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214 results on '"Saishin, Yoshitsugu"'

15. Background Factors Affecting Visual Acuity at Initial Visit in Eyes with Central Retinal Vein Occlusion: Multicenter Study in Japan

Author

Kondo, Mineo, primary, Noma, Hidetaka, additional, Shimura, Masahiko, additional, Sugimoto, Masahiko, additional, Matsui, Yoshitsugu, additional, Kato, Kumiko, additional, Saishin, Yoshitsugu, additional, Ohji, Masahito, additional, Ishikawa, Hiroto, additional, Gomi, Fumi, additional, Iwata, Kensaku, additional, Yoshida, Shigeo, additional, Kusuhara, Sentaro, additional, Hirai, Hiromasa, additional, Ogata, Nahoko, additional, Hirano, Takao, additional, Murata, Toshinori, additional, Tsuboi, Kotaro, additional, Kamei, Motohiro, additional, Kinoshita, Takamasa, additional, Kuwayama, Soichiro, additional, Hirano, Yoshio, additional, Ohta, Manami, additional, Kimura, Kazuhiro, additional, Takayama, Kei, additional, Takeuchi, Masaru, additional, Takamura, Yoshihiro, additional, Okamoto, Fumiki, additional, Mitamura, Yoshinori, additional, Terasaki, Hiroto, additional, Sakamoto, Taiji, additional, and Group, on behalf of Japan Clinical Retina Study (J-CREST), additional

Published
2021
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25. Comparison of Surgical Outcomes Between Two Types of Lamellar Macular Holes

Author

OBATA, Shumpei, ICHIYAMA, Yusuke, KAKINOKI, Masashi, SAWADA, Osamu, SAISHIN, Yoshitsugu, and OHJI, Masahito

Subjects
surgery, visual acuity, genetic structures, lamellar macular hole, Clinical Ophthalmology, sense organs, ellipsoid zone, eye diseases, Original Research
Abstract

Purpose:The classification of lamellar macular holes (LMHs) into two subtypes has recently been proposed. However, the effectiveness of vitrectomy for treatment of each type of LMH is not well established. The goal of this study was to compare functional and anatomic changes after vitrectomy between eyes with degenerative LMH and those with tractional LMH., Patients and methods:This was a retrospective analysis of the medical records of patients with LMH who underwent vitrectomy. Best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measured preoperatively (baseline), as well as at 1, 3 and 12 months postoperatively. BCVA and CMT were compared between eyes with degenerative LMH and those with tractional LMH., Results:Thirty-two eyes met the inclusion criteria. Thirteen eyes were diagnosed with degenerative LMH and 19 eyes were diagnosed with tractional LMH. Compared with baseline BCVA, postoperative BCVA improved significantly at 12 months postoperatively: from 0.33 to 0.12 logarithm of the minimum angle of resolution (logMAR) in eyes with degenerative LMH and from 0.30 to 0.12 logMAR in eyes with tractional LMH (p < 0.05 for both comparisons). BCVA at 12 months postoperatively did not significantly differ between the two groups. CMT decreased significantly from 419.4 µm at baseline to 364.2 µm at 12 months postoperatively in eyes with tractional LMH (p < 0.05); conversely, there was no significant difference in eyes with degenerative LMH (315.5 µm baseline to 314.9 µm at 12 months postoperatively; p > 0.05)., Conclusion:Vitrectomy improved BCVA in eyes with degenerative LMH as well as in eyes with tractional LMH. BCVA at 12 months postoperatively did not differ between the two groups.

Published
2019

34. Comparison of Surgical Outcomes Between Two Types of Lamellar Macular Holes

Author

Obata,Shumpei, Ichiyama,Yusuke, Kakinoki,Masashi, Sawada,Osamu, Saishin,Yoshitsugu, Ohji,Masahito, Obata,Shumpei, Ichiyama,Yusuke, Kakinoki,Masashi, Sawada,Osamu, Saishin,Yoshitsugu, and Ohji,Masahito

