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416 results on '"Sahlas, Demetrios"'

1. Derivation of a clinical prediction score for the diagnosis of clinically significant symptomatic carotid artery disease

Author

Abdulaziz, Kasim E., Taljaard, Monica, Dowlatshahi, Dar, Stiell, Ian G., Wells, George A., Sivilotti, Marco L. A., Émond, Marcel, Sharma, Mukul, Stotts, Grant, Lee, Jacques, Worster, Andrew, Morris, Judy, Cheung, Ka Wai, Jin, Albert Y., Sahlas, Demetrios J., Murray, Heather E., MacKey, Ariane, Verreault, Steve, Camden, Marie-Christine, Yip, Samuel, Teal, Philip, Gladstone, David J., Boulos, Mark I., Chagnon, Nicolas, Shouldice, Elizabeth, Atzema, Clare L., Slaoui, Tarik, Teitlebaum, Jeanne, and Perry, Jeffrey J.

Published
2024
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2. Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke

Author

Yu, Di, Liang, Nuanyi, Zebarth, Julia, Shen, Qing, Ozzoude, Miracle, Goubran, Maged, Rabin, Jennifer S, Ramirez, Joel, Scott, Christopher JM, Gao, Fuqiang, Bartha, Robert, Symons, Sean, Haddad, Seyyed Mohammad Hassan, Berezuk, Courtney, Tan, Brian, Kwan, Donna, Hegele, Robert A, Dilliott, Allison A, Nanayakkara, Nuwan D, Binns, Malcolm A, Beaton, Derek, Arnott, Stephen R, Lawrence‐Dewar, Jane M, Hassan, Ayman, Dowlatshahi, Dar, Mandzia, Jennifer, Sahlas, Demetrios, Casaubon, Leanne, Saposnik, Gustavo, Otoki, Yurika, Lanctôt, Krista L, Masellis, Mario, Black, Sandra E, Swartz, Richard H, Taha, Ameer Y, Swardfager, Walter, Rashkovan, Natalie, Abrahao, Agessandro, Zinman, Lorne, Bonnick, Alisia, Scott, Christopher, Holmes, Melissa, Adamo, Sabrina, Freedman, Morris, Zamyadi, Mojdeh, Arnott, Stephen, Binns, Malcolm, Raamana, Pradeep, Strother, Stephen, Sunderland, Kelly, Theyers, Athena, Uthirakumaran, Abiramy, Levine, Brian, Troyer, Angela, Strong, Michael, Kleinstiver, Peter, Borrie, Michael, Finger, Elizabeth, Shoesmith, Christen, Faria, Frederico, Montero‐Odasso, Manuel, Sarquis‐Adamson, Yanina, Black, Alanna, Dilliott, Allison Ann, Hegele, Rob, Robinson, John, Farhan, Sali, Bartha, Rob, Haddad, Hassan, Nanayakkara, Nuwan, Zou, Guangyong, Pasternak, Stephen, Orange, JB, Roberts, Angela, Jog, Mandar, Seitz, Dallas, Brien, Don, Chen, Ying, Coe, Brian, Munoz, Doug, McLaughlin, Paula, Peltsch, Alicia, Bronskill, Susan, Lou, Wendy, Kumar, Sanjeev, Pollock, Bruce, Rajji, Tarek, Tang‐Wai, David, and Tartaglia, Carmela

Subjects
Biomedical Imaging, Stroke, Brain Disorders, Neurosciences, Humans, Linoleic Acid, Oxylipins, Epoxide Hydrolases, Cerebral Small Vessel Diseases, Magnetic Resonance Imaging, Atrophy, Water, lacunar stroke, oxylipin, small vessel disease, soluble epoxide hydrolase, white matter hyperintensity, ONDRI Investigators [Link], Cardiorespiratory Medicine and Haematology
Abstract

