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3. Endoscopic and Histological Gastritis in University Students with Helicobacter pylori Infection

Author

Okanoue, Shotaro, primary, Sakae, Hiroyuki, additional, Yokota, Kenji, additional, Tanaka, Takehiro, additional, Obayashi, Yuka, additional, Abe, Makoto, additional, Kono, Yoshiyasu, additional, Kanzaki, Hiromitsu, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, Yanai, Hiroyuki, additional, and Okada, Hiroyuki, additional

Published
2024
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7. Degree of pharyngeal deformation caused by pharyngeal endoscopic submucosal dissection is associated with the incidence of aspiration pneumonia

Author

Abe, Makoto, additional, Kawahara, Yoshiro, additional, Obayashi, Yuka, additional, Baba, Yuki, additional, Hamada, Kenta, additional, Sakae, Hiroyuki, additional, Kono, Yoshiyasu, additional, Kanzaki, Hiromitu, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Makino, Takuma, additional, Noda, Yohei, additional, Marunaka, Hidenori, additional, and Okada, Hiroyuki, additional

Published
2023
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9. Risks of refractory chest pain after peroral endoscopic myotomy in achalasia-related esophageal motility disorders: short-term results from a multicenter study in Japan

Author

Fukuda, Hisashi, primary, Sato, Hiroki, additional, Fujiyoshi, Yusuke, additional, Abe, Hirofumi, additional, Okada, Hiroki, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Yamamoto, Hironori, additional, and Inoue, Haruhiro, additional

Published
2022
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10. Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users

Author

Kono, Yoshiyasu, Matsubara, Minoru, Toyokawa, Tatsuya, Takenaka, Ryuta, Suzuki, Seiyu, Nasu, Junichirou, Yoshioka, Masao, Nakagawa, Masahiro, Mizuno, Motowo, Sakae, Hiroyuki, Abe, Makoto, Gotoda, Tatsuhiro, Miura, Ko, Kanzaki, Hiromitsu, Iwamuro, Masaya, Hori, Keisuke, Tsuzuki, Takao, Kita, Masahide, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Published
2017
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12. Site-specific differences in T lymphocyte composition of the gastric mucosa after Helicobacter pylori eradication

Author

Iwamuro, Masaya, primary, Takahashi, Takahide, additional, Watanabe, Natsuki, additional, Abe, Makoto, additional, Sakae, Hiroyuki, additional, Kono, Yoshiyasu, additional, Kanzaki, Hiromitsu, additional, Tanaka, Takehiro, additional, Kawano, Seiji, additional, Otsuka, Fumio, additional, Kawahara, Yoshiro, additional, Yanai, Hiroyuki, additional, and Okada, Hiroyuki, additional

Published
2022
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13. Efficacy of peroral endoscopic myotomy for esophageal motility disorders after gastric surgery: Japan Achalasia Multicenter Study

Author

Nakamura, Jun, primary, Sato, Hiroki, additional, Onimaru, Manabu, additional, Abe, Hirofumi, additional, Shiwaku, Hironari, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Takuto, Hikichi, additional, and Inoue, Haruhiro, additional

Published
2022
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15. Risk scoring system for the preprocedural prediction of the clinical failure of peroral endoscopic myotomy: a multicenter case–control study

Author

Abe, Hirofumi, additional, Tanaka, Shinwa, additional, Sato, Hiroki, additional, Shimamura, Yuto, additional, Okada, Hiroki, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, and Inoue, Haruhiro, additional

Published
2022
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17. Development of Dilated Esophagus, Sigmoid Esophagus, and Esophageal Diverticulum in Patients With Achalasia: Japan Achalasia Multicenter Study

Author

Sato, Hiroki, primary, Fujiyoshi, Yusuke, additional, Abe, Hirofumi, additional, Shiwaku, Hironari, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Terai, Shuji, additional, and Inoue, Haruhiro, additional

Published
2022
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18. Risk scoring system for the preprocedural prediction of the clinical failure of peroral endoscopic myotomy: a multicenter case–control study.

