cultural sensitivity - adapting research protocols for the populations involved. Offering home visits, providing free dietary counseling, reducing the volume of study blood collection, and reducing the frequency of visits were some changes made in the study protocol that increased participant satisfaction.ConclusionAdopting a participant-centered approach with accommodations in the protocol for cultural adaptability and incorporating participant feedback is vital for carrying out research in low-income and middle-income regions.

Published
2023

4. Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria

Author

Olawoye, Idowu B., Oluniyi, Paul E., Oguzie, Judith U., Uwanibe, Jessica N., Kayode, Tolulope A., Olumade, Testimony J., Ajogbasile, Fehintola V., Parker, Edyth, Eromon, Philomena E., Abechi, Priscilla, Sobajo, Tope A., Ugwu, Chinedu A., George, Uwem E., Ayoade, Femi, Akano, Kazeem, Oyejide, Nicholas E., Nosamiefan, Iguosadolo, Fred-Akintunwa, Iyanuoluwa, Adedotun-Sulaiman, Kemi, Brimmo, Farida B., Adegboyega, Babatunde B., Philip, Courage, Adeleke, Richard A., Chukwu, Grace C., Ahmed, Muhammad I., Ope-Ewe, Oludayo O., Otitoola, Shobi G., Ogunsanya, Olusola A., Saibu, Mudasiru F., Sijuwola, Ayotunde E., Ezekiel, Grace O., John, Oluwagboadurami G., Akin-John, Julie O., Akinlo, Oluwasemilogo O., Fayemi, Olanrewaju O., Ipaye, Testimony O., Nwodo, Deborah C., Omoniyi, Abolade E., Omwanghe, Iyobosa B., Terkuma, Christabel A., Okolie, Johnson, Ayo-Ale, Olubukola, Ikponmwosa, Odia, Benevolence, Ebo, Naregose, Grace O., Patience, Akhilomen E., Blessing, Osiemi, Micheal, Airende, Jacqueline, Agbukor, Aiyepada, John O., Ebhodaghe, Paulson, Racheal, Omiunu, Rita, Esumeh, Rosemary, Giwa E., Solomon, Ehikhametalor, Anieno, Ekanem, Edna, Yerumoh, Chris, Aire O., Donatus, Adomeh I., Ogbaini-Emovon, Ephraim, Tatfeng, Mirabeau Y., Omunakwe, Hannah E., Bob-Manuel, Mienye, Ahmed, Rahaman A., Onwuamah, Chika K., Shaibu, Joseph O., Okwuraiwe, Azuka, Ataga, Anthony E., Bock-Oruma, Andrew, Daramola, Funmi, Yusuf, Ibrahim F., Fajola, Akinwumi, Ntia, Nsikak-Abasi, Ekpo, Julie J., Moses, Anietie E., Moore-Igwe, Beatrice W., Fakayode, Oluwatosin E., Akinola, Monilade, Kida, Ibrahim M., Oderinde, Bamidele S., Wudiri, Zara W., Adeyemi, Oluwapelumi O., Akanbi, Olusola A., Ahumibe, Anthony, Akinpelu, Afolabi, Ayansola, Oyeronke, Babatunde, Olajumoke, Omoare, Adesuyi A., Chukwu, Chimaobi, Mba, Nwando G., Omoruyi, Ewean C., Olisa, Olasunkanmi, Akande, Olatunji K., Nwafor, Ifeanyi E., Ekeh, Matthew A., Ndoma, Erim, Ewah, Richard L., Duruihuoma, Rosemary O., Abu, Augustine, Odeh, Elizabeth, Onyia, Venatius, Ojide, Chiedozie K., Okoro, Sylvanus, Igwe, Daniel, Ogah, Emeka O., Khan, Kamran, Ajayi, Nnennaya A., Ugwu, Collins N., Ukwaja, Kingsley N., Ugwu, Ngozi I., Abejegah, Chukwuyem, Adedosu, Nelson, Ayodeji, Olufemi, Liasu, Ahmed A., Isamotu, Rafiu O., Gadzama, Galadima, Petros, Brittany A., Siddle, Katherine J., Schaffner, Stephen F., Akpede, George, Erameh, Cyril Oshomah, Baba, Marycelin M., Oladiji, Femi, Audu, Rosemary, Ndodo, Nnaemeka, Fowotade, Adeola, Okogbenin, Sylvanus, Okokhere, Peter O., Park, Danny J., Mcannis, Bronwyn L., Adetifa, Ifedayo M., Ihekweazu, Chikwe, Salako, Babatunde L., Tomori, Oyewale, Happi, Anise N., Folarin, Onikepe A., Andersen, Kristian G., Sabeti, Pardis C., and Happi, Christian T.

Published
2023
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6. Whole-genome sequencing across 449 samples spanning 47 ethnolinguistic groups provides insights into genetic diversity in Nigeria

Author

Osifo, Ogochukwu Francis, Moddibo, Zahra Isa, Ado-Wanka, Aisha Nabila, Yakubu, Aminu, Oyedele, Olubukunola, Popoola, Jumi, Attipoe, Delali Attiogbe, Eze-Echesi, Golibe, Modibbo, Fatima Z., Ado-Wanka, Nabila, Osakwe, Oluyemisi, Braimah, Onome, Julius-Enigimi, Eramoh, Akindigh, Terver Mark, Kusimo, Bolutife, Akpulu, Chinenye, Nwuba, Chiamaka, Ebong, Ofonime, Anyika, Chinyere, Adewunmi, Oluwatimilehin, Ibrahim, Yusuf, Kashimawo, Janet, Nkwocha, Chidi, Iyitor, Peter, Abiwon, Temi, Adeleye, Adeola, Ode, Abayomi, Ayo-Lawal, Anjola, Akpabio, Kasiena, Edu, Emame, Njoku, Chiemela, Ballew, Bari, Palmer, Cameron, Joshi, Esha, Biddanda, Arjun, O’Dushlaine, Colm, Ene-Obong, Abasi, Bost, Teresia L., Fatumo, Segun, Musa, Abdullahi, Mujtaba, Abdulrasheed M., Popoola, Abiodun, Bello, Abubakar M., Anyanwu, Anthony, Yusuf, Ashiru, Bozimo, Gesiye E.L., Bassey, Goddy, Bala, Hadiza, Bosan, Istifanus Bala, Edah, Jemimah, Jimoh, Mutiu Alani, Nwankwo, Kenneth, Ojo, Olalekan, Inyama, Marcus, Apanpa, Maryam, Mustapha, Mohammed Inuwa, Ali-Gombe, Musa, Ojo, Olubukola, Adeyemi, Oludare F., Ajayi, Samuel, Bala, Sanusi, Ojo, Temitope, Aliyu, Usman Malami, Raji, Yemi, Tanko, Zainab, Mohammed, Amina, Oladele, David, Hamzat, Muhammed, Agaba, Emmanuel, Nwankwo, Emeka, Ulasi, Ifeoma, Musa, Jonah, Odidika, Umeora, Salako, Omolola, Nash, Oyekanmi, Salako, Babatunde L., Nwankwo, Kenneth Chima, Asuquo, Marcus Inyama, Ekwere, Timothy, Aniekwensi, Ezechukwu, Ezeude, Chidi, Awopeju, Olayemi, Kolawole, Tolutope, Adesina, Olubiyi, Ghyi, Vandi, Oni, Olaolu, Gimba, Zumnan, Attipoe, Delali, Dogbo, Estelle, and Salako, Babatunde

Published
2023
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7. Cardiovascular Risk Factor Burden and Association With CKD in Ghana and Nigeria

Author

Olanrewaju, Timothy O., Osafo, Charlotte, Raji, Yemi R., Mamven, Manmak, Ajayi, Samuel, Ilori, Titilayo O., Arogundade, Fatiu A., Ulasi, Ifeoma I., Gbadegesin, Rasheed, Parekh, Rulan S., Tayo, Bamidele, Adeyemo, Adebowale A., Adedoyin, Olanrewaju T., Chijioke, Adindu A., Bewaji, Clement, Grobbee, Diederick E., Blankestijn, Peter J., Klipstein-Grobusch, Kerstin, Salako, Babatunde L., Adu, Dwomoa, and Ojo, Akinlolu O.

Published
2023
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10. Population health outcomes in Nigeria compared with other west African countries, 1998–2019: a systematic analysis for the Global Burden of Disease Study

Author

Angell, Blake, Sanuade, Olutobi, Adetifa, Ifedayo M O, Okeke, Iruka N, Adamu, Aishatu Lawal, Aliyu, Muktar H, Ameh, Emmanuel A, Kyari, Fatima, Gadanya, Muktar A, Mabayoje, Diana A, Yinka-Ogunleye, Adesola, Oni, Tolu, Jalo, Rabiu Ibrahim, Tsiga-Ahmed, Fatimah I, Dalglish, Sarah L, Abimbola, Seye, Colbourn, Tim, Onwujekwe, Obinna, Owoaje, Eme Theodora, Aliyu, Gambo, Aliyu, Sani H, Archibong, Belinda, Ezeh, Alex, Ihekweazu, Chikwe, Iliyasu, Zubairu, Obaro, Stephen, Obadare, Ebenezer Babatunde, Okonofua, Friday, Pate, Muhammed, Salako, Babatunde L, Zanna, Fatima H, Glenn, Scott, Walker, Ally, Ezalarab, Maha, Naghavi, Mohsen, and Abubakar, Ibrahim

Published
2022
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11. The Lancet Nigeria Commission: investing in health and the future of the nation

Author

Abubakar, Ibrahim, Dalglish, Sarah L, Angell, Blake, Sanuade, Olutobi, Abimbola, Seye, Adamu, Aishatu Lawal, Adetifa, Ifedayo M O, Colbourn, Tim, Ogunlesi, Afolabi Olaniyi, Onwujekwe, Obinna, Owoaje, Eme T, Okeke, Iruka N, Adeyemo, Adebowale, Aliyu, Gambo, Aliyu, Muktar H, Aliyu, Sani Hussaini, Ameh, Emmanuel A, Archibong, Belinda, Ezeh, Alex, Gadanya, Muktar A, Ihekweazu, Chikwe, Ihekweazu, Vivianne, Iliyasu, Zubairu, Kwaku Chiroma, Aminatu, Mabayoje, Diana A, Nasir Sambo, Mohammed, Obaro, Stephen, Yinka-Ogunleye, Adesola, Okonofua, Friday, Oni, Tolu, Onyimadu, Olu, Pate, Muhammad Ali, Salako, Babatunde L, Shuaib, Faisal, Tsiga-Ahmed, Fatimah, and Zanna, Fatima H

Published
2022
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14. The CircumVent Project: a CPAP/O2 helmet solution for non-invasive ventilation using an implementation research framework

Author

Ahonkhai, Aimalohi A., Musa, Adesola Z., Fenton, André A., Aliyu, Muktar H., Ofotokun, Igho, Hornstein, Alex, Musa, Baba M., Nwosu, Nnamdi, Ulasi, Ifeoma, Ajayi, Samuel, Falade, Catherine, Dada, Adedamola, Abdu, Aliyu, Sunday, Mogaji, Odewabi, Adenike, Rotimi, Muyiwa K., Ogueh, Onome, Steinbach, Alan, Ogedegbe, Gbenga, Salako, Babatunde L., and Ezechi, Oliver C.

