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Your search keyword '"Sahri, Helene"' showing total 5 results
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5 results on '"Sahri, Helene"'

1. Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)

Author

Press, Neil J., primary, Taylor, Roger J., additional, Fullerton, Joseph D., additional, Tranter, Pamela, additional, McCarthy, Clive, additional, Keller, Thomas H., additional, Arnold, Nicola, additional, Beer, David, additional, Brown, Lyndon, additional, Cheung, Robert, additional, Christie, Julie, additional, Denholm, Alastair, additional, Haberthuer, Sandra, additional, Hatto, Julia D. I., additional, Keenan, Mark, additional, Mercer, Mark K., additional, Oakman, Helen, additional, Sahri, Helene, additional, Tuffnell, Andrew R., additional, Tweed, Morris, additional, and Trifilieff, Alexandre, additional

Published
2015
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2. Solubility-Driven Optimization of Phosphodiesterase-4 Inhibitors Leading to a Clinical Candidate

Author

Press, Neil J., primary, Taylor, Roger J., additional, Fullerton, Joseph D., additional, Tranter, Pamela, additional, McCarthy, Clive, additional, Keller, Thomas H., additional, Arnold, Nicola, additional, Beer, David, additional, Brown, Lyndon, additional, Cheung, Robert, additional, Christie, Julie, additional, Denholm, Alastair, additional, Haberthuer, Sandra, additional, Hatto, Julia D. I., additional, Keenan, Mark, additional, Mercer, Mark K., additional, Oakman, Helen, additional, Sahri, Helene, additional, Tuffnell, Andrew R., additional, Tweed, Morris, additional, Tyler, John W., additional, Wagner, Trixie, additional, Fozard, John R., additional, and Trifilieff, Alexandre, additional

Published
2012
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3. A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential

Author

Press, Neil J., primary, Taylor, Roger J., additional, Fullerton, Joseph D., additional, Tranter, Pamela, additional, McCarthy, Clive, additional, Keller, Thomas H., additional, Brown, Lyndon, additional, Cheung, Robert, additional, Christie, Julie, additional, Haberthuer, Sandra, additional, Hatto, Julia D.I., additional, Keenan, Mark, additional, Mercer, Mark K., additional, Press, Nicola E., additional, Sahri, Helene, additional, Tuffnell, Andrew R., additional, Tweed, Morris, additional, and Fozard, John R., additional

Published
2005
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5. A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential

Author

Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Brown, Lyndon, Cheung, Robert, Christie, Julie, Haberthuer, Sandra, Hatto, Julia D.I., Keenan, Mark, Mercer, Mark K., Press, Nicola E., Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, and Fozard, John R.

Subjects
*ADENINE, *OBSTRUCTIVE lung diseases, *RESPIRATORY allergy, *ALLERGIES
Abstract

Abstract: The synthesis and SAR of 5-heterocycle-substituted aminothiazole adenosine receptor antagonists is described. Several compounds show high affinity and selectivity for the A2B and A3 receptors. One compound (5f) shows good ADME properties in the rat and as such may be an important new compound in testing the current hypotheses proposing a therapeutic role for a dual A2B/A3 antagonist in allergic diseases. [Copyright &y& Elsevier]

Published
2005
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