Background Cerebral small vessel disease is associated with higher ratios of soluble-epoxide hydrolase derived linoleic acid diols (12,13-dihydroxyoctadecenoic acid [DiHOME] and 9,10-DiHOME) to their parent epoxides (12(13)-epoxyoctadecenoic acid [EpOME] and 9(10)-EpOME); however, the relationship has not yet been examined in stroke. Methods and Results Participants with mild to moderate small vessel stroke or large vessel stroke were selected based on clinical and imaging criteria. Metabolites were quantified by ultra-high-performance liquid chromatography-mass spectrometry. Volumes of stroke, lacunes, white matter hyperintensities, magnetic resonance imaging visible perivascular spaces, and free water diffusion were quantified from structural and diffusion magnetic resonance imaging (3 Tesla). Adjusted linear regression models were used for analysis. Compared with participants with large vessel stroke (n=30), participants with small vessel stroke (n=50) had a higher 12,13-DiHOME/12(13)-EpOME ratio (β=0.251, P=0.023). The 12,13-DiHOME/12(13)-EpOME ratio was associated with more lacunes (β=0.266, P=0.028) but not with large vessel stroke volumes. Ratios of 12,13-DiHOME/12(13)-EpOME and 9,10-DiHOME/9(10)-EpOME were associated with greater volumes of white matter hyperintensities (β=0.364, P

Published
2023

3. White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

Author

Ozzoude, Miracle, Varriano, Brenda, Beaton, Derek, Ramirez, Joel, Adamo, Sabrina, Holmes, Melissa F., Scott, Christopher J. M., Gao, Fuqiang, Sunderland, Kelly M., McLaughlin, Paula, Goubran, Maged, Kwan, Donna, Roberts, Angela, Bartha, Robert, Symons, Sean, Tan, Brian, Swartz, Richard H., Abrahao, Agessandro, Saposnik, Gustavo, Masellis, Mario, Lang, Anthony E., Marras, Connie, Zinman, Lorne, Shoesmith, Christen, Borrie, Michael, Fischer, Corinne E., Frank, Andrew, Freedman, Morris, Montero-Odasso, Manuel, Kumar, Sanjeev, Pasternak, Stephen, Strother, Stephen C., Pollock, Bruce G., Rajji, Tarek K., Seitz, Dallas, Tang-Wai, David F., Turnbull, John, Dowlatshahi, Dar, Hassan, Ayman, Casaubon, Leanne, Mandzia, Jennifer, Sahlas, Demetrios, Breen, David P., Grimes, David, Jog, Mandar, Steeves, Thomas D. L., Arnott, Stephen R., Black, Sandra E., Finger, Elizabeth, Rabin, Jennifer, and Tartaglia, Maria Carmela

Published
2023
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4. A Multicentre Prospective Cohort Study to Identify High-Risk Transient Ischemic Attack/Minor Stroke Patients Benefitting from Echocardiography

Author

Perry, Jeffrey J., Alsadoon, Abdulaziz, Nemnom, Marie-Joe, Sivilotti, Marco L.A., Émond, Marcel, Stiell, Ian G., Stotts, Grant, Lee, Jacques S., Worster, Andrew, Morris, Judy, Cheung, Ka Wai, Jin, Albert Y., Sahlas, Demetrios J., Murray, Heather E., Mackey, Ariane, Verreault, Steve, Camden, Marie-Christine, Yip, Samuel, Teal, Philip, Gladstone, David J., Boulos, Mark I., Chagnon, Nicolas, Shouldice, Elizabeth, Atzema, Clare, Slaoui, Tarik, Teitelbaum, Jeanne, Giannakakis, Sophia-Maria, Thiruganasambandamoorthy, Venkatesh, Dowlatshahi, Dar, Wells, George A., and Sharma, Mukul

Published
2024
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5. Risk of stroke is low after transient ischemic attack presentation with isolated dizziness

Author

Bery, Anand K., Sharma, Mukul, Nemnom, Marie-Joe, Johns, Peter, Lelli, Daniel A., Sivilotti, Marco L. A., Émond, Marcel, Stiell, Ian G., Stotts, Grant, Lee, Jacques, Worster, Andrew, Morris, Judy, Cheung, Ka Wai, Jin, Albert Y., Oczkowski, Wieslaw J., Sahlas, Demetrios J., Murray, Heather E., Mackey, Ariane, Verreault, Steve, Camden, Marie-Christine, Yip, Samuel, Teal, Philip, Gladstone, David J., Boulos, Mark I., Chagnon, Nicolas, Shouldice, Elizabeth, Atzema, Clare, Slaoui, Tarik, Teitelbaum, Jeanne, Wells, George A., and Perry, Jeffrey J.

