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Yousef Almoghrabi,1,2,* Hussam Daghistani,1,2,* Hanouf A Niyazi,3,* Hatoon A Niyazi,3,* Hind AbdulMajed,3,* Noha A Juma,3,* Noura Daffa,3,* Noof R Helmi,3,* Mohammed W Al-Rabia,3,4,* Jawahir A Mokhtar,3,5,6,* Bandar Hasan Saleh,3,* Dalya M Attallah,5 Maram Matar,5 Hani Ahmed Shukri,5 Shahd A Moqaddam,5 Sara Alamoudi,5 Khalil K Alkuwaity,6,7,* Turki Abujamel,6,7,* Ahmad M Sait,2,7 Mohammed Mufrrih,7,8 Ibrahim A Al-Zahrani,7,8,* Stephen O’hagan,9 Mazen A Ismail,10,* Ohood S Alharbi,11,* Hattan Jamal Momin,12,* Ibrahim Mohammed Abu,13,* Abdelbagi Alfadil,3,4,* Karem Ibrahem3 1Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 2Regenerative Medicine Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 3Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 4Centre of Research Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, Saudi Arabia; 5Department of Clinical Microbiology Laboratory, King Abdulaziz University Hospital, Jeddah, 21589, Saudi Arabia; 6Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 7Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 8Special Infectious Agents Unit BSL-3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; 9Department of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, UK; 10Department of Medical Education, Faculty of Medicine, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 11Department of Microbiology and Parasitology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 12Medical Service Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 13Department of Community Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, 21589, Saudi Arabia*These authors contributed equally to this workCorrespondence: Karem Ibrahem, Email kaibrahem@kau.edu.saBackground: This six-year retrospective study provides an in-depth analysis of the epidemiological and clinical patterns associated with Acinetobacter baumannii (A. baumannii) infections, focusing on age distribution, antibiotic resistance profiles, and specimen types.Aim: The research examines the incidence and characteristics of both non-Multi-Drug Resistant (non-MDR) and Multi-Drug Resistant (MDR) A. baumannii strains by reviewing patient records from January 2016 to December 2022.Methods: Through a statistical analysis, the study highlights the incidence rates across diverse age groups and explores the impact of antibiotic treatment regimens on infection outcomes. Additionally, it identifies the primary clinical specimen types for each strain, noting an association between non-MDR A. baumannii and midstream urine samples, while MDR A. baumannii strains were more frequently found in respiratory, wound, peripheral, and central line swaps/specimens.Results: The results indicate that in 2016, non-MDR A. baumannii infections were notably more frequent compared to MDR A. baumannii cases. However, a significant shift occurred in 2021 and 2022, with a marked decrease in non-MDR A. baumannii cases and an increase in MDR A. baumannii infections. Antibiotic susceptibility testing revealed that non-MDR strains were commonly tested against cefazolin, ceftazidime, ciprofloxacin, gentamicin, nitrofurantoin, oxacillin, piperacillin/tazobactam, and trimethoprim/sulfamethoxazole. In contrast, MDR strains were frequently tested against amikacin, cefepime, colistin, meropenem, imipenem, and tigecycline.Conclusion: This study enhances the understanding of A. baumannii clinical behaviour and resistance patterns, offering valuable insights to support future research and inform strategies for infectious disease management and control.Keywords: Acinetobacter baumannii, MDR, the epidemiological and clinical patterns

Abstract Alzheimer’s disease (AD), a neurodegenerative disease that mostly affects the elderly, slowly impairs memory, cognition, and daily tasks. AD has long been one of the most debilitating chronic neurological disorders, affecting mostly people over 65. In this study, we investigated the use of Vision Transformer (ViT) for Magnetic Resonance Image processing in the context of AD diagnosis. ViT was utilized to extract features from MRIs, map them to a feature sequence, perform sequence modeling to maintain interdependencies, and classify features using a time series transformer. The proposed model was evaluated using ADNI T1-weighted MRIs for binary and multiclass classification. Two data collections, Complete 1Yr 1.5T and Complete 3Yr 3T, from the ADNI database were used for training and testing. A random split approach was used, allocating 60% for training and 20% for testing and validation, resulting in sample sizes of (211, 70, 70) and (1378, 458, 458), respectively. The performance of our proposed model was compared to various deep learning models, including CNN with BiL-STM and ViT with Bi-LSTM. The suggested technique diagnoses AD with high accuracy (99.048% for binary and 99.014% for multiclass classification), precision, recall, and F-score. Our proposed method offers researchers an approach to more efficient early clinical diagnosis and interventions.