Published
2021
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16. Cost and cost-effectiveness analysis of a bundled intervention to enhance outcomes after stroke in Nigeria: Rationale and design

Author

Olaniyan, Olanrewaju, Owolabi, Mayowa O, Akinyemi, Rufus O, Salako, Babatunde L, Hurst, Samantha, Arulogun, Oyedunni, Gebregziabher, Mulugeta, Uvere, Ezinne, and Ovbiagele, Bruce

Subjects
Health Services and Systems, Health Sciences, Health Services, Clinical Research, Stroke, Brain Disorders, Comparative Effectiveness Research, Cost Effectiveness Research, Health and social care services research, 8.2 Health and welfare economics, 8.1 Organisation and delivery of services, Good Health and Well Being, Cost-effectiveness, Costs and cost analysis, Nigeria
Abstract

The economic and social costs of stroke to the society can be enormous. These costs can cause serious economic damage to both the individual and the nation. It is thus important to conduct a cost effectiveness analysis to indicate whether an intervention provides high value where its health benefits justify its costs. This study will provide evidence based on the costs of stroke with a view of improving intervention and treatments of stoke survivors in Nigeria. This study utilizes two types of economic evaluation methods - cost-effectiveness analysis and cost-benefit analysis - to determine the economic impact of Tailored Hospital-based Risk Reduction to Impede Vascular Events after Stroke (THRIVES) intervention. The study is conducted in four Nigerian hospitals where 400 patients are recruited to participate in the study. The cost-effectiveness of THRIVES post-discharge intervention is compared with the control Intervention scenario, which is the usual and customary care delivered at each health facility in terms of cost per quality adjusted life years (QALYs). It is expected that successful implementation of the project would serve as a model of cost-effective quality stroke care for implementation.

Published
2015

18. Whole-genome sequencing across 449 samples spanning 47 ethnolinguistic groups provides insights into genetic diversity in Nigeria

Author

Joshi, Esha, primary, Biddanda, Arjun, additional, Popoola, Jumi, additional, Yakubu, Aminu, additional, Osakwe, Oluyemisi, additional, Attipoe, Delali, additional, Dogbo, Estelle, additional, Salako, Babatunde, additional, Nash, Oyekanmi, additional, Salako, Omolola, additional, Oyedele, Olubukunola, additional, Eze-Echesi, Golibe, additional, Fatumo, Segun, additional, Ene-Obong, Abasi, additional, O’Dushlaine, Colm, additional, Osifo, Ogochukwu Francis, additional, Moddibo, Zahra Isa, additional, Ado-Wanka, Aisha Nabila, additional, Attipoe, Delali Attiogbe, additional, Modibbo, Fatima Z., additional, Ado-Wanka, Nabila, additional, Braimah, Onome, additional, Julius-Enigimi, Eramoh, additional, Akindigh, Terver Mark, additional, Kusimo, Bolutife, additional, Akpulu, Chinenye, additional, Nwuba, Chiamaka, additional, Ebong, Ofonime, additional, Anyika, Chinyere, additional, Adewunmi, Oluwatimilehin, additional, Ibrahim, Yusuf, additional, Kashimawo, Janet, additional, Nkwocha, Chidi, additional, Iyitor, Peter, additional, Abiwon, Temi, additional, Adeleye, Adeola, additional, Ode, Abayomi, additional, Ayo-Lawal, Anjola, additional, Akpabio, Kasiena, additional, Edu, Emame, additional, Njoku, Chiemela, additional, Ballew, Bari, additional, Palmer, Cameron, additional, Joshi, Esha, additional, Bost, Teresia L., additional, Musa, Abdullahi, additional, Mujtaba, Abdulrasheed M., additional, Popoola, Abiodun, additional, Bello, Abubakar M., additional, Anyanwu, Anthony, additional, Yusuf, Ashiru, additional, Bozimo, Gesiye E.L., additional, Bassey, Goddy, additional, Bala, Hadiza, additional, Bosan, Istifanus Bala, additional, Edah, Jemimah, additional, Jimoh, Mutiu Alani, additional, Nwankwo, Kenneth, additional, Ojo, Olalekan, additional, Inyama, Marcus, additional, Apanpa, Maryam, additional, Mustapha, Mohammed Inuwa, additional, Ali-Gombe, Musa, additional, Ojo, Olubukola, additional, Adeyemi, Oludare F., additional, Ajayi, Samuel, additional, Bala, Sanusi, additional, Ojo, Temitope, additional, Aliyu, Usman Malami, additional, Raji, Yemi, additional, Tanko, Zainab, additional, Mohammed, Amina, additional, Oladele, David, additional, Hamzat, Muhammed, additional, Agaba, Emmanuel, additional, Nwankwo, Emeka, additional, Ulasi, Ifeoma, additional, Musa, Jonah, additional, Odidika, Umeora, additional, Salako, Babatunde L., additional, Nwankwo, Kenneth Chima, additional, Asuquo, Marcus Inyama, additional, Ekwere, Timothy, additional, Aniekwensi, Ezechukwu, additional, Ezeude, Chidi, additional, Awopeju, Olayemi, additional, Kolawole, Tolutope, additional, Adesina, Olubiyi, additional, Ghyi, Vandi, additional, Oni, Olaolu, additional, and Gimba, Zumnan, additional

Published
2023
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20. Cardiovascular Risk Factor Burden and Association With CKD in Ghana and Nigeria

Author

Global Health team 1, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, Olanrewaju, Timothy O., Osafo, Charlotte, Raji, Yemi R., Mamven, Manmak, Ajayi, Samuel, Ilori, Titilayo O., Arogundade, Fatiu A., Ulasi, Ifeoma I., Gbadegesin, Rasheed, Parekh, Rulan S., Tayo, Bamidele, Adeyemo, Adebowale A., Adedoyin, Olanrewaju T., Chijioke, Adindu A., Bewaji, Clement, Grobbee, Diederick E., Blankestijn, Peter J., Klipstein-Grobusch, Kerstin, Salako, Babatunde L., Adu, Dwomoa, Ojo, Akinlolu O., Global Health team 1, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, Olanrewaju, Timothy O., Osafo, Charlotte, Raji, Yemi R., Mamven, Manmak, Ajayi, Samuel, Ilori, Titilayo O., Arogundade, Fatiu A., Ulasi, Ifeoma I., Gbadegesin, Rasheed, Parekh, Rulan S., Tayo, Bamidele, Adeyemo, Adebowale A., Adedoyin, Olanrewaju T., Chijioke, Adindu A., Bewaji, Clement, Grobbee, Diederick E., Blankestijn, Peter J., Klipstein-Grobusch, Kerstin, Salako, Babatunde L., Adu, Dwomoa, and Ojo, Akinlolu O.

Published
2023

21. Cardiovascular Risk Factor Burden and Association With CKD in Ghana and Nigeria

Author

Olanrewaju, Timothy O., primary, Osafo, Charlotte, additional, Raji, Yemi R., additional, Mamven, Manmak, additional, Ajayi, Samuel, additional, Ilori, Titilayo O., additional, Arogundade, Fatiu A., additional, Ulasi, Ifeoma I., additional, Gbadegesin, Rasheed, additional, Parekh, Rulan S., additional, Tayo, Bamidele, additional, Adeyemo, Adebowale A., additional, Adedoyin, Olanrewaju T., additional, Chijioke, Adindu A., additional, Bewaji, Clement, additional, Grobbee, Diederick E., additional, Blankestijn, Peter J., additional, Klipstein-Grobusch, Kerstin, additional, Salako, Babatunde L., additional, Adu, Dwomoa, additional, and Ojo, Akinlolu O., additional

Published
2022
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22. Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria

