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2. A proposal of a diagnostic algorithm with validation of International Consensus Diagnostic Criteria for autoimmune pancreatitis in a Japanese cohort

Author

Sumimoto, Kimi, Uchida, Kazushige, Mitsuyama, Toshiyuki, Fukui, Yuri, Kusuda, Takeo, Miyoshi, Hideaki, Tomiyama, Takashi, Fukata, Norimasa, Koyabu, Masanori, Sakaguchi, Yutaku, Ikeura, Tsukasa, Shimatani, Masaaki, Fukui, Toshiro, Matsushita, Mitsunobu, Takaoka, Makoto, Nishio, Akiyoshi, and Okazaki, Kazuichi

Published
2013
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6. The similarity of Type 1 autoimmune pancreatitis to pancreatic ductal adenocarcinoma with significant IgG4-positive plasma cell infiltration

Author

Fukui, Yuri, Uchida, Kazushige, Sumimoto, Kimi, Kusuda, Takeo, Miyoshi, Hideaki, Koyabu, Masanori, Ikeura, Tsukasa, Sakaguchi, Yutaku, Shimatani, Masaaki, Fukui, Toshiro, Matsushita, Mitsunobu, Takaoka, Makoto, Nishio, Akiyoshi, Shikata, Nobuaki, Sakaida, Noriko, Uemura, Yoshiko, Satoi, Sohei, Kwon, A-hon, and Okazaki, Kazuichi

Published
2013
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11. Long-term outcome of autoimmune pancreatitis

Author

Uchida, Kazushige, Yazumi, Shujiro, Nishio, Akiyoshi, Kusuda, Takeo, Koyabu, Masaki, Fukata, Masanori, Miyoshi, Hideaki, Sakaguchi, Yutaku, Fukui, Toshiro, Matsushita, Mitsunobu, Takaoka, Makoto, and Okazaki, Kazuichi

Published
2009
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14. Small cell carcinoma of the prostate: a case report

Author

Yamamoto, Nae, Kinoshita, Hidefumi, Inoue, Takaaki, Kawakita, Shigenari, Oguchi, Naoki, Muguruma, Kouei, Kawa, Gen, Sakaguchi, Yutaku, Adachi, Yasushi, Sakaida, Noriko, Uemura, Yoshiko, and Matsuda, Tadashi

Subjects
Small cell carcinoma, Prostate cancer, 494.9
Abstract

76歳男。患者は頻尿および排尿困難を主訴とした。前立腺生検を施行し, 低分化型前立腺癌およびGleason score 4+5の診断を得た。Maximum androgen blockade(MBA)療法を開始したところ, PSAは低下し, CT上でリンパ節腫脹の消失を認めた。しかし, その後, 腰背部痛が出現し, 疼痛による歩行困難, 嘔吐, 食事摂取困難が生じ緊急入院となった。所見ではFDG-PETで骨以外の病変として右肺尖部, S状結腸に集積を認め, 肺小細胞癌に準じた化学療法を考慮したが, 全身状態の不良にて施行できないまま急速に病状が悪化した。そして症状出現から約3ヵ月後に患者は死亡となった。尚, 剖検所見から本症例は低分化型前立腺癌が脱分化を来し, 多臓器に転移したものと考えられた。, A 76-year-old man had been treated with maximum androgen blockade therapy for a poorly-differentiated prostate adenocarcinoma (T3cN1M0, prostate specific antigen (PSA) 65 ng/ml, Gleason Score 4+5=9) since September 2002. By August 2003, his serum PSA levels were undetectable and the lymph node swelling had vanished. However, in December 2004, his serum PSA levels started rising gradually up to 0.66 ng/ml. Radiation therapy on the prostate was then performed (66 Gy). At that time, no metastasis was detected by computed tomography and bone scintigraphy. In August 2005, multiple bone metastases were detected. Immunohistochemical examination of a biopsy specimen from the bone lesion revealed a small cell carcinoma/neuroendocrine cell carcinoma. He died with undetectable PSA levels (less than 0.008 ng/ml) in December 2005. The autopsy showed multiple organ metastases including bone, liver, lungs and others. The immunohistochemical examination revealed pure small cell carcinoma in all metastatic lesions. A precise histological examination of the lungs using a 1 cm serial section could not reveal any tumors compatible with primary lung cancer. We concluded from the clinical history and autopsy findings that his initial poorly-differentiated adenocarcinoma of the prostate dedifferentiated into a pure small cell carcinoma with neuroendocrine differentiation.

