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Myocarditis is a cardiovascular disease characterised by inflammation of the heart muscle which can lead to heart failure. There is heterogeneity in the mode of presentation, underlying aetiologies, and clinical outcome with impact on a wide range of age groups which lead to diagnostic challenges. Cardiovascular magnetic resonance (CMR) is the preferred imaging modality in the diagnostic work-up of those with acute myocarditis. There is a need for systematic analytical approaches to improve diagnosis. Artificial intelligence (AI) and machine learning (ML) are increasingly used in CMR and has been shown to match human diagnostic performance in multiple disease categories. In this review article, we will describe the role of CMR in the diagnosis of acute myocarditis followed by a literature review on the applications of AI and ML to diagnose acute myocarditis. Only a few papers were identified with limitations in cases and control size and a lack of detail regarding cohort characteristics in addition to the absence of relevant cardiovascular disease controls. Furthermore, often CMR datasets did not include contemporary tissue characterisation parameters such as T1 and T2 mapping techniques, which are central to the diagnosis of acute myocarditis. Future work may include the use of explainability tools to enhance our confidence and understanding of the machine learning models with large, better characterised cohorts and clinical context improving the diagnosis of acute myocarditis.

Introduction: Patients with hypertrophic cardiomyopathy (HCM) are at risk for lethal ventricular arrhythmia, but the electrophysiological substrate behind this is not well-understood. We used non-invasive electrocardiographic imaging to characterize patients with HCM, including cardiac arrest survivors.Methods: HCM patients surviving ventricular fibrillation or hemodynamically unstable ventricular tachycardia (n = 17) were compared to HCM patients without a personal history of potentially lethal arrhythmia (n = 20) and a pooled control group with structurally normal hearts. Subjects underwent exercise testing by non-invasive electrocardiographic imaging to estimate epicardial electrophysiology.Results: Visual inspection of reconstructed epicardial HCM maps revealed isolated patches of late activation time (AT), prolonged activation-recovery intervals (ARIs), as well as reversal of apico-basal trends in T-wave inversion and ARI compared to controls (p < 0.005 for all). AT and ARI were compared between groups. The pooled HCM group had longer mean AT (60.1 ms vs. 52.2 ms, p < 0.001), activation dispersion (55.2 ms vs. 48.6 ms, p = 0.026), and mean ARI (227 ms vs. 217 ms, p = 0.016) than structurally normal heart controls. HCM ventricular arrhythmia survivors could be differentiated from HCM patients without a personal history of life-threatening arrhythmia by longer mean AT (63.2 ms vs. 57.4 ms, p = 0.007), steeper activation gradients (0.45 ms/mm vs. 0.36 ms/mm, p = 0.011), and longer mean ARI (234.0 ms vs. 221.4 ms, p = 0.026). A logistic regression model including whole heart mean activation time and activation recovery interval could identify ventricular arrhythmia survivors from the HCM cohort, producing a C statistic of 0.76 (95% confidence interval 0.72–0.81), with an optimal sensitivity of 78.6% and a specificity of 79.8%.Discussion: The HCM epicardial electrotype is characterized by delayed, dispersed conduction and prolonged, dispersed activation-recovery intervals. Combination of electrophysiologic measures with logistic regression can improve differentiation over single variables. Future studies could test such models prospectively for risk stratification of sudden death due to HCM.

One of the literary styles that was influenced by the political events of twentieth century Europe is the literature of the absurd. This literary trend affected Europe and Russia. This article is devoted to the consideration of the elements of absurdity in the work The Old Woman by D. Kharms. To achieve the goal in the course of the study, we used such methods as the study of the necessary reliable and main sources of information about the literature of the absurd, the comparison and analysis of the information received about the research topic, the detection and classification of common elements of the absurd, including content and structural elements, and the consideration of these elements in the story The Old Woman. The author raises the question of what elements of absurdity are found in the work under consideration. We make a conclusion that most of the common elements of absurdity, all common content elements such as the aimlessness of man and life, pessimism, hopelessness, helplessness, the absence of a border between reality and fantasy, failure, self-talk are found in the story of The Old Woman by D. Kharms. Among the common structural elements of the absurd in this story are the lack of logic in events, an unclear and unsuccessful or unexpected denouement, and the absence of a causal connection between episodes. Based on the data obtained in the course of the study, it can be concluded that the story The Old Woman by Kharms can be confidently attributed to works of literature of the absurd.