Abstract Tension-type headache (TTH) and migraine are two common primary headaches distinguished by clinical characteristics according to the 3rd edition of the International Classification of Headache Disorders. Migraine is identified by specific features such as being more prevalent in females, being aggravated by physical activity, certain genetic factors, having photophobia, phonophobia, nausea, vomiting, or aura, and responding to specific drugs. Nonetheless, TTH and migraine share some common characteristics, such as onset occurring in the 20 s, and being triggered by psychological factors like stress, moderate pain severity, and mild nausea in chronic TTH. Both conditions involve the trigeminovascular system in their pathophysiology. However, distinguishing between TTH and migraine in clinical practice, research, and epidemiological studies can be challenging, as there is a lack of specific diagnostic tests and biomarkers. Moreover, both conditions may coexist, further complicating the diagnostic process. This review aims to explore the similarities and differences in the pathophysiology, epidemiology, burden and disability, comorbidities, and responses to pharmacological and non-pharmacological treatments of TTH and migraine. The review also discusses future research directions to address the diagnostic challenges and improve the understanding and management of these conditions. Graphical Abstract

Türkler 8. yüzyılın ortalarından itibaren İslâm medeniyetine dâhil olmakla bu kültürün bir parçası olan dînî, ilmî ve edebî müktesebatı tanıma imkânı bulmuş; kısa zamanda bu eserleri hazmedip kendi birikimleri ile harmanlayarak bu ortak kültüre önemli katkılar sunmuşlardır. Metin şerhinde, 13. yüzyıldan 20. yüzyıla kadar çok sayıda eser ortaya koyan Türk âlimleri, Arap ve Fars dilleri ile birlikte Türkçe dînî, ilmî ve edebî pek çok önemli eserin şerhini yapmışlardır. Anadolu sahası klasik Türk edebiyatında, şerh geleneğinin yaygınlaşması 16. yüzyılın ikinci yarısında olmuştur. Günümüzde de devam eden metin şerhi çalışmaları klasik ve modern yaklaşımlarla gerçekleştirilmektedir. Yakın dönem edebiyat araştırmacılarından bazıları metin şerhine dair yaptıkları çalışmalarla tanınmış ve eserleri referans kaynağı olarak kabul görmüştür. Bu çalışma kapsamında incelenen eser, Klasik Türk edebiyatı ve metin şerhi alanının önde gelen hocalarından Prof. Dr. Ali Nihat Tarlan ve Prof. Dr. Âmil Çelebioğlu’nun derslerinde Prof. Dr. Tahir Üzgör tarafından tutulan notların bir araya getirilmesi ile oluşturulmuştur. Tahir Üzgör lisans ve doktora derslerinde yukarıda zikredilen araştırmacıların ilmî birikimini ilk ağızdan dinleme imkânı bulmuş, tuttuğu notlarla da günümüz araştırmacı ve okurlarına ulaşmasını sağlamıştır. “Tahir Üzgör’ün Kaleminden Ali Nihat Tarlan ve Âmil Çelebioğlu’nun Ders Notları” adlı eser Marmara Üniversitesi öğretim üyesi Erdoğan Taştan tarafından hazırlanmıştır.

BackgroundNarrow band green light (NbGL) has been shown to relieve headache in small numbers of subjects but large-scale real-world assessments are lacking. The goal of this prospective, observational, open-label, real world study was to determine whether treatment with NbGL during the ictal phase of migraine, improves patients' perception of their headache, photophobia, anxiety and same-night sleep.MethodsThe study was conducted in purchasers of the NbGL Lamp in two phases. In Phase I purchasers of the Lamp completed a survey and were asked to participate in a 6-week diary study. In Phase 2 participants completed daily diaries for 6 weeks. Specifically, they were asked to use their judgement/impression/perception when choosing between headache-improved or headache-unimproved after using the NbGL during acute attacks. Diary outcomes of interest included rates of attacks improve in responders (≥50%), non-responders (

Abstract Background The goal of this observational, open-label, cohort study was to determine whether prophylactic migraine treatment with galcanezumab, a peripherally acting drug, alters the incidence of premonitory symptoms, and/or occurrence of headache after exposure to triggers or aura episodes in treatment-responders (≥ 50% reduction in monthly migraine days [MMD]), super-responders (≥ 70%), non-responders (

This research aimed to determine the opinions of teacher parents about distance education process during COVID-19. The study was designed as a case study which is one of the methods in qualitative research. The sample of the study composed of 83 teacher parents from different branches in Turkey. Maximum variation and criterion sampling methods were used to select the participants. The data of the study were gathered though open ended questions developed by the researchers and were analyzed through descriptive and content analyses. According to the participants, distance education is perceived and accepted as a means of support rather than an alternative to face-to-face education. Participants mentioned the distance education carried out during the pandemic process as a beneficial practice in order to prevent students from breaking off from education but also they stated administrative issues, lack of computer science knowledge and internet-related problems. The inability to disseminate distance education to all students, especially disadvantaged students due to the lack of infrastructure, indifferent parents and the fact that distance education is insufficient in the education of young children/special education students show that distance education has not yet met the expectations to provide equal opportunities for everyone involved.