Published
2007

15. Regulatory T Cells in Type 1 Autoimmune Pancreatitis

Author

Uchida, Kazushige, Kusuda, Takeo, Koyabu, Masanori, Miyoshi, Hideaki, Fukata, Norimasa, Sumimoto, Kimi, Fukui, Yuri, Sakaguchi, Yutaku, Ikeura, Tsukasa, Shimatani, Masaaki, Fukui, Toshiro, Matsushita, Mitsunobu, Takaoka, Makoto, Nishio, Akiyoshi, and Okazaki, Kazuichi

Subjects
Article Subject, parasitic diseases
Abstract

Autoimmune pancreatitis (AIP) is a newly recognized pancreatic disorder. Recently, International Consensus Diagnostic Criteria for AIP (ICDC) was published. In this ICDC, AIP was classified into Type 1 and Type 2. Patients with Type 1 AIP have several immunologic and histologic abnormalities specific to the disease, including increased levels of serum IgG4 and storiform fibrosis with infiltration of lymphocytes and IgG4-positive plasmacytes in the involved organs. Among the involved organs showing extrapancreatic lesions, the bile duct is the most common, exhibiting sclerosing cholangitis (IgG4-SC). However, the role of IgG4 is unclear. Recently, it has been reported that regulatory T cells (Tregs) are involved in both the development of various autoimmune diseases and the shift of B cells toward IgG4, producing plasmacytes. Our study showed that Tregs were increased in the pancreas with Type 1 AIP and IgG4-SC compared with control. In the patients with Type 1 AIP and IgG4-SC, the numbers of infiltrated Tregs were significantly positively correlated with IgG4-positive plasma cells. In Type 1 AIP, inducible costimulatory molecule (ICOS)+ and IL-10+ Tregs significantly increased compared with control groups. Our data suggest that increased quantities of ICOS+ Tregs may influence IgG4 production via IL-10 in Type 1 AIP.

Published
2012
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16. Smad2/3 Linker Phosphorylation Is a Possible Marker of Cancer Stem Cells and Correlates with Carcinogenesis in a Mouse Model of Colitis-Associated Colorectal Cancer

Author

Suzuki, Ryo, primary, Fukui, Toshiro, additional, Kishimoto, Masanobu, additional, Miyamoto, Sachi, additional, Takahashi, Yu, additional, Takeo, Masahiro, additional, Mitsuyama, Toshiyuki, additional, Sakaguchi, Yutaku, additional, Uchida, Kazushige, additional, Nishio, Akiyoshi, additional, and Okazaki, Kazuichi, additional

Published
2015
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17. Phosphorylation of Smad2/3 at Specific Linker Threonine Indicates Slow-Cycling Intestinal Stem-Like Cells Before Reentry to Cell Cycle

Author

Kishimoto, Masanobu, primary, Fukui, Toshiro, additional, Suzuki, Ryo, additional, Takahashi, Yu, additional, Sumimoto, Kimi, additional, Okazaki, Takashi, additional, Sakao, Masayuki, additional, Sakaguchi, Yutaku, additional, Yoshida, Katsunori, additional, Uchida, Kazushige, additional, Nishio, Akiyoshi, additional, Matsuzaki, Koichi, additional, and Okazaki, Kazuichi, additional

Published
2014
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21. Infiltration of IgG4-positive cells in pancreatic ductal adenocarcinoma