Sheep pox is a highly contagious infectious viral disease (F/Poxviridae, G/Capripoxvirus), still causing economic damage in endemic zones like northern Africa, the Middle East, and many regions in Asia. Nevertheless, the clinical symptoms caused by sheep pox virus (SPPV) is similar to those caused by genetically related viruses, notably goat pox virus (GTPV) and lumpy skin disease virus (LSDV). One of the main objectives of the current study is to characterize the virus; nasal swabs were taken from sheep showing SPPV clinical signs, submitted to molecular sequencing based on the P32 gene marker, and proceeded to genetic comparisons. Phylogenetic results showed that all virus isolate sequences cluster in the SPPV clade, thus distinguishing them from those of GTPV and LSDV. These results give an accurate diagnostic and a clear view of endemic viral strains, guiding veterinary managers in control politics, especially in the choice of a homologous vaccine.

Rabbit hemorrhagic disease (RHD) is a highly contagious viral disease that causes fatal acute hepatitis in domestic and wild lagomorphs. It has taken on major economic importance in countries like Morocco. In addition to the classical virus (RHDV), a novel emerged genotype (RHDV2) is circulating, especially in the north shore of the Mediterranean basin since 2010. Many small animal farmers reported clinical cases from several rabbitries in Agadir (Morocco) despite systematic vaccination against the RHDV. The main objective was to characterize the current RHDV strains circulating in the studied area to help to choose an adequate vaccine. For that, we extracted viral RNA from rabbit livers, carried out the PCR analyses, and we sequenced the viral structural capsid protein (VP60) of the RHDV. The phylogenetic analysis results allowed us to state that the novel genotype (RHDV2) is circulating in the studied geographical area, and to characterize the isolated sequences. As a conclusion, we recommend updating RHD epidemiological relating data and reviewing the vaccine protocols by both targeting RHDV (GI.1) and RHDV2 (GI.2) in any future preventive program.

The COVID-19 crisis has attracted attention worldwide to supply chain disruptions and resilience. Several supply chain risk management approaches have been revisited or reapplied in the literature; however, collaborative resource sharing is less researched. This study aimed to investigate the current academic state of the art and advances in using collaborative resource sharing as a reactive method to facilitate supply chain recovery in the presence of disruptive events. More specifically we considered the role of different collaborative resource-sharing strategies that organizations can adopt to support supply chain functionalities during times of disruption. We conducted a systematic literature review (SLR) to analyze academic articles that were published online from 2000 to 2022. In order to analyze the literature, we adopted a combination of text-mining, automatic and manual categorization of selected articles, and exploratory analyses such as cluster analysis and relational indicators. We also consider the machine learning classification algorithm i.e. agglomerative hierarchical clustering for the categorization of clusters. The findings show that, for disruptive risks, collaborative sharing of labour and material resources is effective for the recovery of supply chains. More so, labour resources tend to contribute more to the recovery of supply chains through the physical and mental recreation of recovery activities and experiences. Whilst information resources and a mix of information and material resources are highly important in reducing the impact of COVID-19 disruptive supply chain risk. In conclusion, collaborating on the three resources, namely labour, material, and information resources can be an effective post-disruption recovery strategy for supply chains.

The environmentally sustainable production of biodiesel is important for providing both a renewable alternative transportation fuel as well as a fuel for power generation using diesel engines. This research evaluates the use of inexpensive catalysts derived from waste materials for converting triglycerides in seed oils into biodiesel composed of fatty acid methyl esters. The performance of CaO catalysts derived from the shells of oysters, mussels, lobsters, and chicken eggs was investigated. The shell-derived powders were calcined with and without the addition of zinc nitrate at 700–1000 °C for 4 h to yield CaO whereas the CaO-ZnO mixed catalyst were prepared by wet impregnation followed by calcination at 700 °C. The catalysts were characterized by XRF, XRD, TGA, SEM, FTIR and GC-MS. The CaO-ZnO catalysts showed slightly better conversion efficiency compared to CaO catalysts for the transesterification of canola oil. The mixed CaO-ZnO catalysts derived mainly from oyster shells showed the highest catalytic activity with >90% biodiesel yield at a 9:1 methanol-to-oil mole ratio within 10 min of ultrasonication. The reduction of toxicant emission from the generator is 43% and 60% for SO2, 11% and 26% for CO, were observed for the biodiesel blending levels of B20 and B40, respectively.