Author

Abe, Hirofumi, Tanaka, Shinwa, Sato, Hiroki, Shimamura, Yuto, Okada, Hiroki, Shiota, Junya, Sato, Chiaki, Sakae, Hiroyuki, Ominami, Masaki, Hata, Yoshitaka, Fukuda, Hisashi, Ogawa, Ryo, Nakamura, Jun, Tatsuta, Tetsuya, Ikebuchi, Yuichiro, Yokomichi, Hiroshi, and Inoue, Haruhiro

Subjects
DISEASE risk factors, LOG-rank test, MYOTOMY, DECISION making, CASE-control method, FORECASTING
Abstract

Background Peroral endoscopic myotomy (POEM) is effective for the management of achalasia and its variants; however, it can be ineffective in some patients. We aimed to develop and validate a risk scoring system to predict the clinical failure of POEM preoperatively. Methods Consecutive patients who underwent POEM in 14 high volume centers between 2010 and 2020 were enrolled in this study. Clinical failure was defined as an Eckardt score of ≥ 4 or retreatment. A risk scoring system to predict the short-term clinical failure of POEM was developed using multivariable logistic regression and internally validated using bootstrapping and decision curve analysis. Results Of the 2740 study patients, 112 (4.1 %) experienced clinical failure 6 months after POEM. Risk scores were assigned for three preoperative factors as follows: preoperative Eckardt score (1 point), manometric diagnosis (−4 points for type II achalasia), and a history of prior treatments (1 point for pneumatic dilation or 12 points for surgical/endoscopic myotomy). The discriminative capacity (concordance statistics 0.68, 95 %CI 0.62–0.72) and calibration (slope 1.15, 95 %CI 0.87–1.40) were shown. Decision curve analysis demonstrated its clinical usefulness. Patients were categorized into low (0–8 points; estimated risk of clinical failure < 5 %) and high risk (9–22 points; ≥ 5 %) groups. The proportions of clinical failure for the categories were stratified according to the mid-term outcomes (log-rank test, P < 0.001). Conclusions This risk scoring system can predict the clinical failure of POEM preoperatively and provide useful information when making treatment decisions. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Correction: Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan

Author

Shiwaku, Hironari, additional, Sato, Hiroki, additional, Shimamura, Yuto, additional, Abe, Hirofumi, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Ominami, Masaki, additional, Sakae, Hiroyuki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Hasegawa, Suguru, additional, and Inoue, Haruhiro, additional

Published
2022
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20. Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan

Author

Shiwaku, Hironari, additional, Sato, Hiroki, additional, Shimamura, Yuto, additional, Abe, Hirofumi, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Ominami, Masaki, additional, Sakae, Hiroyuki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Hasegawa, Suguru, additional, and Inoue, Haruhiro, additional

Published
2022
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22. Esophageal carcinoma in achalasia patients managed with endoscopic submucosal dissection and peroral endoscopic myotomy: Japan Achalasia Multicenter Study

Author

Sato, Hiroki, primary, Nishikawa, Yohei, additional, Abe, Hirofumi, additional, Shiwaku, Hironari, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Terai, Shuji, additional, and Inoue, Haruhiro, additional

Published
2021
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25. Impact of the COVID‐19 pandemic on high‐resolution manometry and peroral endoscopic myotomy for esophageal motility disorder in Japan

Author

Ominami, Masaki, primary, Sato, Hiroki, additional, Fujiyoshi, Yusuke, additional, Abe, Hirofumi, additional, Shiwaku, Hironari, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Fujiwara, Yasuhiro, additional, and Inoue, Haruhiro, additional

Published
2021
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26. Erratum to: Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users