Background: Treatment with OnabotulinumtoxinA (BoNT-A) is effective as a preventive treatment for chronic migraine (CM). Preclinical studies suggest that the mechanism of action of BoNT-A in migraine is based on blocking unmyelinated C fibers. We aimed to investigate whether the muscle-relaxing effect of BoNT-A is associated with the preventive mechanism in patients with chronic migraine by measuring the stiffness, pain thresholds, and tenderness of the BoNT-A-applied muscles. Methods: A total of 22 patients with CM who were already in BoNT-A treatment participated in this longitudinal prospective study. Pericranial muscle stiffness was measured using ultrasound shear wave elastography, which measures the speed of shear waves propagating through the muscle. Pressure pain thresholds (PPT) were obtained via algometry, and muscle tenderness was measured via manual palpation. Measurements were made before BoNT-A injections and six weeks after the treatment. The measurements were performed while the muscles were maximally relaxed. The patients also completed daily diaries on headache and neck pain. Results: No change was observed in muscle stiffness (p = 0.737) or pericranial muscle tenderness (p = 0.400). The PPT over the trapezius muscles increased from 250 kPa before treatment to 304 kPa six weeks after treatment (p = 0.027). No change was observed on the temporalis muscles (p = 0.200) nor the non-dominant index finger (p = 0.067). BoNT-A decreased neck pain (p = 0.008) and headache (p = 0.007). Conclusions: The findings suggest that BoNT-A leads to the desensitization of cutaneous and muscle nociceptors in the head and neck regions, whereas muscle relaxation might not be an important part of the anti-migraine effect.

Abstract Objective To investigate whether persistent post-traumatic headache attributed to mild traumatic brain injury (TBI) is associated with more pronounced pericranial tenderness and lower pressure pain thresholds (PPTs) in the head and neck region, compared with healthy controls. Methods Patients with persistent post-traumatic headache (n = 100) and age- and gender-matched healthy controls (n = 100) were included between July 2018 and June 2019. Total tenderness score (TTS) was used to assess pericranial tenderness by bilateral manual palpation in eight muscles or tendon insertions. Summation was then used to calculate a TTS from 0 to 48 based on individual right- and left-sided scores; higher TTS score indicated more pronounced pericranial tenderness. PPTs were examined in m. temporalis and m. trapezius (upper and middle part) using an electronic pressure algometer that applies increasing blunt pressure at a constant rate. Results The TTS score was higher in patients with persistent post-traumatic headache (median, 21; IQR, 12–31), compared with healthy controls (median, 10; IQR, 6–17; P

Biological systems where order arises from disorder inspires for many metaheuristic optimization techniques. Self-organization and evolution are the common behaviour of chaos and optimization algorithms. Chaos can be defined as an ordered state of disorder that is hypersensitive to initial conditions. Therefore, chaos can help create order out of disorder. In the scope of this work, Golden Ratio Guided Local Search method was improved with inspiration by chaos and named as Chaotic Golden Ratio Guided Local Search (CGRGLS). Chaos is used as a random number generator in the proposed method. The coefficient in the equation for determining adaptive step size was derived from the Singer Chaotic Map. Performance evaluation of the proposed method was done by using CGRGLS in the local search part of MLSHADE-SPA algorithm. The experimental studies carried out with the electroencephalographic signal decomposition-based optimization problems, named as Big Data optimization problem (Big-Opt), introduced at the Congress on Evolutionary Computing Big Data Competition (CEC’2015). Experimental results have shown that the local search method developed using chaotic maps has an effect that increases the performance of the algorithm.

