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4. The SPRi determination of cathepsin L and S in plasma and peritoneal fluid of women with endometriosis

Author

Załęcka, Julia, Zielińska, Zuzanna, Ołdak, Łukasz, Sakowicz, Agata, Mańka, Grzegorz, Kiecka, Mariusz, Spaczyński, Robert, Piekarski, Piotr, Banaszewska, Beata, Jakimiuk, Artur, Issat, Tadeusz, Młodawski, Jakub, Szubert, Maria, Sieroszewski, Piotr, Raba, Grzegorz, Szczupak, Kamil, Kluz, Tomasz, Kluza, Marek, Pierzyński, Piotr, Ciebiera, Michał, Wojtyła, Cezary, Lipa, Michał, Warzecha, Damian, Wielgoś, Mirosław, Cendrowski, Krzysztof, Gorodkiewicz, Ewa, and Laudański, Piotr

Published
2024
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5. Is the leptin/BMI ratio a reliable biomarker for endometriosis?

Author

Zyguła, Aleksandra, primary, Sankiewicz, Anna, additional, Sakowicz, Agata, additional, Dobrzyńska, Ewa, additional, Dakowicz, Agnieszka, additional, Mańka, Grzegorz, additional, Kiecka, Mariusz, additional, Spaczynski, Robert, additional, Piekarski, Piotr, additional, Banaszewska, Beata, additional, Jakimiuk, Artur, additional, Issat, Tadeusz, additional, Rokita, Wojciech, additional, Młodawski, Jakub, additional, Szubert, Maria, additional, Sieroszewski, Piotr, additional, Raba, Grzegorz, additional, Szczupak, Kamil, additional, Kluza, Tomasz, additional, Kluza, Marek, additional, Pierzyński, Piotr, additional, Wojtyla, Cezary, additional, Lipa, Michal, additional, Warzecha, Damian, additional, Wielgos, Miroslaw, additional, Cendrowski, Krzysztof, additional, Gorodkiewicz, Ewa, additional, and Laudanski, Piotr, additional

Published
2024
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16. Diagnostic usefulness of spiroergometry and risk factors of long COVID in patients with normal left ventricular ejection fraction

Author

Gryglewska-Wawrzak, Katarzyna, Sakowicz, Agata, Banach, Maciej, Bytyci, Ibadete, Bielecka-Dabrowa, Agata, Gryglewska-Wawrzak, Katarzyna, Sakowicz, Agata, Banach, Maciej, Bytyci, Ibadete, and Bielecka-Dabrowa, Agata

Abstract

The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic has brought forth various clinical manifestations and long-term complications, including a condition known as long COVID. Long COVID refers to a persistent set of symptoms that continue beyond the acute phase of the disease. This study investigated the risk factors and the utility of spiroergometry parameters for diagnosing patients with long COVID symptoms. The 146 patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with normal left ventricular ejection fraction and without respiratory diseases were included and divided into two groups: the group demonstrating long COVID symptoms [n = 44] and the group without long COVID symptoms [n = 102]. The clinical examinations, laboratory test results, echocardiography, non-invasive body mass analysis, and spiroergometry were evaluated. ClinicalTrials.gov Identifier: NCT04828629. Patients with long COVID symptoms had significantly higher age [58 (vs.) 44 years; p < 0.0001], metabolic age [53 vs. 45 years; p = 0.02)], left atrial diameter (LA) [37 vs. 35 mm; p = 0.04], left ventricular mass index (LVMI) [83 vs. 74 g/m2, p = 0.04], left diastolic filling velocity (A) [69 vs. 64 cm/s, p = 0.01], the ratio of peak velocity of early diastolic transmitral flow to peak velocity of early diastolic mitral annular motion (E/E’) [7.35 vs. 6.05; p = 0.01], and a lower ratio of early to late diastolic transmitral flow velocity (E/A) [1.05 vs. 1.31; p = 0.01] compared to the control group. In cardiopulmonary exercise testing (CPET), long COVID patients presented lower forced vital capacity (FVC) [3.6 vs. 4.3 L; p < 0.0001], maximal oxygen consumption measured during incremental exercise indexed per kilogram (VO2max) [21 vs. 23 mL/min/kg; p = 0.04], respiratory exchange ratio (RER) [1.0 vs. 1.1; p = 0.04], forced expiratory volume in one second (FEV1) [2.90 vs. 3.25 L; p = 0.04], and a higher ratio of forced expiratory volume in one seco

