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6. The prevalence and risk factors for urinary incontinence among inpatients, a multicenter study from Turkey

Author

Kocak, Fatma Ozge Kayhan, Ozturk, Zeynel Abidin, Varli, Murat, Erdinçler, Deniz Suna, Esme, Mert, Nalbant, Selim, Cankurtaran, Mustafa, Özer, Firuzan Fırat, Atlı, Teslime, Akcicek, Fehmi, Savas, Sumru, Saka, Bülent, Akın, Sibel, Tasci, Ilker, Tasar, Pinar Tosun, Tufan, Asli, Yavuzer, Hakan, Balci, Cafer, Sezgin, Gülbüz, and Karan, Mehmet Akif

Published
2020
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9. THE DIAGNOSTIC ROLE OF 18F-FDG-PET/CT IN PATIENTS WITH CONSTITUTIONAL SYMPTOMS.

Author

ALTINKAYNAK, Mustafa, KAHVECİ, Nevzat, GÖKSOY, Yağmur, GÖKNUR IŞIK, Emine, ERTEN, Sebile Nilgün, SAKA, Bülent, and AKPINAR, Timur

Subjects
SYMPTOMS, RHEUMATISM, INTERNAL medicine, COMPUTED tomography, DIAGNOSIS methods
Abstract

Copyright of Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi is the property of Istanbul Tip Fakultesi Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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10. Solitary waves of the RLW equation via least squares method.

Author

Hepson, Ozlem Ersoy, Dag, Idris, Saka, Bülent, and Ay, Buket

Subjects
WAVE equation, BOUNDARY value problems, INITIAL value problems, ALGEBRAIC equations, CRANK-nicolson method
Abstract

Integration using least squares method in space and Crank–Nicolson approach in time is managed to set up an algorithm to solve the RLW equation numerically. Trial functions in the least square method consist of a combination of the quartic B-spline functions. Integration of the RLW equation gives a system of algebraic equations. The solutions consisting of a combination of the quartic B-splines are given for some initial and boundary value problems of RLW equation. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Which factors influence the prevalence of institution‐acquired falls? Results from an international, multi‐center, cross‐sectional survey

Author

Hoedl, Manuela, primary, Eglseer, Doris, additional, Bernet, Niklaus, additional, Everink, Irma, additional, Gordon, Adam L, additional, Lohrmann, Christa, additional, Osmancevic, Selvedina, additional, Saka, Bülent, additional, Schols, Jos M. G. A., additional, Thomann, Silvia, additional, and Bauer, Silvia, additional

Published
2021
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15. Prevalence of Care Problems in Older Adults in Turkish Hospitals

Author

Soysal, Tuba, primary, Akın, Sibel, additional, Taşçı, İlker, additional, Tosun Taşar, Pınar, additional, Savaş, Sumru, additional, Tufan Çinçin, Aslı, additional, Yavuzer, Hakan, additional, Erdinçler, Deniz Suna, additional, Balcı, Cafer, additional, Eşme, Mert, additional, Öztürk, Zeynel Abidin, additional, Sezgin, Gülbüz, additional, Nalbant, Selim, additional, Varlı, Murat, additional, Karan, Mehmet Akif, additional, and Saka, Bülent, additional

Published
2021
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23. SARCOPENIA IN HOSPITALIZED PATIENTS AND RELATED FACTORS: A MULTICENTER STUDY

Author

BALCI, CAFER, Fırat Özer, Firuzan, AKIN, SİBEL, TAŞÇI, İLKER, TOSUN TAŞAR, PINAR, SAVAŞ, EMİNE SUMRU, TUFAN ÇİNÇİN, ASLI, YAVUZER, HAKAN, ERDİNÇLER, ÜLEV DENİZ, ÖZTÜRK, ZEYNEL ABİDİN, SEZGİN, GÜLBÜZ, NALBANT, SELİM, VARLI, MURAT, KARAN, MEHMET AKİF, and SAKA, BÜLENT

Published
2020

26. Which factors influence the prevalence of institution‐acquired falls? Results from an international, multi‐center, cross‐sectional survey.