Author

Olawoye, Idowu B., primary, Oluniyi, Paul E., additional, Oguzie, Judith U., additional, Uwanibe, Jessica N., additional, Kayode, Adeyemi T., additional, Olumade, Testimony J., additional, Ajogbasile, Fehintola V., additional, Parker, Edyth, additional, Eromon, Philomena E., additional, Abechi, Priscilla, additional, Sobajo, Tope, additional, Ugwu, Chinedu, additional, Uwem, George, additional, Ayoade, Femi, additional, Akano, Kazeem, additional, Oyejide, Nicholas, additional, Fred-Akintunwa, Iyanuoluwa, additional, Adedotun-Sulaiman, Kemi, additional, Brimmo, Farida, additional, Adegboyega, Benjamin, additional, Philip, Courage, additional, Adeleke, Ayomide, additional, Chukwu, Grace C., additional, Muhammad, Ahmed I., additional, Ope-ewe, Oludayo O., additional, Otitoola, Shobi, additional, Ogunsanya, Olusola A., additional, Saibu, Mudasiru F., additional, Sijuwola, Ayotunde E., additional, Ezekiel, Grace O., additional, John, Oluwagboadurami G., additional, Akin-John, Julie O., additional, Akinlo, Oluwasemilogo O., additional, Fayemi, Olanrewaju O., additional, Ipaye, Testimony O., additional, Nwodo, Deborah C., additional, Omoniyi, Abolade E., additional, Omwanghe, Iyobosa B., additional, Terkuma, Christabel A., additional, Okolie, Johnson, additional, Ayo-Ale, Olubukola, additional, Ikponmwosa, Odia, additional, Benevolence, Ebo, additional, Naregose, Okonofua, additional, Patience, Akhilomen, additional, Blessing, Osiemi, additional, Micheal, Airende, additional, Jacqueline, Agbukor, additional, John, Aiyepada, additional, Ebhodaghe, Paulson, additional, Racheal, Omiunu, additional, Rita, Esumeh, additional, Rosemary, Giwa, additional, Solomon, Ehikhametalor, additional, Anieno, Ekanem, additional, Edna, Yerumoh, additional, Chris, Aire, additional, Donatus, Adomeh, additional, Ogbaini, Ephraim, additional, Tatfeng, Mirabeau Y., additional, Omunakwe, Hannah E., additional, Bob-Manuel, Mienye, additional, Ahmed, Rahaman, additional, Onwuamah, Chika, additional, Shaibu, Joseph, additional, Okwuraiwe, Azuka, additional, Atage, Anthony E., additional, Bock-Oruma, Andrew, additional, Daramola, Funmi, additional, Fajola, Akinwumi, additional, Ntia, Nsikak-Abasi, additional, Ekpo, Julie J., additional, Moses, Anietie, additional, Moore-Igwe, Worbianueri B., additional, Yusuf, Ibrahim F., additional, Fakayode, Enoch O., additional, Akinola, Monilade, additional, Kida, Ibrahim, additional, Oderinde, Bamidele S., additional, Wudiri, Zara, additional, Adeyemi, Olufemi O., additional, Akanbi, Olusola, additional, Ahumibe, Anthony, additional, Akinpelu, Afolabi, additional, Ayansola, Oyeronke, additional, Babatunde, Olajumoke, additional, Omoare, Adesuyi, additional, Chukwu, Chimaobi, additional, Mba, Nwando, additional, Omoruyi, Ewean C., additional, Adeniji, Johnson A., additional, Adewunmi, Moses O., additional, Olayinka, Oluseyi, additional, Olasunkanmi, Olisa, additional, Akande, Olatunji, additional, Nwafor, Ifeanyi, additional, Ekeh, Matthew, additional, Ndoma, Erim, additional, Ewah, Richard, additional, Duruihuoma, Rosemary, additional, Abu, Augustine, additional, Odeh, Elizabeth, additional, Onyia, Venatious, additional, Ojide, Kingsley C., additional, Okoro, Sylvanus, additional, Igwe, Daniel, additional, Khan, Kamran, additional, Ajayi, Anthony N., additional, Ugwu, Ebhodaghe Ngozi, additional, Ugwu, Collins N., additional, Ukwuaja, Kingsley, additional, Ogah, Emeka O., additional, Abejegah, Chukwuyem, additional, Adedosu, Nelson, additional, Ayodeji, Olufemi, additional, Isamotu, Rafiu O., additional, Gadzama, Galadima, additional, Petros, Brittany, additional, Siddle, Katherine J., additional, Schaffner, Stephen, additional, Akpede, George, additional, Erameh, Cyril Oshomah, additional, Baba, Marycelin, additional, Oladiji, Femi, additional, Audu, Rosemary, additional, Ndodo, Nnaemeka, additional, Fowotade, Adeola, additional, Okogbenin, Sylvanus, additional, Okokhere, Peter, additional, Park, Danny, additional, Mcannis, Bronwyn, additional, Adetifa, Ifedayo, additional, Ihekweazu, Chikwe, additional, Salako, Babatunde L., additional, Tomori, Oyewale, additional, Happi, Anise N., additional, Folarin, Onikepe A., additional, Andersen, Kristian G., additional, Sabeti, Pardis C., additional, and Happi, Christian T., additional

Published
2022
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23. Implementation of a Non-Invasive Helmet Ventilation Solution for the Management of Severe COVID-19 Respiratory Disease in Nigeria: The CircumVent Project

Author

Ahonkhai, Aima A., primary, Abdu, Aliyu, additional, Adekanmbi, Olukemi, additional, Ajayi, Nnennaya A., additional, Ajayi, Samuel, additional, Akpobi, Happy, additional, Akpochafo, Ejiro Benjamin, additional, Aliyu, Muktar H., additional, Ayuk, Adaeze C, additional, Dada, Adedamola A., additional, Ezechi, Oliver C., additional, Falade, Catherine O., additional, Horstein, Alex, additional, Olusola, Idowu, additional, Idigbe, Ifeoma, additional, Mogaj, Sunday, additional, Morenikeji, Aleem A., additional, Musa, Baba M., additional, Nwosu, Nnamdi I., additional, Odewabi, Adenike A, additional, Ofokotun, Igho, additional, Ogedegbe, Gbenga, additional, Ogueh, Onome, additional, Oyewole, Temitope O, additional, Sotannde, Adeshola I., additional, Steinbach, Alan B., additional, Ulasi, Ifeoma I., additional, Ukwaj, Kingsley N., additional, Unigwe, Uchechukwu S., additional, Usman, Olagoke A., additional, Uzoke, Cyril, additional, Musa, Adesola Z., additional, Rotimi, Muyiwa K., additional, Akase, Iorhen E., additional, Adeyemo, Wasiu L., additional, Fenton, André A., additional, and Salako, Babatunde L., additional

Published
2022
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24. Acute and Subacute Oral Toxicity Characterization and Safety Assessment of COVID Organics® (Madagascar's Anti-COVID Herbal Tea) in Animal Models.

Author

Aina, Oluwagbemiga Olarewaju, Okoyenta, Onyinye Celestina, Okolo, Clemen Abu, Kareem, Kafilat Olaide, Ajibaye, Olusola, Adeogun, Adedapo O., and Salako, Babatunde L.

Subjects
SARS-CoV-2, HERBAL teas, ACUTE toxicity testing, COVID-19, POISONS, CORONAVIRUS diseases
Abstract

Copyright of Annals of African Medicine is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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27. A Multicentre Observational Study of HIV, TB and Risk of Chronic Lung Disease in Urban West Africa

Author

Fink, Douglas Lidgard, primary, Oladele, David A., additional, Slack, Abigail Jane, additional, Odubela, Oluwatosin, additional, Musari-Martins, Tomilola, additional, Okechukwu, Adaobi, additional, Adetayo, Kemi, additional, Opaneye, Sola, additional, Abubakar, Rufai, additional, David, Agatha, additional, Cai, James, additional, Quaderi, Shumonta, additional, Abubakar, Ibrahim, additional, Ezechi, Oliver C., additional, Hurst, John R., additional, Lipman, Marc, additional, and Salako, Babatunde L., additional

Published
2022
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30. HIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruria

Author

Kruzel-Davila, Etty, primary, Sankofi, Barbara Mensah, additional, Kubi Amos-Abanyie, Ernestine, additional, Ghansah, Anita, additional, Nyarko, Alexander, additional, Agyemang, Seth, additional, Awandare, Gordon A., additional, Szwarcwort-Cohen, Moran, additional, Reiner-Benaim, Anat, additional, Hijazi, Basem, additional, Ulasi, Ifeoma, additional, Raji, Yemi Raheem, additional, Boima, Vincent, additional, Osafo, Charlotte, additional, May Adabayeri, Victoria, additional, Matekole, Michael, additional, Olanrewaju, Timothy O., additional, Ajayi, Samuel, additional, Mamven, Manmak, additional, Antwi, Sampson, additional, Ademola, Adebowale D., additional, Plange-Rhule, Jacob, additional, Arogundade, Fatiu, additional, Akyaw, Priscilla Abena, additional, Winkler, Cheryl A., additional, Salako, Babatunde L., additional, Ojo, Akinlolu, additional, Skorecki, Karl, additional, and Adu, Dwomoa, additional

Published
2021
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31. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Author