Author

Kono, Yoshiyasu, Matsubara, Minoru, Toyokawa, Tatsuya, Takenaka, Ryuta, Suzuki, Seiyu, Nasu, Junichirou, Yoshioka, Masao, Nakagawa, Masahiro, Mizuno, Motowo, Sakae, Hiroyuki, Abe, Makoto, Gotoda, Tatsuhiro, Miura, Ko, Kanzaki, Hiromitsu, Iwamuro, Masaya, Hori, Keisuke, Tsuzuki, Takao, Kita, Masahide, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Published
2017
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27. Esophageal carcinoma in achalasia patients managed with endoscopic submucosal dissection and peroral endoscopic myotomy: Japan Achalasia Multicenter Study.

Author

Sato, Hiroki, Nishikawa, Yohei, Abe, Hirofumi, Shiwaku, Hironari, Shiota, Junya, Sato, Chiaki, Sakae, Hiroyuki, Ominami, Masaki, Hata, Yoshitaka, Fukuda, Hisashi, Ogawa, Ryo, Nakamura, Jun, Tatsuta, Tetsuya, Ikebuchi, Yuichiro, Yokomichi, Hiroshi, Terai, Shuji, and Inoue, Haruhiro

Subjects
ESOPHAGEAL achalasia, ESOPHAGEAL motility disorders, MYOTOMY, ALCOHOL, ENDOSCOPIC surgery, ALCOHOL drinking
Abstract

Objectives: Indications for peroral endoscopic myotomy (POEM) and endoscopic submucosal dissection (ESD) in patients with achalasia concomitant with esophageal carcinoma (EC) are unclear. This study aimed to clarify the role of POEM in cases of achalasia concomitant with EC and to elucidate the indications for ESD and efficient surveillance for EC. Methods: We conducted a multicenter cohort study at 14 hospitals in Japan, including 3707 cases of achalasia‐related esophageal motility disorders (EMDs). Factors contributing to EC risk, the characteristics of EC, and clinical outcomes of POEM/ESD were analyzed. Results: In patients undergoing POEM, screening and surveillance endoscopy throughout a 1‐year period resulted in diagnosis of 72.1% new EC cases. Of 62 patients with 123 ECs, 40.3% had multiple or metachronous lesions within 37.5 months. EC was predominantly observed in the middle thoracic esophagus (58.5%) and posteriorly (73.2%). POEM had comparable safety and efficacy in cases of concomitant EC even after ESD. Endoscopic en bloc resection was performed in 95.8% and 89.3% of ECs diagnosed before and after POEM, respectively (P = 0.351); however, ESD on the POEM‐line was impaired by fibrosis. Multivariate analysis revealed risk factors for EC, including regular alcohol consumption, a history of smoking, advanced age, and extended disease duration. Alcohol intake and smoking had a synergistic effect on EC development. Conclusions: Screening and surveillance of POEM help in detecting EC. ESD is feasible in achalasia, although on the POEM‐line is challenging. Surveillance endoscopy for EC is recommended for cases with specific risks and a history of ECs. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Linked Color Imaging (LCI) Emphasizes the Color Changes in the Gastric Mucosa After Helicobacter pylori Eradication

Author

Sakae, Hiroyuki, primary, Kanzaki, Hiromitsu, additional, Satomi, Takuya, additional, Okanoue, Shotaro, additional, Obayashi, Yuka, additional, Hamada, Kenta, additional, Abe, Makoto, additional, Kono, Yoshiyasu, additional, Miura, Ko, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, Tanaka, Takehiro, additional, Yanai, Hiroyuki, additional, and Okada, Hiroyuki, additional

Published
2021
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31. Risk Factors for Gastric Cancer after the Eradication of Helicobacter pylori Evaluated Based on the Background Gastric Mucosa: A Propensity Score-matched Case-control Study

Author

Obayashi, Yuka, primary, Kawano, Seiji, additional, Sakae, Hiroyuki, additional, Abe, Makoto, additional, Kono, Yoshiyasu, additional, Kanzaki, Hiromitsu, additional, Iwamuro, Masaya, additional, Kawahara, Yoshiro, additional, Tanaka, Takehiro, additional, Yanai, Hiroyuki, additional, and Okada, Hiroyuki, additional

Published
2021
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33. Impact of the COVID‐19 pandemic on high‐resolution manometry and peroral endoscopic myotomy for esophageal motility disorder in Japan.

