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Your search keyword '"Sakaki, Setsuko"' showing total 13 results
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13 results on '"Sakaki, Setsuko"'

2. The effect of Dunaliella tertiolectasupplementation on diet-induced obesity in UCP1-deficient mice

Author

Yamashita, Yukari, Takeuchi, Tamaki, Endo, Yuki, Goto, Ayumi, Uno, Misa, Sakaki, Setsuko, Yamaguchi, Yuji, Takenaka, Hiroyuki, and Yamashita, Hitoshi

Abstract

We previously demonstrated that dietary supplementation with Dunaliella tertiolecta(DT) increases uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT) and improves diet-induced obesity (DIO) in C57BL/6 J mice at thermoneutrality (30 °C). Here, we investigated whether DT improves DIO in a thermoneutral UCP1-deficient (KO) animal. KO mice were fed a high-fat diet supplemented with DT for 12 weeks. Compared to control group without DT, body weight was significantly reduced in DT group with no difference in food intake. Dunaliella tertiolecta-supplemented mice exhibited lower adiposity and well-maintained multilocular morphology in BAT, in which a significant increase in gene expression of PR domain containing 16 was detected in DT group compared to control group. Moreover, increase in UCP2 level and/or decrease in ribosomal protein S6 phosphorylation were detected in adipose tissues of DT group relative to control group. These results suggest that DT supplementation improves DIO by stimulating UCP1-independent energy dissipation at thermoneutrality.Graphical AbstractDunaliella tertiolectasupplementation improves diet-induced obesity by stimulating UCP1-independent energy dissipation at thermoneutrality.

Published
2024
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10. Production of Rubratoxin B by Penicillium purpurogenumStoll

Author

Natori, Shinsaku, Sakaki, Setsuko, Kurata, Hiroshi, Udagawa, Shun-Ichi, Ichinoe, Masakatsu, Saito, Mamoru, Umeda, Makoto, and Ohtsubo, Kohichiro

Abstract

Culture filtrates and chloroform extracts from Penicillium purpurogenumisolated from foodstuffs were subjected to preliminary survey for toxic effects on HeLa cells and mice. The toxic metabolite was isolated in a crystalline form from P. purpurogenumand was identified as rubratoxin B. Pathological findings observed in HeLa cells and mice treated with the metabolite are briefly described.

Published
1970
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