Author

Fukui, Yuri, primary, Uchida, Kazushige, additional, Sumimoto, Kimi, additional, Kusuda, Takeo, additional, Miyoshi, Hideaki, additional, Fukata, Norimasa, additional, Koyabu, Masanori, additional, Ikeura, Tsukasa, additional, Sakaguchi, Yutaku, additional, Shimatani, Masaaki, additional, Fukui, Toshiro, additional, Matsushita, Mitsunobu, additional, Takaoka, Makoto, additional, Nishio, Akiyoshi, additional, Shikata, Nobuaki, additional, Sakaida, Noriko, additional, Uemura, Yoshiko, additional, Satoi, Sohei, additional, Kwon, A-hon, additional, and Okazaki, Kazuichi, additional

Published
2014
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23. The similarity of IgG4-positive plasma cell infiltration in type 1 autoimmune pancreatitis and pancreatic ductal adenocarcinoma

Author

Uchida, Kazushige, primary, Fukui, Yuri, additional, Mitsuyama, Toshiyuki, additional, Sumimoto, Kimi, additional, Kusuda, Takeo, additional, Miyoshi, Hideaki, additional, Koyabu, Masanori, additional, Ikeura, Tsukasa, additional, Sakaguchi, Yutaku, additional, Shimatani, Masaaki, additional, Fukui, Toshiro, additional, Matsushita, Mitsunobu, additional, Takaoka, Makoto, additional, Nishio, Akiyoshi, additional, Satoi, Sohei, additional, Kwon, A. Hon, additional, and Okazaki, Kazuichi, additional

Published
2013
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24. Su1786 Increased Peripheral Cd19+CD24HiCd38Hi Regulatory B Cells May Be Involved in the Pathophysiology of Type 1 Autoimmune Pancreatitis

Author

Sumimoto, Kimi, primary, Uchida, Kazushige, additional, Mitsuyama, Toshiyuki, additional, Fukui, Yuri, additional, Kusuda, Takeo, additional, Miyoshi, Hideaki, additional, Fukata, Norimasa, additional, Koyabu, Masanori, additional, Sakaguchi, Yutaku, additional, Ikeura, Tsukasa, additional, Shimatani, Masaaki, additional, Fukui, Toshiro, additional, Matsushita, Mitsunobu, additional, Takaoka, Makoto, additional, Nishio, Akiyoshi, additional, and Okazaki, Kazuichi, additional

Published
2013
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26. This title is unavailable for guests, please login to see more information.

Author

Yamamoto, Nae, Kinoshita, Hidefumi, Inoue, Takaaki, Kawakita, Shigenari, Oguchi, Naoki, Muguruma, Kouei, Kawa, Gen, Sakaguchi, Yutaku, Adachi, Yasushi, Sakaida, Noriko, Uemura, Yoshiko, Matsuda, Tadashi, Yamamoto, Nae, Kinoshita, Hidefumi, Inoue, Takaaki, Kawakita, Shigenari, Oguchi, Naoki, Muguruma, Kouei, Kawa, Gen, Sakaguchi, Yutaku, Adachi, Yasushi, Sakaida, Noriko, Uemura, Yoshiko, and Matsuda, Tadashi

Abstract

A 76-year-old man had been treated with maximum androgen blockade therapy for a poorly-differentiated prostate adenocarcinoma (T3cN1M0, prostate specific antigen (PSA) 65 ng/ml, Gleason Score 4+5=9) since September 2002. By August 2003, his serum PSA levels were undetectable and the lymph node swelling had vanished. However, in December 2004, his serum PSA levels started rising gradually up to 0.66 ng/ml. Radiation therapy on the prostate was then performed (66 Gy). At that time, no metastasis was detected by computed tomography and bone scintigraphy. In August 2005, multiple bone metastases were detected. Immunohistochemical examination of a biopsy specimen from the bone lesion revealed a small cell carcinoma/neuroendocrine cell carcinoma. He died with undetectable PSA levels (less than 0.008 ng/ml) in December 2005. The autopsy showed multiple organ metastases including bone, liver, lungs and others. The immunohistochemical examination revealed pure small cell carcinoma in all metastatic lesions. A precise histological examination of the lungs using a 1 cm serial section could not reveal any tumors compatible with primary lung cancer. We concluded from the clinical history and autopsy findings that his initial poorly-differentiated adenocarcinoma of the prostate dedifferentiated into a pure small cell carcinoma with neuroendocrine differentiation.