de las Fuentes, Lisa, Sung, Yun Ju, Noordam, Raymond, Winkler, Thomas, Feitosa, Mary F., Schwander, Karen, Bentley, Amy R., Brown, Michael R., Guo, Xiuqing, Manning, Alisa, Chasman, Daniel I., Aschard, Hugues, Bartz, Traci M., Bielak, Lawrence F., Campbell, Archie, Cheng, Ching-Yu, Dorajoo, Rajkumar, Hartwig, Fernando P., Horimoto, A.R.V.R., Li, Changwei, Li-Gao, Ruifang, Liu, Yongmei, Marten, Jonathan, Musani, Solomon K., Ntalla, Ioanna, Rankinen, Tuomo, Richard, Melissa, Sim, Xueling, Smith, Albert V., Tajuddin, Salman M., Tayo, Bamidele O., Vojinovic, Dina, Warren, Helen R., Xuan, Deng, Alver, Maris, Boissel, Mathilde, Chai, Jin-Fang, Chen, Xu, Christensen, Kaare, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Girotto, Giorgia, Harris, Sarah E., He, Meian, Hsu, Fang-Chi, Kühnel, Brigitte, Laguzzi, Federica, Li, Xiaoyin, Lyytikäinen, Leo-Pekka, Nolte, Ilja M., Poveda, Alaitz, Rauramaa, Rainer, Riaz, Muhammad, Rueedi, Rico, Shu, Xiao-ou, Snieder, Harold, Sofer, Tamar, Takeuchi, Fumihiko, Verweij, Niek, Ware, Erin B., Weiss, Stefan, Yanek, Lisa R., Amin, Najaf, Arking, Dan E., Arnett, Donna K., Bergmann, Sven, Boerwinkle, Eric, Brody, Jennifer A., Broeckel, Ulrich, Brumat, Marco, Burke, Gregory, Cabrera, Claudia P., Canouil, Mickaël, Chee, Miao Li, Chen, Yii-Der Ida, Cocca, Massimiliano, Connell, John, de Silva, H. Janaka, de Vries, Paul S., Eiriksdottir, Gudny, Faul, Jessica D., Fisher, Virginia, Forrester, Terrence, Fox, Ervin F., Friedlander, Yechiel, Gao, He, Gigante, Bruna, Giulianini, Franco, Gu, Chi Charles, Gu, Dongfeng, Harris, Tamara B., He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hunt, Steven, Ikram, M. Arfan, Irvin, Marguerite R., Kähönen, Mika, Kavousi, Maryam, Khor, Chiea Chuen, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Komulainen, Pirjo, Kraja, Aldi T., Krieger, J.E., Langefeld, Carl D., Li, Yize, Liang, Jingjing, Liewald, David C. M., Liu, Ching-Ti, Liu, Jianjun, Lohman, Kurt K., Mägi, Reedik, McKenzie, Colin A., Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Milani, Lili, Mook-Kanamori, Dennis O., Nalls, Mike A., Nelson, Christopher P., Norris, Jill M., O’Connell, Jeff, Ogunniyi, Adesola, Padmanabhan, Sandosh, Palmer, Nicholette D., Pedersen, Nancy L., Perls, Thomas, Peters, Annette, Petersmann, Astrid, Peyser, Patricia A., Polasek, Ozren, Porteous, David J., Raffel, Leslie J., Rice, Treva K., Rotter, Jerome I., Rudan, Igor, Rueda-Ochoa, Oscar-Leonel, Sabanayagam, Charumathi, Salako, Babatunde L., Schreiner, Pamela J., Shikany, James M., Sidney, Stephen S., Sims, Mario, Sitlani, Colleen M., Smith, Jennifer A., Starr, John M., Strauch, Konstantin, Swertz, Morris A., Teumer, Alexander, Tham, Yih Chung, Uitterlinden, André G., Vaidya, Dhananjay, van der Ende, M. Yldau, Waldenberger, Melanie, Wang, Lihua, Wang, Ya-Xing, Wei, Wen-Bin, Weir, David R., Wen, Wanqing, Yao, Jie, Yu, Bing, Yu, Caizheng, Yuan, Jian-Min, Zhao, Wei, Zonderman, Alan B., Becker, Diane M., Bowden, Donald W., Deary, Ian J., Dörr, Marcus, Esko, Tõnu, Freedman, Barry I., Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Jonas, Jost Bruno, Kammerer, Candace M., Kato, Norihiro, Lakka, Timo A., Leander, Karin, Lehtimäki, Terho, Magnusson, Patrik K. E., Marques-Vidal, Pedro, Penninx, Brenda W. J. H., Samani, Nilesh J., van der Harst, Pim, Wagenknecht, Lynne E., Wu, Tangchun, Zheng, Wei, Zhu, Xiaofeng, Bouchard, Claude, Cooper, Richard S., Correa, Adolfo, Evans, Michele K., Gudnason, Vilmundur, Hayward, Caroline, Horta, Bernardo L., Kelly, Tanika N., Kritchevsky, Stephen B., Levy, Daniel, Palmas, Walter R., Pereira, A.C., Province, Michael M., Psaty, Bruce M., Ridker, Paul M., Rotimi, Charles N., Tai, E. Shyong, van Dam, Rob M., van Duijn, Cornelia M., Wong, Tien Yin, Rice, Kenneth, Gauderman, W. James, Morrison, Alanna C., North, Kari E., Kardia, Sharon L. R., Caulfield, Mark J., Elliott, Paul, Munroe, Patricia B., Franks, Paul W., Rao, Dabeeru C., Fornage, Myriam, de las Fuentes, Lisa, Sung, Yun Ju, Noordam, Raymond, Winkler, Thomas, Feitosa, Mary F., Schwander, Karen, Bentley, Amy R., Brown, Michael R., Guo, Xiuqing, Manning, Alisa, Chasman, Daniel I., Aschard, Hugues, Bartz, Traci M., Bielak, Lawrence F., Campbell, Archie, Cheng, Ching-Yu, Dorajoo, Rajkumar, Hartwig, Fernando P., Horimoto, A.R.V.R., Li, Changwei, Li-Gao, Ruifang, Liu, Yongmei, Marten, Jonathan, Musani, Solomon K., Ntalla, Ioanna, Rankinen, Tuomo, Richard, Melissa, Sim, Xueling, Smith, Albert V., Tajuddin, Salman M., Tayo, Bamidele O., Vojinovic, Dina, Warren, Helen R., Xuan, Deng, Alver, Maris, Boissel, Mathilde, Chai, Jin-Fang, Chen, Xu, Christensen, Kaare, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Girotto, Giorgia, Harris, Sarah E., He, Meian, Hsu, Fang-Chi, Kühnel, Brigitte, Laguzzi, Federica, Li, Xiaoyin, Lyytikäinen, Leo-Pekka, Nolte, Ilja M., Poveda, Alaitz, Rauramaa, Rainer, Riaz, Muhammad, Rueedi, Rico, Shu, Xiao-ou, Snieder, Harold, Sofer, Tamar, Takeuchi, Fumihiko, Verweij, Niek, Ware, Erin B., Weiss, Stefan, Yanek, Lisa R., Amin, Najaf, Arking, Dan E., Arnett, Donna K., Bergmann, Sven, Boerwinkle, Eric, Brody, Jennifer A., Broeckel, Ulrich, Brumat, Marco, Burke, Gregory, Cabrera, Claudia P., Canouil, Mickaël, Chee, Miao Li, Chen, Yii-Der Ida, Cocca, Massimiliano, Connell, John, de Silva, H. Janaka, de Vries, Paul S., Eiriksdottir, Gudny, Faul, Jessica D., Fisher, Virginia, Forrester, Terrence, Fox, Ervin F., Friedlander, Yechiel, Gao, He, Gigante, Bruna, Giulianini, Franco, Gu, Chi Charles, Gu, Dongfeng, Harris, Tamara B., He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hunt, Steven, Ikram, M. Arfan, Irvin, Marguerite R., Kähönen, Mika, Kavousi, Maryam, Khor, Chiea Chuen, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Komulainen, Pirjo, Kraja, Aldi T., Krieger, J.E., Langefeld, Carl D., Li, Yize, Liang, Jingjing, Liewald, David C. M., Liu, Ching-Ti, Liu, Jianjun, Lohman, Kurt K., Mägi, Reedik, McKenzie, Colin A., Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Milani, Lili, Mook-Kanamori, Dennis O., Nalls, Mike A., Nelson, Christopher P., Norris, Jill M., O’Connell, Jeff, Ogunniyi, Adesola, Padmanabhan, Sandosh, Palmer, Nicholette D., Pedersen, Nancy L., Perls, Thomas, Peters, Annette, Petersmann, Astrid, Peyser, Patricia A., Polasek, Ozren, Porteous, David J., Raffel, Leslie J., Rice, Treva K., Rotter, Jerome I., Rudan, Igor, Rueda-Ochoa, Oscar-Leonel, Sabanayagam, Charumathi, Salako, Babatunde L., Schreiner, Pamela J., Shikany, James M., Sidney, Stephen S., Sims, Mario, Sitlani, Colleen M., Smith, Jennifer A., Starr, John M., Strauch, Konstantin, Swertz, Morris A., Teumer, Alexander, Tham, Yih Chung, Uitterlinden, André G., Vaidya, Dhananjay, van der Ende, M. Yldau, Waldenberger, Melanie, Wang, Lihua, Wang, Ya-Xing, Wei, Wen-Bin, Weir, David R., Wen, Wanqing, Yao, Jie, Yu, Bing, Yu, Caizheng, Yuan, Jian-Min, Zhao, Wei, Zonderman, Alan B., Becker, Diane M., Bowden, Donald W., Deary, Ian J., Dörr, Marcus, Esko, Tõnu, Freedman, Barry I., Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Jonas, Jost Bruno, Kammerer, Candace M., Kato, Norihiro, Lakka, Timo A., Leander, Karin, Lehtimäki, Terho, Magnusson, Patrik K. E., Marques-Vidal, Pedro, Penninx, Brenda W. J. H., Samani, Nilesh J., van der Harst, Pim, Wagenknecht, Lynne E., Wu, Tangchun, Zheng, Wei, Zhu, Xiaofeng, Bouchard, Claude, Cooper, Richard S., Correa, Adolfo, Evans, Michele K., Gudnason, Vilmundur, Hayward, Caroline, Horta, Bernardo L., Kelly, Tanika N., Kritchevsky, Stephen B., Levy, Daniel, Palmas, Walter R., Pereira, A.C., Province, Michael M., Psaty, Bruce M., Ridker, Paul M., Rotimi, Charles N., Tai, E. Shyong, van Dam, Rob M., van Duijn, Cornelia M., Wong, Tien Yin, Rice, Kenneth, Gauderman, W. James, Morrison, Alanna C., North, Kari E., Kardia, Sharon L. R., Caulfield, Mark J., Elliott, Paul, Munroe, Patricia B., Franks, Paul W., Rao, Dabeeru C., and Fornage, Myriam

Abstract

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P < 5 × 10-8). Two novel loci were identified based on the 1DF test of interaction with educational attainment, while the remaining 16 loci were identified through the 2DF joint test of genetic and interaction effects. Ten novel loci were identified in individuals of African ancestry. Several novel loci show strong biological plausibility since they involve physiologic systems implicated in BP regulation. They include genes involved in the central nervous system-adrenal signaling axis (ZDHHC17, CADPS, PIK3C2G), vascular structure and function (GNB3, CDON), and renal function (HAS2 and HAS2-AS1, SLIT3). Collectively, these findings suggest a role of educational attainment or SES in further dissection of the genetic architecture of BP.

Published
2021
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32. Salivary electrolytes, total protein and immunoglobulin a in patients with chronic kidney disease: A case control study

Author

Lasisi, Taye J., Raji, Yemi R., and Salako, Babatunde L.

Subjects
Saliva, electrolytes, total protein, correlation, chronic kidney disease
Abstract

Summary: The objectives of this study were to compare levels salivary electrolytes, total protein and immunoglobulin A (IgA) in patients with chronic kidney disease (CKD) and healthy individuals; and to determine the relationship between the salivary and blood levels of these factors between the two groups. Ninety-eight participants consisting of 48 patients with CKD and 50 healthy individuals (age and gender matched) were included. Whole saliva and blood samples were collected and analyzed for concentrations of electrolytes (K+, Na+, Ca2+, Cl-, and HCO32-), total protein and IgA. Data were analyzed using Independent-Samples t-test and Pearson correlation test. Concentrations of salivary K+, Ca2+, Cl-, and total protein were higher; while concentrations of salivary Na+, HCO32- were lower in patients with CKD compared with healthy individuals. There was no difference in the salivary IgA levels in patients with CKD compared with healthy individuals. Salivary calcium level showed linear correlation with the plasma calcium level while salivary chloride level showed negative correlation with plasma chloride level among patients with CKD. These findings indicate that saliva and plasma from patients with CKD are characterized by higher potassium, chloride, and lower sodium concentrations than their levels in healthy individuals; thus, suggesting a possible increased adrenal-cortical activity in patients with CKD.Keywords: Saliva, electrolytes, total protein, correlation, chronic kidney diseaseNiger. J. Physiol. Sci. 33(December 2018) 177-182

Published
2020

33. COVID-19 Experience: Taking the Right Steps at the Right Time to Prevent Avoidable Morbidity and Mortality in Nigeria and Other Nations of the World

Author

Oleribe,Obinna O, Osita-Oleribe,Princess, Salako,Babatunde L, Ishola,Temitope A, Fertleman,Michael, Taylor-Robinson,Simon D, Oleribe,Obinna O, Osita-Oleribe,Princess, Salako,Babatunde L, Ishola,Temitope A, Fertleman,Michael, and Taylor-Robinson,Simon D

