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2. Italian Society of Interventional Cardiology (GISE) and Italian Society of Arterial Hypertension (SIIA) Position Paper on the role of renal denervation in the management of the difficult-to-treat hypertension

Author

Stabile, E, Muiesan, M, Ribichini, F, Sangiorgi, G, Taddei, S, Versaci, F, Villari, B, Bacca, A, Benedetto, D, Fioretti, V, Laurenzano, E, Scapaticci, M, Saia, F, Tarantini, G, Grassi, G, Esposito, G, Muiesan, ML, Ribichini, FL, Stabile, E, Muiesan, M, Ribichini, F, Sangiorgi, G, Taddei, S, Versaci, F, Villari, B, Bacca, A, Benedetto, D, Fioretti, V, Laurenzano, E, Scapaticci, M, Saia, F, Tarantini, G, Grassi, G, Esposito, G, Muiesan, ML, and Ribichini, FL

Abstract

Renal denervation (RDN) is a safe and effective strategy for the treatment of difficult to treat hypertension. The blood pressure (BP)-lowering efficacy of RDN is comparable to those of many single antihypertensive medications and it allows to consider the RDN as a valuable option for the treatment of difficult to treat hypertension together with lifestyle modifications and medical therapy. A multidisciplinary team is of pivotal importance from the selection of the patient candidate for the procedure to the post-procedural management. Further studies are needed to investigate the effect of RDN on clinical outcomes and to better identify the predictors of BP response to RDN in order to recognize the patients who are more likely to benefit from the procedure.

Published
2024

3. The potential role of the aortic valve calcium score by computed tomography scan in the diagnosis of concomitant cardiac amyloidosis in patients with severe aortic stenosis

Author

Ponziani, A, primary, Saturi, G, additional, Caponetti, A G, additional, Accietto, A, additional, Giovannetti, A, additional, Longhi, S, additional, Gagliardi, C, additional, Laurenzano, F, additional, Cecchieri, F, additional, Ini, E, additional, Parisi, V, additional, Saia, F, additional, Attina, D, additional, Galie, N, additional, and Biagini, E, additional

Published
2023
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4. Transcatheter edge to edge repair of functional mitral regurgitation as bridge to heart transplantation: 2-years follow up results from MitraBridge international registry

Author

Marcelli, C, primary, Munafo', A R, additional, Estevez-Loureiro, R, additional, Adamo, M, additional, Guerin, P, additional, Arzamendi, D, additional, Ho, E C, additional, Asgar, A, additional, Petronio, A S, additional, Grasso, C, additional, Van Mieghem, N M, additional, Tarantini, G, additional, Potena, L, additional, Saia, F, additional, and Godino, C, additional

Published
2023
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5. Acute changes of right ventricular longitudinal strain after transcatheter edge-to-edge repair in patients with functional mitral regurgitation

Author

Ruotolo, I, primary, Marcelli, C, additional, Barile, L, additional, Catalano, C, additional, Saturi, G, additional, Ditaranto, R, additional, Parisi, V, additional, Baldassarre, R, additional, Di Nicola, F, additional, Nardi, E, additional, Palmerini, T, additional, Saia, F, additional, Galie', N, additional, Berardini, A, additional, and Biagini, E, additional

Published
2023
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6. Italian Society of Interventional Cardiology (GISE) and Italian Society of Arterial Hypertension (SIIA) Consensus document on the role of renal denervation in the management of the difficult to treat hypertension [Documento di consenso della Società Italiana di Cardiologia Interventistica (GISE) e della Società Italiana dell’Ipertensione arteriosa (SIIA) sul ruolo della denervazione renale nella gestione dell’ipertensione arteriosa difficile da trattare]

Author

Stabile, E, Muiesan, M, Ribichini, F, Sangiorgi, G, Taddei, S, Versaci, F, Villari, B, Bacca, A, Benedetto, D, Fioretti, V, Liccardo, G, Laurenzano, E, Scappaticci, M, Saia, F, Tarantini, G, Grassi, G, Esposito, G, Stabile, Eugenio, Muiesan, Maria Lorenza, Ribichini, Flavio Luciano, Sangiorgi, Giuseppe, Taddei, Stefano, Versaci, Francesco, Villari, Bruno, Bacca, Alessandra, Benedetto, Daniela, Fioretti, Vincenzo, Liccardo, Gaetano, Laurenzano, Eugenio, Scappaticci, Massimiliano, Saia, Francesco, Tarantini, Giuseppe, Grassi, Guido, Esposito, Giovanni, Stabile, E, Muiesan, M, Ribichini, F, Sangiorgi, G, Taddei, S, Versaci, F, Villari, B, Bacca, A, Benedetto, D, Fioretti, V, Liccardo, G, Laurenzano, E, Scappaticci, M, Saia, F, Tarantini, G, Grassi, G, Esposito, G, Stabile, Eugenio, Muiesan, Maria Lorenza, Ribichini, Flavio Luciano, Sangiorgi, Giuseppe, Taddei, Stefano, Versaci, Francesco, Villari, Bruno, Bacca, Alessandra, Benedetto, Daniela, Fioretti, Vincenzo, Liccardo, Gaetano, Laurenzano, Eugenio, Scappaticci, Massimiliano, Saia, Francesco, Tarantini, Giuseppe, Grassi, Guido, and Esposito, Giovanni

Abstract

Arterial hypertension is the most prevalent cardiovascular risk factor worldwide. Despite the availability of many and effective antihypertensive medications, the prevalence of uncontrolled blood pressure (BP) remains high. As sympathetic hyperactivity has long been recognized as a major contributor to resistant hypertension, catheter-based renal denervation (RDN) has emerged as a new strategy to reduce BP. RDN aims to interrupt the activity of renal sympathetic nerves by applying radiofrequency (RF) energy, ultrasound (US) energy, or injection of alcohol in the perivascular space. The Symplicity HTN-3 trial, the largest sham-controlled trial using the first-generation RF-based RDN device, failed to significantly reduce BP. Since then, new devices and techniques have been developed and consequently many sham-controlled trials using second-generation RF or US-based RDN devices have demonstrated the BP lowering efficacy and safety of the procedure. A multidisciplinary team involving hypertension experts, interventionalists with expertise in renal interventions and anesthesiologists, plays a pivotal role from the selection of the patient candidate for the procedure to the post-procedural care. The aim of this consensus document is to summarize the current evidence about the use of RDN in difficult to treat hypertension and to propose a management strategy from the selection of the patient candidate for the procedure to the post-procedural care.

Published
2023

13. 14 Morbidly obese patients with symptomatic severe aortic stenosis, what is the optimal treatment strategy? A propensity score matched analysis of transcatheter versus surgical aortic valve replacement

Author

McInerney, A, primary, Rodés-Cabau, J, additional, Veiga, G, additional, Lopez-Otero, D, additional, Muñoz-Garcia, E, additional, Campelo, F, additional, Oteo, JF, additional, Carnero, M, additional, Tafur Soto, JD, additional, Amat-Santos, I, additional, Travieso, A, additional, Mohammadi, S, additional, Barbanti, M, additional, Cheema, AN, additional, Toggweiler, S, additional, Saia, F, additional, Dabrowski, M, additional, Serra, V, additional, Alfonso, F, additional, Barbosa, H, additional, Regueiro, A, additional, Alperi, A, additional, Ongay, AG, additional, Martinez Cereijo, JM, additional, Muñoz-Garcia, AJ, additional, Matta, A, additional, Arellano-Serrano, C, additional, Barrero, A, additional, Tirado-Conte, G, additional, Gonzalo, N, additional, Sanmartin, XC, additional, de la Torre Hernández, JM, additional, Kalavrouziotis, D, additional, Maroto, L, additional, Forteza-Gil, A, additional, Cobiella, J, additional, Escaned, J, additional, and Nombela-Franco, L, additional

Published
2022
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14. 24h SCAI stage reclassification to predict outcome. Insights from the prospective Altshock-2 registry

Author

Morici, N, primary, Frea, S, additional, Ditali, V, additional, Briani, M, additional, Bertaina, M, additional, Ravera, A, additional, Sorini Dini, C, additional, Moltrasio, M, additional, Saia, F, additional, Corrada, E, additional, De Ferrari, G M, additional, Garatti, L, additional, Colombo, C, additional, Tavazzi, G, additional, and Pappalardo, F, additional

Published
2022
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17. PROGNOSTIC VALUE OF PULMONARY ARTERY DIAMETER IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION

Author

DARDI, F., primary, SAIA, F., additional, PALAZZINI, M., additional, DONATO, F., additional, NIRO, F., additional, GUARINO, D., additional, RUSSO, V., additional, TAGLIERI, N., additional, DE LORENZIS, A., additional, ROTUNNO, M., additional, BALLERINI, A., additional, CHIETERA, F., additional, BERTOZZI, R., additional, MANES, A., additional, LOVATO, L., additional, MARROZZINI, C., additional, and GALIÈ, N., additional

Published
2022
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18. [Italian Society of Interventional Cardiology (SICI-GISE) Position paper: Transcatheter left atrial appendage occlusion in patients with non-valvular atrial fibrillation]

Author

Berti, S., Tondo, C., Basso, C., Gaspardone, A., Golino, P., Meucci, F., Montorfano, M., Parodi, G., Russo, F., Saia, F., Cardaioli, F., Santoro, G., Rapacciuolo, A., Tondo, A., Esposito, G., and Tarantini, G.

