Search

Your search keyword '"Sainte-Catherine, Odile"' showing total 32 results
Start Over Author "Sainte-Catherine, Odile"
32 results on '"Sainte-Catherine, Odile"'

2. Cover Feature: Iron Oxide Nanoparticles Functionalized with Fucoidan: a Potential Theranostic Nanotool for Hepatocellular Carcinoma (ChemBioChem 16/2022)

Author

Geinguenaud, Frédéric, primary, Sainte‐Catherine, Odile, additional, Poirier, Florence, additional, Besnard, Valérie, additional, Haddad, Oualid, additional, Chaubet, Frédéric, additional, Lalatonne, Yoann, additional, Lutomski, Didier, additional, Sutton, Angela, additional, and Motte, Laurence, additional

Published
2022
Full Text
View/download PDF

5. miR‐126‐3p is essential for CXCL12‐induced angiogenesis

Author

Bassand, Kévin, primary, Metzinger, Laurent, additional, Naïm, Meriem, additional, Mouhoubi, Nesrine, additional, Haddad, Oualid, additional, Assoun, Vincent, additional, Zaïdi, Naïma, additional, Sainte‐Catherine, Odile, additional, Butt, Amena, additional, Guyot, Erwan, additional, Oudar, Olivier, additional, Laguillier‐Morizot, Christelle, additional, Sutton, Angela, additional, Charnaux, Nathalie, additional, Metzinger‐Le Meuth, Valérie, additional, and Hlawaty, Hanna, additional

Published
2021
Full Text
View/download PDF

7. USPIO–PEG nanoparticles functionalized with a highly specific collagen-binding peptide: a step towards MRI diagnosis of fibrosis

Author

Belkahla, Hanene, primary, Antunes, Joana C., additional, Lalatonne, Yoann, additional, Sainte Catherine, Odile, additional, Illoul, Corinne, additional, Journé, Clément, additional, Jandrot-Perrus, Martine, additional, Coradin, Thibaud, additional, Gigoux, Véronique, additional, Guenin, Erwann, additional, Motte, Laurence, additional, and Helary, Christophe, additional

Published
2020
Full Text
View/download PDF

11. SYNTHESIS OF NEW INTERCALATED QUINONES AND THEIR CYTOTOXIC EFFECTS ON CANCER CELL LINES

Author

Dridi, Feyriel, Bar, Nathalie, Sainte-Catherine, Odile, Hachemi, Messaoud, Lecouvey, Marc, Villemin, Didier, Laboratoire de chimie moléculaire et thioorganique (LCMT), Centre National de la Recherche Scientifique (CNRS)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU), Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Nord, Polytech'Paris - Sorbonne Université, and Sorbonne Université (SU)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, benzofurane, benzodioxine, naphthoquinone, cytotoxicity, [CHIM]Chemical Sciences, antitumor activity, [SDV.CAN]Life Sciences [q-bio]/Cancer, ComputingMilieux_MISCELLANEOUS, 3. Good health
Abstract

Naphthoquinones with benzofuran or benzodioxan ring were obtained from dichloronaphthoquinone and were fully characterized. The new benzodioxanes were tested on 4 cancer cells and one of them, a derivative from methyl pyrogallate was found very cytotoxic for cancer cells., European Chemical Bulletin, Vol 3, No 10-12 (2014): European Chemical Bulletin

Published
2014
Full Text
View/download PDF

12. C‑Glycoside Mimetics Inhibit Glioma Stem Cell Proliferation, Migration, and Invasion

Author

Clarion, Ludovic, Jacquard, Carine, Sainte-Catherine, Odile, Decoux, Marc, Loiseau, Séverine, Rolland, Marc, Lecouvey, Marc, Marc, Lecouvey, Hugnot, Jean-Philippe, Volle, Jean-Noël, Virieux, David, Pirat, Jean-Luc, Bakalara, Norbert, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Européen des membranes (IEM), and Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)

Subjects
Antineoplastic Agents, Chemistry Techniques, Synthetic, medicine.disease_cause, 01 natural sciences, Mice, 03 medical and health sciences, Cell Movement, Laminin, Glioma, Drug Discovery, medicine, Animals, Humans, Glycosides, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, Cell Proliferation, 030304 developmental biology, Neurons, 0303 health sciences, Molecular Structure, biology, Brain Neoplasms, 010405 organic chemistry, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Molecular Mimicry, Monosaccharides, medicine.disease, Molecular biology, Rats, 0104 chemical sciences, 3. Good health, Fibronectin, Molecular mimicry, medicine.anatomical_structure, Astrocytes, Cancer cell, Neoplastic Stem Cells, biology.protein, Molecular Medicine, Vitronectin, Drug Screening Assays, Antitumor, Stem cell, Glioblastoma, Astrocyte
Abstract