Author

Ominami, Masaki, Sato, Hiroki, Fujiyoshi, Yusuke, Abe, Hirofumi, Shiwaku, Hironari, Shiota, Junya, Sato, Chiaki, Sakae, Hiroyuki, Hata, Yoshitaka, Fukuda, Hisashi, Ogawa, Ryo, Nakamura, Jun, Tatsuta, Tetsuya, Ikebuchi, Yuichiro, Yokomichi, Hiroshi, Fujiwara, Yasuhiro, and Inoue, Haruhiro

Subjects
COVID-19, ESOPHAGEAL motility disorders, ESOPHAGEAL motility, COVID-19 pandemic, MYOTOMY, PERSONAL protective equipment
Abstract

Aim: To elucidate the impact of the coronavirus disease 2019 (COVID‐19) on the practice of high‐resolution manometry (HRM) and peroral endoscopic myotomy (POEM) in Japan. Methods: We utilized a large‐scale database involving 14 high‐volume centers in Japan to investigate changes in the numbers of HRM and POEM procedures performed and outcomes of POEM between 2019 and 2020. A questionnaire survey was also conducted to analyze pandemic‐associated changes in the HRM and POEM protocols. Results: Compared to that in 2019, the number of HRM and POEM procedures decreased by 17.2% (1587–1314) and 20.9% (630–498), respectively. These declines were prominent during the state of emergency from April to May 2020, particularly in pandemic areas. HRM and POEM in nonpandemic areas were relatively unaffected. From 2019 to 2020, there was a 0.4% (254–248) decrease in POEM cases within the prefecture, but the number outside the prefecture decreased by 33.6% (372–247). During the pandemic, the safety and efficacy of POEM were maintained. The implementation of personal protective equipment (PPE) measures varied among facilities, and PPE for POEM was relatively insufficient compared to that for HRM. Conclusion: The COVID‐19 pandemic influenced HRM and POEM practices in Japan. It is necessary to establish a sufficient system for HRM and POEM in each hospital as well as countrywide to overcome the effects of the pandemic. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Blue laser imaging and linked color imaging improve the color difference value and visibility of colorectal polyps in underwater conditions

Author

Yamasaki, Yasushi, primary, Harada, Keita, additional, Yamamoto, Shumpei, additional, Yasutomi, Eriko, additional, Okanoue, Shotaro, additional, Hirai, Mami, additional, Oka, Shohei, additional, Obayashi, Yuka, additional, Sakae, Hiroyuki, additional, Hamada, Kenta, additional, Inokuchi, Toshihiro, additional, Kinugasa, Hideaki, additional, Sugihara, Yuusaku, additional, Takahara, Masahiro, additional, Tanaka, Takehiro, additional, Hiraoka, Sakiko, additional, Kawahara, Yoshiro, additional, and Okada, Hiroyuki, additional

Published
2020
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44. Increase in antibiotic resistant Helicobacter pylori in a University Hospital in Japan

Author

Kageyama, Chihiro, Sato, Mayu, Sakae, Hiroyuki, Obayashi, Yuka, Kawahara, Yoshiro, Mima, Takehiko, Matsushita, Osamu, Yokota, Kenji, Mizuno, Motowo, and Okada, Hiroyuki

Subjects
resistance, amoxicillin, Helicobacter pylori, Infection and Drug Resistance, genotype, clarithromycin, University Hospital, Original Research
Abstract