Published
2007

27. Possible Involvement of Foxp3+Regulatory T Cells in the Development of Immune-Mediated Pancreatitis in MRL/Mp Mice Treated with Polyinosinic:Polycytidylic Acid

Author

Koyabu, Masanori, primary, Uchida, Kazushige, additional, Sakaguchi, Yutaku, additional, Fukata, Norimasa, additional, Kusuda, Takeo, additional, Miyoshi, Hideaki, additional, Yoshida, Katsunori, additional, Sumimoto, Kimi, additional, Mitsuyama, Toshiyuki, additional, Fukui, Toshiro, additional, Nishio, Akiyoshi, additional, and Okazaki, Kazuichi, additional

Published
2013
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28. The similarity of Type 1 autoimmune pancreatitis to pancreatic ductal adenocarcinoma with significant IgG4-positive plasma cell infiltration

Author

Fukui, Yuri, primary, Uchida, Kazushige, additional, Sumimoto, Kimi, additional, Kusuda, Takeo, additional, Miyoshi, Hideaki, additional, Koyabu, Masanori, additional, Ikeura, Tsukasa, additional, Sakaguchi, Yutaku, additional, Shimatani, Masaaki, additional, Fukui, Toshiro, additional, Matsushita, Mitsunobu, additional, Takaoka, Makoto, additional, Nishio, Akiyoshi, additional, Shikata, Nobuaki, additional, Sakaida, Noriko, additional, Uemura, Yoshiko, additional, Satoi, Sohei, additional, Kwon, A-hon, additional, and Okazaki, Kazuichi, additional

Published
2012
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29. 265a Comparison of International Consensus Diagnostic Criteria and Major Diagnostic Criteria for Autoimmune Pancreatitis

Author

Sumimoto, Kimi, primary, Uchida, Kazushige, additional, Fukui, Yuri, additional, Kusuda, Takeo, additional, Miyoshi, Hideaki, additional, Fukata, Norimasa, additional, Koyabu, Masanori, additional, Sakaguchi, Yutaku, additional, Ikeura, Tsukasa, additional, Shimatani, Masaaki, additional, Fukui, Toshiro, additional, Matsushita, Mitsunobu, additional, Takaoka, Makoto, additional, Nishio, Akiyoshi, additional, and Okazaki, Kazuichi, additional

Published
2012
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35. M1398 Possible Role of Regulatory T Cells in Producing IgG4 in the Involved Organs With Autoimmune Pancreatitis

Author

Koyabu, Masanori, primary, Uchida, Kazushige, additional, Miyoshi, Hideaki, additional, Kusuda, Takeo, additional, Fukata, Norimasa, additional, Ikeura, Tsukasa, additional, Sakaguchi, Yutaku, additional, Yoshida, Katsunori, additional, Fukui, Toshiro, additional, Matsushita, Mitsunobu, additional, Takaoka, Makoto, additional, Nishio, Akiyoshi, additional, and Okazaki, Kazuichi, additional

Published
2010
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36. Idiopathic Duct-Centric Pancreatitis (IDCP) with Immunological Studies

Author

Kusuda, Takeo, primary, Uchida, Kazushige, additional, Satoi, Sohei, additional, Koyabu, Masanori, additional, Fukata, Norimasa, additional, Miyoshi, Hideaki, additional, Ikeura, Tsukasa, additional, Sakaguchi, Yutaku, additional, Yoshida, Katsunori, additional, Fukui, Toshiro, additional, Shimatani, Masaaki, additional, Matsushita, Mitsunobu, additional, Takaoka, Makoto, additional, Nishio, Akiyoshi, additional, Uemura, Yoshiko, additional, Kwon, A-Hon, additional, and Okazaki, Kazuichi, additional