This paper reports the design and synthesis of C-glycoside mimetics (d-glycero-d-talo- and d-glycero-d-galactopyranose analogues), a subset of the recently published phostines, belonging to the [1,2]oxaphosphinane core. Eighteen new compounds were tested against 11 cancer cell types belonging to six categories of tumor tissues and three different species. The hit compound 5.3d inhibited invasion and migration of both GBM stem cells (Gli7 and Gli4) and GBM cancer cell lines (C6, SNB75) on fibronectin, vitronectin, and laminin. Ki values for Gli7 and Gli4 migration inhibition on fibronectin were 16 and 31 nM respectively. Ki values for invasion inhibition in a 3D system were 46 nM for Gli7 and 290 nM for Gli4. These activities were associated with an antiproliferative effect on Gli4 (EC50 = 5.20 μM) and Gli7 (EC50 = 2.33 μM). In conclusion, the heptopyranose mimetic 5.3d, devoid of toxicity on astrocyte and cortical neuron cultures at concentrations below 100 μM, opens new therapeutic perspectives against glioblastoma.

Published
2014

14. Oxaphosphinanes: New Therapeutic Perspectives for Glioblastoma

Author

Clarion, Ludovic, primary, Jacquard, Carine, additional, Sainte-Catherine, Odile, additional, Loiseau, Séverine, additional, Filippini, Damien, additional, Hirlemann, Marie-Hélène, additional, Volle, Jean-Noël, additional, Virieux, David, additional, Lecouvey, Marc, additional, Pirat, Jean-Luc, additional, and Bakalara, Norbert, additional

Published
2012
Full Text
View/download PDF

15. Invading Basement Membrane Matrix Is Sufficient for MDA-MB-231 Breast Cancer Cells to Develop a Stable In Vivo Metastatic Phenotype

Author

Abdelkarim, Mohamed, primary, Vintonenko, Nadejda, additional, Starzec, Anna, additional, Robles, Aniela, additional, Aubert, Julie, additional, Martin, Marie-Laure, additional, Mourah, Samia, additional, Podgorniak, Marie-Pierre, additional, Rodrigues-Ferreira, Sylvie, additional, Nahmias, Clara, additional, Couraud, Pierre-Olivier, additional, Doliger, Christelle, additional, Sainte-Catherine, Odile, additional, Peyri, Nicole, additional, Chen, Lei, additional, Mariau, Jérémie, additional, Etienne, Monique, additional, Perret, Gerard-Yves, additional, Crepin, Michel, additional, Poyet, Jean-Luc, additional, Khatib, Abdel-Majid, additional, and Di Benedetto, Mélanie, additional

Published
2011
Full Text
View/download PDF

20. Glycosaminoglycans and their synthetic mimetics inhibit RANTES-induced migration and invasion of human hepatoma cells

Author

Sutton, Angela, primary, Friand, Veronique, additional, Papy-Garcia, Dulce, additional, Dagouassat, Maylis, additional, Martin, Loïc, additional, Vassy, Roger, additional, Haddad, Oualid, additional, Sainte-Catherine, Odile, additional, Kraemer, Michel, additional, Saffar, Line, additional, Perret, Gerard Yves, additional, Courty, Jose, additional, Gattegno, Liliane, additional, and Charnaux, Nathalie, additional

Published
2007
Full Text
View/download PDF

21. Stromal Cell–Derived Factor-1/Chemokine (C-X-C Motif) Ligand 12 Stimulates Human Hepatoma Cell Growth, Migration, and Invasion

Author

Sutton, Angela, primary, Friand, Veronique, additional, Brulé-Donneger, Severine, additional, Chaigneau, Thomas, additional, Ziol, Marianne, additional, Sainte-Catherine, Odile, additional, Poiré, Aurelie, additional, Saffar, Line, additional, Kraemer, Michel, additional, Vassy, Jany, additional, Nahon, Pierre, additional, Salzmann, Jean-Loup, additional, Gattegno, Liliane, additional, and Charnaux, Nathalie, additional

Published
2007
Full Text
View/download PDF

27. Structural Characterization and Cytotoxic Properties of a 4-O-Methylglucuronoxylan from Castanea sativa

Author

Moine, Charlotte, Krausz, Pierre, Chaleix, Vincent, Sainte-Catherine, Odile, Kraemer, Michel, and Gloaguen, Vincent