In this study; The effects of using urea as top fertilizer and "Nutrisphere-N-Urea" fertilizer, which is a nitrogen stabilizer, on some yield and quality criteria of bread wheat and corn were investigated. Experiments were carried out in the fields of the Eastern Mediterranean Agricultural Research Institute according to a randomized block design with four replications. In the wheat trial; control (no fertilizer), conventional-DAP (15 kg/da)+Urea (29 kg/da), DAP (15 kg/da)+Nutrisphere-N-Urea (15 kg/da) and DAP (15 kg/da)+Nutrisphere-N-Urea (29 kg/da) subjects including were studied. In the corn trial; 25 kg DAP/da+without top fertilizer; 25 kg DAP/da+60 kg Urea/da and 25 kg DAP/da+60 kg Nutrisphere-N-Urea/da were the subject of the research. As a result of the observations and analysis of variance, the effect of the use of "Nutrisphere-N-Urea" on yield and yield criteria in wheat, despite the classical top fertilizer (Urea) application, was found to be statistically significant. While the yield per decare was 326.88 kg in the traditional application, it was found to be 388.46 kg when Nutrisphere-N-Urea (15 kg/da) was used. In the corn trial; While the effect of the use of "Nutrisphere-N-Urea" on plant height, first ear height and hectoliter weight was found to be statistically insignificant compared to the control subject, it was seen that it caused statistically significant differences on stem diameter and yield values. The highest yield (1774.31 kg/da) and crude protein (8.95%) and low starch ratio (67.73%) were obtained from the “25 kg DAP/da+60 kg Nutrisphere-N-Urea/da” application.

Migraine is underpinned by central nervous system neuroplastic alterations thought to be caused by the repetitive peripheral afferent barrage the brain receives during the headache phase (cortical hyperexcitability). Calcitonin gene-related peptide monoclonal antibodies (anti-CGRP-mAbs) are highly effective migraine preventative treatments. Their ability to alter brain morphometry in treatment-responders vs. non-responders is not well understood. Our aim was to determine the effects of the anti-CGRP-mAb galcanezumab on cortical thickness after 3-month treatment of patients with high-frequency episodic or chronic migraine. High-resolution magnetic resonance imaging was performed pre- and post-treatment in 36 migraine patients. In this group, 19 patients were classified responders (≥50 % reduction in monthly migraine days) and 17 were considered non-responders (

Abstract Objective To investigate the association of psychiatric and cognitive comorbidities with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI). Methods A total of 100 patients with persistent PTH attributed to mild TBI and 100 age- and gender-matched healthy controls free of mild TBI were enrolled between July 2018 and June 2019. Quality of sleep was evaluated using the Pittsburgh Sleep Quality Index, while symptoms of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Cognitive impairment was evaluated using the Montreal Cognitive Assessment questionnaire, while post-traumatic stress disorder (PTSD) was assessed using the Harvard Trauma Questionnaire. Results In 100 patients with persistent PTH, 85% reported poor quality sleep, compared with 42% of healthy controls (P

This study aims at revealing the individual and organizational factors that affect teachers’ innovative behaviors and examining and evaluating the results of organizational intelligence in these factors. The study group of the research included 20 teachers with different levels of education and different branches working in public schools affiliated with the Turkish Ministry of National Education (MoNE) in Ankara during the 2020-2021 school year. This study was designed in the basic qualitative research design, one of the qualitative research methods. The data collection tool was an open-ended questionnaire. Descriptive analysis and content analysis techniques were used to analyze the obtained data. In addition, direct quotations were included in this study to enable participant teachers to reveal their opinions more clearly. In line with the participants' opinions, it was determined that organizational intelligence produced results stimulating and strengthening individual and organizational factors that were effective in teachers’ innovative practices. Therefore, it can be concluded that organizational intelligence with all its dimensions positively affects teachers’ innovative work behaviors.

Non-compliance is a challenge for practitioners serving children with and without disabilities. Many interventions have been developed to increase compliance. High-probability request sequences (HPRS), an antecedent-based intervention that is based on behavioral momentum theory, is one way to increase compliant behavior. HPRS includes the presentation of two-to-five easy or known tasks with a high probability of compliance immediately before requesting tasks with a low probability of compliance. The purpose of the current meta-analysis was to review the literature in the last 40 years on high-p request sequences as an intervention to improve compliance in children with autism spectrum disorder (ASD). Specifically, we examined the methodological rigor of the high-p single-case research for students with autism, identified the descriptive characteristics of these studies, and estimated treatment effects with Tau-U to determine whether HPRS is an evidence-based practice (EBP) for increasing compliance in children with ASD. Our results showed that HPRS is a very effective practice in increasing compliance in children with ASD (Tau-U = .87) and a promising EBP for improving compliance in children with ASD. Implications for future research and practice are discussed.