Subjects
Stroke, Thromboembolism, Atrial Fibrillation, Cardiology, Humans, Atrial fibrillation, Left atrial appendage occlusion, Atrial Appendage
Abstract

Atrial fibrillation (AF) is the most common arrhythmia worldwide. Thromboembolism from the left atrial appendage (LAA) is the most feared complication in patients with AF. The cornerstone for the management of AF is oral anticoagulation to reduce the incidence of cardioembolic stroke. There is, however, a significant proportion of patients who cannot undergo long-term oral anticoagulation. Transcatheter LAA occlusion is an evolving technology with proven benefits in terms of AF-related stroke prevention, representing a valid alternative to anticoagulation for high-risk patients with contraindications for long-term oral anticoagulation. This has resulted in the development of a plethora of transcatheter devices to achieve endocardial occlusion or epicardial exclusion of the LAA.A panel of expert Italian cardiologists gathered under the aegis of the Italian Society of Interventional Cardiology (SICI-GISE) with the aim of reviewing the most relevant aspects of LAA occlusion, underlying anatomy and pathophysiology, summarizing current clinical knowledge, and discussing the practicalities of available devices and imaging techniques. Finally, the position paper highlights the importance of an adequate environment and of an appropriate organization in order to optimize all steps of the procedure.

Published
2022

19. [GISE (Italian Society of Interventional Cardiology) Position paper: Short-term hospitalization for percutaneous coronary intervention; a helpful tool to manage post-COVID-19 backlogs]

Author

Violini, R., De Rosa, S., Leonardi, S., Doronzo, B., Cremonesi, A., Callea, G., Spandonaro, F., Tarantini, G., Esposito, G., Cernetti, C., Indolfi, C., Berti, S., Marchese, A., Saia, F., and Monti, F.

Subjects
Hospitalization, Percutaneous Coronary Intervention, Cardiology, COVID-19, Humans, Length of Stay, Pandemics
Abstract

Minimization of hospital lengths of stay has always been a key goal for healthcare systems. More so during the current COVID-19 pandemic. In fact, we have faced a reduction in no-COVID-19 admissions with the generation of huge backlogs. Low-risk patients undergoing elective percutaneous coronary intervention (PCI) can be candidate for short-term hospitalization, with consequent reduction of waiting lists. Several single-center and multicenter observational studies, multiple randomized trials and some meta-analyses have addressed this topic.In this position paper, we present a proposal for short hospitalization for elective PCI procedures in selected patients who present complications only exceptionally and exclusively immediately after the procedure, if the inclusion and exclusion criteria are met. Each Center can choose between admission in day surgery or one day surgery, extending hospital length of stay only for patients who present complications or who are candidate for urgent surgery. Short-term hospitalization considerably reduces costs even if, with the current model, it generally results in a parallel reduction in reimbursement. Hence, we present an actual model, already tested successfully in an Italian hospital, that warrants sustainability. This approach can then be tailored to single Centers.

Published
2022

20. Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration

Author

Paschou, P., Jin, Y., Müller-Vahl, K., Möller, H.E., Rizzo, R., Hoekstra, P.J., Roessner, V., Debes, N. Mol, Worbe, Y., Hartmann, A., Mir, P., Cath, D., Neuner, I., Eichele, H., Zhang, C, Lewandowska, K., Munchau, A., Verrel, J., Musil, R., Silk, T.J., Hanlon, C.A., Bihun, E.D., Brandt, V., Dietrich, A., Forde, N., Ganos, C., Greene, D.J., Chu, C., Grothe, M.J., Hershey, T., Janik, P., Koller, J.M., Martin-Rodriguez, J.F., Müller, K., Palmucci, S., Prato, A., Ramkiran, S., Saia, F., Szejko, N., Torrecuso, R., Tumer, Z., Uhlmann, A., Veselinovic, T., Wolańczyk, T., Zouki, J.J., Jain, P., Topaloudi, A., Kaka, M., Yang, Z, Drineas, P., Thomopoulos, S.I., White, T., Veltman, D.J., Schmaal, L., Stein, D.J., Buitelaar, J.K., Franke, B., Heuvel, O. van den, Jahanshad, N., Thompson, P.M., Black, K.J., Paschou, P., Jin, Y., Müller-Vahl, K., Möller, H.E., Rizzo, R., Hoekstra, P.J., Roessner, V., Debes, N. Mol, Worbe, Y., Hartmann, A., Mir, P., Cath, D., Neuner, I., Eichele, H., Zhang, C, Lewandowska, K., Munchau, A., Verrel, J., Musil, R., Silk, T.J., Hanlon, C.A., Bihun, E.D., Brandt, V., Dietrich, A., Forde, N., Ganos, C., Greene, D.J., Chu, C., Grothe, M.J., Hershey, T., Janik, P., Koller, J.M., Martin-Rodriguez, J.F., Müller, K., Palmucci, S., Prato, A., Ramkiran, S., Saia, F., Szejko, N., Torrecuso, R., Tumer, Z., Uhlmann, A., Veselinovic, T., Wolańczyk, T., Zouki, J.J., Jain, P., Topaloudi, A., Kaka, M., Yang, Z, Drineas, P., Thomopoulos, S.I., White, T., Veltman, D.J., Schmaal, L., Stein, D.J., Buitelaar, J.K., Franke, B., Heuvel, O. van den, Jahanshad, N., Thompson, P.M., and Black, K.J.

Abstract

Contains fulltext : 281802.pdf (Publisher’s version ) (Open Access), Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.

Published
2022

21. Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration

Author

Paschou, P, Jin, Y, Mueller-Vahl, K, Moeller, HE, Rizzo, R, Hoekstra, PJ, Roessner, V, Debes, NM, Worbe, Y, Hartmann, A, Mir, P, Cath, D, Neuner, I, Eichele, H, Zhang, C, Lewandowska, K, Munchau, A, Verrel, J, Musil, R, Silk, TJ, Hanlon, CA, Bihun, ED, Brandt, V, Dietrich, A, Forde, N, Ganos, C, Greene, DJ, Chu, C, Grothe, MJ, Hershey, T, Janik, P, Koller, JM, Francisco Martin-Rodriguez, J, Mueller, K, Palmucci, S, Prato, A, Ramkiran, S, Saia, F, Szejko, N, Torrecuso, R, Tumer, Z, Uhlmann, A, Veselinovic, T, Wolanczyk, T, Zouki, J-J, Jain, P, Topaloudi, A, Kaka, M, Yang, Z, Drineas, P, Thomopoulos, S, White, T, Veltman, DJ, Schmaal, L, Stein, DJ, Buitelaar, J, Franke, B, van den Heuvel, O, Jahanshad, N, Thompson, PM, Black, KJ, Paschou, P, Jin, Y, Mueller-Vahl, K, Moeller, HE, Rizzo, R, Hoekstra, PJ, Roessner, V, Debes, NM, Worbe, Y, Hartmann, A, Mir, P, Cath, D, Neuner, I, Eichele, H, Zhang, C, Lewandowska, K, Munchau, A, Verrel, J, Musil, R, Silk, TJ, Hanlon, CA, Bihun, ED, Brandt, V, Dietrich, A, Forde, N, Ganos, C, Greene, DJ, Chu, C, Grothe, MJ, Hershey, T, Janik, P, Koller, JM, Francisco Martin-Rodriguez, J, Mueller, K, Palmucci, S, Prato, A, Ramkiran, S, Saia, F, Szejko, N, Torrecuso, R, Tumer, Z, Uhlmann, A, Veselinovic, T, Wolanczyk, T, Zouki, J-J, Jain, P, Topaloudi, A, Kaka, M, Yang, Z, Drineas, P, Thomopoulos, S, White, T, Veltman, DJ, Schmaal, L, Stein, DJ, Buitelaar, J, Franke, B, van den Heuvel, O, Jahanshad, N, Thompson, PM, and Black, KJ

Abstract

Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.

Published
2022

22. Transcatheter Aortic Valve Replacement in Patients at High Risk of Coronary Obstruction

Author

Ahmad, Y., Oakley, L., Yoon, S., Kaewkes, D., Chakravarty, T., Patel, C., Palmerini, Tullio, Bruno, A. G., Saia, Francesco, Testa, L., Bedogni, Francesco, Chieffo, Alaide, Montorfano, M., Bartorelli, A. L., Porto, Italo, Grube, E., Nickenig, G., Sinning, J. -M., De Carlo, M., Petronio, A. S., Barbanti, M., Tamburino, C., Iadanza, A., Burzotta, Francesco, Trani, Carlo, Fraccaro, C., Tarantini, G., Aranzulla, T. C., Musumeci, Giampaolo, Stefanini, G. G., Taramasso, M., Kim, H. -S., Codner, P., Kornowski, R., Pelliccia, F., Vignali, L., Makkar, R. R., Palmerini T., Saia F., Bedogni F., Chieffo A., Porto I. (ORCID:0000-0002-9854-5046), Burzotta F. (ORCID:0000-0002-6569-9401), Trani C. (ORCID:0000-0001-9777-013X), Musumeci G., Ahmad, Y., Oakley, L., Yoon, S., Kaewkes, D., Chakravarty, T., Patel, C., Palmerini, Tullio, Bruno, A. G., Saia, Francesco, Testa, L., Bedogni, Francesco, Chieffo, Alaide, Montorfano, M., Bartorelli, A. L., Porto, Italo, Grube, E., Nickenig, G., Sinning, J. -M., De Carlo, M., Petronio, A. S., Barbanti, M., Tamburino, C., Iadanza, A., Burzotta, Francesco, Trani, Carlo, Fraccaro, C., Tarantini, G., Aranzulla, T. C., Musumeci, Giampaolo, Stefanini, G. G., Taramasso, M., Kim, H. -S., Codner, P., Kornowski, R., Pelliccia, F., Vignali, L., Makkar, R. R., Palmerini T., Saia F., Bedogni F., Chieffo A., Porto I. (ORCID:0000-0002-9854-5046), Burzotta F. (ORCID:0000-0002-6569-9401), Trani C. (ORCID:0000-0001-9777-013X), and Musumeci G.