Published
2023
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27. Finding NEMO in preeclampsia

Author

Sakowicz, Agata, Hejduk, Paulina, Pietrucha, Tadeusz, Nowakowska, Magdalena, Płuciennik, Elżbieta, Pospiech, Karolina, Gach, Agnieszka, Rybak-Krzyszkowska, Magda, Sakowicz, Bartosz, Kaminski, Marek, Krasomski, Grzegorz, and Biesiada, Lidia

Published
2016
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28. Finding NEMO in Preeclampsia

Author

Sakowicz, Agata, Hejduk, Paulina, Pietrucha, Tadeusz, Nowakowska, Magdalena, Płuciennik, Elżbieta, Pospiech, Karolina, Gach, Agnieszka, Rybak-Krzyszkowska, Magda, Sakowicz, Bartosz, Kaminski, Marek, Krasomski, Grzegorz, and Biesiada, Lidia

Published
2017
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31. Effects of Implementing Personalized Health Education in Ambulatory Care on Cardiovascular Risk Factors, Compliance and Satisfaction with Treatment.

Author

Bielecka-Dabrowa, Agata, Lewek, Joanna, Sakowicz, Agata, Paduszyńska, Aleksandra, Dąbrowa, Marek, Orszulak-Michalak, Daria, and Banach, Maciej

Subjects
PATIENT satisfaction, CARDIOVASCULAR diseases risk factors, PATIENT compliance, HEALTH education, OUTPATIENT medical care, ALCOHOL
Abstract

Aim and Methods: Data from the CARDIOPLUS study (a prospective, multicenter, non-interventional study, which was conducted among patients and physicians from ambulatory patient care in Poland) were used to assess whether primary care behavioral counseling interventions to improve diet, increase physical activity, stop smoking and reduce alcohol consumption improve outcomes associated with cardiovascular (CVD) risk factors, metabolic parameters, compliance and satisfaction with treatment in adults. The study was carried out throughout Poland in the period from July to December 2019. Results: The study included 8667 patients—49% women and 51% men aged (63 ± 11 years)—and 862 physician-researchers. At the 3-month follow-up, there was a significant reduction in body weight (p = 0.008); reduction of peripheral arterial pressure, both systolic (p < 0.001) and diastolic (p < 0.001); reduction in total cholesterol levels (p < 0.001), triglycerides (p < 0.001), and LDL cholesterol (p < 0.001). The percentage of respondents who fully complied with the doctor's recommendations increased significantly. The respondents assessed their own satisfaction with the implemented treatment as higher (by about 20%). Conclusions: As a result of pro-health education in the field of lifestyle modifications, a significant reduction of risk factors for cardiovascular diseases, as well as improved compliance and satisfaction with pharmacological treatment, was observed. Thus, appropriate personalized advice on lifestyle habits should be given to each examinee in a positive, systematic way following the periodic health check-ups in order to reduce the person's risk and improve the effectiveness of the treatment. [ABSTRACT FROM AUTHOR]

Published
2022
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33. The Preeclamptic Environment Promotes the Activation of Transcription Factor Kappa B by P53/RSK1 Complex in a HTR8/SVneo Trophoblastic Cell Line

Author

Sakowicz, Agata, primary, Bralewska, Michalina, additional, Pietrucha, Tadeusz, additional, Figueras, Francesc, additional, Habrowska-Górczyńska, Dominika E., additional, Piastowska-Ciesielska, Agnieszka W., additional, Gach, Agnieszka, additional, Sakowicz, Bartosz, additional, Rybak-Krzyszkowska, Magda, additional, Huras, Hubert, additional, Grzesiak, Mariusz, additional, and Biesiada, Lidia, additional

Published
2021
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35. Left ventricular diastolic dysfunction as predictor of unfavorable prognosis after ESUS

