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Your search keyword '"Saito, Ako"' showing total 26 results
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26 results on '"Saito, Ako"'

23. Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene–α (Gro-α) from endometrioma stromal cells

Author

Takamura, Masashi, primary, Osuga, Yutaka, additional, Izumi, Gentaro, additional, Yoshino, Osamu, additional, Koga, Kaori, additional, Saito, Ako, additional, Hirata, Tetsuya, additional, Hirota, Yasushi, additional, Harada, Miyuki, additional, Hasegawa, Akiko, additional, and Taketani, Yuji, additional

Published
2012
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26. Fucoidan prevents concanavalin A-induced liver injury through induction of endogenous IL-10 in mice

Author

Saito, Ako, Yoneda, Masashi, Yokohama, Shiro, Okada, Mitsuyoshi, Haneda, Masakazu, and Nakamura, Kimihide

Subjects
*POLYSACCHARIDES, *CYTOKINES, *GENE expression, *INTERLEUKIN-10, *TUMOR necrosis factors
Abstract

Abstract: Fucoidan is a complex of sulfated polysaccharides derived from non-mammalian origin such as marine brown algae and induces cytokine expression. We investigated the effect of fucoidan on concanavalin A (Con A)-induced liver injury in mice. Liver injury was induced by an intravenous injection of Con A (18.5mg/kg). Various doses of fucoidan (1–30mg/kg) were intravenously administered 30min before Con A injection. The plasma alanine aminotransferase (ALT) and several cytokines levels were determined, and hepatic histological changes were also assessed. The effect of fucoidan administration by itself on induction of interleukin (IL)-10 in plasma and liver tissue was investigated. Con A administration induced an elevation of plasma ALT level, and fucoidan administration dose-dependently prevented the Con A-induced elevation of plasma ALT. Con A administration increased plasma TNF-α and IFN-γ levels, and fucoidan pretreatment significantly inhibited these alterations and increased plasma IL-10 level. The inhibitory effect of fucoidan on Con A-induced liver injury and production of proinflammatory cytokines were reversed by anti-mouse IL-10 antibody pretreatment. Fucoidan induced the IL-10 production in plasma and liver tissue. These findings suggest that fucoidan prevents Con A-induced liver injury by mediating the endogenous IL-10 production and the inhibition of proinflammatory cytokine in mice. [Copyright &y& Elsevier]

Published
2006
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