Abstract

Background: Coronary obstruction following transcatheter aortic valve replacement (TAVR) is a life-threatening complication. For patients at elevated risk, it is not known how valve choice is influenced by clinical and anatomic factors and how outcomes differ between valve platforms. For patients at high risk of coronary obstruction, we sought to describe the anatomical and clinical characteristics of patients treated with both balloon-expandable (BE) and self-expanding (SE) valves. Methods: This was a multicenter international registry of patients undergoing TAVR who are considered to be at high risk of coronary obstruction and receiving pre-emptive coronary protection. Results: A total of 236 patients were included. Patients receiving SE valves were more likely to undergo valve-in-valve procedures and also had smaller sinuses of Valsalva and valve-to-coronary distance. Three-year cardiac mortality was 21.6% with SE vs 3.7% with BE valves. This was primarily driven by increased rates of definite or probable coronary occlusion, which occurred in 12.1% of patients with SE valves vs 2.1% in patients with BE valves. Conclusions: In patients undergoing TAVR with coronary protection, those treated with SE valves had increased rates of clinical and anatomic features that increase the risk of coronary obstruction. These include an increased frequency of valve-in-valve procedures, smaller sinuses of Valsalva, and smaller valve-to-coronary distances. These patients were observed to have increased cardiac mortality compared with patients treated with BE valves, but this is likely due to their higher risk clinical and anatomic phenotypes rather than as a function of the valve type itself.

Published
2022

23. L’angioplastica delle arterie polmonari nel cuore polmonare cronico tromboembolico: 5 anni di esperienza in Italia

Author

Saia F., Dardi F., Taglieri N., Rotunno M., Manes A., Guarino D., Zuffa E., De Lorenzis A., Magnani I., Ballerini A., Niro F., Martin Suarez S., Pacini D., Gotti E., Galie N., Palazzini M., Saia F., Dardi F., Taglieri N., Rotunno M., Manes A., Guarino D., Zuffa E., De Lorenzis A., Magnani I., Ballerini A., Niro F., Martin Suarez S., Pacini D., Gotti E., Galie N., and Palazzini M.

Subjects
Pulmonary embolism, Chronic thromboembolic pulmonary hypertension, Balloon angioplasty
Abstract

BACKGROUND: Balloon pulmonary angioplasty (BPA) represents a therapeutic option for the treatment of chronic thromboembolic pulmonary hypertension (CTEPH) in patients who are not eligible for surgical pulmonary endarterectomy (PEA) or with persistent/recurrent symptomatic pulmonary arterial hypertension after PEA. This study evaluated the safety of BPA during 5 years of experience of the only Italian center systematically performing this procedure. METHODS: The BPA program was activated at the S. Orsola Polyclinic in Bologna in June 2015. Life-threatening periprocedural complications were defined as: death

Published
2021

24. Peripheral intravascular lithotripsy to facilitate transfemoral TAVR: a multicentric prospective registry

Author

Nardi, G., Backer, O., Ristalli, F., Meucci, F., Stolcova, M., Wang, X. I., Sondergaard, L., Tullio Palmerini, Bruno, A. G., Al Jabri, A. G., Ielasi, A. G., Berti, S., Saia, F., and Di Mario, C.

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background The presence of severe calcific atherosclerotic disease at iliac artery level is a contraindication to transfemoral (TF) TAVI procedures, challenging TF delivery in 15–20% of cases. Many case reports described the efficacy of Intravascular lithotripsy (IVL) to facilitate TF access but only one prospective registry has been reported in literature and dates back 2018. For this reason a new multicenter prospective registry was ideated to confirm the role of IVL technology in facilitating TF TAVR. Aims The aims of this study were 1)to analyze the trend of TF TAVR compared to alternative approaches in the last 5 years and 2)to evaluate the prevalence of IVLassistedTAVR since it was introduced in this specific setting in 2018 3) to evaluate the success rate in terms of valve performance and procedural success of TF-TAVR system delivery after IVL lesion preparation. Materials and methods We prospectively collected data from all consecutive TAVRprocedures performed between Jan2016 andDec2020 at 4Italian and 1 Denmark centres. All patients underwent CT angiography of lower extremity before the procedure in order to assess the severity of aorto-iliac-femoral calcification and to select those patients who required specific lesion preparation to preserve TF access. For each target calcified lesion we measured length, diameter and %of stenosis, circumferential extension and minimal cross-sectional area. Angiographic IVL-related and access site complications (dissection, perforation, major bleeding) were examined. Results Between 2016 and 2020, a total of 3710 TAVR were performed, 3428 (92%) via TF route while the remaining 240 (8%) included alternative approaches mainly represented by subclavian and transapical access. IVL-assisted TAVR were 0 in 2016 and 2017, 13 (2%) in 2018 when the first IVL-assisted aortic valve implantation was performed and doubled in 2019, reaching a total of 112 in the whole 5-year period considered. The number of IVL-facilitated TAVR has been increased in the 5-year period, achieving 7% of the TF procedures while non-TF TAVR decreased considerably from 10% to 6%. Common and external iliac axis was the target lesion in the majority of cases (54%) followed by common iliac artery alone. lesion minimum diameter 4.7mm, with average stenosis of 50%. The maximum calcium angle was 332°. The majority of IVL was performed with a 7-mm catheter (78.6%). 1 balloon per lesion was employed. 1 perforation and 2 severe dissections occurred, that required stent placement. In 55% of cases the aortic regurgitation was absent or minimal. Conclusions TF approach remained the first choice for TAVR procedure in the majority of cases compared to non-TF thanks to the progressive increase of IVLassistedTAVR that allowed operators to preserve TF route. Peripheral IVL appeared feasible, safe and effective in patients with severe peripheral artery disease, with high success rate in terms of valve performance and low rate of complications. Funding Acknowledgement Type of funding sources: None.

Published
2021
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26. Different aortic valve calcium scores by computed tomography scan in patients with severe aortic stenosis and concomitant cardiac amyloidosis

Author

Saturi, G, primary, Santona, L, additional, Sguazzotti, M S, additional, Caponetti, A G, additional, Massa, P, additional, Ponziani, A, additional, Gagliardi, C, additional, Giovannetti, A G, additional, Lovato, L, additional, Attina, D, additional, Bonfiglioli, R, additional, Saia, F, additional, Galie, N, additional, Biagini, E, additional, and Longhi, S, additional

Published
2021
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27. Management strategies for acutely decompensated aortic stenosis

Author

Orzalkiewicz, M, primary, Donati, F, additional, Santona, L, additional, Marcelli, C, additional, Chietera, F, additional, Bendandi, F, additional, Bruno, A G, additional, Ghetti, G, additional, Taglieri, N, additional, Palmerini, T, additional, Marrozzini, C, additional, Galie, N, additional, and Saia, F, additional

Published
2021
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28. 2020 EAPCI core curriculum for percutaneous cardiovascular interventions

Author

Van Belle, E, Teles, RC, Pyxaras, SA, Kalpak, O, Johnson, T, Barbash, IM, De Luca, G, Kostov, J, Parma, R, Vincent, F, Brugaletta, S, Debry, N, Toth, GG, Ghazzal, Z, Deharo, P, Milasinovic, D, Kaspar, K, Saia, F, Mauri, J, Kammler, J, Muir, D, O'Connor, S, Mehilli, J, Thiele, H, Weilenmann, D, Witt, N, Joshi, F, Kharbanda, R, Piroth, Z, Wojakowski, W, Geppert, A, Di Gioia, G, Pires-Morais, G, Petronio, AS, Estevez-Loureiro, R, Ruzsa, Z, Kefer, J, Kunadian, V, Van Mieghem, N, Windecker, S, Baumbach, A, Haude, M, Dudek, D, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)

Subjects
Cardiology and Cardiovascular Medicine, Miscellaneous
Abstract

Funding Information: A. Baumbach received institutional research support from Abbott Vascular, consultation and speaker fees from AstraZeneca, Sinomed, MicroPort, Abbott Vascular, Cardinal Health, KSH, and Medtronic. R. Estevez-Loureiro reports grants and personal fees from Abbott Vascular and personal fees from Boston Scientific, outside the submitted work. A. Geppert reports lecture fees from Medtronic, Abbott and Abiomed, consulting fees from Abbott and Abiomed, congress grants from Asahi and Terumo, outside the submitted work. J. Kefer reports proctorship and speaker fees from Medtronic and Abbott, and speaker fees from Servier. D. Milasinovic reports personal fees from Abbot, Biosensors, Terumo, AstraZeneca and Sanofi, outside the submitted work. D. Muir is a proctor and advisory board member for Abbott Vascular, and received proctor, advisory board and speaker fees from Edwards Lifesciences. A.S. Petronio received proctor and advisory board fees from Abbott Vascular, and received proctor, advisory board and speaker fees from Edwards Lifesciences. G. Pires-Morais received speaker fees from Abbott Vascular. S. Pyxaras received consultancy fees from Abiomed and Boston Scientific and proctor fees from Boston Scientific. R. Parma received speaker fees from Boston Scientific, Edwards Lifesciences and Medtronic. F. Saia reports personal fees from Abbott Vascular, Boston Scientific, Edwards, Medtronic, Biotronik, Amgen, AstraZeneca, Daiichi Sankyo, Bayer and Boehringer-Ingelheim, outside the submitted work. N. Van Mieghem reports advisor fees from PulseCath BV and Abiomed. S. Windecker reports grants from Abbott, Amgen, BMS, Bayer, Boston Scientific, Biotronik, Cardinal Health, CSL Behring, Daiichi Sankyo, Edwards Lifesciences, Johnson and Johnson, Medtronic, Quebert, Polares, Sanofi and Terumo, outside the submitted work. E. Van Belle reports personal fees from HeartFlow and Philips, outside the submitted work. The other authors have no conflicts of interest to declare. Publisher Copyright: © Europa Digital & Publishing 2021. All rights reserved. The proposed 2020 Core Curriculum for Percutaneous Cardiovascular Interventions aims to provide an updated European consensus that defines the level of experience and knowledge in the field of percutaneous cardiovascular intervention (PCI). It promotes homogenous education and training programmes among countries, and is the cornerstone of the new EAPCI certification, designed to support the recognition of competencies at the European level and the free movement of certified specialists in the European Community. It is based on a thorough review of the ESC guidelines and of the EAPCI textbook on percutaneous interventional cardiovascular medicine. The structure of the current core curriculum evolved from previous EAPCI core curricula and from the "2013 core curriculum of the general cardiologist"to follow the current ESC recommendations for core curricula. In most subject areas, there was a wide - if not unanimous - consensus among the task force members on the training required for the interventional cardiologist of the future. The document recommends that acquisition of competence in interventional cardiology requires at least two years of postgraduate training, in addition to four years devoted to cardiology. The first part of the curriculum covers general aspects of training and is followed by a comprehensive description of the specific components in 54 chapters. Each of the chapters includes statements of the objectives, and is further subdivided into the required knowledge, skills, behaviours, and attitudes. publishersversion published