Author

Hoedl, Manuela, Eglseer, Doris, Bernet, Niklaus, Everink, Irma, Gordon, Adam L, Lohrmann, Christa, Osmancevic, Selvedina, Saka, Bülent, Schols, Jos M. G. A., Thomann, Silvia, and Bauer, Silvia

Subjects
HOSPITALS, RESEARCH, KRUSKAL-Wallis Test, NEUROLOGICAL disorders, CROSS-sectional method, MANN Whitney U Test, HEALTH outcome assessment, NURSING care facilities, RISK assessment, CRONBACH'S alpha, ACCIDENTAL falls, DEMENTIA, DESCRIPTIVE statistics, QUESTIONNAIRES, DISEASE prevalence, SCALE analysis (Psychology), CHI-squared test, LOGISTIC regression analysis, DATA analysis software, DEPENDENCY (Psychology)
Abstract

Purpose: Falls are a highly prevalent problem in hospitals and nursing homes with serious negative consequences such as injuries, increased care dependency, or even death. The aim of this study was to provide a comprehensive insight into institution‐acquired fall (IAF) prevalence and risk factors for IAF in a large sample of hospital patients and nursing home residents among five different countries. Design: This study reports the outcome of a secondary data analysis of cross‐sectional data collected in Austria, Switzerland, the Netherlands, Turkey, and the United Kingdom in 2017 and 2018. These data include 58,319 datapoints from hospital patients and nursing home residents. Methods: Descriptive statistics, statistical tests, logistic regression, and generalized estimating equation (GEE) models were used to analyze the data. Findings: IAF prevalence in hospitals and nursing homes differed significantly between the countries. Turkey (7.7%) had the highest IAF prevalence rate for hospitals, and Switzerland (15.8%) had the highest IAF prevalence rate for nursing homes. In hospitals, our model revealed that IAF prevalence was associated with country, age, care dependency, number of medical diagnoses, surgery in the last two weeks, and fall history factors. In nursing homes, care dependency, diseases of the nervous system, and fall history were identified as significant risk factors for IAF prevalence. Conclusions: This large‐scale study reveals that the most important IAF risk factor is an existing history of falls, independent of the setting. Whether a previous fall has occurred within the last 12 months is a simple question that should be included on every (nursing) assessment at the time of patient or resident admission. Our results guide the development of tailored prevention programs for persons at risk of falling in hospitals and nursing homes. [ABSTRACT FROM AUTHOR]

Published
2022
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27. İstanbul Tıp Fakültesi Klinik Nütrisyon ve Mikrobiyota Araştırma Laboratuvarı Bakteriyel Topluluk Analiz Algoritması

Author

SEVER KAYA, Dilek and SAKA, Bülent

Subjects
16S rRNA,gut microbiota,next-generation sequencing, Medicine, 16S rRNA,bağırsak mikrobiyomu,yeni nesil dizileme, Tıp
Abstract