BackgroundAnxiety, depression, post-traumatic stress disorder (PTSD), and sleep disturbance are reported following whiplash injury. However, the prevalence of these condition varies among studies. In this review, anxiety, depression, PTSD, and sleep disturbance will be referred as psychiatric outcomes.MethodsWe performed a systematic literature search on PubMed and Embase (from database inception until March 20, 2021) to identify studies reporting on the relative frequency of these psychiatric outcomes. Three independent investigators screened titles, abstracts and full-texts. Studies including patients with whiplash injury and where the number of patients with whiplash and anxiety, depression, PTSD, or sleep disturbances could be extrapolated, were included. Furthermore, to be included, studies had to defined psychiatric outcomes in accordance with diagnostic criteria [i.e., Diagnostic and Statistical Manual of Mental Disorders (DSM) or the International Classification of Diseases (ICD)] or by use of a validated instrument with cut-off scores for assessing psychiatric symptoms. Quality rating was done using the Newcastle-Ottawa Scale (NOS) on the included studies. A protocol was registered with PROSPERO (CRD42021232037).ResultsThe literature search identified 5,068 citations, of which five articles were eligible for inclusion. The relative frequency of depressive symptoms following whiplash injury was 32.8% at 6 months, and 34.0% at 6–12 months. The relative frequency of PTSD symptoms after whiplash injury was 9.0–22.3% at 3 months, 15.8% at 6 months and 14.6–17.1% at 12 months. No studies evaluating the relative frequency of anxiety and sleep disturbances were eligible for inclusion.Discussion and ConclusionOur results suggest that there are persistent psychiatric outcomes following whiplash trauma. However, we found considerable heterogeneity among the studies. Thus, we have focused on the most notable limitations of the included studies: 1) small sample sizes, 2) differences in enrollment criteria, 3) lack of control groups, 4) considerable variation in the method used for outcome assessment, 5) directionality of association is difficult to determine and 6) incomplete assessment of compensation factors. We highlight these methodological limitations and outline recommendations for future research. Since psychiatric outcomes are potentially modifiable, future studies should optimize and address the identified methodological limitations so psychiatric sequelae following whiplash injury may be prevented.

We present a new software module, QRCODE (Quantum Research for Calculating Optically Driven Excitations), for massively parallelized real-time time-dependent density functional theory (RT-TDDFT) calculations of periodic systems in the open-source Qbox software package. Our approach utilizes a custom implementation of a fast Fourier transformation scheme that significantly reduces inter-node message passing interface (MPI) communication of the major computational kernel and shows impressive scaling up to 16,344 CPU cores. In addition to improving computational performance, QRCODE contains a suite of various time propagators for accurate RT-TDDFT calculations. As benchmark applications of QRCODE, we calculate the current density and optical absorption spectra of hexagonal boron nitride (h-BN) and photo-driven reaction dynamics of the ozone-oxygen reaction. We also calculate the second and higher harmonic generation of monolayer and multi-layer boron nitride structures as examples of large material systems. Our optimized implementation of RT-TDDFT in QRCODE enables large-scale calculations of real-time electron dynamics of chemical and material systems with enhanced computational performance and impressive scaling across several thousand CPU cores.

Abstract Chronic traumatic encephalopathy (CTE) is a perplexing condition characterized by a broad and diverse range of neuropathology and psychopathology. While there are no agreed upon or validated clinical criteria for CTE, case series of CTE have described a wide range of neuropsychiatric symptoms that have been attributed to repetitive traumatic brain injuries (rTBI). However, the direct links between the psychopathology of psychiatric and neurological conditions from rTBI to CTE remains poorly understood. Prior studies suggest that repetitive cerebral injuries are associated with damage to neural circuitry involved in emotional and memory processes, but these studies do not offer longitudinal assessments that prove causation. More recent studies on novel targets, such as transmission of misfolded proteins, as well as newly advanced non-invasive imaging techniques may offer more direct evidence of the pathogenesis of CTE by tracing the progression of pathology and display of related behavioral impairments. Understanding this interface in the context of rTBI can play an important role in future approaches to the definition, assessment, prevention, and treatment of CTE and mental illnesses.

This study was conducted to determine the effects of “biofertilizers” (N 8%, P2O5 1%, 9% K2O, 3% Iron, 0.06% Zinc, Bacillus subtilis (GBO3), Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens ve Bacillus pumilus) eaf applications on yield and quality parameters of bread wheat at different developmental stages. The experiment carried out for this purpose was conducted in the wheat sowing seasons of 2017-2018 and 2018-2019 at Doğankent location of the Eastern Mediterranean Agricultural Research Institute. In this research, “biofertilizers” leaf applications were applied to the wheat in different stages of development. For this purpose, 4 themes were worked out as; control, tillering, tillering + stem elengation and stem elengation. Biofertilizers doses of 100 gr/da in the first year and 0.75 gr/da in the second year were investigated. As a basic fertilizer for all experiment subjects; 15 kg DAP per decar were given during sowing period and 29 kg Urea during the tillering period, as a result of the research carried out; using biofertilizers in wheat farming, both in tillering and stem elengation periods, increased the yield 12.67% more efficiency in the first year and 13.16% more in the second year than the control subject. There were no statistically significant effects on quality parameters of wheat by using “biofertilizers” in foliar applications.