Published
2021

30. [Position paper of the Italian Society of Interventional Cardiology (SICI-GISE): Management of patent foramen ovale in patients with cerebral or systemic thromboembolism - 2020]

Author

Tarantini G, D'Amico G, Baracchini C, Berni A, Berti S, Chessa M, Esposito G, Gaspardone A, Menozzi A, Meucci F, Musumeci G, Onorato E, Rigattieri S, Saia F, Santoro P, Scacciatella P, Trabattoni D, Fraccaro C, Pristipino C., Tarantini, G, D'Amico, G, Baracchini, C, Berni, A, Berti, S, Chessa, M, Esposito, G, Gaspardone, A, Menozzi, A, Meucci, F, Musumeci, G, Onorato, E, Rigattieri, S, Saia, F, Santoro, P, Scacciatella, P, Trabattoni, D, Fraccaro, C, and Pristipino, C.

Published
2020

31. Impact of COVID-19 pandemic on structural heart interventions in Italy

Author

Tarantini G., Nai Fovino L., Scotti A., Marchese A., Berti S., Saia F., Gregori D., Chieffo A., Musumeci G., Esposito G., Tarantini, G., Nai Fovino, L., Scotti, A., Marchese, A., Berti, S., Saia, F., Gregori, D., Chieffo, A., Musumeci, G., and Esposito, G.

Subjects
Male, Elective Surgical Procedure, Time Factor, Pandemic, SARS-CoV-2, COVID-19, Foramen Ovale, Patent, Transcatheter Aortic Valve Replacement, Italy, Prevalence, Cardiac Surgical Procedure, Mitral Valve, Atrial Appendage, Female, Confidence Interval, Human
Abstract

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has led to deferral of many non-urgent procedures in most healthcare systems worldwide. With this study we aimed to quantify the impact of COVID-19 on interventional treatment of structural heart disease (SHD) in Italy. METHODS: Numbers of transfemoral transcatheter aortic valve replacement (TAVR), percutaneous mitral valve repair (PMVR), left atrial appendage occlusion (LAAO), patent foramen ovale (PFO) closures performed over a 4-week period during the national lockdown in Italian centers performing over 60 structural heart interventions (SHI)/year were compared with the same 4-week period in 2019. Incidence rate reductions (IRR) were estimated by zero-inflated negative binomial regression. RESULTS: According to our nationwide analysis, SHIs were reduced by 79% as compared to the same period in 2019 (IRR 0.21, 95% confidence interval [CI] 0.15-0.29). This reduction was more substantial for PFO closure (IRR 0.03, 95% CI 0.01-0.07), LAAO (IRR 0.11, 95% CI 0.05-0.25) and PMVR (IRR 0.12, 95% CI 0.04-0.36) as compared to TAVR (IRR 0.31, 95% CI 0.22-0.47). CONCLUSIONS: The COVID-19 pandemic caused a 79% drop in SHI volumes in Italy. PFO closure, LAAO and PMVR decreased more significantly as compared to TAVR. Further studies are needed to evaluate the impact of this reduction on outcomes of patients with SHD.

Published
2020

32. Target Lesion Failure With Current Drug-Eluting Stents: Evidence From a Comprehensive Network Meta-Analysis

Author

Taglieri N., Bruno A. G., Ghetti G., Marrozzini C., Saia F., Galie N., Palmerini T., Taglieri N., Bruno A.G., Ghetti G., Marrozzini C., Saia F., Galie N., and Palmerini T.

Subjects
bioabsorbable polymer, Percutaneous Coronary Intervention, Treatment Outcome, Sirolimu, Drug-Eluting Stents, Coronary Artery Disease, drug-eluting stent(s), thin strut, Prosthesis Design, Network Meta-Analysi, Human
Abstract

Objectives: The aim of this study was to investigate the efficacy and safety of currently used drug-eluting stents (DES). Background: Head-to-head comparisons among newer DES have shown conflicting results. Methods: For this network meta-analysis, randomized controlled trials comparing different types of currently used DES were searched in PubMed, Scopus, and proceedings of international meetings. The primary endpoint was target lesion failure (TLF) at 1 year and at long-term follow-up. Results: Seventy-seven trials with 99,039 patients were selected for this network meta-analysis. Among the 10 DES included in the meta-analysis, 4 received the most extensive investigation: Orsiro, XIENCE, Nobori/BioMatrix, and Resolute. At 1 year, the Orsiro stent was associated with lower rates of TLF compared with XIENCE (odds ratio [OR]: 0.84; 95% confidence interval [CI]: 0.71 to 0.98; p = 0.03), Resolute (OR: 0.81; 95% CI: 0.68 to 0.95; p = 0.01), and Nobori/BioMatrix (OR: 0.81; 95% CI: 0.67 to 0.98; p = 0.03). Orsiro had the highest probability to be the best (70.8%), with a surface under the cumulative ranking curve value of 95.9%. However, after a median follow-up period of 50 months (range: 24 to 60 months), no significant difference was apparent in the rates of TLF between any DES, although Orsiro still ranked as the best stent (58.6% probability to be the best). In addition, Orsiro had a lower rate of long-term definite stent thrombosis compared with Nobori/BioMatrix (OR: 0.60; 95% CI: 0.36 to 0.98; p = 0.04) and lower rates of definite and probable stent thrombosis compared with Resolute (OR: 0.66; 95% CI: 0.45 to 0.99; p = 0.04). No differences in cardiac mortality between any DES were observed. Conclusions: Orsiro is associated with a lower 1-year rate of TLF compared with XIENCE, Resolute, and Nobori/BioMatrix but with an attenuation of the efficacy signal at long-term follow-up.

Published
2020

36. Assessing the cardiology community position on transradial intervention and the use of bivalirudin in patients with acute coronary syndrome undergoing invasive management: results of an EAPCI survey