Abstract

Obinna O Oleribe,1 Princess Osita-Oleribe,2 Babatunde L Salako,3 Temitope A Ishola,4 Michael Fertleman,5 Simon D Taylor-Robinson6 1Excellence and Friends Management Care Centre, Abuja, Nigeria; 2Centre for Family Health Initiative, Abuja, Nigeria; 3Nigeria Institute for Medical Research, Lagos, Nigeria; 4Department of Biochemistry, Covenant University, Ota, Nigeria; 5Cutrale Perioperative & Ageing Group, Department of Bioengineering, Imperial College London, London, UK; 6Department of Surgery and Cancer, Imperial College London, London, UKCorrespondence: Michael Fertleman Cutrale Perioperative & Ageing Group, Department of Bioengineering, 86 Wood Lane, London W12 0BZ, UKEmail m.fertleman@imperial.ac.ukAbstract: The 2020 Coronavirus pandemic has caused countless governmental and societal challenges around the world. Nigeria, Africa’s most populous nation, has been exposed in recent years to a series of epidemics including Ebola and Lassa fever. In this paper, we document our perception of the national response to COVID-19 in Nigeria. The response to the pandemic is with a healthcare system that has changed as a result of previous infectious disease outbreaks but in the context of scarce resources typical of many low-middle income countries. We make recommendations regarding what measures should be in place for future epidemics.Keywords: Nigeria, COVID-19, pandemic, prevention

Published
2020

40. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Author

Sung, Yun Ju, de Las Fuentes, Lisa, Winkler, Thomas W., Chasman, Daniel, I, Bentley, Amy R., Kraja, Aldi T., Ntalla, Ioanna, Warren, Helen R., Guo, Xiuqing, Schwander, Karen, Manning, Alisa K., Brown, Michael R., Aschard, Hugues, Feitosa, Mary F., Franceschini, Nora, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Marten, Jonathan, Musani, Solomon K., Kilpelainen, Tuomas O., Richard, Melissa A., Aslibekyan, Stella, Bartz, Traci M., Dorajoo, Rajkumar, Li, Changwei, Liu, Yongmei, Rankinen, Tuomo, Smith, Albert Vernon, Tajuddin, Salman M., Tayo, Bamidele O., Zhao, Wei, Zhou, Yanhua, Matoba, Nana, Sofer, Tamar, Alver, Maris, Amini, Marzyeh, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Gandin, Ilaria, Gao, Chuan, Giulianini, Franco, Goel, Anuj, Harris, Sarah E., Hartwig, Fernando P., He, Meian, Horimoto, Andrea R. V. R., Hsu, Fang-Chi, Jackson, Anne U., Kammerer, Candace M., Kasturiratne, Anuradhani, Komulainen, Pirjo, Kuehnel, Brigitte, Leander, Karin, Lee, Wen-Jane, Lin, Keng-Hung, Luan, Jian'an, Lyytikainen, Leo-Pekka, McKenzie, Colin A., Nelson, Christopher P., Noordam, Raymond, Scott, Robert A., Sheu, Wayne H. H., Stancakova, Alena, Takeuchi, Fumihiko, van Der Most, Peter J., Varga, Tibor V., Waken, Robert J., Wang, Heming, Wang, Yajuan, Ware, Erin B., Weiss, Stefan, Wen, Wanqing, Yanek, Lisa R., Zhang, Weihua, Zhao, Jing Hua, Afaq, Saima, Alfred, Tamuno, Amin, Najaf, Arking, Dan E., Aung, Tin, Barr, R. Graham, Bielak, Lawrence F., Boerwinkle, Eric, Bottinger, Erwin P., Braund, Peter S., Brody, Jennifer A., Broeckel, Ulrich, Cade, Brian, Campbell, Archie, Canouil, Mickael, Chakravarti, Aravinda, Cocca, Massimiliano, Collins, Francis S., Connell, John M., de Mutsert, Renee, de Silva, H. Janaka, Doerr, Marcus, Duan, Qing, Eaton, Charles B., Ehret, Georg, Evangelou, Evangelos, Faul, Jessica D., Forouhi, Nita G., Franco, Oscar H., Friedlander, Yechiel, Gao, He, Gigante, Bruna, Gu, C. Charles, Gupta, Preeti, Hagenaars, Saskia P., Harris, Tamara B., He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hofman, Albert, Howard, Barbara, V, Hunt, Steven C., Irvin, Marguerite R., Jia, Yucheng, Katsuya, Tomohiro, Kaufman, Joel, Kerrison, Nicola D., Khor, Chiea Chuen, Koh, Woon-Puay, Koistinen, Heikki A., Kooperberg, Charles B., Krieger, Jose E., Kubo, Michiaki, Kutalik, Zoltan, Kuusisto, Johanna, Lakka, Timo A., Langefeld, Carl D., Langenberg, Claudia, Launer, Lenore J., Lee, Joseph H., Lehne, Benjamin, Levy, Daniel, Lewis, Cora E., Li, Yize, Lim, Sing Hui, Liu, Ching-Ti, Liu, Jianjun, Liu, Jingmin, Liu, Yeheng, Loh, Marie, Lohman, Kurt K., Louie, Tin, Magi, Reedik, Matsuda, Koichi, Meitinger, Thomas, Metspalu, Andres, Milani, Lili, Momozawa, Yukihide, Mosley, Thomas H., Jr., Nalls, Mike A., Nasri, Ubaydah, O'Connell, Jeff R., Ogunniyi, Adesola, Palmas, Walter R., Palmer, Nicholette D., Pankow, James S., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Porteous, David, Raitakari, Olli T., Renström, Frida, Rice, Treva K., Ridker, Paul M., Robino, Antonietta, Robinson, Jennifer G., Rose, Lynda M., Rudan, Igor, Sabanayagam, Charumathi, Salako, Babatunde L., Sandow, Kevin, Schmidt, Carsten O., Schreiner, Pamela J., Scott, William R., Sever, Peter, Sims, Mario, Sitlani, Colleen M., Smith, Blair H., Smith, Jennifer A., Snieder, Harold, Starr, John M., Strauch, Konstantin, Tang, Hua, Taylor, Kent D., Teo, Yik Ying, Tham, Yih Chung, Uitterlinden, Andre G., Waldenberger, Melanie, Wang, Lihua, Wang, Ya Xing, Wei, Wen Bin, Wilson, Gregory, Wojczynski, Mary K., Xiang, Yong-Bing, Yao, Jie, Yu, Caizheng, Yuan, Jian-Min, Zonderman, Alan B., Becker, Diane M., Boehnke, Michael, Bowden, Donald W., Chambers, John C., Chen, Yii-Der Ida, Weir, David R., de Faire, Ulf, Deary, Ian J., Esko, Tonu, Farrall, Martin, Forrester, Terrence, Freedman, Barry, I, Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Horta, Bernardo Lessa, Hung, Yi-Jen, Jonas, Jost Bruno, Kato, Norihiro, Kooner, Jaspal S., Laakso, Markku, Lehtimaki, Terho, Liang, Kae-Woei, Magnusson, Patrik K. E., Oldehinkel, Albertine J., Pereira, Alexandre C., Perls, Thomas, Rauramaa, Rainer, Redline, Susan, Rettig, Rainer, Samani, Nilesh J., Scott, James, Shu, Xiao-Ou, van Der Harst, Pim, Wagenknecht, Lynne E., Wareham, Nicholas J., Watkins, Hugh, Wickremasinghe, Ananda R., Wu, Tangchun, Kamatani, Yoichiro, Laurie, Cathy C., Bouchard, Claude, Cooper, Richard S., Evans, Michele K., Gudnason, Vilmundur, Hixson, James, Kardia, Sharon L. R., Kritchevsky, Stephen B., Psaty, Bruce M., van Dam, Rob M., Arnett, Donna K., Mook-Kanamori, Dennis O., Fornage, Myriam, Fox, Ervin R., Hayward, Caroline, van Duijn, Cornelia M., Tai, E. Shyong, Wong, Tien Yin, Loos, Ruth J. F., Reiner, Alex P., Rotimi, Charles N., Bierut, Laura J., Zhu, Xiaofeng, Cupples, L. Adrienne, Province, Michael A., Rotter, Jerome, I, Franks, Paul W., Rice, Kenneth, Elliott, Paul, Caulfield, Mark J., Gauderman, W. James, Munroe, Patricia B., Rao, Dabeeru C., Morrison, Alanna C., Sung, Yun Ju, de Las Fuentes, Lisa, Winkler, Thomas W., Chasman, Daniel, I, Bentley, Amy R., Kraja, Aldi T., Ntalla, Ioanna, Warren, Helen R., Guo, Xiuqing, Schwander, Karen, Manning, Alisa K., Brown, Michael R., Aschard, Hugues, Feitosa, Mary F., Franceschini, Nora, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Marten, Jonathan, Musani, Solomon K., Kilpelainen, Tuomas O., Richard, Melissa A., Aslibekyan, Stella, Bartz, Traci M., Dorajoo, Rajkumar, Li, Changwei, Liu, Yongmei, Rankinen, Tuomo, Smith, Albert Vernon, Tajuddin, Salman M., Tayo, Bamidele O., Zhao, Wei, Zhou, Yanhua, Matoba, Nana, Sofer, Tamar, Alver, Maris, Amini, Marzyeh, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Gandin, Ilaria, Gao, Chuan, Giulianini, Franco, Goel, Anuj, Harris, Sarah E., Hartwig, Fernando P., He, Meian, Horimoto, Andrea R. V. R., Hsu, Fang-Chi, Jackson, Anne U., Kammerer, Candace M., Kasturiratne, Anuradhani, Komulainen, Pirjo, Kuehnel, Brigitte, Leander, Karin, Lee, Wen-Jane, Lin, Keng-Hung, Luan, Jian'an, Lyytikainen, Leo-Pekka, McKenzie, Colin A., Nelson, Christopher P., Noordam, Raymond, Scott, Robert A., Sheu, Wayne H. H., Stancakova, Alena, Takeuchi, Fumihiko, van Der Most, Peter J., Varga, Tibor V., Waken, Robert J., Wang, Heming, Wang, Yajuan, Ware, Erin B., Weiss, Stefan, Wen, Wanqing, Yanek, Lisa R., Zhang, Weihua, Zhao, Jing Hua, Afaq, Saima, Alfred, Tamuno, Amin, Najaf, Arking, Dan E., Aung, Tin, Barr, R. Graham, Bielak, Lawrence F., Boerwinkle, Eric, Bottinger, Erwin P., Braund, Peter S., Brody, Jennifer A., Broeckel, Ulrich, Cade, Brian, Campbell, Archie, Canouil, Mickael, Chakravarti, Aravinda, Cocca, Massimiliano, Collins, Francis S., Connell, John M., de Mutsert, Renee, de Silva, H. Janaka, Doerr, Marcus, Duan, Qing, Eaton, Charles B., Ehret, Georg, Evangelou, Evangelos, Faul, Jessica D., Forouhi, Nita G., Franco, Oscar H., Friedlander, Yechiel, Gao, He, Gigante, Bruna, Gu, C. Charles, Gupta, Preeti, Hagenaars, Saskia P., Harris, Tamara B., He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hofman, Albert, Howard, Barbara, V, Hunt, Steven C., Irvin, Marguerite R., Jia, Yucheng, Katsuya, Tomohiro, Kaufman, Joel, Kerrison, Nicola D., Khor, Chiea Chuen, Koh, Woon-Puay, Koistinen, Heikki A., Kooperberg, Charles B., Krieger, Jose E., Kubo, Michiaki, Kutalik, Zoltan, Kuusisto, Johanna, Lakka, Timo A., Langefeld, Carl D., Langenberg, Claudia, Launer, Lenore J., Lee, Joseph H., Lehne, Benjamin, Levy, Daniel, Lewis, Cora E., Li, Yize, Lim, Sing Hui, Liu, Ching-Ti, Liu, Jianjun, Liu, Jingmin, Liu, Yeheng, Loh, Marie, Lohman, Kurt K., Louie, Tin, Magi, Reedik, Matsuda, Koichi, Meitinger, Thomas, Metspalu, Andres, Milani, Lili, Momozawa, Yukihide, Mosley, Thomas H., Jr., Nalls, Mike A., Nasri, Ubaydah, O'Connell, Jeff R., Ogunniyi, Adesola, Palmas, Walter R., Palmer, Nicholette D., Pankow, James S., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Porteous, David, Raitakari, Olli T., Renström, Frida, Rice, Treva K., Ridker, Paul M., Robino, Antonietta, Robinson, Jennifer G., Rose, Lynda M., Rudan, Igor, Sabanayagam, Charumathi, Salako, Babatunde L., Sandow, Kevin, Schmidt, Carsten O., Schreiner, Pamela J., Scott, William R., Sever, Peter, Sims, Mario, Sitlani, Colleen M., Smith, Blair H., Smith, Jennifer A., Snieder, Harold, Starr, John M., Strauch, Konstantin, Tang, Hua, Taylor, Kent D., Teo, Yik Ying, Tham, Yih Chung, Uitterlinden, Andre G., Waldenberger, Melanie, Wang, Lihua, Wang, Ya Xing, Wei, Wen Bin, Wilson, Gregory, Wojczynski, Mary K., Xiang, Yong-Bing, Yao, Jie, Yu, Caizheng, Yuan, Jian-Min, Zonderman, Alan B., Becker, Diane M., Boehnke, Michael, Bowden, Donald W., Chambers, John C., Chen, Yii-Der Ida, Weir, David R., de Faire, Ulf, Deary, Ian J., Esko, Tonu, Farrall, Martin, Forrester, Terrence, Freedman, Barry, I, Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Horta, Bernardo Lessa, Hung, Yi-Jen, Jonas, Jost Bruno, Kato, Norihiro, Kooner, Jaspal S., Laakso, Markku, Lehtimaki, Terho, Liang, Kae-Woei, Magnusson, Patrik K. E., Oldehinkel, Albertine J., Pereira, Alexandre C., Perls, Thomas, Rauramaa, Rainer, Redline, Susan, Rettig, Rainer, Samani, Nilesh J., Scott, James, Shu, Xiao-Ou, van Der Harst, Pim, Wagenknecht, Lynne E., Wareham, Nicholas J., Watkins, Hugh, Wickremasinghe, Ananda R., Wu, Tangchun, Kamatani, Yoichiro, Laurie, Cathy C., Bouchard, Claude, Cooper, Richard S., Evans, Michele K., Gudnason, Vilmundur, Hixson, James, Kardia, Sharon L. R., Kritchevsky, Stephen B., Psaty, Bruce M., van Dam, Rob M., Arnett, Donna K., Mook-Kanamori, Dennis O., Fornage, Myriam, Fox, Ervin R., Hayward, Caroline, van Duijn, Cornelia M., Tai, E. Shyong, Wong, Tien Yin, Loos, Ruth J. F., Reiner, Alex P., Rotimi, Charles N., Bierut, Laura J., Zhu, Xiaofeng, Cupples, L. Adrienne, Province, Michael A., Rotter, Jerome, I, Franks, Paul W., Rice, Kenneth, Elliott, Paul, Caulfield, Mark J., Gauderman, W. James, Munroe, Patricia B., Rao, Dabeeru C., and Morrison, Alanna C.