Abstract

Shumpei Obata, Yusuke Ichiyama, Masashi Kakinoki, Osamu Sawada, Yoshitsugu Saishin, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Shiga, JapanCorrespondence: Shumpei ObataShiga University of Medical Science, 520 – 2192, Seta Tsukinowacho, Otsu City, Shiga, JapanTel +81-77-548-2276Fax +81-77-548-2279Email obata326@belle.shiga-med.ac.jpPurpose: The classification of lamellar macular holes (LMHs) into two subtypes has recently been proposed. However, the effectiveness of vitrectomy for treatment of each type of LMH is not well established. The goal of this study was to compare functional and anatomic changes after vitrectomy between eyes with degenerative LMH and those with tractional LMH.Patients and methods: This was a retrospective analysis of the medical records of patients with LMH who underwent vitrectomy. Best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measured preoperatively (baseline), as well as at 1, 3 and 12 months postoperatively. BCVA and CMT were compared between eyes with degenerative LMH and those with tractional LMH.Results: Thirty-two eyes met the inclusion criteria. Thirteen eyes were diagnosed with degenerative LMH and 19 eyes were diagnosed with tractional LMH. Compared with baseline BCVA, postoperative BCVA improved significantly at 12 months postoperatively: from 0.33 to 0.12 logarithm of the minimum angle of resolution (logMAR) in eyes with degenerative LMH and from 0.30 to 0.12 logMAR in eyes with tractional LMH (p < 0.05 for both comparisons). BCVA at 12 months postoperatively did not significantly differ between the two groups. CMT decreased significantly from 419.4 μm at baseline to 364.2 μm at 12 months postoperatively in eyes with tractional LMH (p < 0.05); conversely, there was no significant difference in eyes with degenerative LMH (315.5 μm baseline to 314.9 μm at 12 months postoperatively; p > 0.05).Conclusion: Vit

Published
2019

35. Effect of internal limiting membrane peeling on postoperative visual acuity in macula-off rhegmatogenous retinal detachment.

Author

Obata, Shumpei, Kakinoki, Masashi, Sawada, Osamu, Saishin, Yoshitsugu, Ichiyama, Yusuke, and Ohji, Masahito

Subjects
RETINAL detachment, PROGNOSIS, PERIMETRY, CATARACT surgery, INTRAOCULAR pressure, MEDICAL records
Abstract

Purpose: To investigate the effects of internal limiting membrane (ILM) peeling on visual acuity (VA) after rhegmatogenous retinal detachment (RRD) surgery. Methods: This retrospective analysis examined the medical records of patients with RRD who underwent vitrectomy at 26 institutions. To detect prognostic factors of VA at 6 months postoperatively (post-VA), multivariate linear regression was performed with post-VA as the objective variable; ILM peeling, sex, age, preoperative VA (pre-VA), intraocular pressure, axial length, duration of RRD, and cataract surgery served as explanatory variables. Recurrence of RRD and epiretinal membrane formation within 6 months postoperatively were compared between groups of patients with and without ILM peeling, among patients with macula-on and macula-off RRD. Results: The inclusion criteria were met by 523 eyes with a macula-on RRD and 364 eyes with a macula-off RRD. ILM peeling was performed in 85 eyes with a macula-on RRD and 57 eyes with a macula-off RRD. In eyes with a macula-on RRD, ILM peeling did not affect post-VA (p = 0.72). Vitrectomy without cataract surgery and poor pre-VA were significantly associated with poor post-VA (p = 0.01 and p < 0.001, respectively). In eyes with a macula-off RRD, ILM peeling, long duration of RRD, and poor pre-VA were significantly associated with poor post-VA (p = 0.037, p = 0.007, and p < 0.001, respectively). Recurrence of RRD and epiretinal membrane formation were similar between groups of patients with and without ILM peeling, among patients with macula-on and macula-off RRD. Retina sensitivity was not evaluated by microperimetry. Conclusion: ILM peeling did not affect post-VA in eyes with a macula-on RRD, whereas post-VA was worse in eyes with ILM peeling than in eyes without peeling, among eyes with a macula-off RRD. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Repeated Intravitreal Triamcinolone Injections in Behcet Disease That Is Resistant to Conventional Therapy: One-year Results

Author

Ohguro, Nobuyuki, Yamanaka, Emiko, Otori, Yasumasa, Saishin, Yoshitsugu, and Tano, Yasuo

Subjects
Triamcinolone, Steroids, Corticosteroids, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajo.2005.08.013 Byline: Nobuyuki Ohguro, Emiko Yamanaka, Yasumasa Otori, Yoshitsugu Saishin, Yasuo Tano Abstract: To determine whether repeated intravitreal triamcinolone (IVTA) injections in patients with Behcet disease that is resistant to conventional therapy will prevent recurrences of uveitis. Author Affiliation: Department of Ophthalmology, Osaka University Medical School, Osaka, Japan Article History: Accepted 2 August 2005

Published
2006

42. An Attachment Including a +20-D Lens to Gain Extended Field Images in Wide-Angle Optical Coherence Tomography Angiography

Author

Sawada, Osamu, Mori, Takamasa, Ichiyama, Yusuke, Obata, Shumpei, Kakinoki, Masashi, Sawada, Tomoko, Saishin, Yoshitsugu, and Ohji, Masahito