Author

Adamo, Marianna, Byrne, Robert A., Baumbach, Andreas, Haude, Michael, Windecker, Stephan, Valgimigli, Marco, Aaroe, J., Abdeltawab, A. A., Accardi, R., Addad, F., Agostoni, P., Alajab, A., Alcázar, E., Alhabil, B., Altug Cakmak, H., Amico, F., Amoroso, G., Anderson, R., Andò, G., Andreou, A. Y., Antoniadis, D., Aquilina, M., Aramberry, L., Auer, J., Auffret, V., Ausiello, A., Austin, D., Avram, A., Ayman, E., Babunashvili, V., Bagur, R., Bakotic, Z., Balducelli, M., Ballesteros, S. M., Baptista, S., Baranauskas, A., Barbeau, G., Bax, M., Benchimol, C., Berroth, R., Biasco, L., Bilal, A., Binias, K., Blanco Mata, R., Boccuzzi, G., Bolognese, L., Boskovic, S., Bourboulis, N., Briguori, C., Bunc, M., Buysschaert, I., Calabro’, P., Campo, G., Candiello, A., Caprotta, U. F., Cardenas, M., Carrilho-Ferreira, P., Carrizo, S., Caruso, M., Cassar, A., Cernigliaro, C., Chacko, G., Chamie, D., Clapp, B., Coceani, M., Colangelo, S., Colombo, A., Comeglio, M., Connaughton, M., Conway, D., Cortese, B., Cosgrave, J., Costa, F., Couvoussis, E., Crimi, G., Crook, R., Cruz-Alvarado, J. E., Curello, S., D’Ascenzo, F., D’Urbano, M., Dana, A., De Backer, O., De Carlo, M., De Cesare, N., De Iaco, G., De La Torre, H. J. M., De Oliveira Netoj, B., Devlin, G. P., Di Lorenzo, E., Díaz, A., Dina, C., Dorsel, T. H., Eberli, F. R., Echeverría, R., Eftychiou, C., Elguindy, A., Ercilla, J., Ernst, A., Esposito, G., Ettori, F., Eufracino, Null, Ezquerra Aguilera, W., Falcone, C., Falu, R. M., Feres, F., Ferlini, M., Fernández, G., Fernández-Rodríguez, D., Fileti, L., Fischetti, D., Florescu, N., Formigli, D., Fouladvand, F., Franco, N., Fresco, C., Frigoli, E., Furmaniuk, J., Gabaldo, K., Galli, M., Galli, S., Garbo, R., Garducci, S., Garg, S., Gavrielatos, G., Gensch, J., Giacchi, G., Giunio, L., Giustino, G., Goldberg, L., Goldsmit, R., Gommeaux, A., González Godínez, H., Gosselin, G., Govorov, A., Grimfjard, P., Gross, E., Grosz, C., Guagliumi, G., Hadad, W., Hadadi, L., Hansen, P. R., Harb, S., Hatrick, R., Hayrapetyan, H. G., Hernández-Enríquez, M., Ho Heo, J., Horvath, I. G., Huan Loh, P., Ibrahim, A. M., Ierna, S., Ilic, I., Imperadore, F., Ionescu-Silva, E., Jacksch, R., James, S., Janiak, B., Jensen, S. E., Jeroen, S., Jugessur, R. K., Kala, P., Kambis, M., Kanakakis, J., Karamasis, G., Karchevsky, D., Karpovskiy, A., Kayaert, P., Kedev, S., Kemala, E., Ketteler, T., Khan, S. Q., Kharlamov, A., Kiernan, T., Kiviniem, T., Koltowski, L., Koskinas, K. C., Kouloumpinis, A., Kraaijeveld, A. O., Krizanic, F., Krötz, B., Kuczmik, W., Kukreja, N., Kuksa, D., Yav, K., Kyriakos, D., Labrunie, A., Laine, M., Lapin, O., Larosa, C., Latib, A., Lattuca, B., Lauer, B., Lefèvre, T., Legrand, V., Lehto, P., Leiva-Pons, J. L., Leone, A. M., Lev, G., Lim, R., Limbruno, U., Linares Vicente, J. A., Lindsay, S., Linnartz, C., Liso, A., Lluberas, R., Locuratolo, N., Lokshyn, S., Lunde, K., Lupi, A., Magnavacchi, P., Maia, F., Mainar, V., Mancone, M., Manolios, M. G., Mansour, S., Mariano, E., Marques, K., Martins, H., Mckenzie, D., Meco, S., Meemook, K., Mehmed, K., Melikyan, A., Mellwig, K. P., Mendiz, O. A., Merkulov, E., Mesquita, H. G., Mezzapelle, G., Miloradovic, V., Mohamed, S., Mohammed, B., Mohammed, F., Mohammed, K., Mohanad, A., Morawiec, B., More, R., Moreno-Martínez, F. L., Mrevlje, B., Muhammad, F., Näveri, H., Nazzaro, M. S., Neary, P., Negus, B. H., Nelson Durval, F. G., Nick, H., Nilva, E., Oldroyd, K. G., Olivares Asencio, C., Omerovic, E., Ortiz, M. A., Ota, H., Otasevic, P., Otieno, H. A., Paizis, I., Papp, E., Pasquetto, G., Patsourakos, N. G., Peels, J., Pelliccia, F., Pennacchi, M., Penzo, C., Perez, P., Perkan, A., Petrou, E., Phipathananunth, W., Pierri, A., Pinheiro, L. F., Pipa, J. L., Piva, T., Polad, J., Porto, I., Poveda, J., Predescu, L., Prog, R., Puri, R., Raco, D. L., Ramazan, O., Ramazzotti, V., Rao, S. V., Raungaard, B., Reczuch, K., Rekik, S., Rhouati, A., Rigattieri, S., Rodríguez-Olivares, R., Roik, M., Romagnoli, E., Román, A. J., Routledge, H., Rubartelli, P., Rubboli, A., Ruiz-García, J., Russo, F., Ruzsa, Z., Ryding, A., Saad, Aly, Sabate, M., Sabouret, P., Sadowski, M., Saia, F., Sanchez Perez, I., Santoro, G. M., Sarenac, D., Saririan, M., Sarma, J., Schuetz, T., Sciahbasi, A., Sebastian, M., Sebik, R., Sesana, M., Hur, Seung-Ho, Sganzerla, P., Shalva, R., Sharma, S., Sheiban, I., Shein, K. K., Shiekh, I. A., Sinha, M., Slhessarenko, J., Smith, D., Smyth, D. W., Sönmez, K., Sood, N., Sourgounis, A., Srdanovic, I., Stables, R. H., Stefanini, G. G., Stewart, J., Stoyanov, N., Suliman, A. A., Suryadevara, R., Suwannasom, P., Tange Veien, K., Tauchert, S., Tebet, M., Testa, L., Thury, A., Tilsted, H. H., Tiroch, K., Torres, A., Tosi, P., Traboulsi, M., Trani, C., Tresoldi, S., Tsigkas, G., Tueller, D., Turri, M., Udovichenko, A. E., Uretsky, B., Van Der Harst, P., Van Houwelingen, K. G., Vandoni, P., Vandormael, M., Varbella, F., Venkitachalam, C. G., Vercellino, M., Vidal-Perez, R., Vigna, C., Vignali, L., Vogt, F., Voudris, V., Vranckx, P., Vrolix, M., Vydt, T., Webster, M., Wijns, W., Woody, W., Wykrzykowska, J., Yazdani, S., Yildiz, A., Yurlevich, D., Zauith, R., Zekanovic, D., Zhao, M., Zimarino, M., Zingarelli, A., Abdelsamad, A. Y., Abo Shaera, E. S., Afshar, M. S., Agatiello, C., Aguiar, P., Ahmad, A. M., Akin, I., Alameda, M., Alegría-Barrero, E., Alejos, R., Alkhashab, K., Alkutshan, R. S. A., Almorraweh, A., Altnji, I., Alvarez Iorio, C., Anchidin, O., Angel, J., Antonopoulos, A., Apshilava, G., Arana, C., Ashikaga, T., Assomull, R., Atef, S. Z., Azmus, A. D., Azzalini, L., Azzouz, A., Baglioni, P., Bampas, G., Basil, M. P., Baumbach, A., Besh, D., Bhushan Sharm, A., Bien Hsien, H., Bihui, L., Bing-Chen, L., Biryukov, S., Blatt, A., Bocchi, E., Boghdady, A., Bonarjee, V. V. S., Bosnjak, I., Bravo Baptista, S., Brinckman, S. L., Buchter, B., Burzotta, F., Cacucci, M., Cagliyan, C. E., Calabrò, P., Cernetti, C., Chávez Mizraym, R., Choo, W. S., Choudhury, R., Cicco, N., Cisneros Clavijo, P., Çitaku, H., Collet, J. P., Consuegra-Sánchez, L., Conte, M., Corral, J. M., Damonte, A., Dangoisse, V., Dastani, M., Della Rosa, F., Deora, S., Devadathan, S., Dharma, S., Di Giorgio, A., Diez, J. L., Dinesha, B., Duplančić, D., El Behwashi, M. F., Elghawaby, H., Elshahawy, O., Eskola, M. J., Etman, A., Eun Gyu, L., Fabiano, L., Facta, A., Fan, Y., Fang-Yang, H., Farag, E., Fathi, Y., Fazeli, N., Federico, P., Fereidoun, M. Z., Fernandez-Nofrerias, E., Flensted Lassen, J., Flessas, D., Fouad, H., Franco-Pelaez, J. A., Fu, Q., Furtado, R., Gadepalli, R., Gallino, R., Gasparetto, V., Gentiletti, A., Gholoobi, A., Ghosh, A. K., Gkizas, S., Golchha, S. K., Goncharov, A., Gössl, M., Götberg, M., Greco, F., Grundeken, M. J., Gupta, D., Gupta, S., Guray, U., Hahalis, G., Hakim Vista, J., Hamid, M. A., Hammoudeh, A., Hasan, A. R. I., Hatsumura, F. E., Heintzen, M. P., Helal, T., Hetherington, S., Hewarathna, U. I., Hioki, H., Hissein, F., Ho-Ping, Y., Homs, S., Huber, K., Ibarra, F. M., Ielasi, A., Ipek, E., Jambunathan, R., Jamshidi, P., Jarrad, I., Javier, W., Jensen, J., Jimenez-Quevedo, P., Kalpak, O., Kan, J., Kanaan, T., Kao, D. H. M., Karamfiloff, K., Karegren, A., Karjalainen, P. P., Kasabov, R., Katsimagklis, G. D., Kaul, U., Khan, A., Kiemeneij, E., Kiviniemi, T., Kleiban, A., Komiyama, N., Konteva, M., Koshy, G., Krepsky, A. M., Kuljit, S., Kulkarni, P., Kumar, V., Kuznetsov, I., Lai, G., Lateef, M. A., Lawand, S., Le Hong, T., Lettieri, C., Levy, G., Lindvall, P., Maitra, A., Makowski, M., Mamas, M. A., Mandal, S. C., Mangalanandan, P., Marin, R., Mashhadi, M., Matsukage, T., Meier, B., Milosavljevic, B., Miro, S. S., Mitov, A., Moeriel, M., Moguel, R., Mohanty, A., Montalescot, G., Mörsdorf, W., Moscato, F., Muniz, A., Muraglia, S., Myć, J., Nada, A., Nair, P., Namazi, M. H., Naraghipour, F., Nguyen, Q. N., Nicosia, A., Nikas, D., Ober, M., Ocaranza-Sánchez, R., Olivecrona, G., Pahlajani, D., Pandey, B. P., Parma, A., Parma, R., Patsilinakos, S. P., Pattam, J., Peddi, S., Perez, P. R., Peruga, J. Z., Pescoller, F., Petrov, I., Piatti, L., Pico-Aracil, F., Pina, J., Piroth, Z., Popa, V., Pourbehi, M. R., Pradhan, A. K., Prida, X. E., Purohit, B. V., Pyun, W. B., Quang Hung, D., Rada, I., Rafizadeh, O., Rahman, M. A., Rai, L., Ramsewak, A., Ravindran, R., Rodriguez De Leiras, O. S., Rodríguez Esteban, M., Roque Figueira, H., Saket, A., Sakhov, O., Saktheeswaran, M. K., Salachas, A., Sallam, A., Sampaolesi, A., Samy, A., Sanchis, J., Santaera, O., Santarelli, A., Santharaj, W. S., Sarango, B., Satheesh, S., Schmitz, T., Schühlen, H., Seewoosagur, R., Segev, A., Seisembekov, V., Semitko, S., Sengottuvelu, G., Sepulveda Varela, P., Sethi, A., Sharma, A., Sharma, R. K., Shi, Hy., Şimşek, M. A., Siqueira, B., Skalidis, E., Slawin, J., Sorokhtey, L., Spaulding, C., Srinivas, B., Srinivasan, M., Stakos, D., Stefanini, G., Stojkovic, S., Tacoy, G., Tawade, M., Tiecco, F., Tondi, S., Torresani, E. M., Tousek, P., Tran, T., Trantalis, G., Triantafyllou, K., Trivedi, R., Trivisonno, A., Tsui, K. L., Türkoğlu, C., Tzung-Dau, W., Ueno, H., Urban, U., Uretsky, B. F., Uscumlic, A., Venugopal, V., Verney, R., Vilar, J. V., Villacorta, V. G., Vishwanath, R., Vlachojannis, G. J., Vlachojannis, M., Vlad, V., Von