Introduction: Hypertrophic cardiomyopathy (HCM) patients with left ventricular (LV) mid-cavity obstruction (LVMCO) often experience severe drug-refractory symptoms thought to be related to intraventricular obstruction. We tested whether ventricular pacing, guided by invasive haemodynamic assessment, reduced LVMCO and improved refractory symptoms. Methods: Between December 2008 and December 2017, 16 HCM patients with severe refractory symptoms and LVMCO underwent device implantation with haemodynamic pacing study to assess the effect on invasively defined LVMCO gradients. The effect on the gradient of atrioventricular (AV) synchronous pacing from sites including right ventricular (RV) apex and middle cardiac vein (MCV) was retrospectively assessed. Results: Invasive haemodynamic data were available in 14 of 16 patients. Mean pre-treatment intracavitary gradient was 77 ± 22 mmHg (in sinus rhythm) versus 21 ± 21 mmHg during pacing from optimal ventricular site (95% CI: −70.86 to −40.57, p

The concept of organizational leadership has engendered a lot of arguments. This is because the effect of leadership on every human endeavor cannot be over emphasized. This study examines the effect of organizational leadership styles, particularly transformational and servant leadership styles on deposit money banks (DMBs) employees’ performance in Nigeria. The study employs survey research design, through the administration of structured questionnaire on some selected employees of Guaranty Trust Bank, United Bank for Africa and First Bank. The research instrument was validated through content validity index, while test-retest method was employed in ascertaining the reliability of the research instrument. The findings revealed that transformational leadership and servant leadership styles have positive and significant combined effect on deposit money banks employees’ performance (F-stat= 58.02 *0.000). The adjusted coefficient of determination (adjusted R2) suggested that, 39.4% variation in employees’ performance is accounted for by transformational leadership and servant leadership styles. The t-value revealed that when the two variables (transformational leadership and servant leadership styles) are combined, they both have positive and significant effect on deposit money banks employees’ performance. Therefore, it can be concluded that transformational leadership and servant leadership styles both have individual as well as combined positive and significant effect on deposit money banks employees’ performance.

A valid method to evaluate decisions of a project proposal is the so-called cost-benefit analysis. Criteria are selected and properly weighted to determine if the project is effective and feasible. The present research study is focused on methodical selection of design parameters to install two propeller mixers inside anaerobic digesters of biogas plants. A cylindrical tank of 1400 m3 was considered. For the model-based optimisation, the substrate was considered as a non-Newtonian fluid with a density of 1090 kg/m3. The Oswald-de Waele power-law model was selected to account for the rheological behaviour of the fluid. Installation parameters of the mixers were rotational angles and heights of the shafts of the two propellers. A computational model was developed to simulate the fluid dynamics depending on the mixing process inside the tank. Several configurations were analysed according to evaluating criteria such as the value of the fluid velocity, its distribution along the three spatial dimensions, and the power consumption to rotate the mixers. The maximum fluid velocity and minimum power consumption were observed when the propellers are located at intermediate height inside the tank and with the shafts perpendicular to the tank radius. With this configuration, the fluid reaches a maximum velocity of 0.28 m/s. According to the investigation, it is evident that mixing systems with propeller shafts deep-seated and parallel to the tank radius should be avoided, both in term of efficiency of the fluid mixing distribution and in term of power consumption.

Protostrongylids, small nematode lungworms, are an integral part of the wild ruminant helminth community, which can damage animals’ health when they are held in captivity or semi-captive conditions. The Sahelo-Saharan antelope species dorcas gazelle (Gazella dorcas), the scimitar-horned oryx (Oryx dammah), and the addax (Addax nasomacculatus), reintroduced to Souss-Massa National Park in Morocco, could be host to many species of Protostrongylids. This study was conducted from January to July 2015 to identify infecting parasite species, and determine their prevalence and abundance in all three antelope species. A total of 180 individual fecal samples were collected, morphologically examined by the Baermann technique, and molecularly identified by PCR amplification and sequencing of the second internal transcribed spacer region of the rDNA (ITS-2).