Abstract

Purpose: This article evaluates the clinical usefulness of an attachment involving a +20-D lens to gain extended field images on wide-angle optical coherence tomography angiography (OCTA).Methods: An attachment with a +20-D lens was developed to take OCTA images of anterior segments, and it was used to obtain extended field images of the posterior segment in this study. Ten eyes of 5 individuals who did not have a history of ocular or systemic disease underwent wide-angle OCTA with a 12 × 12-mm center field using the PLEX Elite 9000 with and without the attachment. The ratio of the area of the center field to the area of the extended field with the attachment was calculated.Results: The mean area of the center image was 125 disc areas and that of the field extended by the attachment was 210 disc areas. The mean ratio between the center field and the extended field was 1.67.Conclusions: The attachment involving the +20-D lens seems to be clinically useful to gain extended field images on wide-angle OCTA.

Published
2020
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43. Characterization of a mouse colonic system [B.sup.0+] amino acid transporter related to amino acid absorption in colon

Author

UGAWA, SHINYA, SUNOUCHI, YOKO, UEDA, TAKASHI, TAKAHASHI, ERI, SAISHIN, YOSHITSUGU, and SHIMADA, SHOICHI

Subjects
Colon (Anatomy) -- Physiological aspects, Amino acids -- Physiological aspects, Epithelial cells -- Physiological aspects, Biological sciences
Abstract

Previous experiments have shown that an amino acid transport system [B.sup.0+] transporter in cultured colonic epithelial cells mediates amino acid absorption. Here we describe the cloning and functional characterization of a system [B.sup.0+] transporter selectively expressed in the colon. Using the combination of an expressed sequence tag database search and RT-PCR approaches, we cloned a mouse colonic amino acid transporter, designated [mCATB.sup.0+]. Northern blot analysis revealed that [mCATB.sup.0+] was selectively expressed in the large intestine. In situ hybridization showed the [mCATB.sup.0+] mRNA to be localized in absorptive epithelial cells. When expressed in Xenopus oocytes, [mCATB.sup.0+] exhibited a [Na.sup.+]-dependent stereoselective uptake and a broad specificity for neutral and cationic amino acids, which is characteristic of amino acid transport system [B.sup.0+]. In vivo [[sup.3]H]glycine uptake assay demonstrated that a system [B.sup.0+]-like transporter protein was expressed on the apical surface of the colonic absorptive cells. Our data suggest that a mouse colonic amino acid transporter [mCATB.sup.0+] may absorb amino acids from the intestinal contents in the colon. cDNA cloning; absorptive epithelial cell

Published
2001

48. Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion

Author

Ito,Yuka, Saishin,Yoshitsugu, Sawada,Osamu, Kakinoki,Masashi, Miyake,Taichiro, Sawada,Tomoko, Kawamura,Hajime, Ohji,Masahito, Ito,Yuka, Saishin,Yoshitsugu, Sawada,Osamu, Kakinoki,Masashi, Miyake,Taichiro, Sawada,Tomoko, Kawamura,Hajime, and Ohji,Masahito

Abstract

Yuka Ito, Yoshitsugu Saishin, Osamu Sawada, Masashi Kakinoki, Taichiro Miyake, Tomoko Sawada, Hajime Kawamura, Masahito Ohji Department of Ophthalmology, Shiga University of Medical Science, Otsu, Shiga, Japan Purpose: Our aim was to compare the 1 year efficacy and safety results of intravitreal bevacizumab (IVB) in two prospective, consecutive groups of patients with macular edema (ME) following branch retinal vein occlusion (BRVO).Patients and methods: Twenty-five eyes with ME after BRVO received one IVB injection (single-injection group) and 27 eyes received three monthly IVB injections (three-injection group). Both groups were followed monthly for 12 months. The best-corrected visual acuity (BCVA) and the central foveal thickness (CFT) on optical coherence tomography were evaluated before and after treatment. Patients were eligible to receive an IVB injection if the mean CFT increased 100 µm or more or the BCVA decreased 0.1 logarithm of the minimum angle of resolution (logMAR) unit or more compared with values measured on the last visit.Results: The mean logMAR BCVA and CFT, respectively, improved from 0.56 to 0.33 and from 598 µm to 348 µm in the single-injection group (P<0.001) and from 0.55 to 0.26 and from 514 µm to 293 µm in the three-injection group (P<0.001). During the study period, the mean total number of injections was significantly smaller in the single-injection group than in the three-injection group (2.1 and 4.3, respectively, P<0.001). No serious complications related to the IVB injections developed in either group.Conclusion: The single-injection group achieved similar visual outcomes for ME secondary to BRVO with fewer injections compared with the three-injection group. Keywords: branch retinal vein occlusion, bevacizumab, single intravitreal injection, three monthly intravitreal injections

Published
2015

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