Objective:This study aims to more efficiently use the data obtained from a bacterial community analysis performed using next-generation sequencing based on the 16S ribosomal RNA (rRNA) amplicon sequencing (AS) strategy by creating a bacterial community analysis algorithm. Materials and Methods:The V3–V4 16S rRNA hypervariable regions of 96 human gut microbiota samples were sequenced using the Illumina MiSeq system by the paired-end sequencing method. Bioinformatics analysis was performed by the QIIME 2 open-source software. Results:The V3–V4 16S rRNA hypervariable regions of 96 gut samples were sequenced successfully using 16S rRNA AS. At the end of the study, the total reading was 23.42 M, the cluster density was 883 K/mm2, the cluster density passing the filter was 92.13%, and the quality scores were >Q30 = 76.7%. Our laboratory created a bacterial community analysis algorithm from the data we have obtained in this study and based on our experience and knowledge during the study process. Conclusion: Our bacterial community analysis algorithm will be used to carry out similar studies in our laboratory within the same, comparable standards. We believe that this algorithm will serve as a reference for researchers in Turkey. In addition, if different research centers will use this algorithm, their data will be comparable to those of our laboratory and other centers in our country and the world using the same protocol. In this way, we can help increase the efficiency of studies and the value of the data obtained from the human gut microbiota., Amaç:Bu çalışmada, “Bakteriyel Topluluk Analiz Algoritması” oluşturularak 16S ribozomal RNA (rRNA) Amplikon Dizileme (AD) stratejisine dayalı Yeni Nesil Dizileme Teknolojisi kullanılarak gerçekleştirilen bakteriyel topluluk analizlerinden elde edilen verilerin daha verimli kullanılabilmesi amaçlanmıştır. Gereç ve Yöntem:Çalışmamızda, 96 insan bağırsak mikrobiyota örneğinin 16S rRNA genlerinin V3-V4 bölgeleri İllumina MiSeq sistemi kullanılarak çift-sonlu dizileme yöntemiyle dizilenmiştir. Biyoinformatik analizler QIIME 2 açık kaynaklı yazılımı ile gerçekleştirilmiştir. Bulgular:16S rRNA AD koşumundaki 96 örneğin tamamının 16S rRNA V3-V4 bölgeleri başarıyla dizilenmiştir. Çalışmanın sonunda toplam okuma 23.42 M, kümelenme yoğunluğu 883 K/mm2, filtreyi geçen küme yoğunluğu % 92.13, kalite skorları ise > Q30 = % 76,7 olarak tespit edilmiştir. Bu çalışmada elde ettiğimiz veriler ve çalışma sürecinde oluşan tecrübe ve bilgi birikimimiz sonucunda laboratuvarımız tarafından bir Bakteriyel Topluluk Analiz Algoritması oluşturulmuştur. Sonuç:“İstanbul Tıp Fakültesi, Klinik Nütrisyon ve Mikrobiyota Araştırma Laboratuvarı Bakteriyel Topluluk Analiz Algoritması” laboratuvarımızda gerçekleştirdiğimiz çalışmaların aynı standartlarda ve karşılaştırılabilir olması için kullanılacaktır. Bu algoritmanın ülkemizdeki araştırmacılar için bir referans niteliğinde olacağını düşünmekteyiz. Ayrıca farklı merkezlerin bu algoritmayı kullanmaları durumunda elde edilecek veriler laboratuvarımızın verileriyle ve bu protokolü kullanan ülkemizdeki veya Dünyadaki diğer merkezlerin verileriyle karşılaştırılabilir olacaktır. Bu şekilde ülkemizdeki insan bağırsak mikrobiyotası ile ilgili yapılan çalışmaların veriminin ve elde edilen verilerin değerinin arttırılmasına katkıda bulunmayı hedefliyoruz.

Published
2020

28. The prevalence and risk factors for urinary incontinence among inpatients, a multicenter study from Turkey

Author

Savaş, Sumru, Saka, Bülent, Akın, Sibel, Taşçı, İlker, Tosun Tasar, Pınar, Tufan, Aslı, Yavuzer, Hakan, Balcı, Cafer, Kayhan Koçak, Fatma Özge, Öztürk, Zeynel Abidin, Varlı, Murat, Erdinçler, Deniz Suna, Karan, Mehmet Akif, Esme, Murat, Cankurtaran, Mustafa, Fırat Özer, Firuzan, Atlı, Teslime, Akçiçek,Fehmi, Maltepe Üniversitesi, Tıp Fakültesi, Sezgin, Gülbüz, and Nalbant, Selim

Subjects
Hospitalization, Older adults, Prevalence, Urinary incontinence, Risk factor
Abstract