Birgelen, C., Vukcevic, V., Wahab, A., Waksman, R., Wei-Wen, L., Weisz, G., Whittaker, A., Yadav, A., Yokoi, Y., Zacharoulis, A., Zahran, M., Zamani, J., Ziakas, A., Zimmermann, J. P., Adamo, M., Byrne, R. A., Baumbach, A., Haude, M., Windecker, S., Valgimigli, M., Aaroe, J., Abdeltawab, A. A., Accardi, R., Addad, F., Agostoni, P., Alajab, A., Alcazar, E., Alhabil, B., Altug Cakmak, H., Amico, F., Amoroso, G., Anderson, R., Ando, G., Andreou, A. Y., Antoniadis, D., Aquilina, M., Aramberry, L., Auer, J., Auffret, V., Ausiello, A., Austin, D., Avram, A., Ayman, E., Babunashvili, V., Bagur, R., Bakotic, Z., Balducelli, M., Ballesteros, S. M., Baptista, S., Baranauskas, A., Barbeau, G., Bax, M., Benchimol, C., Berroth, R., Biasco, L., Bilal, A., Binias, K., Blanco Mata, R., Boccuzzi, G., Bolognese, L., Boskovic, S., Bourboulis, N., Briguori, C., Bunc, M., Buysschaert, I., Calabro', P., Campo, G., Candiello, A., Caprotta, U. F., Cardenas, M., Carrilho-Ferreira, P., Carrizo, S., Caruso, M., Cassar, A., Cernigliaro, C., Chacko, G., Chamie, D., Clapp, B., Coceani, M., Colangelo, S., Colombo, A., Comeglio, M., Connaughton, M., Conway, D., Cortese, B., Cosgrave, J., Costa, F., Couvoussis, E., Crimi, G., Crook, R., Cruz-Alvarado, J. E., Curello, S., D'Ascenzo, F., D'Urbano, M., Dana, A., De Backer, O., De Carlo, M., De Cesare, N., De Iaco, G., De La Torre, H. J. M., De Oliveira Netoj, B., Devlin, G. P., Di Lorenzo, E., Diaz, A., Dina, C., Dorsel, T. H., Eberli, F. R., Echeverria, R., Eftychiou, C., Elguindy, A., Ercilla, J., Ernst, A., Esposito, G., Ettori, F., Eufracino, Ezquerra Aguilera, W., Falcone, C., Falu, R. M., Feres, F., Ferlini, M., Fernandez, G., Fernandez-Rodriguez, D., Fileti, L., Fischetti, D., Florescu, N., Formigli, D., Fouladvand, F., Franco, N., Fresco, C., Frigoli, E., Furmaniuk, J., Gabaldo, K., Galli, M., Galli, S., Garbo, R., Garducci, S., Garg, S., Gavrielatos, G., Gensch, J., Giacchi, G., Giunio, L., Giustino, G., Goldberg, L., Goldsmit, R., Gommeaux, A., Gosselin, G., Govorov, A., Gonzalez Godinez, H., Gross, E., Grosz, C., Guagliumi, G., Hadad, W., Hadadi, L., Hansen, P. R., Harb, S., Hatrick, R., Hayrapetyan, H. G., Hernandez-Enriquez, M., Ho Heo, J., Horvath, I. G., Huan Loh, P., Ibrahim, A. M., Ierna, S., Ilic, I., Imperadore, F., Ionescu-Silva, E., Jacksch, R., James, S., Janiak, B., Jensen, S. E., Jeroen, S., Jugessur, R. K., Kala, P., Kambis, M., Kanakakis, J., Karamasis, G., Karchevsky, D., Karpovskiy, A., Kayaert, P., Kedev, S., Kemala, E., Ketteler, T., Khan, S. Q., Kharlamov, A., Kiernan, T., Kiviniem, T., Koltowski, L., Koskinas, K. C., Kouloumpinis, A., Kraaijeveld, A. O., Krizanic, F., Krotz, B., Kuczmik, W., Kukreja, N., Kuksa, D., Yav, K., Kyriakos, D., Labrunie, A., Laine, M., Lapin, O., Larosa, C., Latib, A., Lattuca, B., Lauer, B., Lefevre, T., Legrand, V., Lehto, P., Leiva-Pons, J. L., Leone, A. M., Lev, G., Lim, R., Limbruno, U., Linares Vicente, J. A., Lindsay, S., Linnartz, C., Liso, A., Lluberas, R., Locuratolo, N., Lokshyn, S., Lunde, K., Lupi, A., Magnavacchi, P., Maia, F., Mainar, V., Mancone, M., Manolios, M. G., Mansour, S., Mariano, E., Marques, K., Martins, H., Mckenzie, D., Meco, S., Meemook, K., Mehmed, K., Melikyan, A., Mellwig, K. P., Mendiz, O. A., Merkulov, E., Mesquita, H. G., Mezzapelle, G., Miloradovic, V., Mohamed, S., Mohammed, B., Mohammed, F., Mohammed, K., Mohanad, A., Morawiec, B., More, R., Moreno-Martinez, F. L., Mrevlje, B., Muhammad, F., Naveri, H., Nazzaro, M. S., Neary, P., Negus, B. H., Nelson Durval, F. G., Nick, H., Nilva, E., Oldroyd, K. G., Olivares Asencio, C., Omerovic, E., Ortiz, M. A., Ota, H., Otasevic, P., Otieno, H. A., Paizis, I., Papp, E., Pasquetto, G., Patsourakos, N. G., Peels, J., Pelliccia, F., Pennacchi, M., Penzo, C., Perez, P., Perkan, A., Petrou, E., Phipathananunth, W., Pierri, A., Pinheiro, L. F., Pipa, J. L., Piva, T., Polad, J., Porto, I., Poveda, J., Predescu, L., Prog, R., Puri, R., Raco, D. L., Ramazan, O., Ramazzotti, V., Rao, S. V., Raungaard, B., Reczuch, K., Rekik, S., Rhouati, A., Rigattieri, S., Rodriguez-Olivares, R., Roik, M., Romagnoli, E., Roman, A. J., Routledge, H., Rubartelli, P., Rubboli, A., Ruiz-Garcia, J., Russo, F., Ruzsa, Z., Ryding, A., Saad, A., Sabate, M., Sabouret, P., Sadowski, M., Saia, F., Sanchez Perez, I., Santoro, G. M., Sarenac, D., Saririan, M., Sarma, J., Schuetz, T., Sciahbasi, A., Sebastian, M., Sebik, R., Sesana, M., Hur, S. -H., Sganzerla, P., Shalva, R., Sharma, S., Sheiban, I., Shein, K. K., Shiekh, I. A., Sinha, M., Slhessarenko, J., Smith, D., Smyth, D. W., Sonmez, K., Sood, N., Sourgounis, A., Srdanovic, I., Stables, R. H., Stefanini, G. G., Stewart, J., Stoyanov, N., Suliman, A. A., Suryadevara, R., Suwannasom, P., Tange Veien, K., Tauchert, S., Tebet, M., Testa, L., Thury, A., Tilsted, H. H., Tiroch, K., Torres, A., Tosi, P., Traboulsi, M., Trani, C., Tresoldi, S., Tsigkas, G., Tueller, D., Turri, M., Udovichenko, A. E., Uretsky, B., Van Der Harst, P., Van Houwelingen, K. G., Vandoni, P., Vandormael, M., Varbella, F., Venkitachalam, C. G., Vercellino, M., Vidal-Perez, R., Vigna, C., Vignali, L., Vogt, F., Voudris, V., Vranckx, P., Vrolix, M., Vydt, T., Webster, M., Wijns, W., Woody, W., Wykrzykowska, J., Yazdani, S., Yildiz, A., Yurlevich, D., Zauith, R., Zekanovic, D., Zhao, M., Zimarino, M., Zingarelli, A., Abdelsamad, A. Y., Abo Shaera, E. S., Afshar, M. S., Agatiello, C., Aguiar, P., Ahmad, A. M., Akin, I., Alameda, M., Alegria-Barrero, E., Alejos, R., Alkhashab, K., Alkutshan, R. S. A., Almorraweh, A., Altnji, I., Alvarez Iorio, C., Anchidin, O., Angel, J., Antonopoulos, A., Apshilava, G., Arana, C., Ashikaga, T., Assomull, R., Atef, S. Z., Azmus, A. D., Azzalini, L., Azzouz, A., Baglioni, P., Bampas, G., Basil, M. P., Besh, D., Bhushan Sharm, A., Bien Hsien, H., Bihui, L., Bing-Chen, L., Biryukov, S., Blatt, A., Bocchi, E., Boghdady, A., Bonarjee, V. V. S., Bosnjak, I., Bravo Baptista, S., Brinckman, S. L., Buchter, B., Burzotta, F., Cacucci, M., Cagliyan, C. E., Cernetti, C., Chavez Mizraym, R., Choo, W. S., Choudhury, R., Cicco, N., Cisneros Clavijo, P., Citaku, H., Collet, J. P., Consuegra-Sanchez, L., Conte, M., Corral, J. M., Damonte, A., Dangoisse, V., Dastani, M., Della Rosa, F., Deora, S., Devadathan, S., Dharma, S., Di Giorgio, A., Diez, J. L., Dinesha, B., Duplancic, D., El Behwashi, M. F., Elghawaby, H., Elshahawy, O., Eskola, M. J., Etman, A., Eun Gyu, L., Fabiano, L., Facta, A., Fan, Y., Fang-Yang, H., Farag, E., Fathi, Y., Fazeli, N., Federico, P., Fereidoun, M. Z., Fernandez-Nofrerias, E., Flensted Lassen, J., Flessas, D., Fouad, H., Franco-Pelaez, J. A., Fu, Q., Furtado, R., Gadepalli, R., Gallino, R., Gasparetto, V., Gentiletti, A., Gholoobi, A., Ghosh, A. K., Gkizas, S., Golchha, S. K., Goncharov, A., Gossl, M., Gotberg, M., Greco, F., Grundeken, M. J., Gupta, D., Gupta, S., Guray, U., Hahalis, G., Hakim Vista, J., Hamid, M. A., Hammoudeh, A., Hasan, A. R. I., Hatsumura, F. E., Heintzen, M. P., Helal, T., Hetherington, S., Hewarathna, U. I., Hioki, H., Hissein, F., Ho-Ping, Y., Homs, S., Huber, K., Ibarra, F. M., Ielasi, A., Ipek, E., Jambunathan, R., Jamshidi, P., Jarrad, I., Javier, W., Jensen, J., Jimenez-Quevedo, P., Kalpak, O., Kan, J., Kanaan, T., Kao, D. H. M., Karamfiloff, K., Karegren, A., Karjalainen, P. P., Kasabov, R., Katsimagklis, G. D., Kaul, U., Khan, A., Kiemeneij, E., Kiviniemi, T., Kleiban, A., Komiyama, N., Konteva, M., Koshy, G., Krepsky, A. M., Kuljit, S., Kulkarni, P., Kumar, V., Kuznetsov, I., Lai, G., Lateef, M. A., Lawand, S., Le Hong, T., Lettieri, C., Levy, G., Lindvall, P., Maitra, A., Makowski, M., Mamas, M. A., Mandal, S. C., Mangalanandan, P., Marin, R., Mashhadi, M., Matsukage, T., Meier, B., Milosavljevic, B., Miro, S. S., Mitov, A., Moeriel, M., Moguel, R., Mohanty, A., Montalescot, G., Morsdorf, W., Moscato, F., Muniz, A., Muraglia, S., Myc, J., Nada, A., Nair, P., Namazi, M. H., Naraghipour, F., Nguyen, Q. N., Nicosia, A., Nikas, D., Ober, M., Ocaranza-Sanchez, R., Olivecrona, G., Pahlajani, D., Pandey, B. P., Parma, A., Parma, R., Patsilinakos, S. P., Pattam, J., Peddi, S., Perez, P. R., Peruga, J. Z., Pescoller, F., Petrov, I., Piatti, L., Pico-Aracil, F., Pina, J., Piroth, Z., Popa, V., Pourbehi, M. R., Pradhan, A. K., Prida, X. E., Purohit, B. V., Pyun, W. B., Quang Hung, D., Rada, I., Rafizadeh, O., Rahman, M. A., Rai, L., Ramsewak, A., Ravindran, R., Rodriguez De Leiras, O. S., Rodriguez Esteban, M., Roque Figueira, H., Saket, A., Sakhov, O., Saktheeswaran, M. K., Salachas, A., Sallam, A., Sampaolesi, A., Samy, A., Sanchis, J., Santaera, O., Santarelli, A., Santharaj, W. S., Sarango, B., Satheesh, S., Schmitz, T., Schuhlen, H., Seewoosagur, R., Segev, A., Seisembekov, V., Semitko, S., Sengottuvelu, G., Sepulveda Varela, P., Sethi, A., Sharma, A., Sharma, R. K., Shi, Hy., Simsek, M. A., Siqueira, B., Skalidis, E., Slawin, J., Sorokhtey, L., Spaulding, C., Srinivas, B., Srinivasan, M., Stakos, D., Stojkovic, S., Tacoy, G., Tawade, M., Tiecco, F., Tondi, S., Torresani, E. M., Tousek, P., Tran, T., Trantalis, G., Triantafyllou, K., Trivedi, R., Trivisonno, A., Tsui, K. L., Turkoglu, C., Tzung-Dau, W., Ueno, H., Urban, U., Uretsky, B. F., Uscumlic, A., Venugopal, V., Verney, R., Vilar, J. V., Villacorta, V. G., Vishwanath, R., Vlachojannis, G. J., Vlachojannis, M., Vlad, V., Von Birgelen, C., Vukcevic, V., Wahab, A., Waksman, R., Wei-Wen, L., Weisz, G., Whittaker, A., Yadav, A., Yokoi, Y., Zacharoulis, A., Zahran, M., Zamani, J., Ziakas, A., Zimmermann, J. P., and Cardiology