Abstract

Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings.

Published
2019
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41. The LancetNigeria Commission: investing in health and the future of the nation

Author

Abubakar, Ibrahim, Dalglish, Sarah L, Angell, Blake, Sanuade, Olutobi, Abimbola, Seye, Adamu, Aishatu Lawal, Adetifa, Ifedayo M O, Colbourn, Tim, Ogunlesi, Afolabi Olaniyi, Onwujekwe, Obinna, Owoaje, Eme T, Okeke, Iruka N, Adeyemo, Adebowale, Aliyu, Gambo, Aliyu, Muktar H, Aliyu, Sani Hussaini, Ameh, Emmanuel A, Archibong, Belinda, Ezeh, Alex, Gadanya, Muktar A, Ihekweazu, Chikwe, Ihekweazu, Vivianne, Iliyasu, Zubairu, Kwaku Chiroma, Aminatu, Mabayoje, Diana A, Nasir Sambo, Mohammed, Obaro, Stephen, Yinka-Ogunleye, Adesola, Okonofua, Friday, Oni, Tolu, Onyimadu, Olu, Pate, Muhammad Ali, Salako, Babatunde L, Shuaib, Faisal, Tsiga-Ahmed, Fatimah, and Zanna, Fatima H

Published
2022
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44. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Author