Objective: To determine the prevalence and the factors associated with urinary incontinence (UI) among inpatients in Turkey. Method: The population of this study comprised of patients screened by the "National Prevalence Measurement of Quality of Care (LPZ)" study in 2017 and 2018. Age, gender, comorbidities, length of hospital stay, sedative medications, SARC-F score, anthropometric measurements, and care parameters such as malnutrition, falls, UI-fecal incontinence (FI), restraints, and care dependency score (CDS) were noted. The LPZ questionnaire was performed by trained researchers, and multiple logistic regression analysis was performed to determine the factors associated with UI. Results: The prevalence of UI was 29.4 % among 1176 inpatients, and 41.6 % in patients ≥65 years. Urinary incontinence was associated with older age (OR, 1.966, 95 % CI 1.330-2.905), female sex (OR, 2.055, 95 % CI 1.393-3.030), CDS (OR, 3.236, 95 % CI 2.080-5.035), the number of comorbidities (OR, 1.312, 95 % CI 1.106-1.556), end-of life management (OR, 3.156, 95 % CI 1.412-7.052), sedative medications (OR, 1.981, 95 % CI 1.230-3.191), and FI (OR, 12.533, 95 % CI 4.892-32.112) in all adults, where CDS (OR, 2.589, 95% CI 1.458-4.599), end-of life management (OR, 2.851, 95 % CI 1.095-7.424), sedative medications (OR, 2.529, 95 % CI 1.406-4.548), and FI (OR, 13.138, 95 % CI 4.352-39.661) were associated with UI among geriatric patients. Conclusions: The factors associated with UI in geriatric and all adult inpatients are CDS, sedative medications, end-of life management, and FI plus older age, female sex, and comorbidities for the latter. The factors associated with UI vary in different age groups.

Published
2020

33. The cubic B-spline least-squares finite-element method for the numerical solutions of regularized long-wave equation.

Author

Hepson, Ozlem Ersoy, Dağ, İdris, Saka, Bülent, and Ay, Buket

Subjects
FINITE element method, ALGEBRAIC equations, SPLINE theory, EQUATIONS
Abstract

A new least-squares method based on cubic B-spline functions is presented to solve regularized long-wave (RLW) equation numerically. An algebraic system of equations is obtained by employing the least-squares method based on cubic B-spline approximation for spatial discretization and the Crank–Nicolson technique for time discretization for integrating the RLW equation. The two test problems are implemented to show suitability of the proposed scheme. New results have been compared with those of some previous studies available in the literature. [ABSTRACT FROM AUTHOR]

Published
2022
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37. The prevalence and risk factors for urinary incontinence among inpatients, a multicenter study from Turkey

Author

Savas, Sumru, primary, Saka, Bülent, additional, Akın, Sibel, additional, Tasci, Ilker, additional, Tasar, Pinar Tosun, additional, Tufan, Asli, additional, Yavuzer, Hakan, additional, Balci, Cafer, additional, Sezgin, Gülbüz, additional, Karan, Mehmet Akif, additional, Kocak, Fatma Ozge Kayhan, additional, Ozturk, Zeynel Abidin, additional, Varli, Murat, additional, Erdinçler, Deniz Suna, additional, Esme, Mert, additional, Nalbant, Selim, additional, Cankurtaran, Mustafa, additional, Özer, Firuzan Fırat, additional, Atlı, Teslime, additional, and Akcicek, Fehmi, additional

Published
2020
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39. European Academy for medicine of ageing session participants' report on malnutrition assessment and diagnostic methods; an international survey

Author

Sanchez-Rodriguez, Dolores, primary, Annweiler, Cédric, additional, Marco, Ester, additional, Hope, Suzy, additional, Piotrowicz, Karolina, additional, Surquin, Murielle, additional, Ranhoff, Annette, additional, Van Den Noortgate, Nele, additional, Andersen-Ranberg, Karen, additional, Bonin-Guillaume, Sylvie, additional, Conroy, Simon, additional, Gordon, Adam, additional, Grodziki, Tomasz, additional, Landi, Francesco, additional, Martínez-Velilla, Nicolás, additional, Münzer, Thomas, additional, Ranhoff, Anette Hylen, additional, Roller-Wirnsberger, Regina, additional, Singler, Katrin, additional, Al Hamad, Hanadi Khamis, additional, Beuscart, Jean-Baptiste, additional, Blanc, Frédéric, additional, Ciurea, Annette, additional, Cobbaert, Katrien, additional, Dallmeier, Dhayana, additional, Dinan, Pascale, additional, Engvig, Andreas, additional, Højmann, Anette Hansen, additional, Hosia, Helka, additional, Kerminen, Hanna-Maria, additional, Knapskog, Anne-Brita, additional, Koutsouri, Anastasia, additional, Laurent, Marie, additional, Lilamand, Matthieu, additional, Marien, Sophie, additional, Mellingsaeter, Marte, additional, Mendes, Aline, additional, Nguyen, Sylvain, additional, Ogugua, Chile, additional, Ommundsen, Nina, additional, Périvier, Samuel, additional, Rapo-Pylkkö, Susanna, additional, Roitto, Hanna-Maria, additional, Roubaud-Baudron, Claire, additional, Saka, Bülent, additional, Sanchez-Rodriguez, Dolores, additional, Tarazona, Francisco, additional, Toscano-Rico, Miguel, additional, Tschurr, Gaudenz, additional, Vande Walle, Natalie, additional, Vetrano, Davide, additional, and Yavuz, Burcu-Balam, additional