Subjects
Hirudin, Percutaneous, Antithrombin, medicine.medical_treatment, Psychological intervention, 030204 cardiovascular system & hematology, medical, 0302 clinical medicine, Peptide Fragment, Surveys and Questionnaires, Surveys and Questionnaire, Medicine, Bivalirudin, 030212 general & internal medicine, Societies, Medical, Transradial, Anticoagulant, Hirudins, Middle Aged, Recombinant Protein, Recombinant Proteins, Femoral Artery, Radial Artery, Cardiology, acute coronary syndrome, bivalirudin, transradial, adult, antithrombins, cardiology, femoral artery, hirudins, humans, middle aged, peptide fragments, percutaneous coronary intervention, recombinant proteins, societies, medical, surveys and questionnaires, attitude of health personnel, radial artery, Acute coronary syndrome, Cardiology and Cardiovascular Medicine, Human, medicine.drug, Adult, medicine.medical_specialty, Attitude of Health Personnel, medicine.drug_class, MEDLINE, Antithrombins, 03 medical and health sciences, societies, Percutaneous Coronary Intervention, Internal medicine, Humans, Acute Coronary Syndrome, Peptide Fragments, Management of acute coronary syndrome, business.industry, Percutaneous coronary intervention, medicine.disease, business
Abstract

AIMS Our aim was to report on a survey initiated by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) collecting the opinion of the cardiology community on the invasive management of acute coronary syndrome (ACS), before and after the MATRIX trial presentation at the American College of Cardiology (ACC) 2015 Scientific Sessions. METHODS AND RESULTS A web-based survey was distributed to all individuals registered on the EuroIntervention mailing list (n=15,200). A total of 572 and 763 physicians responded to the pre- and post-ACC survey, respectively. The radial approach emerged as the preferable access site for ACS patients undergoing invasive management with roughly every other responder interpreting the evidence for mortality benefit as definitive and calling for a guidelines upgrade to class I. The most frequently preferred anticoagulant in ACS patients remains unfractionated heparin (UFH), due to higher costs and greater perceived thrombotic risks associated with bivalirudin. However, more than a quarter of participants declared the use of bivalirudin would increase after MATRIX. CONCLUSIONS The MATRIX trial reinforced the evidence for a causal association between bleeding and mortality and triggered consensus on the superiority of the radial versus femoral approach. The belief that bivalirudin mitigates bleeding risk is common, but UFH still remains the preferred anticoagulant based on lower costs and thrombotic risks.

Published
2016
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37. Impact on clinical outcomes of right ventricular response to percutaneous correction of secondary mitral regurgitation

Author

Caiffa, T, primary, Castrichini, M, additional, Biagini, E, additional, De Luca, A, additional, Compagnone, M, additional, Berardini, A, additional, Merlo, M, additional, Fabris, E, additional, Vitrella, G, additional, Pinamonti, B, additional, Korcova, R, additional, Barbati, G, additional, Saia, F, additional, Stolfo, D, additional, and Sinagra, G, additional

Published
2021
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38. Prognostic value of pulmonary artery diameter in patients with pulmonary arterial hypertension

Author

Zuffa, E, primary, Dardi, F, additional, Saia, F, additional, Niro, F, additional, Palazzini, M, additional, Russo, V, additional, Taglieri, N, additional, Lovato, L, additional, De Lorenzis, A, additional, Pasca, F, additional, Guarino, D, additional, Magnani, I, additional, Marrozzini, C, additional, Manes, A, additional, and Galie, N, additional

Published
2020
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40. Incidence, mechanisms and clinical impact of largely uncovered struts in current generation drug-eluting-stents: insight from the TRANSFORM-OCT Study

Author

Bernelli, C, primary, Pellegrini, D, additional, Pescetelli, I, additional, Garbo, R, additional, Sirbu, V, additional, Fiocca, L, additional, Canova, P, additional, Colombo, F, additional, Cereda, A, additional, Boccuzzi, G, additional, Rodriguez Pereira, G.T, additional, Bezerra, H, additional, Saia, F, additional, Capodanno, D, additional, and Guagliumi, G, additional

Published
2020
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41. 3 Impact of morbid obesity and obesity phenotype on outcomes post transcatheter aortic valve replacement

Author

McInerney, A, primary, Tirado-Conte, G, additional, Rodes-Cabau, J, additional, Campelo-Parada, F, additional, Tafur Soto, JD, additional, Barbanti, M, additional, Muñoz-Garcia, E, additional, Arif, M, additional, Lopez, D, additional, Toggweiler, S, additional, Veiga, G, additional, Pylko, A, additional, Sevilla, T, additional, Compagnone, M, additional, Regueiro, A, additional, Serra, V, additional, Carnero, M, additional, Oteo, JF, additional, Rivero, F, additional, Barbosa Ribeiro, H, additional, Guimaraes, L, additional, Matta, A, additional, Giraldo Echavarria, N, additional, Valvo, R, additional, Moccetti, F, additional, Muñoz-Garcia, AJ, additional, Lopez-Pais, J, additional, Garcia del Blanco, B, additional, Carter Campanha Borges, D, additional, Gonzalo, N, additional, Dumont, E, additional, Criscione, E, additional, Dabrowski, M, additional, Alfonso, F, additional, de la Torre Hernández, JM, additional, Cheema, AN, additional, Amat-Santos, I, additional, Saia, F, additional, Escaned, J, additional, and Nombela-Franco, L, additional

Published
2020
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42. A strategic roadmap of the Italian Society of Interventional Cardiology (SICI-GISE) to ensure patient's access to appropriate treatment

Author

Tarantini G., Musumeci G., Esposito Giovanni, Mauro C., La Manna A. G., Limbruno U., Tarantino F. F., Castiglioni B., Rigattieri S., Longoni M., Marchese A., Masiero G., Mattesini A., Berti S., Saia F., Tarantini, G., Musumeci, G., Esposito, Giovanni, Mauro, C., La Manna, A. G., Limbruno, U., Tarantino, F. F., Castiglioni, B., Rigattieri, S., Longoni, M., Marchese, A., Masiero, G., Mattesini, A., Berti, S., and Saia, F.