Aims: To determine financial implications of implementing cardiac magnetic resonance imaging (CMR) in the diagnostic pathway of a population with unexplained acute myocardial injury and normal coronary angiography.Methods and Results: We performed a focused cost-benefit analysis using a hypothetical population of 2,000 patients with unexplained acute myocardial injury and normal coronary angiography divided into two groups to receive either standard or CMR guided management over a 10-year period. As healthcare practice and costs considerably vary geographically and over time, an algorithm with 15 key variables was developed to permit user-defined calculations of cost-benefit and other analyses. Using current UK costs, routine use of CMR increases healthcare spending by 14% per patient in the first year. After 7 years, CMR guided practice is cost neutral, reducing cost by 3% per patient 10 years following presentation. In addition, CMR -guided therapy results in 7 fewer myocardial infarctions and 14 fewer major bleeding events per 1,000 patients over a 10-year period. The three most sensitive variables were, in decreasing order, the cost of CMR, the cost of ticagrelor and the percentage of the population with MI requiring DAPT.Conclusion: Routine use of CMR in patients with unexplained acute myocardial injury and normal coronary angiography is associated with cost reductions in the medium to long term. The initial higher cost of CMR is offset over time and delivers a more personalized and higher quality of care.

Abstract Background Many subsistence farmers in rural southeastern Tanzania regularly relocate to distant farms in river valleys to tend to crops for several weeks or months each year. While there, they live in makeshift semi-open structures, usually far from organized health systems and where insecticide-treated nets (ITNs) do not provide adequate protection. This study evaluated the potential of a recently developed technology, eave ribbons treated with the spatial repellent transfluthrin, for protecting migratory rice farmers in rural southeastern Tanzania against indoor-biting and outdoor-biting mosquitoes. Methods In the first test, eave ribbons (0.1 m × 24 m each) treated with 1.5% transfluthrin solution were compared to untreated ribbons in 24 randomly selected huts in three migratory communities over 48 nights. Host-seeking mosquitoes indoors and outdoors were monitored nightly (18.00–07.00 h) using CDC light traps and CO2-baited BG malaria traps, respectively. The second test compared efficacies of eave ribbons treated with 1.5% or 2.5% transfluthrin in 12 huts over 21 nights. Finally, 286 farmers were interviewed to assess perceptions about eave ribbons, and their willingness to pay for them. Results In the two experiments, when treated eave ribbons were applied, the reduction in indoor densities ranged from 56 to 77% for Anopheles arabiensis, 36 to 60% for Anopheles funestus, 72 to 84% for Culex, and 80 to 98% for Mansonia compared to untreated ribbons. Reduction in outdoor densities was 38 to 77% against An. arabiensis, 36 to 64% against An. funestus, 63 to 88% against Culex, and 47 to 98% against Mansonia. There was no difference in protection between the two transfluthrin doses. In the survey, 58% of participants perceived the ribbons to be effective in reducing mosquito bites. Ninety per cent were willing to pay for the ribbons, the majority of whom were willing to pay but less than US$2.17 (5000 TZS), one-third of the current prototype cost. Conclusions Transfluthrin-treated eave ribbons can protect migratory rice farmers, living in semi-open makeshift houses in remote farms, against indoor-biting and outdoor-biting mosquitoes. The technology is acceptable to users and could potentially complement ITNs. Further studies should investigate durability and epidemiological impact of eave ribbons, and the opportunities for improving affordability to users.

Cut in greenhouse gas emissions, increment of energy from renewables and improvement in energy efficiency represent the three key targets for future energy systems. Among the available bioenergy technologies, biogas production via biodegradation and anaerobic digestion is a widely applied approach, not only to produce biofuels but also to manage industrial and domestic organic waste. Within the biogas production, a sufficient mixing of the organic mass is a crucial step to ensure high biogas yields by bacteria and enzymes. Measurements of the electric power consumption of biogas plants revealed that the electrical energy demand of the stirrer system has a high share of the total electricity consumption of a biogas plant. Investigations on real biogas digesters to optimize the mixing process are cost and time intensive. Therefore, laboratory prototypes and computational simulations represent promising alternatives to analyse and improve the efficiency of mixing systems. In this paper, a computational fluid dynamics (CFD) model is presented, which is applied to commercial stirring systems. The case of two propeller stirrers, located in diametrically opposite positions in a tank filled with ca. 1400 m3 of substrate is described in detail. For the simulation, the rheology of the fluid is adapted to a biomass with 12 wt % dry matter content and obeying the non-Newtonian generalized Ostwald-de Waele power law. The developed simulation procedure considers the rotation angle of each propeller and its height. A total of 441 mixing configurations are calculated and evaluated in terms of the technical benefit. The investigation reveals that locations of the rotors far away from the bottom and high rotational angles cause advantageous fluid dynamics.