Author

Bielecka-Dabrowa, Agata, Gasiorek, Paulina, Wittczak, Andrzej, Sakowicz, Agata, Bytyci, Ibadete, Banach, Maciej, Bielecka-Dabrowa, Agata, Gasiorek, Paulina, Wittczak, Andrzej, Sakowicz, Agata, Bytyci, Ibadete, and Banach, Maciej

Abstract

Objective: Identification of echocardiographic, hemodynamic and biochemical predictors of unfavorable prognosis after embolic strokes of undetermined etiology (ESUS) in patients at age <65. Patients and Methods: Out of 520 ischemic stroke patients we selected 64 diagnosed with ESUS and additional 36 without stroke but with similar risk profile. All patients underwent echocardiography, non-invasive assessment of hemodynamic parameters using SphygmoCor tonometer and measurements of selected biomarkers. Follow-up time was 12 months. Results: Nine percent of patients died, and recurrent ischemic stroke occurred in 9% of patients only in the ESUS group. Atrial fibrillation (AF) occurred in 10% of patients and the ESUS group had a significantly poorer outcome of AF in the first 2 months after hospitalization. The outcome of re-hospitalization was 28% in the ESUS group and 17% in the control group. In the multivariate analysis mean early diastolic (E’) mitral annular velocity (OR 0.75, 95% CI: 0.6–0.94; p=0.01) was significantly associated with cardiovascular hospitalizations. The only independent predictor of recurrent stroke was the ratio of peak velocity of early diastolic transmitral flow to peak velocity of early diastolic mitral annular motion (E/E’) (OR 0.75, 95% CI: 0.6–0.94; p=0.01). E/E’ was independently associated with composite endpoint (death, hospitalization and recurrent stroke) (OR 1.90, 95% CI 1.1–3.2, p=0.01). Conclusion: The indices of diastolic dysfunction are significantly associated with unfavorable prognosis after ESUS. There is a robust role for outpatient cardiac monitoring especially during the first 2 months after ESUS to detect potential AF.

Published
2021
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36. Left Ventricular Diastolic Dysfunction as Predictor of Unfavorable Prognosis After ESUS

Author

Bielecka-Dabrowa,Agata, Gasiorek,Paulina, Wittczak,Andrzej, Sakowicz,Agata, Bytyci,Ibadete, Banach,Maciej, Bielecka-Dabrowa,Agata, Gasiorek,Paulina, Wittczak,Andrzej, Sakowicz,Agata, Bytyci,Ibadete, and Banach,Maciej

Abstract

Agata Bielecka-Dabrowa, 1, 2 Paulina Gasiorek, 2 Andrzej Wittczak, 2 Agata Sakowicz, 3 Ibadete Bytyçi, 4, 5 Maciej Banach 1, 2 1Heart Failure Unit, Department of Cardiology and Congenital Diseases of Adults, Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; 2Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland; 3Department of Medical Biotechnology, Medical University of Lodz, Lodz, Poland; 4Clinic of Cardiology, University Clinical Centre of Kosovo, Prishtina, Kosovo; 5Institute of Public Health and Clinical Medicine, Umeå University, Umeå, SwedenCorrespondence: Agata Bielecka-DabrowaHeart Failure Unit¸ Department of Cardiology and Congenital Diseases of Adults, Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Rzgowska 281/289, Lodz, 93-338, PolandTel +48 42 271 15 97Fax +48 42 271 15 91Email agatbiel7@poczta.onet.plObjective: Identification of echocardiographic, hemodynamic and biochemical predictors of unfavorable prognosis after embolic strokes of undetermined etiology (ESUS) in patients at age < 65.Patients and Methods: Out of 520 ischemic stroke patients we selected 64 diagnosed with ESUS and additional 36 without stroke but with similar risk profile. All patients underwent echocardiography, non-invasive assessment of hemodynamic parameters using SphygmoCor tonometer and measurements of selected biomarkers. Follow-up time was 12 months.Results: Nine percent of patients died, and recurrent ischemic stroke occurred in 9% of patients only in the ESUS group. Atrial fibrillation (AF) occurred in 10% of patients and the ESUS group had a significantly poorer outcome of AF in the first 2 months after hospitalization. The outcome of re-hospitalization was 28% in the ESUS group and 17% in the control group. In the multivariate analysis mean early diastolic (E’) mitral annular velocity (OR 0.75, 95% CI