Abstract

A glucuronoxylan was purified from a delignified holocellulose alkaline extract of Castanea sativa(Spanish chestnut) and its structure analyzed by means of FT-IR, GC of the per-trimethylsilylated methylglycoside derivatives, and 1H and 13C NMR spectroscopy. The results supported a structure based on a linear polymer of xylopyranose units linked with (1→4) bonds in which, on average, one out of every six units is substituted at C-2 by a 4-O-methylglucuronic acid unit; this structure is typical of a hardwood acidic 4-O-methylglucuronoxylan (MGX) with an estimated degree of polymerization of 200. The MGX from C. sativainhibited the proliferation of A431 human epidermoid carcinoma cells with an IC50value of 50 M. In addition, this xylan inhibited A431 cell migration and invasion. Preliminary experiments showing that secretion of metalloproteinases MMP2 and MMP9 by A431 tumor cells was inhibited by the purified C. sativaMGX strongly suggest that this mechanism of action may play a role in its antimigration and anti-invasive properties.

Published
2007
Full Text
View/download PDF

28. Superparamagnetic nanovector with anti-cancer properties: γFe2O3@Zoledronate

Author

Benyettou, Farah, Lalatonne, Yoann, Sainte-Catherine, Odile, Monteil, Maelle, and Motte, Laurence

Subjects
*IMMUNOLOGICAL adjuvants, *IRON oxides, *MAGNETIC materials, *ANTINEOPLASTIC agents, *CONTRAST media, *BREAST cancer treatment, *PANCREATIC cancer, *NANOPARTICLES
Abstract

Abstract: We elaborate a magnetic nanovector to vectorize Zoledronate, an anti-cancer interest molecule of the hydroxmethylenebisphosphonate''s family. In fact, Zoledronate is a powerful adjuvant in the treatment of bone diseases such as osteoporosis and Paget''s disease. But, recent studies have shown that in addition to anti-osteoclastic properties, it presents antitumour properties notably in the case of breast and prostate cancer. However, these properties cannot be exploited due to their very high affinity to divalent cations and their preferentially accumulation in bone. To overcome this problem, one strategy is the vectorization trough maghemite nanocrystal functionalization. The specific surface coating permits to consider γFe2O3@Zoledronate as a drug delivery vehicle for therapeutic activity. The anchoring to the nanoparticle''s surface allowed to increase their hydrophobicity and also to change the therapeutic target, increasing the Zoledronate intestinal absorption instead of their accumulation in bone. We show that Zoledronate link the nanoparticle surface through phosphonate groups. The biological in vitro tests performed on breast cancer cell line, MDA-MB 231, showed that γFe2O3@Zoledronate have antiproliferative activity. In addition, the γFe2O3 core could be used as MRI contrast agent for a good therapeutic evaluation. [Copyright &y& Elsevier]

Published
2009
Full Text
View/download PDF

29. C-glycoside mimetics inhibit glioma stem cell proliferation, migration, and invasion.

Author

Clarion L, Jacquard C, Sainte-Catherine O, Decoux M, Loiseau S, Rolland M, Lecouvey M, Hugnot JP, Volle JN, Virieux D, Pirat JL, and Bakalara N

Subjects
Animals, Astrocytes drug effects, Brain Neoplasms drug therapy, Brain Neoplasms pathology, Cell Movement drug effects, Cell Proliferation drug effects, Cells, Cultured, Chemistry Techniques, Synthetic, Drug Screening Assays, Antitumor, Glioblastoma drug therapy, Glioblastoma pathology, Glioma pathology, Glycosides, Humans, Mice, Molecular Mimicry, Molecular Structure, Neoplastic Stem Cells pathology, Neurons drug effects, Rats, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Glioma drug therapy, Monosaccharides chemistry, Neoplastic Stem Cells drug effects
Abstract

This paper reports the design and synthesis of C-glycoside mimetics (d-glycero-d-talo- and d-glycero-d-galactopyranose analogues), a subset of the recently published phostines, belonging to the [1,2]oxaphosphinane core. Eighteen new compounds were tested against 11 cancer cell types belonging to six categories of tumor tissues and three different species. The hit compound 5.3d inhibited invasion and migration of both GBM stem cells (Gli7 and Gli4) and GBM cancer cell lines (C6, SNB75) on fibronectin, vitronectin, and laminin. Ki values for Gli7 and Gli4 migration inhibition on fibronectin were 16 and 31 nM respectively. Ki values for invasion inhibition in a 3D system were 46 nM for Gli7 and 290 nM for Gli4. These activities were associated with an antiproliferative effect on Gli4 (EC50 = 5.20 μM) and Gli7 (EC50 = 2.33 μM). In conclusion, the heptopyranose mimetic 5.3d, devoid of toxicity on astrocyte and cortical neuron cultures at concentrations below 100 μM, opens new therapeutic perspectives against glioblastoma.