This study investigated the effect of business process reengineering on the performance of insurance firms in Nigeria, by employing two components of business process reengineering. Survey research design was adopted, through the administration of structured questionnaires on some selected staff of insurance companies at their head offices in Lagos, Nigeria. The research instrument was validated through content validity index (CVI), while the reliability of the research instrument was tested through test-retest method. The findings revealed that, the two components of business process reengineering adopted for this study have individual positive significant effect on insurance firms’ performance and adoption of new process. The F-statistics revealed that the two components of business process reengineering adopted for this study have positive significant combined effect on insurance firms’ performance in Nigeria. The adjusted coefficient of determination implied that, change in insurance firms’ performance is explained by the combined business process reengineering components. It is therefore concluded that, business process reengineering components are important drivers of insurance firms’ performance. It is recommended that, insurance firms should introduce new technology that will aid insurance penetration, especially information communication technology (ICT). The deployment of ICT tends to make it easier for existing and new customers to pick-up insurance policies through their smart phones or personal computers. Furthermore, insurance firms should equally come up with reengineered processes. The process of serving their customers should be enhanced.

Background Recognizing the etiology of sudden cardiac arrest (SCA) has an enormous impact on the management of victims and their immediate families. A significant proportion of SCA survivors with a structurally normal heart are not offered a diagnosis and there is no clear consensus on the type and duration of follow‐up. We aimed to assess the utility of a multidisciplinary approach in optimizing diagnosis of cardiac arrest etiology during follow‐up. Methods and Results We retrospectively assessed 327 consecutive SCA survivors (mean age 61.9±16.2 years, 80% men) who underwent secondary prevention implantable cardioverter defibrillators between May 2015 and November 2018. The initial diagnosis was recorded at the time of admission and follow‐up diagnosis was deduced from subsequent clinic records, investigations, and outcomes of multidisciplinary team meetings. Structural heart disease accounted for 282 (86%) of SCAs. Forty‐five (14%) patients had a structurally normal heart and underwent comprehensive testing and follow‐up (mean duration 93±52 weeks). On initial evaluation, 14/45 (31%) of these received a diagnosis, rising to 29/45 (64%) with serial reviews during follow‐up. Discussion in multidisciplinary team meetings and imaging reassessment accounted for 47% of new diagnoses. No additional diagnoses were made beyond 96 weeks. Nineteen (5.8%) fatalities occurred in the entire cohort, exclusively in patients with structural heart disease. Conclusions Systematic comprehensive testing combined with multidisciplinary expert team review of SCA survivors without structural heart disease improves the yield and time to diagnosis compared with previously published studies. This approach has positive implications in the management of SCA survivors and their families.

Aim: Left ventricular non-compaction (LVNC) is perceived as a rare high-risk cardiomyopathy characterized by excess left ventricular (LV) trabeculation. However, there is increasing evidence contesting the clinical significance of LV hyper-trabeculation and the existence of LVNC as a distinct cardiomyopathy. The aim of this study is to assess the association of LV trabeculation extent with cardiovascular morbidity and all-cause mortality in patients undergoing clinical cardiac magnetic resonance (CMR) scans across 57 European centers from the EuroCMR registry.Methods and Results: We studied 822 randomly selected cases from the EuroCMR registry. Image acquisition was according to international guidelines. We manually segmented images for LV chamber quantification and measurement of LV trabeculation (as per Petersen criteria). We report the association between LV trabeculation extent and important cardiovascular morbidities (stroke, atrial fibrillation, heart failure) and all-cause mortality prospectively recorded over 404 ± 82 days of follow-up. Maximal non-compaction to compaction ratio (NC/C) was mean (standard deviation) 1.81 ± 0.67, from these, 17% were above the threshold for hyper-trabeculation (NC/C > 2.3). LV trabeculation extent was not associated with increased risk of the defined outcomes (morbidities, mortality, LV CMR indices) in the whole cohort, or in sub-analyses of individuals without ischaemic heart disease, or those with NC/C > 2.3.Conclusion: Among 882 patients undergoing clinical CMR, excess LV trabeculation was not associated with a range of important cardiovascular morbidities or all-cause mortality over ~12 months of prospective follow-up. These findings suggest that LV hyper-trabeculation alone is not an indicator for worse cardiovascular prognosis.