Abstract Background We evaluated the efficacy of fremanezumab, a fully humanized monoclonal antibody that selectively targets calcitonin gene-related peptide, in patients with chronic migraine (CM) with and without medication overuse (MO). Methods In a 12-week, phase 3 trial, patients with CM were randomized to fremanezumab quarterly (675 mg/placebo/placebo), monthly (675 mg/225 mg/225 mg), or placebo. Post hoc analyses assessed the impact of fremanezumab in patients with and without MO (monthly use of acute headache medication ≥15 days, migraine-specific acute medication ≥10 days, or combination medication ≥10 days) on efficacy outcomes, including headache days of at least moderate severity (HDs), and six-item Headache Impact Test (HIT-6) and Migraine-Specific Quality of Life (MSQoL) questionnaire scores. Results Of 1130 patients enrolled, 587 (51.9%) had baseline MO. Fremanezumab reduced placebo-adjusted least-squares mean (95% confidence interval) monthly HDs (− 2.2 [− 3.1 to − 1.2] and − 2.7 [− 3.7 to − 1.8]; P

Pelatihan berbasis kompetensi adalah sebuah kombinasi yang kompleks dari atribut-atribut yang terdapat dalam kriteria kinerja yang menggunakan proses belajar dan standar-standar kompetensi yang terukur. Oleh karena itu pelatihan berbasis kompetensi tidak hanya bergantung pada standar-standar performance tetapi juga melatih peserta untuk terlibat secara aktif dalam training program dan berhubungan dengan proses belajar mandiri setelah para peserta pelatihan memperoleh standar-standar kompetensi yang diterima selama pelatihan. Dalam hubungannya dengan Lembaga Administrasi Negara sebagai instansi Pembina Diklat PNS, meskipun sejak tahun 2001 telah mengembangkan kurikulum berbasis kompetensi yang selanjutnya disebut sebagai Diklatpim namun kendala-kendala seperti ketidakjelasan konsep kompetensi, absennya standar-standar pengukuran kompetensi, lemahnya hubungan antara Diklat dengan pengembangan karir serta intervesi politik dalam peningkatan pejabat struktural menjadi hambatan utama dalam pelaksanaan Diklat berbasis kompetensi khususnya bagi Diklatpim TK II.

The aim of this study was to investigate the antimicrobial activity of an autochthonous probiotic strain of bacteriocin-like inhibitory substances (BLIS)-producing Lactobacillus plantarum, previously isolated from a Tulum cheese and satisfied technological criteria as adjunct culture in cheese production, in reducing Staphylococcus aureus during production and ripening of white-brined cheeses. Cheeses were manufactured in two trials from pasteurized milk artificially contaminated with S. aureus to the mean level of 6.243 log MPN mL-1. Lb. plantarum BG33 was added at 1% as adjunct to the starter culture. The study was also carried out with control group cheeses produced without the adjunct culture. S. aureus counts were monitored for up to 90 days by BAM’s 5-tube MPN method and each positive tube of MPN (most probable number) method was confirmed by PCR amplification of a 400 bp fragment of the nuc gene, which encodes the thermostable nuclease of S. aureus. The capacity of Lb. plantarum BG33 to reduce S. aureus count was found as 0.9 log unit on the 18th day of ripening. After 39 and 59 days of ripening, Lb. plantarum BG33 lowered S. aureus count by 1.9 and 2.0 log units, respectively, when compared to control group cheeses in which it was lowered by 0.5 and 1.0 log units, respectively. As a result, the BLIS activity of Lb. plantarum BG33 throughout ripening of white-brined cheese could make it useful as bioprotective adjunct culture in white-brined cheese production to prevent S. aureus growth which is an important foodborne pathogen in respect of safe cheese production.inhibitory substances (BLIS)-producing Lactobacillus plantarum, previously isolated from a Tulum cheese and satisfied technological criteria as adjunct culture in cheese production, in reducing Staphylococcus aureus during production and ripening of white-brined cheeses. Cheeses were manufactured in two trials from pasteurized milk artificially contaminated with S. aureus to the mean level of 6.243 log MPN mL-1. Lb. plantarum BG33 was added at 1% as adjunct to the starter culture. The study was also carried out with control group cheeses produced without the adjunct culture. S. aureus counts were monitored for up to 90 days by BAM’s 5-tube MPN method and each positive tube of MPN (most probable number) method was confirmed by PCR amplification of a 400 bp fragment of the nuc gene, which encodes the thermostable nuclease of S. aureus. The capacity of Lb. plantarum BG33 to reduce S. aureus count was found as 0.9 log unit on the 18th day of ripening. After 39 and 59 days of ripening, Lb. plantarum BG33 lowered S. aureus count by 1.9 and 2.0 log units, respectively, when compared to control group cheeses in which it was lowered by 0.5 and 1.0 log units, respectively. As a result, the BLIS activity of Lb. plantarum BG33 throughout ripening of white-brined cheese could make it useful as bioprotective adjunct culture in white-brined cheese production to prevent S. aureus growth which is an important foodborne pathogen in respect of safe cheese production.