Published
2010
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37. Primary sclerosing cholangitis with elevated serum IgG4 levels and/or infiltration of abundant IgG4-positive plasma cells

Author

Koyabu, Masanori, primary, Uchida, Kazushige, additional, Fukata, Norimasa, additional, Kusuda, Takeo, additional, Ikeura, Tsukasa, additional, Sakaguchi, Yutaku, additional, Yoshida, Katsunori, additional, Shimatani, Masaaki, additional, Fukui, Toshiro, additional, Matsushita, Mitsunobu, additional, Uemura, Yoshiko, additional, Kaibori, Masaki, additional, Takaoka, Makoto, additional, Nishio, Akiyoshi, additional, and Okazaki, Kazuichi, additional

Published
2009
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41. Long-Term Donor-Specific Tolerance in Rat Cardiac Allografts by Intrabone Marrow Injection of Donor Bone Marrow Cells

Author

Guo, Kequan, primary, Inaba, Muneo, additional, Li, Ming, additional, An, Jun, additional, Cui, Wenhao, additional, Song, Changye, additional, Wang, Jianfeng, additional, Cui, Yunze, additional, Sakaguchi, Yutaku, additional, Tsuda, Masanobu, additional, Omae, Mariko, additional, Ando, Yugo, additional, Li, Qing, additional, Wang, Xiaoli, additional, Feng, Wei, additional, and Ikehara, Susumu, additional

Published
2008
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42. Extensive Studies on Perfusion Method Plus Intra-Bone Marrow-Bone Marrow Transplantation Using Cynomolgus Monkeys

Author

Inaba, Muneo, primary, Adachi, Yasushi, additional, Hisha, Hiroko, additional, Hosaka, Naoki, additional, Maki, Masahiko, additional, Ueda, Yusuke, additional, Koike, Yasushi, additional, Miyake, Takeshi, additional, Fukui, Junichi, additional, Cui, Yunze, additional, Mukaide, Hiromi, additional, Koike, Naoko, additional, Omae, Mariko, additional, Mizokami, Tomomi, additional, Shigematsu, Akio, additional, Sakaguchi, Yutaku, additional, Tsuda, Masanobu, additional, Okazaki, Satoshi, additional, Wang, Xiaoli, additional, Li, Qing, additional, Nishida, Akihisa, additional, Ando, Yugo, additional, Guo, Kequan, additional, Song, Changye, additional, Cui, Wenhao, additional, Feng, Wei, additional, Katou, Junko, additional, Sado, Katuyuki, additional, Nakamura, Shuji, additional, and Ikehara, Susumu, additional

Published
2007
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45. Expression and localization of cartilage-specific matrix protein chondromodulin-I mRNA in salivary pleomorphic adenomas

Author

Kusafuka, Kimihide, primary, Nakano, Keisuke, additional, Hiraki, Yuji, additional, Shukunami, Chisa, additional, Nagatsuka, Hitoshi, additional, Nagai, Noriyuki, additional, Takemura, Tamiko, additional, Sakaguchi, Yutaku, additional, Okazaki, Kazuichi, additional, Kusafuka, Michi, additional, Hisha, Hiroko, additional, and Ikehara, Susumu, additional

Published
2004
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46. Sa1795 Regulatory B Cells in Type 1 Autoimmune Pancreatitis

Author

Sumimoto, Kimi, Uchida, Kazushige, Mitsuyama, Toshiyuki, Fukui, Yuri, Kusuda, Takeo, Miyoshi, Hideaki, Fukata, Norimasa, Koyabu, Masanori, Sakaguchi, Yutaku, Ikeura, Tsukasa, Shimatani, Masaaki, Fukui, Toshiro, Matsushita, Mitsunobu, Takaoka, Makoto, Nishio, Akiyoshi, and Okazaki, Kazuichi

Published
2014
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47. Establishment of Animal Models for Three Types of Pancreatitis and Analyses of Regeneration Mechanisms

Author

Sakaguchi, Yutaku, Inaba, Muneo, Kusafuka, Kimihide, Okazaki, Kazuichi, and Ikehara, Susumu

Abstract

To investigate the mechanisms underlying the onset and progress of pancreatitis, 3 animal models (chronic, acute, and severe pancreatitis) were established by double ligature of the pancreatic duct, injection with cerulein, or injection with cerulein + double ligature of the pancreatic duct.