Published
2014
Full Text
View/download PDF

30. Superparamagnetic nanovector with anti-cancer properties: gamma Fe2O3@Zoledronate.

Author

Benyettou F, Lalatonne Y, Sainte-Catherine O, Monteil M, and Motte L

Subjects
Antineoplastic Agents administration & dosage, Cell Line, Tumor, Diphosphonates administration & dosage, Drug Carriers administration & dosage, Drug Carriers chemistry, Ferric Compounds administration & dosage, Humans, Imidazoles administration & dosage, Nanoparticles administration & dosage, Zoledronic Acid, Antineoplastic Agents chemistry, Diphosphonates chemistry, Ferric Compounds chemistry, Imidazoles chemistry, Magnetics, Nanoparticles chemistry
Abstract

We elaborate a magnetic nanovector to vectorize Zoledronate, an anti-cancer interest molecule of the hydroxmethylenebisphosphonate's family. In fact, Zoledronate is a powerful adjuvant in the treatment of bone diseases such as osteoporosis and Paget's disease. But, recent studies have shown that in addition to anti-osteoclastic properties, it presents antitumour properties notably in the case of breast and prostate cancer. However, these properties cannot be exploited due to their very high affinity to divalent cations and their preferentially accumulation in bone. To overcome this problem, one strategy is the vectorization trough maghemite nanocrystal functionalization. The specific surface coating permits to consider gamma Fe(2)O(3)@Zoledronate as a drug delivery vehicle for therapeutic activity. The anchoring to the nanoparticle's surface allowed to increase their hydrophobicity and also to change the therapeutic target, increasing the Zoledronate intestinal absorption instead of their accumulation in bone. We show that Zoledronate link the nanoparticle surface through phosphonate groups. The biological in vitro tests performed on breast cancer cell line, MDA-MB 231, showed that gamma Fe(2)O(3)@Zoledronate have antiproliferative activity. In addition, the gamma Fe(2)O(3) core could be used as MRI contrast agent for a good therapeutic evaluation.

Published
2009
Full Text
View/download PDF

31. Structural characterization and cytotoxic properties of a 4-O-methylglucuronoxylan from castanea sativa. 2. Evidence of a structure-activity relationship.

Author

Barbat A, Gloaguen V, Moine C, Sainte-Catherine O, Kraemer M, Rogniaux H, Ropartz D, and Krausz P

Subjects
Cell Line, Tumor, Chromatography, Gas, Drug Screening Assays, Antitumor, Humans, Magnetic Resonance Spectroscopy, Molecular Structure, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Structure-Activity Relationship, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Fagaceae chemistry, Xylans chemistry, Xylans pharmacology
Abstract

Xylans were purified from delignified holocellulose alkaline extracts of Castanea sativa (Spanish chestnut) and Argania spinosa (Argan tree) and their structures analyzed by means of GC of their per-trimethylsilylated methylglycoside derivatives and (1)H NMR spectroscopy. The structures deduced were characteristic of a 4-O-methylglucuronoxylan (MGX) and a homoxylan (HX), respectively, with degrees of polymerization ranging from 182 to 360. In the case of MGX, the regular or random distribution of 4-O-methylglucuronic acid along the xylosyl backbone--determined by MALDI mass spectrometry after autohydrolysis of the polysaccharide--varied and depended both on the botanical source from which they were extracted and on the xylan extraction procedure. The MGX also inhibited in different ways the proliferation as well as the migration and invasion capability of A431 human epidermoid carcinoma cells. These biological properties could be correlated with structural features including values of the degree of polymerization, 4-O-MeGlcA to xylose ratios, and distribution of 4-O-MeGlcA along the xylosyl backbone, giving evidence of a defined structure-activity relationship.

Published
2008
Full Text
View/download PDF

32. Synthesis and biological activity of mustard derivatives of thymine.

Author

Hadj-Bouazza A, Teste K, Colombeau L, Chaleix V, Zerrouki R, Kraemer M, and Sainte Catherine O

Subjects
Antineoplastic Agents, Alkylating chemical synthesis, Antineoplastic Agents, Alkylating chemistry, Antineoplastic Agents, Alkylating pharmacology, Cell Line, Tumor, Cell Proliferation drug effects, Chemotaxis drug effects, Humans, Matrix Metalloproteinase 2, Matrix Metalloproteinase Inhibitors, Neoplasm Invasiveness prevention & control, Nitrogen Mustard Compounds chemistry, Thymine chemistry, Thymine pharmacology, Nitrogen Mustard Compounds chemical synthesis, Nitrogen Mustard Compounds pharmacology, Thymine analogs & derivatives
Abstract

The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results