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Your search keyword '"Sakisaka, Toshihiro"' showing total 15 results
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15 results on '"Sakisaka, Toshihiro"'

8. Repair of the TGFBI gene in human corneal keratocytes derived from a granular corneal dystrophy patient via CRISPR/Cas9-induced homology-directed repair

Author

Taketani, Yukako, primary, Kitamoto, Kohdai, additional, Sakisaka, Toshihiro, additional, Kimakura, Mikiko, additional, Toyono, Tetsuya, additional, Yamagami, Satoru, additional, Amano, Shiro, additional, Kuroda, Masahiko, additional, Moore, Tara, additional, Usui, Tomohiko, additional, and Ouchi, Yasuo, additional

Published
2017
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10. Risk factors for corneal endothelial cell loss by cataract surgery in eyes with pseudoexfoliation syndrome

Author

Hasegawa,Yumi, Nejima,Ryohei, Mori,Yosai, Sakisaka,Toshihiro, Minami,Keiichiro, Miyata,Kazunori, Oshika,Tetsuro, Hasegawa,Yumi, Nejima,Ryohei, Mori,Yosai, Sakisaka,Toshihiro, Minami,Keiichiro, Miyata,Kazunori, and Oshika,Tetsuro

Abstract

Yumi Hasegawa,1,2 Ryohei Nejima,1 Yosai Mori,1 Toshihiro Sakisaka,1 Keiichiro Minami,1 Kazunori Miyata,1 Tetsuro Oshika2 1Miyata Eye Hospital, Miyazaki, 2Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan Purpose: The aim of this study was to investigate the factors associated with decreases in corneal endothelial cell density (ECD) resulting from cataract surgery in eyes with pseudoexfoliation syndrome (PEX). Methods: The clinical records of 78 eyes of 78 patients with PEX who had undergone cataract surgery were reviewed. ECD was measured preoperatively and at 3 months postoperatively with specular microscopy. Multiple regression analysis was used to assess the factors that were significantly related to the rate of ECD loss. Explanatory variables included age, preoperative ECD, pupil diameter, cataract grade, concomitance of glaucoma or diabetes mellitus, preoperative anterior chamber depth, surgery time, total time and power of ultrasound, performance of intraoperative pupillary enlargement manipulation, and postoperative aqueous flare intensity at 1 week and 1 month. Results: ECD before and after surgery was 2,464±337 cells/mm2 and 2,400±347 cells/mm2, respectively, with an ECD loss rate of 2.6%±5.1% (mean ± SD). Multiple regression analysis revealed that ECD loss was significantly associated with the cataract grade (P=0.019) and preoperative anterior chamber depth (P=0.023). Conclusion: With modern small incision cataract surgery, the ECD loss varied with surgical invasions due to severe cataract and shallow anterior chamber, and the presence of PEX was least affected. Keywords: pseudoexfoliation syndrome, corneal endothelial cell loss, cataract surgery

Published
2016

15. Outcomes of cataract surgeries performed in 8 eyes of centenarians.

Author

Ono T, Fukuda T, Iwasaki T, Sakisaka T, Mori Y, Nejima R, Miyai T, and Miyata K

Subjects
Humans, Female, Retrospective Studies, Aged, 80 and over, Male, Intraocular Pressure physiology, Cataract, Treatment Outcome, Lens Implantation, Intraocular methods, Lens Implantation, Intraocular statistics & numerical data, Cataract Extraction methods, Cataract Extraction statistics & numerical data, Japan epidemiology, Visual Acuity, Phacoemulsification methods
Abstract

Cataract surgery outcomes in centenarian patients have not previously been explored. This study aimed to examine characteristics and report clinical results of people aged ≥100 years undergoing cataract surgery. This was a retrospective observational study, including patients aged ≥100 years who underwent cataract surgery between 2003 and 2021 at Miyata Eye Hospital in Japan. Medical charts were reviewed for information on cataract severity, surgery type, anesthesia, as well as ocular and medical comorbidities. Using Mann-Whitney test, visual acuity, intraocular pressure, and corneal endothelial cell density were compared before and after surgery. Eight eyes of 5 patients were included in the study (mean age, 101.5 ± 1.2 years). Seven of these eyes (87.5%) belonged to women. All surgeries were performed under topical anesthesia using phacoemulsification and insertion of the intraocular lens fixed in the bag. All patients had multiple preoperative medical comorbidities; however, there were no intraoperative, postoperative ocular, or general complications. The postoperative best-corrected visual acuity was significantly improved compared to that before surgery (1.18 ± 0.74 and 0.29 ± 0.52, respectively, P = .004). Neither intraocular pressure nor corneal endothelial cell density demonstrated a significant difference postoperatively. Cataract surgery can be safely performed under topical anesthesia in centenarians without complications using proper perioperative medical control and preparation., Competing Interests: The authors have no funding and conflicts of interest to disclose., (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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