1. Conversion of Aryl Azides to Aminopyridines
- Author
-
Sajan C. Patel and Noah Z. Burns
- Subjects
Oxygen ,Azides ,Aniline Compounds ,Colloid and Surface Chemistry ,Nitrogen ,Pyridines ,Aminopyridines ,Benzene ,General Chemistry ,Biochemistry ,Carbon ,Catalysis - Abstract
A longstanding challenge in fundamental functional group interconversion has been the direct transformation of benzene into pyridine via nitrogen insertion and carbon deletion. Herein, we report a protocol for the transformation of aryl azides, easily accessible from their corresponding anilines, to 2-aminopyridines using blue light and oxygen. Mechanistic studies corroborate that the arene to pyridine conversion is achieved by nitrogen insertion into the benzene ring followed by oxidative carbon extrusion.
- Published
- 2022