Sung, Yun J., Winkler, Thomas W., de las Fuentes, Lisa, Bentley, Amy R., Brown, Michael R., Kraja, Aldi T., Schwander, Karen, Ntalla, Ioanna, Guo, Xiuqing, Franceschini, Nora, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Marten, Jonathan, Musani, Solomon K., Li, Changwei, Feitosa, Mary F., Kilpelainen, Tuomas O., Richard, Melissa A., Noordam, Raymond, Aslibekyan, Stella, Aschard, Hugues, Bartz, Traci M., Dorajoo, Rajkumar, Liu, Yongmei, Manning, Alisa K., Rankinen, Tuomo, Smith, Albert Vernon, Tajuddin, Salman M., Tayo, Bamidele O., Warren, Helen R., Zhao, Wei, Zhou, Yanhua, Matoba, Nana, Sofer, Tamar, Alver, Maris, Amini, Marzyeh, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Gandin, Ilaria, Gao, Chuan, Giulianini, Franco, Goel, Anuj, Harris, Sarah E., Hartwig, Fernando Pires, Horimoto, Andrea R. V. R., Hsu, Fang-Chi, Jackson, Anne U., Kahonen, Mika, Kasturiratne, Anuradhani, Kuhnel, Brigitte, Leander, Karin, Lee, Wen-Jane, Lin, Keng-Hung, Luan, Jian' an, McKenzie, Colin A., Meian, He, Nelson, Christopher P., Rauramaa, Rainer, Schupf, Nicole, Scott, Robert A., Sheu, Wayne H. H., Stancakova, Alena, Takeuchi, Fumihiko, van der Most, Peter J., Varga, Tibor V., Wang, Heming, Wang, Yajuan, Ware, Erin B., Weiss, Stefan, Wen, Wanqing, Yanek, Lisa R., Zhang, Weihua, Zhao, Jing Hua, Afaq, Saima, Alfred, Tamuno, Amin, Najaf, Arking, Dan, Aung, Tin, Barr, R. Graham, Bielak, Lawrence F., Boerwinkle, Eric, Bottinger, Erwin P., Braund, Peter S., Brody, Jennifer A., Broeckel, Ulrich, Cabrera, Claudia P., Cade, Brian, Caizheng, Yu, Campbell, Archie, Canouil, Mickael, Chakravarti, Aravinda, Chauhan, Ganesh, Christensen, Kaare, Cocca, Massimiliano, Collins, Francis S., Connell, John M., de Mutsert, Renee, de Silva, H. Janaka, Debette, Stephanie, Dorr, Marcus, Duan, Qing, Eaton, Charles B., Ehret, Georg, Evangelou, Evangelos, Faul, Jessica D., Fisher, Virginia A., Forouhi, Nita G., Franco, Oscar H., Friedlander, Yechiel, Gao, He, Gigante, Bruna, Graff, Misa, Gu, C. Charles, Gu, Dongfeng, Gupta, Preeti, Hagenaars, Saskia P., Harris, Tamara B., He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hirata, Makoto, Hofman, Albert, Howard, Barbara V., Hunt, Steven, Irvin, Marguerite R., Jia, Yucheng, Joehanes, Roby, Justice, Anne E., Katsuya, Tomohiro, Kaufman, Joel, Kerrison, Nicola D., Khor, Chiea Chuen, Koh, Woon-Puay, Koistinen, Heikki A., Komulainen, Pirjo, Kooperberg, Charles, Krieger, Jose E., Kubo, Michiaki, Kuusisto, Johanna, Langefeld, Carl D., Langenberg, Claudia, Launer, Lenore J., Lehne, Benjamin, Lewis, Cora E., Li, Yize, Lim, Sing Hui, Lin, Shiow, Liu, Ching-Ti, Liu, Jianjun, Liu, Jingmin, Liu, Kiang, Liu, Yeheng, Loh, Marie, Lohman, Kurt K., Long, Jirong, Louie, Tin, Magi, Reedik, Mahajan, Anubha, Meitinger, Thomas, Metspalu, Andres, Milani, Lili, Momozawa, Yukihide, Morris, Andrew P., Mosley, Thomas H., Jr., Munson, Peter, Murray, Alison D., Nalls, Mike A., Nasri, Ubaydah, Norris, Jill M., North, Kari, Ogunniyi, Adesola, Padmanabhan, Sandosh, Palmas, Walter R., Palmer, Nicholette D., Pankow, James S., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Raitakari, Olli T., Renström, Frida, Rice, Treva K., Ridker, Paul M., Robino, Antonietta, Robinson, Jennifer G., Rose, Lynda M., Rudan, Igor, Sabanayagam, Charumathi, Salako, Babatunde L., Sandow, Kevin, Schmidt, Carsten O., Schreiner, Pamela J., Scott, William R., Seshadri, Sudha, Sever, Peter, Sitlani, Colleen M., Smith, Jennifer A., Snieder, Harold, Starr, John M., Strauch, Konstantin, Tang, Hua, Taylor, Kent D., Teo, Yik Ying, Tham, Yih Chung, Ultterlinden, Andre G., Waldenberger, Melanie, Wang, Lihua, Wang, Ya X., Bin Wei, Wen, Williams, Christine, Wilson, Gregory, Wojczynski, Mary K., Yao, Jie, Yuan, Jian-Min, Zonderman, Alan B., Becker, Diane M., Boehnke, Michael, Bowden, Donald W., Chambers, John C., Chen, Yii-Der Ida, de Faire, Ulf, Deary, Ian J., Esko, Tonu, Farrall, Martin, Forrester, Terrence, Franks, Paul W., Freedman, Barry I., Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Horta, Bernardo Lessa, Hung, Yi-Jen, Jonas, Jost B., Kato, Norihiro, Kooner, Jaspal S., Laakso, Markku, Lehtimaki, Terho, Liang, Kae-Woei, Magnusson, Patrik K. E., Newman, Anne B., Oldehinkel, Albertine J., Pereira, Alexandre C., Redline, Susan, Rettig, Rainer, Samani, Nilesh J., Scott, James, Shu, Xiao-Ou, van der Harst, Pim, Wagenknecht, Lynne E., Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wickremasinghe, Ananda R., Wu, Tangchun, Zheng, Wei, Kamatani, Yoichiro, Laurie, Cathy C., Bouchard, Claude, Cooper, Richard S., Evans, Michele K., Gudnason, Vilmundur, Kardia, Sharon L. R., Kritchevsky, Stephen B., Levy, Daniel, O'Connell, Jeff R., Psaty, Bruce M., van Dam, Rob M., Sims, Mario, Arnett, Donna K., Mook-Kanamori, Dennis O., Kelly, Tanika N., Fox, Ervin R., Hayward, Caroline, Fornage, Myriam, Rotimi, Charles N., Province, Michael A., van Duijn, Cornelia M., Tai, E. Shyong, Wong, Tien Yin, Loos, Ruth J. F., Reiner, Alex P., Rotter, Jerome I., Zhu, Xiaofeng, Bierut, Laura J., Gauderman, W. James, Caulfield, Mark J., Elliott, Paul, Rice, Kenneth, Munroe, Patricia B., Morrison, Alanna C., Cupples, L. Adrienne, Rao, Dabeeru C., Chasman, Daniel I., Sung, Yun J., Winkler, Thomas W., de las Fuentes, Lisa, Bentley, Amy R., Brown, Michael R., Kraja, Aldi T., Schwander, Karen, Ntalla, Ioanna, Guo, Xiuqing, Franceschini, Nora, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Marten, Jonathan, Musani, Solomon K., Li, Changwei, Feitosa, Mary F., Kilpelainen, Tuomas O., Richard, Melissa A., Noordam, Raymond, Aslibekyan, Stella, Aschard, Hugues, Bartz, Traci M., Dorajoo, Rajkumar, Liu, Yongmei, Manning, Alisa K., Rankinen, Tuomo, Smith, Albert Vernon, Tajuddin, Salman M., Tayo, Bamidele O., Warren, Helen R., Zhao, Wei, Zhou, Yanhua, Matoba, Nana, Sofer, Tamar, Alver, Maris, Amini, Marzyeh, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Gandin, Ilaria, Gao, Chuan, Giulianini, Franco, Goel, Anuj, Harris, Sarah E., Hartwig, Fernando Pires, Horimoto, Andrea R. V. R., Hsu, Fang-Chi, Jackson, Anne U., Kahonen, Mika, Kasturiratne, Anuradhani, Kuhnel, Brigitte, Leander, Karin, Lee, Wen-Jane, Lin, Keng-Hung, Luan, Jian' an, McKenzie, Colin A., Meian, He, Nelson, Christopher P., Rauramaa, Rainer, Schupf, Nicole, Scott, Robert A., Sheu, Wayne H. H., Stancakova, Alena, Takeuchi, Fumihiko, van der Most, Peter J., Varga, Tibor V., Wang, Heming, Wang, Yajuan, Ware, Erin B., Weiss, Stefan, Wen, Wanqing, Yanek, Lisa R., Zhang, Weihua, Zhao, Jing Hua, Afaq, Saima, Alfred, Tamuno, Amin, Najaf, Arking, Dan, Aung, Tin, Barr, R. Graham, Bielak, Lawrence F., Boerwinkle, Eric, Bottinger, Erwin P., Braund, Peter S., Brody, Jennifer A., Broeckel, Ulrich, Cabrera, Claudia P., Cade, Brian, Caizheng, Yu, Campbell, Archie, Canouil, Mickael, Chakravarti, Aravinda, Chauhan, Ganesh, Christensen, Kaare, Cocca, Massimiliano, Collins, Francis S., Connell, John M., de Mutsert, Renee, de Silva, H. Janaka, Debette, Stephanie, Dorr, Marcus, Duan, Qing, Eaton, Charles B., Ehret, Georg, Evangelou, Evangelos, Faul, Jessica D., Fisher, Virginia A., Forouhi, Nita G., Franco, Oscar H., Friedlander, Yechiel, Gao, He, Gigante, Bruna, Graff, Misa, Gu, C. Charles, Gu, Dongfeng, Gupta, Preeti, Hagenaars, Saskia P., Harris, Tamara B., He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hirata, Makoto, Hofman, Albert, Howard, Barbara V., Hunt, Steven, Irvin, Marguerite R., Jia, Yucheng, Joehanes, Roby, Justice, Anne E., Katsuya, Tomohiro, Kaufman, Joel, Kerrison, Nicola D., Khor, Chiea Chuen, Koh, Woon-Puay, Koistinen, Heikki A., Komulainen, Pirjo, Kooperberg, Charles, Krieger, Jose E., Kubo, Michiaki, Kuusisto, Johanna, Langefeld, Carl D., Langenberg, Claudia, Launer, Lenore J., Lehne, Benjamin, Lewis, Cora E., Li, Yize, Lim, Sing Hui, Lin, Shiow, Liu, Ching-Ti, Liu, Jianjun, Liu, Jingmin, Liu, Kiang, Liu, Yeheng, Loh, Marie, Lohman, Kurt K., Long, Jirong, Louie, Tin, Magi, Reedik, Mahajan, Anubha, Meitinger, Thomas, Metspalu, Andres, Milani, Lili, Momozawa, Yukihide, Morris, Andrew P., Mosley, Thomas H., Jr., Munson, Peter, Murray, Alison D., Nalls, Mike A., Nasri, Ubaydah, Norris, Jill M., North, Kari, Ogunniyi, Adesola, Padmanabhan, Sandosh, Palmas, Walter R., Palmer, Nicholette D., Pankow, James S., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Raitakari, Olli T., Renström, Frida, Rice, Treva K., Ridker, Paul M., Robino, Antonietta, Robinson, Jennifer G., Rose, Lynda M., Rudan, Igor, Sabanayagam, Charumathi, Salako, Babatunde L., Sandow, Kevin, Schmidt, Carsten O., Schreiner, Pamela J., Scott, William R., Seshadri, Sudha, Sever, Peter, Sitlani, Colleen M., Smith, Jennifer A., Snieder, Harold, Starr, John M., Strauch, Konstantin, Tang, Hua, Taylor, Kent D., Teo, Yik Ying, Tham, Yih Chung, Ultterlinden, Andre G., Waldenberger, Melanie, Wang, Lihua, Wang, Ya X., Bin Wei, Wen, Williams, Christine, Wilson, Gregory, Wojczynski, Mary K., Yao, Jie, Yuan, Jian-Min, Zonderman, Alan B., Becker, Diane M., Boehnke, Michael, Bowden, Donald W., Chambers, John C., Chen, Yii-Der Ida, de Faire, Ulf, Deary, Ian J., Esko, Tonu, Farrall, Martin, Forrester, Terrence, Franks, Paul W., Freedman, Barry I., Froguel, Philippe, Gasparini, Paolo, Gieger, Christian, Horta, Bernardo Lessa, Hung, Yi-Jen, Jonas, Jost B., Kato, Norihiro, Kooner, Jaspal S., Laakso, Markku, Lehtimaki, Terho, Liang, Kae-Woei, Magnusson, Patrik K. E., Newman, Anne B., Oldehinkel, Albertine J., Pereira, Alexandre C., Redline, Susan, Rettig, Rainer, Samani, Nilesh J., Scott, James, Shu, Xiao-Ou, van der Harst, Pim, Wagenknecht, Lynne E., Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wickremasinghe, Ananda R., Wu, Tangchun, Zheng, Wei, Kamatani, Yoichiro, Laurie, Cathy C., Bouchard, Claude, Cooper, Richard S., Evans, Michele K., Gudnason, Vilmundur, Kardia, Sharon L. R., Kritchevsky, Stephen B., Levy, Daniel, O'Connell, Jeff R., Psaty, Bruce M., van Dam, Rob M., Sims, Mario, Arnett, Donna K., Mook-Kanamori, Dennis O., Kelly, Tanika N., Fox, Ervin R., Hayward, Caroline, Fornage, Myriam, Rotimi, Charles N., Province, Michael A., van Duijn, Cornelia M., Tai, E. Shyong, Wong, Tien Yin, Loos, Ruth J. F., Reiner, Alex P., Rotter, Jerome I., Zhu, Xiaofeng, Bierut, Laura J., Gauderman, W. James, Caulfield, Mark J., Elliott, Paul, Rice, Kenneth, Munroe, Patricia B., Morrison, Alanna C., Cupples, L. Adrienne, Rao, Dabeeru C., and Chasman, Daniel I.

Abstract

Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined similar to 18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 x 10(-8)) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p < 5 x 10(-8)). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling MSRA, EBF2).