Chihiro Kageyama,1 Mayu Sato,1 Hiroyuki Sakae,2 Yuka Obayashi,2 Yoshiro Kawahara,2 Takehiko Mima,3 Osamu Matsushita,3 Kenji Yokota,1 Motowo Mizuno,4 Hiroyuki Okada2 1Graduate School of Health Science, Medical Technology, Okayama University, Okayama 700-8558, Japan; 2Gastroenterology and Hepatology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan; 3Bacteriology, Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan; 4Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, 710-8602, Japan Background: Eradication effectively prevents Helicobacter pylori-associated diseases; however, H. pylori antibiotic resistance has increased throughout Japan and worldwide. This study aimed to assess rates of resistance to antibiotics; amoxicillin, clarithromycin and metronidazole in a University Hospital in Japan. Materials and methods: H. pylori (208 strains) were isolated from patients at the Okayama University Hospital in Japan. The minimum inhibitory concentrations (MIC) were determined using the mean values of the E-test to determine the antimicrobial susceptibilities of the strains. Sequencing and gene analysis were performed to analyze resistance genes to clarithromycin and amoxicillin. Results: Rates of amoxicillin, clarithromycin, and metronidazole resistance were 13%, 48%, and 49%, respectively. Genetic analysis indicated that the A2143G point mutation in 23S rDNA is closely associated with the MIC of clarithromycin. The MIC in amoxicillin-resistant strains increased with an increase in the number of PBP1A amino acids mutations. Conclusion: Genetic analysis for resistant strains is not clinically effective in cases of amoxicillin resistance. Numerous bacteria with already high antibiotic resistance rates have been isolated in large hospitals such as a University Hospital. For effective eradication therapy, MIC measurement should be considered via several methods. Keywords: Helicobacter pylori, resistance, clarithromycin, amoxicillin, University Hospital, genotype

Published
2019

46. A Case of Diffuse Esophageal Spasm Treated with Peroral Endoscopic Myotomy

Author

Sugihara, Yuusaku, Harada, Keita, Kato, Ryo, Yamauchi, Kenji, Sakae, Hiroyuki, Kawano, Seiji, Hiraoka, Sakiko, Kawahara, Yoshiro, Otsuka, Fumio, and Okada, Hiroyuki

Subjects
diffuse esophageal spasm (DES), Male, otorhinolaryngologic diseases, Humans, diverticulum, peroral endoscopic myotomy (POEM), high-resolution manometry (HRM), Endoscopy, Gastrointestinal, Aged, Esophageal Spasm, Diffuse, Myotomy
Abstract

The indications for peroral endoscopic myotomy (POEM) have been expanded to include diffuse esophageal spasm (DES). A 67-year-old Japanese man presented with a 4-year history of dysphagia. Endoscopy and upper gastrography revealed abnormal peristaltic movements involving interruption of normal peristalsis, and a diverticulum located at the 2 o’clock esophageal position. High-resolution manometry indicated DES. POEM with a long (15 cm) myotomy was performed for the abnormal contractions, which subsequently disappeared along with dysphagia improvement. Our results suggest that esophageal motility disorders accompanying a diverticulum may be eliminated by POEM without treating the diverticulum itself. We speculate that POEM ameliorates esophageal diverticulum by reducing internal esophageal pressure.

Published
2018

47. Evaluation of the Usefulness and Convenience of the Kyoto Classification of Gastritis in the Endoscopic Diagnosis of the Helicobacter pylori Infection Status

Author

Sakae, Hiroyuki, primary, Iwamuro, Masaya, additional, Okamoto, Yuki, additional, Obayashi, Yuka, additional, Baba, Yuki, additional, Hamada, Kenta, additional, Gotoda, Tatsuhiro, additional, Abe, Makoto, additional, Kono, Yoshiyasu, additional, Kanzaki, Hiromitsu, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, Tanaka, Takehiro, additional, Yanai, Hiroyuki, additional, and Okada, Hiroyuki, additional

Published
2019
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