The research was carried out in the Eastern Mediterranean Agricultural Research Institute-Hacı Ali location with 4 replications according to the randomized block trial design in 2013-2014. 13 public and 1 private sector maize variety were used as material in the trials. According to the results of the analysis, it was determined that the maize varieties examined showed statistically significant differences in plant properties, dry grass and silage quality. Average plant height, number of leaves, leaf ratio, stem diameter, number of cob, stem ratio, cob ratio and green grass yield were 249.9 cm, 12.97 plant/piece, 19.24%, 22.08 mm, 0.93 plant/unit, 38.40% and 4,251.57 kg/da respectively. According to the analysis, it was observed that the average crude protein content, ADF ratio, NDF ratio, crude ash content, digestible dry matter ratio, crude protein yield, dry matter rate, dry matter yield and hay yield were 8.80%, 34.91%, 59.7%, 7.2%, 61.7%, 993.9 kg/ha, 29.4%, 11,640 kg/ha 12,570 kg/ha in dry grass, respectively. For the silage of varieties, the average crude protein content, ADF ratio, NDF ratio, pH, digestible dry matter rate, dry matter ratio, crude protein yield and Fleig score were 8.22%, 29.27%, 50.48%, 3.57, 66.1%, 28.14%, 926 kg/ha and 118.35, respectively. Burak, Sasa 1 and Ada 334 genotypes performed better in terms of green yield per hectare (53,650, 50,290 and 45,630 kg/ha) and dry matter yield (14,710, 12,810 and 12,410 kg/ha). These varieties can be recommended to producers as silage maize varieties under second crop conditions in Çukurova region of Turkey.

Azot ve kükürt uygulaması, ekmek yapım sürecini etkileyen buğdayın depo proteinlerinin kalitesi ve niceliği üzerinde önemli etkiye sahiptir. Bu çalışmada tarla koşullarında, vejetatif ve generatif dönemlerde, yapraktan üre, potasyum sülfat (K2SO4) ve çinko sülfat heptahidrat (ZnSO4.7H2O) uygulamalarının ekmeklik buğdayın protein kalitesi (SDS Sedimantasyon ve STK-Laktik Asit değerleri), GlutoPik parametreleri [PMT (s), BM (BE), BEM (BE) ve PM (BE)] ve hamur reolojik özellikleri [stabilite (dak), yumuşama derecesi (BU)] üzerine etkileri araştırılmıştır. Denemeler iki grup halinde yürütülmüştür. İlk denemede, yapraktan yapılan uygulamalar %0 (Kontrol); %0,5 Üre; %1 Üre; %0,5 ZnSO4.7H2O; %0,5 Üre+0,5% ZnSO4.7H2O; %1 Üre+%0,5 ZnSO4.7H2O; %0,5 K2SO4 ve %1 K2SO4 şeklinde; ikinci denemede, %0; %0,5 Üre+%0,5 K2SO4; %0,5 Üre+%1 K2SO4; %1 Üre +%0,5 K2SO4; %1 Üre+%1 K2SO4 şeklinde olmuştur.Uygulamalar arasında birinci denemede; %0,5 Üre, %1 Üre+%0,5 ZnSO4 ve %0,5 K2SO4, ikinci denemede ise %1 Üre+%0,5 K2SO4 konuları tüm özellikler bir arada değerlendirildiğinde öne çıkan uygulamalar olmuştur. Elde edilen sonuçlara göre; üre, potasyum sülfat ve çinko sülfat uygulamalarının protein kalitesi, gluten reolojisi ve hamur reolojisi üzerini etkisinin oldukça önemli olduğu belirlenmiştir.