Published
2020
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44. Effects of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on the body composition and muscle strength in the elderly

Author

Saka, Bülent, primary, Şahin, Sevnaz, additional, Kılıç, Diclehan, additional, Öztürk, Levent, additional, Yılmaz, Hasan, additional, Doğanay, Mutlu, additional, Türkyılmaz, Serdar, additional, Menteş, Selahattin, additional, Usluer, Ozan, additional, Arıkan, Kürşat, additional, Çomoğlu, Selçuk, additional, Güngör, Levent, additional, Ziyade, Sedat, additional, Kanat, Özkan, additional, Şeker, Duray, additional, Canoler, Özgür, additional, Gözke, Eren, additional, Akın, Sibel, additional, Sücüllü, İlker, additional, and Tufan, Fatih, additional

Published
2019
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46. Association of inflammation with nutritional status, lean body mass, and physical activity in non-dialysis-dependent chronic kidney disease

Author

Aksoy, Aysun, primary, Akpınar, Timur Selçuk, additional, Yıldız, Alattin, additional, Usta Akgül, Sebahat, additional, Torun, Ege Sinan, additional, Savran Oğuz, Fatma, additional, Yazıcı, Halil, additional, Erten, Nilgün, additional, Taşçıoğlu, Cemil, additional, and Saka, Bülent, additional

Published
2019
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50. The Role of the Local Bone Marrow Renin-Angiotensin System in Multiple Myeloma.

Author

Saka, Bülent, Sayitoğlu, Müge, İstemihan, Zülal, Karan, M. Akif, Erten, Nilgün, Doğan, Öner, Özbek, Uğur, Genç, Sema, Taşçıoğlu, Cemil, and Kalayoğlu-Beşışık, Sevgi

Subjects
*BLOOD coagulation factors, *BONE marrow, *CELL receptors, *COMPARATIVE studies, *IMMUNOHISTOCHEMISTRY, *MESSENGER RNA, *MULTIPLE myeloma, *NEOVASCULARIZATION, *POLYMERASE chain reaction, *STAINS & staining (Microscopy), *RENIN-angiotensin system, *QUANTITATIVE research, *VASCULAR endothelial growth factors, *REVERSE transcriptase polymerase chain reaction
Abstract

Objective: Angiotensin II promotes growth and angiogenesis via type 1 receptors (AGTR1) in certain tumors. In this study, we examine the bone marrow AGTR1 expression in multiple myeloma (MM) and its relationship with the regulation of angiogenesis and prognostic factors. Materials and Methods: Bone marrow AGTR1 mRNA levels of 39 MM patients and 15 healthy controls were analyzed with quantitative RT-PCR. Immunohistochemical staining of the tissue vascular endothelial growth factor (VEGF), CD34, and factor VIIIrAg (fVIIIrAg) was used to assess bone marrow angiogenesis. Results: Bone marrow samples of the patients showed increased VEGF, fVIIIrAg, and CD34 staining and higher AGTR1 expression levels when compared to controls. Patients with severe-diffuse bone marrow infiltration showed higher bone marrow VEGF, fVIIIrAg, CD34, and AGTR1 mRNA levels when compared to other patients. Conclusion: AGTR1 expression was found positively correlated with plasma β2-microglobulin level and patients with increased AGTR1 expression showed increased bone marrow CD34 levels. [ABSTRACT FROM AUTHOR]

Published
2019
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