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A novel 12-step procedure was developed for preparing methyl 14-isocyano-3-methyltetradecanoate. "2+1B" tricarbonyl complexes [99mTc(CO)3(N^N)CN(CH2)11CH(CH3)CH2COOMe]+, where N^N = 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [99mTc(CO)3(N^N)(H2O,EtOH)]+ with methyl 14-isocyano-3-methyltetradecanoate in aqueous ethanol. The formation of technetium-99m complexes was confirmed by HPLC, and the partition coefficient (n-octanol/water) of these complexes was measured. [ABSTRACT FROM AUTHOR]

The crystal and molecular structures of the complex [99TcCl(CO)3(C5H8O2)]2 (C5H8O2 = Hacac = acetylacetone) formed in the course of prolonged standing of a [99Tc(acac)(CO)4] solution in ССl4/CDCl3 and of its analog containing no organic ligand, [99TcCl(CO)4]2, were determined. Both complexes contain a [Tc2(μ-Cl)2] four-membered ring. The remaining sites in the coordination sphere of the Tc atom are occupied by carbonyl ligands, and in the case of [99TcCl(CO)3(Hacac)]2, also by the neutral acetylacetone molecule in the enol form. The Hacac molecules in the binuclear complex are in the cis position to the Cl atoms in the octahedral surrounding of the Тс atoms and in the trans position to each other relative to the [Tc2(μ-Cl)2] ring. A comparative analysis of the geometries of the complexes and their known analogs was performed. [ABSTRACT FROM AUTHOR]

"2+1B" tricarbonyl complexes of the general formula [M(CO)3(N^N)CN(CH2)4CH(COOMe)SC10H21]-ClO4, where M = 99mTc or Re, N^N = 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [M(CO)3(N^N)(MeOH)]ClO4 with methyl 2-(decylthio)-6-isocyanohexanoate in methanol. The rhenium complexes were isolated and characterized by 1H NMR and IR spectroscopy. The formation of technetium-99m complexes was confirmed by HPLC. The lipophilicity of the technetium complexes was measured. [ABSTRACT FROM AUTHOR]

Technetium(I) and rhenium(I) hexacarbonyl cations were prepared for the first time at atmospheric pressure and room temperature by treatment of dichloromethane or chloroform solutions of [99TcBr(CO)5] and [ReCl(CO)5] with carbon monoxide in the presence of dry aluminum trichloride. The yield was 17.0 % and 3.1 %, respectively. [ABSTRACT FROM AUTHOR]

The crystal and molecular structures of the complex [99TcCl(CO)3(C5H8O2)]2 (C5H8O2 = Hacac = acetylacetone) formed in the course of prolonged standing of a [99Tc(acac)(CO)4] solution in ССl4/CDCl3 and of its analog containing no organic ligand, [99TcCl(CO)4]2, were determined. Both complexes contain a [Tc2(μ-Cl)2] four-membered ring. The remaining sites in the coordination sphere of the Tc atom are occupied by carbonyl ligands, and in the case of [99TcCl(CO)3(Hacac)]2, also by the neutral acetylacetone molecule in the enol form. The Hacac molecules in the binuclear complex are in the cis position to the Cl atoms in the octahedral surrounding of the Тс atoms and in the trans position to each other relative to the [Tc2(μ-Cl)2] ring. A comparative analysis of the geometries of the complexes and their known analogs was performed. [ABSTRACT FROM AUTHOR]