Abstract Background Post-traumatic headache (PTH) is associated with considerable disability and reduced health-related quality of life. Despite the very high prevalence of PTH, there are no evidence-based guidelines for PTH treatment. Thus, we found it timely to provide a systematic review of the current literature on acute and preventive pharmacological treatment of PTH using PubMed and Embase databases. Findings Included studies involved acute and preventive pharmacological treatment of headache attributed to traumatic injury to the head in adherence to the International Classification of Headache Disorders (ICHD) criteria. Of 1424 potentially relevant articles identified, 63 were retrieved for detailed evaluation and seven studies (one prospective and six retrospective) met the inclusion criteria. None of the seven included studies were randomized clinical trials (RCTs) or used a placebo-controlled study design. Conclusion We found that there is a lack of high-quality evidence-based studies on the pharmacological treatment of PTH. Future studies are highly needed and must emphasize open-label studies with rigorous methodology or RCTs with a placebo-controlled design.

The aim of the study was to determine the relationsip between deontic justice attitudes among prospective teachers and their tendencies towards academic dishonesty. Participants in the study were 403 university students attending different departments of the Education Faculty of the Hacettepe University, a state university in the Central Anatolia Region of Turkey. The sample was determined by means of a stratified sampling technique, and students were chosen randomly from different departments. Attitudes towards deontic justice and tendencies towards academic dishonesty among the participants were stratified in terms of gender and students’ affiliation to a specific department of education. The findings suggested that female students and participants from the English Language Education Department had the highest deontic justice attitudes; male students and participants from the Physical Education and Sports Department had the highest tendencies towards academic dishonesty. A low, negative and statistically significant relationship between deontic justice attitudes and academic dishonesty tendencies exists.

Introduction: Bovine parainfluenza virus-3 (BPIV3) and bovine respiratory syncytial virus (BRSV) are the cause of respiratory disease in cattle worldwide. With other pathogens, they cause bovine respiratory disease complex (BRDC) in ruminants. The aim of the study was the detection and molecular characterisation of BPIV3 and BRSV from nasal swabs and lung samples of cows in and around the Erzurum region of eastern Turkey. Material and Methods: In total, 155 samples were collected. Of animals used in the study 92 were males and 63 females. The age of the animals was between 9 months and 5 years, mean 1.4 years. Most males were in the fattening period and being raised in open sheds; females were in the lactating period and kept in free stall barns. All samples were tested for the presence of viral genes using RT-PCR. Gene-specific primers in a molecular method (RT-PCR) identified BRSV (fusion gene) and BPIV3 (matrix gene) strains at the genus level. Results: RNA from BRSV and BPIV3 was detected in two (1.29%) and three (1.93%) samples, respectively, one of each of which was sequenced and the sequences were aligned with reference virus strains. Phylogenetic analyses clustered the strains in genotype C/BPIV3 and subgroup III/BRSV. Conclusion: The results indicate that BRSV and BPIV3 contribute to bovine respiratory disease cases in Turkey. This is the first report on their detection and molecular characterisation in ruminants in Turkey.

The aim of this study was to investigate how wet cupping effects performance and certain blood parameters of athletes. The athletes participating in the study (n=23) were divided into control group (CG, n=11) and experimental group (EG, n=12) by using random sample method. The athletes in sample group were selected in accordance with following criteria; age average: 20,36±1,286 year, average training age: 7,45±4,132 year, average stature: 177,82±6,585 cm, average body weight: 74,09±11,476 kg. The same criteria for the athletes in experimental group (EG) (n=11) were as follows; age average: 21,17±2,290 year, average training age: 9,08±3,825 year, average stature: 179,67±8,553 cm, average body weight: 71,25±10,314 kg. Leg force, acceleration, speed, vertical jump and standing long jump values of the participants were measured along with their blood parameters such as WBC, RBC, HGB, PLT and HCT levels. In statistical analyses of the study, arithmetic mean and standard deviation values were used as descriptive statistics, and Shapiro-Wilks was made in order to analyze the normality of distributions. Independent-Sample t-Test was made to determine the difference between the groups and Paired Sample t-Test to determine the difference within each group. Significance level was taken as p

The present research aims to examine the opinions of Erasmus+ exchange program students going abroad with the program as part of their experiences. Descriptive phenomenology, one of the qualitative research designs, was used in this study. Thus, open-ended opinion forms, which were answered by 14 students who went abroad in the 2016-2017 academic years with the Erasmus+ exchange program were analyzed by content analysis. The data obtained from the participants were handled under three themes: information acquisition and application; overseas process; contribution, expectation and suggestion. The findings obtained in this study suggest that it is important for the coordinators to keep the interaction with the students at the highest level to run the program in a healthier way. Besides, it is recommended that informative meetings are held at universities about exchange programs for students and that the peers participating in the Erasmus+ exchange program are given a voice in the meetings.