Published
2006
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48. Possible Involvement of Foxp3(+) Regulatory T Cells in the Development of Immune-Mediated Pancreatitis in MRL/Mp Mice Treated with Polyinosinic:Polycytidylic Acid.

Author

Koyabu M, Uchida K, Sakaguchi Y, Fukata N, Kusuda T, Miyoshi H, Yoshida K, Sumimoto K, Mitsuyama T, Fukui T, Nishio A, and Okazaki K

Abstract

Objectives. This study was conducted to clarify whether or not Tregs are involved in the development of immune-mediated pancreatitis in MRL/Mp mice as an AIP (autoimmune pancreatitis) model, in order to understand more clearly the pathogenic mechanism of AIP. Methods. We compared the immunohistochemical features of pancreatic forkhead box P3 (Foxp3) in the administration of poly I:C in MRL/Mp mice and two types of control mice (BALB/c and C57BL/6). As a contrast, we analyzed three mouse models of pancreatitis without autoimmune mechanism (Cerulein-, Ligation-, and Ligation + Cerulein-treated mice). After staining these specimens, we compared the ratios of Foxp3-positive cells to infiltrated mononuclear cells (Foxp3/Mono). Results. Our immunohistochemical study of Foxp3 revealed that the infiltration of Foxp3-positive cells increased in poly I:C-treated MRL/Mp mice. The histopathological score of pancreatitis showed no difference among poly I:C-treated MRL/Mp, Ligation-, and Ligation + Cerulein-treated mice; however, the Foxp3/Mono ratio in poly I:C-treated MRL/Mp mice was significantly increased compared with Ligation- and Ligation + Cerulein-treated mice. Conclusions. MRL/Mp mice treated with poly I:C showed early development of pancreatitis with abundant infiltration of Foxp3-positive cells. There may be a possibility that Tregs are involved in the development of pancreatitis in these mice.

Published
2013
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49. [Small cell carcinoma of the prostate: a case report].

Author

Yamamoto N, Kinoshita H, Inoue T, Kawakita S, Oguchi N, Muguruma K, Kawa G, Sakaguchi Y, Adachi Y, Sakaida N, Uemura Y, and Matsuda T

Subjects
Adenocarcinoma pathology, Aged, Cell Transformation, Neoplastic, Humans, Male, Neoplasm Metastasis, Carcinoma, Small Cell pathology, Prostatic Neoplasms pathology
Abstract

A 76-year-old man had been treated with maximum androgen blockade therapy for a poorly-differentiated prostate adenocarcinoma (T3cN1M0, prostate specific antigen (PSA) 65 ng/ml, Gleason Score 4+5=9) since September 2002. By August 2003, his serum PSA levels were undetectable and the lymph node swelling had vanished. However, in December 2004, his serum PSA levels started rising gradually up to 0.66 ng/ml. Radiation therapy on the prostate was then performed (66 Gy). At that time, no metastasis was detected by computed tomography and bone scintigraphy. In August 2005, multiple bone metastases were detected. Immunohistochemical examination of a biopsy specimen from the bone lesion revealed a small cell carcinoma/neuroendocrine cell carcinoma. He died with undetectable PSA levels (less than 0.008 ng/ml) in December 2005. The autopsy showed multiple organ metastases including bone, liver, lungs and others. The immunohistochemical examination revealed pure small cell carcinoma in all metastatic lesions. A precise histological examination of the lungs using a 1 cm serial section could not reveal any tumors compatible with primary lung cancer. We concluded from the clinical history and autopsy findings that his initial poorly-differentiated adenocarcinoma of the prostate dedifferentiated into a pure small cell carcinoma with neuroendocrine differentiation.

Published
2007

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