Published
2019

43. Prognostic Value of Pulmonary Artery Diameter in Patients with Pulmonary Arterial Hypertension

Author

Dardi, F., primary, Saia, F., additional, Niro, F., additional, Palazzini, M., additional, Donato, F., additional, Russo, V., additional, Taglieri, N., additional, Lovato, L., additional, Zuffa, E., additional, De Lorenzis, A., additional, Pasca, F., additional, Guarino, D., additional, Magnani, I., additional, Rotunno, M., additional, Ballerini, A., additional, Marrozzini, C., additional, Manes, A., additional, and Galiè, N., additional

Published
2020
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44. A Multidisciplinary Approach on the Perioperative Antithrombotic Management of Patients With Coronary Stents Undergoing Surgery: Surgery After Stenting 2

Author

Rossini, R, Tarantini, G, Musumeci, G, Masiero, G, Barbato, E, Calabrò, P, Capodanno, D, Leonardi, S, Lettino, M, Limbruno, U, Menozzi, A, Marchese, U, Saia, F, Valgimigli, M, Ageno, W, Falanga, A, Corcione, A, Locatelli, A, Montorsi, M, Piazza, D, Stella, A, Bozzani, A, Parolari, A, Carone, R, Angiolillo, D, Rossini R, Tarantini G, Musumeci G, Masiero G, Barbato E, Calabrò P, Capodanno D, Leonardi S, Lettino M, Limbruno U, Menozzi A, Marchese UOA, Saia F, Valgimigli M, Ageno W, Falanga A, Corcione A, Locatelli A, Montorsi M, Piazza D, Stella A, Bozzani A, Parolari A, Carone R, Angiolillo DJ, Rossini, R, Tarantini, G, Musumeci, G, Masiero, G, Barbato, E, Calabrò, P, Capodanno, D, Leonardi, S, Lettino, M, Limbruno, U, Menozzi, A, Marchese, U, Saia, F, Valgimigli, M, Ageno, W, Falanga, A, Corcione, A, Locatelli, A, Montorsi, M, Piazza, D, Stella, A, Bozzani, A, Parolari, A, Carone, R, Angiolillo, D, Rossini R, Tarantini G, Musumeci G, Masiero G, Barbato E, Calabrò P, Capodanno D, Leonardi S, Lettino M, Limbruno U, Menozzi A, Marchese UOA, Saia F, Valgimigli M, Ageno W, Falanga A, Corcione A, Locatelli A, Montorsi M, Piazza D, Stella A, Bozzani A, Parolari A, Carone R, and Angiolillo DJ

Abstract

Perioperative management of antithrombotic therapy in patients treated with coronary stents undergoing surgery remains poorly defined. Importantly, surgery represents a common reason for premature treatment discontinuation, which is associated with an increased risk in mortality and major adverse cardiac events. However, maintaining antithrombotic therapy to minimize the incidence of perioperative ischemic complications may increase the risk of bleeding complications. Although guidelines provide some recommendations with respect to the perioperative management of antithrombotic therapy, these have been largely developed according to the thrombotic risk of the patient and a definition of the hemorrhagic risk specific to each surgical procedure, key to defining the trade-off between ischemia and bleeding, is not provided. These observations underscore the need for a multidisciplinary collaboration among cardiologists, anesthesiologists, hematologists and surgeons to reach this goal. The present document is an update on practical recommendations for standardizing management of antithrombotic therapy management in patients treated with coronary stents (Surgery After Stenting 2) in various types of surgery according to the predicted individual risk of thrombotic complications against the anticipated risk of surgical bleeding complications. Cardiologists defined the thrombotic risk using a “combined ischemic risk” approach, while surgeons classified surgeries according to their inherent hemorrhagic risk. Finally, a multidisciplinary agreement on the most appropriate antithrombotic treatment regimen in the perioperative phase was reached for each surgical procedure.

Published
2018

45. Coronary artery disease and reasonably incomplete coronary revascularization in high-risk patients undergoing transcatheter aortic valve implantation

Author

Saia F., Palmerini T., Compagnone M., Battistini P., Moretti C., Taglieri N., Bruno A. G., Ghetti G., Corsini A., Bacchi Reggiani M. -L., Marrozzini C., Rapezzi C., Marcelli C., PALMERINI, TULLIO, Policlinico S. Orsola-malpighi, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Servizio sanitario regionale Emilia-Romagna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Mobilités : Vieillissement, Pathologie, Santé (COMETE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Saia F., Palmerini T., Compagnone M., Battistini P., Moretti C., Taglieri N., Marcelli C., Bruno A.G., Ghetti G., Corsini A., Bacchi Reggiani M.-L., Marrozzini C., and Rapezzi C.

Subjects
Male, Time Factors, coronary artery disease, heart team, revascularization, transcatheter aortic valve replacement, Databases, Factual, medicine.medical_treatment, [SDV]Life Sciences [q-bio], [SHS.PSY]Humanities and Social Sciences/Psychology, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Ventricular Function, Left, Coronary artery disease, 0302 clinical medicine, Risk Factors, Myocardial Revascularization, Prevalence, 030212 general & internal medicine, Hospital Mortality, Registries, Aged, 80 and over, Ejection fraction, Incidence (epidemiology), General Medicine, 3. Good health, Prosthesis Failure, Treatment Outcome, Aortic Valve, Heart Valve Prosthesis, Cardiology, Female, Cardiology and Cardiovascular Medicine, Acute coronary syndrome, medicine.medical_specialty, Transcatheter aortic, Revascularization, Risk Assessment, NO, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, Internal medicine, Heart team, medicine, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Acute Coronary Syndrome, Aged, Retrospective Studies, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Stroke Volume, Aortic Valve Stenosis, medicine.disease, Coronary revascularization, business
Abstract

International audience; ObjectivesTo evaluate the long-term impact of coronary artery disease (CAD) and heart team-guided incomplete coronary revascularization in patients undergoing transcatheter aortic valve implantation (TAVI).BackgroundRevascularization strategy of CAD diagnosed with routine coronary angiography before TAVI is uncertain.MethodsFive hundred and forty consecutive TAVI patients were classified as having CAD or normal coronary arteries (no-CAD). Within the CAD group, patients were further classified as those with complete (CR) versus incomplete revascularization (IR). Revascularization strategy was guided by the Heart Team following an algorithm largely based on current guidelines. Main outcome of interest was the incidence of 5-year cardiovascular (CV) death.ResultsPrevalence of CAD was 53.9%. CAD patients showed significantly lower left ventricular ejection fraction (LVEF: 55.8 ± 13.4% CAD vs. 61.4% ± 12.1 no-CAD, p

Published
2018
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47. Coronary Protection to Prevent Coronary Obstruction During TAVR: A Multicenter International Registry

Author

Palmerini, T., Chakravarty, T., Saia, F., Bruno, A. G., Bacchi-Reggiani, M. -L., Marrozzini, C., Patel, C., Patel, V., Testa, L., Bedogni, F., Ancona, M., Montorfano, M., Chieffo, A., Olivares, P., Bartorelli, A. L., Buscaglia, A., Porto, I., Nickenig, G., Grube, E., Sinning, J. -M., De Carlo, M., Petronio, A. S., Barbanti, M., Tamburino, C., Iadanza, A., Burzotta, F., Trani, C., Fraccaro, C., Tarantini, G., Aranzulla, T. C., De Benedictis, M., Pagnotta, P., Stefanini, G. G., Miura, M., Taramasso, M., Kang, J. -H., Kim, H. -S., Codner, P., Kornowski, R., Pelliccia, F., Vignali, L., Taglieri, N., Ghetti, G., Leone, A., Galie, N., and Makkar, R.

Subjects
Male, Time Factors, Computed Tomography Angiography, Coronary Angiography, Prosthesis Design, Transcatheter Aortic Valve Replacement, Percutaneous Coronary Intervention, Risk Factors, coronary obstruction, stent thrombosis, transcatheter aortic valve replacement, 80 and over, Humans, Registries, Aged, Retrospective Studies, Aged, 80 and over, Aortic Valve, Coronary Stenosis, Female, Stents, Treatment Outcome, Coronary Vessels, Heart Valve Prosthesis, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE
Abstract

The aim of this study was to investigate the safety and efficacy of coronary protection by preventive coronary wiring and stenting across the coronary ostia in patients at high risk for coronary obstruction after transcatheter aortic valve replacement (TAVR).Coronary obstruction following TAVR is a life-threatening complication with high procedural and short-term mortality.Data were collected retrospectively from a multicenter international registry between April 2011 and February 2019.Among 236 patients undergoing coronary protection with preventive coronary wiring, 143 had eventually stents implanted across the coronary ostia after valve deployment. At 3-year follow-up, rates of cardiac death were 7.8% in patients receiving stents and 15.7% in those not receiving stents (adjusted hazard ratio: 0.42; 95% confidence interval: 0.14 to 1.28; p = 0.13). There were 2 definite stent thromboses (0.9%) in patients receiving stents, both occurring after TAVR in "valve-in-valve" procedures. In patients not receiving stents, there were 4 delayed coronary occlusions (DCOs) (4.3%), occurring from 5 min to 6 h after wire removal. Three cases occurred in valve-in-valve procedures and 1 in a native aortic valve procedure. Distance between the virtual transcatheter valve and the protected coronary ostia 4 mm was present in 75.0% of patients with DCO compared with 30.4% of patients without DCO (p = 0.19).In patients undergoing TAVR at high risk for coronary obstruction, preventive stent implantation across the coronary ostia is associated with good mid-term survival rates and low rates of stent thrombosis. Patients undergoing coronary protection with wire only have a considerable risk for DCO.

Published
2020

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