Published
2021

42. New findings in oligogenic inheritance of congenital hypogonadotropic hypogonadism.

Author

Gach, Agnieszka, Pinkier, Iwona, Wysocka, Urszula, Sałacińska, Kinga, Salachna, Dominik, Szarras-Czapnik, Maria, Pietrzyk, Aleksandra, Sakowicz, Agata, Nykel, Anna, Rutkowska, Lena, Rybak-Krzyszkowska, Magda, Socha, Magda, Jamsheer, Aleksander, and Jakubowski, Lucjusz

Subjects
HEREDITY, KALLMANN syndrome, HYPOGONADISM, GENITALIA, NUCLEOTIDE sequencing, GONAD development
Abstract

Introduction: Congenital hypogonadotropic hypogonadism results from a dysfunction of the hypothalamic-pituitary-gonadal axis, which is essential for the development and function of the reproductive system. It may be associated with anosmia, referred to as Kallmann syndrome, or a normal sense of smell. Numerous studies have proven that hypogonadotropic hypogonadism is not simply a monogenic Mendelian disease, but that more than one gene may be involved in its pathogenesis in a single patient. The oligogenic complex architecture underlying the disease is still largely unknown.Material and methods: Targeted next-generation sequencing (NGS) was used to screen for DNA variants in a cohort of 47 patients with congenital hypogonadotropic hypogonadism. The NGS panel consists of over 50 well-known and candidate genes, associated with hypogonadotropic state.Results: Here we report the identification of new oligogenic variants in SPRY4/SEMA3A, SRA1/SEMA7A, CHD7/SEMA7A, CCDC141/POLR3B/POLR3B, and PROKR2/SPRY4/NSMF. These genes are known to contribute to the phenotype of hypogonadotropic hypogonadism, yet our results point to potential new "partners" underlying digenic and trigenic patterns.Conclusions: The finding supports the importance of oligogenic inheritance and demonstrates the complexity of genetic architecture in hypogonadotropic hypogonadism. It also underlines the necessity for developing fine-tuned guidelines to provide a tool for adequate and precise sequence variant classification in non-Mendelian conditions. [ABSTRACT FROM AUTHOR]

Published
2022
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43. New findings in oligogenic inheritance of congenital hypogonadotropic hypogonadism

Author

Gach, Agnieszka, primary, Pinkier, Iwona, additional, Wysocka, Urszula, additional, Sałacińska, Kinga, additional, Salachna, Dominik, additional, Szarras-Czapnik, Maria, additional, Pietrzyk, Aleksandra, additional, Sakowicz, Agata, additional, Nykel, Anna, additional, Rutkowska, Lena, additional, Rybak-Krzyszkowska, Magda, additional, Socha, Magda, additional, Jamsheer, Aleksander, additional, and Jakubowski, Lucjusz, additional

Published
2020
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44. Canonical, Non-Canonical and Atypical Pathways of Nuclear Factor кb Activation in Preeclampsia

Author

Sakowicz, Agata, primary, Bralewska, Michalina, additional, Pietrucha, Tadeusz, additional, Habrowska-Górczyńska, Dominika E, additional, Piastowska-Ciesielska, Agnieszka W, additional, Gach, Agnieszka, additional, Rybak-Krzyszkowska, Magda, additional, Witas, Piotr J, additional, Huras, Hubert, additional, Grzesiak, Mariusz, additional, and Biesiada, Lidia, additional

Published
2020
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50. Placental Expression of NEMO Protein in Normal Pregnancy and Preeclampsia

Author

Sakowicz, Agata, primary, Lisowska, Michalina, additional, Biesiada, Lidia, additional, Płuciennik, Elżbieta, additional, Gach, Agnieszka, additional, Rybak-Krzyszkowska, Magda, additional, Huras, Hubert, additional, Sakowicz, Bartosz, additional, Romanowicz, Hanna, additional, Piastowska-Ciesielska, Agnieszka W., additional, Grzesiak, Mariusz, additional, and Pietrucha, Tadeusz, additional

Published
2019
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