Published
2018
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47. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Author

Sung, Yun J., primary, Winkler, Thomas W., additional, de las Fuentes, Lisa, additional, Bentley, Amy R., additional, Brown, Michael R., additional, Kraja, Aldi T., additional, Schwander, Karen, additional, Ntalla, Ioanna, additional, Guo, Xiuqing, additional, Franceschini, Nora, additional, Lu, Yingchang, additional, Cheng, Ching-Yu, additional, Sim, Xueling, additional, Vojinovic, Dina, additional, Marten, Jonathan, additional, Musani, Solomon K., additional, Li, Changwei, additional, Feitosa, Mary F., additional, Kilpeläinen, Tuomas O., additional, Richard, Melissa A., additional, Noordam, Raymond, additional, Aslibekyan, Stella, additional, Aschard, Hugues, additional, Bartz, Traci M., additional, Dorajoo, Rajkumar, additional, Liu, Yongmei, additional, Manning, Alisa K., additional, Rankinen, Tuomo, additional, Smith, Albert Vernon, additional, Tajuddin, Salman M., additional, Tayo, Bamidele O., additional, Warren, Helen R., additional, Zhao, Wei, additional, Zhou, Yanhua, additional, Matoba, Nana, additional, Sofer, Tamar, additional, Alver, Maris, additional, Amini, Marzyeh, additional, Boissel, Mathilde, additional, Chai, Jin Fang, additional, Chen, Xu, additional, Divers, Jasmin, additional, Gandin, Ilaria, additional, Gao, Chuan, additional, Giulianini, Franco, additional, Goel, Anuj, additional, Harris, Sarah E., additional, Hartwig, Fernando Pires, additional, Horimoto, Andrea R.V.R., additional, Hsu, Fang-Chi, additional, Jackson, Anne U., additional, Kähönen, Mika, additional, Kasturiratne, Anuradhani, additional, Kühnel, Brigitte, additional, Leander, Karin, additional, Lee, Wen-Jane, additional, Lin, Keng-Hung, additional, ’an Luan, Jian, additional, McKenzie, Colin A., additional, Meian, He, additional, Nelson, Christopher P., additional, Rauramaa, Rainer, additional, Schupf, Nicole, additional, Scott, Robert A., additional, Sheu, Wayne H.H., additional, Stančáková, Alena, additional, Takeuchi, Fumihiko, additional, van der Most, Peter J., additional, Varga, Tibor V., additional, Wang, Heming, additional, Wang, Yajuan, additional, Ware, Erin B., additional, Weiss, Stefan, additional, Wen, Wanqing, additional, Yanek, Lisa R., additional, Zhang, Weihua, additional, Zhao, Jing Hua, additional, Afaq, Saima, additional, Alfred, Tamuno, additional, Amin, Najaf, additional, Arking, Dan, additional, Aung, Tin, additional, Barr, R. Graham, additional, Bielak, Lawrence F., additional, Boerwinkle, Eric, additional, Bottinger, Erwin P., additional, Braund, Peter S., additional, Brody, Jennifer A., additional, Broeckel, Ulrich, additional, Cabrera, Claudia P., additional, Cade, Brian, additional, Caizheng, Yu, additional, Campbell, Archie, additional, Canouil, Mickaël, additional, Chakravarti, Aravinda, additional, Chauhan, Ganesh, additional, Christensen, Kaare, additional, Cocca, Massimiliano, additional, Collins, Francis S., additional, Connell, John M., additional, de Mutsert, Renée, additional, de Silva, H. Janaka, additional, Debette, Stephanie, additional, Dörr, Marcus, additional, Duan, Qing, additional, Eaton, Charles B., additional, Ehret, Georg, additional, Evangelou, Evangelos, additional, Faul, Jessica D., additional, Fisher, Virginia A., additional, Forouhi, Nita G., additional, Franco, Oscar H., additional, Friedlander, Yechiel, additional, Gao, He, additional, Gigante, Bruna, additional, Graff, Misa, additional, Gu, C. Charles, additional, Gu, Dongfeng, additional, Gupta, Preeti, additional, Hagenaars, Saskia P., additional, Harris, Tamara B., additional, He, Jiang, additional, Heikkinen, Sami, additional, Heng, Chew-Kiat, additional, Hirata, Makoto, additional, Hofman, Albert, additional, Howard, Barbara V., additional, Hunt, Steven, additional, Irvin, Marguerite R., additional, Jia, Yucheng, additional, Joehanes, Roby, additional, Justice, Anne E., additional, Katsuya, Tomohiro, additional, Kaufman, Joel, additional, Kerrison, Nicola D., additional, Khor, Chiea Chuen, additional, Koh, Woon-Puay, additional, Koistinen, Heikki A., additional, Komulainen, Pirjo, additional, Kooperberg, Charles, additional, Krieger, Jose E., additional, Kubo, Michiaki, additional, Kuusisto, Johanna, additional, Langefeld, Carl D., additional, Langenberg, Claudia, additional, Launer, Lenore J., additional, Lehne, Benjamin, additional, Lewis, Cora E., additional, Li, Yize, additional, Lim, Sing Hui, additional, Lin, Shiow, additional, Liu, Ching-Ti, additional, Liu, Jianjun, additional, Liu, Jingmin, additional, Liu, Kiang, additional, Liu, Yeheng, additional, Loh, Marie, additional, Lohman, Kurt K., additional, Long, Jirong, additional, Louie, Tin, additional, Mägi, Reedik, additional, Mahajan, Anubha, additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Milani, Lili, additional, Momozawa, Yukihide, additional, Morris, Andrew P., additional, Mosley, Thomas H., additional, Munson, Peter, additional, Murray, Alison D., additional, Nalls, Mike A., additional, Nasri, Ubaydah, additional, Norris, Jill M., additional, North, Kari, additional, Ogunniyi, Adesola, additional, Padmanabhan, Sandosh, additional, Palmas, Walter R., additional, Palmer, Nicholette D., additional, Pankow, James S., additional, Pedersen, Nancy L., additional, Peters, Annette, additional, Peyser, Patricia A., additional, Polasek, Ozren, additional, Raitakari, Olli T., additional, Renström, Frida, additional, Rice, Treva K., additional, Ridker, Paul M., additional, Robino, Antonietta, additional, Robinson, Jennifer G., additional, Rose, Lynda M., additional, Rudan, Igor, additional, Sabanayagam, Charumathi, additional, Salako, Babatunde L., additional, Sandow, Kevin, additional, Schmidt, Carsten O., additional, Schreiner, Pamela J., additional, Scott, William R., additional, Seshadri, Sudha, additional, Sever, Peter, additional, Sitlani, Colleen M., additional, Smith, Jennifer A., additional, Snieder, Harold, additional, Starr, John M., additional, Strauch, Konstantin, additional, Tang, Hua, additional, Taylor, Kent D., additional, Teo, Yik Ying, additional, Tham, Yih Chung, additional, Uitterlinden, André G., additional, Waldenberger, Melanie, additional, Wang, Lihua, additional, Wang, Ya X., additional, Wei, Wen Bin, additional, Williams, Christine, additional, Wilson, Gregory, additional, Wojczynski, Mary K., additional, Yao, Jie, additional, Yuan, Jian-Min, additional, Zonderman, Alan B., additional, Becker, Diane M., additional, Boehnke, Michael, additional, Bowden, Donald W., additional, Chambers, John C., additional, Chen, Yii-Der Ida, additional, de Faire, Ulf, additional, Deary, Ian J., additional, Esko, Tõnu, additional, Farrall, Martin, additional, Forrester, Terrence, additional, Franks, Paul W., additional, Freedman, Barry I., additional, Froguel, Philippe, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Horta, Bernardo Lessa, additional, Hung, Yi-Jen, additional, Jonas, Jost B., additional, Kato, Norihiro, additional, Kooner, Jaspal S., additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Liang, Kae-Woei, additional, Magnusson, Patrik K.E., additional, Newman, Anne B., additional, Oldehinkel, Albertine J., additional, Pereira, Alexandre C., additional, Redline, Susan, additional, Rettig, Rainer, additional, Samani, Nilesh J., additional, Scott, James, additional, Shu, Xiao-Ou, additional, van der Harst, Pim, additional, Wagenknecht, Lynne E., additional, Wareham, Nicholas J., additional, Watkins, Hugh, additional, Weir, David R., additional, Wickremasinghe, Ananda R., additional, Wu, Tangchun, additional, Zheng, Wei, additional, Kamatani, Yoichiro, additional, Laurie, Cathy C., additional, Bouchard, Claude, additional, Cooper, Richard S., additional, Evans, Michele K., additional, Gudnason, Vilmundur, additional, Kardia, Sharon L.R., additional, Kritchevsky, Stephen B., additional, Levy, Daniel, additional, O’Connell, Jeff R., additional, Psaty, Bruce M., additional, van Dam, Rob M., additional, Sims, Mario, additional, Arnett, Donna K., additional, Mook-Kanamori, Dennis O., additional, Kelly, Tanika N., additional, Fox, Ervin R., additional, Hayward, Caroline, additional, Fornage, Myriam, additional, Rotimi, Charles N., additional, Province, Michael A., additional, van Duijn, Cornelia M., additional, Tai, E. Shyong, additional, Wong, Tien Yin, additional, Loos, Ruth J.F., additional, Reiner, Alex P., additional, Rotter, Jerome I., additional, Zhu, Xiaofeng, additional, Bierut, Laura J., additional, Gauderman, W. James, additional, Caulfield, Mark J., additional, Elliott, Paul, additional, Rice, Kenneth, additional, Munroe, Patricia B., additional, Morrison, Alanna C., additional, Cupples, L. Adrienne, additional, Rao, Dabeeru C., additional, and Chasman, Daniel I., additional

Published
2018
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48. Sudden sensorineural hearing loss and hemodialysis

Author

Lasisi, Olawale A., Salako, Babatunde L., Kadiri, Solomon, Arije, Ayo, Oko-Jaja, Richard, Ipadeola, Arinola, and Olatoke, Fatai

Subjects
Neurologic manifestations of general diseases -- Causes of -- Complications and side effects, Kidney failure -- Complications and side effects, Hemodialysis -- Complications and side effects, Hearing loss -- Causes of -- Complications and side effects, Health
Abstract

Abstract The etiology of sensorineural hearing loss (SNHL) associated with renal failure and hemodialysis is controversial. Possible mechanisms include a shared antigenicity between the kidney and the labyrinths, osmotic alteration [...]

Published
2006

49. Global Kidney Health Atlas (GKHA): design and methods

Author

Bello, Aminu K., primary, Johnson, David W., additional, Feehally, John, additional, Harris, David, additional, Jindal, Kailash, additional, Lunney, Meaghan, additional, Okpechi, Ikechi G., additional, Salako, Babatunde L., additional, Wiebe, Natasha, additional, Ye, Feng, additional, Tonelli, Marcello, additional, and Levin, Adeera, additional

Published
2017
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50. Assessment of Global Kidney Health Care Status

Author

Bello, Aminu K., primary, Levin, Adeera, additional, Tonelli, Marcello, additional, Okpechi, Ikechi G., additional, Feehally, John, additional, Harris, David, additional, Jindal, Kailash, additional, Salako, Babatunde L., additional, Rateb, Ahmed, additional, Osman, Mohamed A., additional, Qarni, Bilal, additional, Saad, Syed, additional, Lunney, Meaghan, additional, Wiebe, Natasha, additional, Ye, Feng, additional, and Johnson, David W., additional

Published
2017
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