Published
2022
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6. Abstract 13954: The Canadian Tia Score as a Predictor of Ischemic Lesion on Magnetic Resonance Imaging in Transient Ischemic Attack or Minor Stroke Following a Negative Computed Tomography Scan

Author

Robitaille, Matthieu, Sharma, Mukul, Emond, Marcel, Mackey, Ariane, Blanchard, Pierre-Gilles, Nemnom, Marie-Joe, Sivilotti, Marco, STIELL, Ian, Stotts, Grant, Lee, Jacques, Worster, Andrew, Morris, Judy, Cheung, Ka Wai, Jin, Albert, Oczkowski, Wieslaw J, Sahlas, Demetrios, Murray, Heather, Verreault, Steve, Camden, Marie-Christine, Yip, Samuel, Teal, Philip A, GLADSTONE, David J, Boulos, Mark, Chagnon, Nicholas, Shouldice, Elizabeth, Atzema, Clare, Slaoui, Tarik, Teitelbaum, Jeanne S, Wells, George A, and Perry, Jeffrey J

Published
2023
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7. Language discordance as a marker of disparities in cerebrovascular risk and stroke outcomes: A multi-center Canadian study

Author

Muir, Ryan T., Kapoor, Arunima, Cayley, Megan L., Sicard, Michelle N, Lien, Karen, Southwell, Alisia, Dowlatshahi, Dar, Sahlas, Demetrios J., Saposnik, Gustavo, Mandzia, Jennifer, Casaubon, Leanne K., Hassan, Ayman, Perez, Yael, Selchen, Daniel, Murray, Brian J., Lanctot, Krista, Kapral, Moira K., Herrmann, Nathan, Strother, Stephen, Yu, Amy．Y．X, Austin, Peter C., Bronskill, Susan E., and Swartz, Richard H.

Published
2023
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8. Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases

Author

Ozzoude, Miracle, Varriano, Brenda, Beaton, Derek, Ramirez, Joel, Holmes, Melissa F., Scott, Christopher J. M., Gao, Fuqiang, Sunderland, Kelly M., McLaughlin, Paula, Rabin, Jennifer, Goubran, Maged, Kwan, Donna, Roberts, Angela, Bartha, Robert, Symons, Sean, Tan, Brian, Swartz, Richard H., Abrahao, Agessandro, Saposnik, Gustavo, Masellis, Mario, Lang, Anthony E., Marras, Connie, Zinman, Lorne, Shoesmith, Christen, Borrie, Michael, Fischer, Corinne E., Frank, Andrew, Freedman, Morris, Montero-Odasso, Manuel, Kumar, Sanjeev, Pasternak, Stephen, Strother, Stephen C., Pollock, Bruce G., Rajji, Tarek K., Seitz, Dallas, Tang-Wai, David F., Turnbull, John, Dowlatshahi, Dar, Hassan, Ayman, Casaubon, Leanne, Mandzia, Jennifer, Sahlas, Demetrios, Breen, David P., Grimes, David, Jog, Mandar, Steeves, Thomas D. L., Arnott, Stephen R., Black, Sandra E., Finger, Elizabeth, and Tartaglia, Maria Carmela

Published
2022
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9. Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment

Author

Yu, Di, Hennebelle, Marie, Sahlas, Demetrios J, Ramirez, Joel, Gao, Fuqiang, Masellis, Mario, Cogo-Moreira, Hugo, Swartz, Richard H, Herrmann, Nathan, Chan, Pak Cheung, Pettersen, Jacqueline A, Stuss, Donald T, Black, Sandra E, Taha, Ameer Y, and Swardfager, Walter

Subjects
Aged, Biomarkers, Cerebral Ventricles, Cognitive Dysfunction, Cross-Sectional Studies, Epoxide Hydrolases, Female, Humans, Linoleic Acid, Male, Oxylipins, Vascular Diseases, White Matter, Small vessel disease, Vascular cognitive impairment, Soluble epoxide hydrolase, Linoleic acid, Clinical Sciences, Neurosciences, Public Health and Health Services
Abstract

White matter hyperintensities (WMH) are presumed to indicate subcortical ischemic vascular disease but their underlying pathobiology remains incompletely understood. The soluble epoxide hydrolase (sEH) enzyme converts anti-inflammatory and vasoactive cytochrome p450-derived polyunsaturated fatty acid epoxides into their less active corresponding diol species. Under the hypothesis that the activity of sEH might be associated with subcortical ischemic vascular disease and vascular cognitive impairment, this study aimed to compare the relative abundance of sEH substrates and products in peripheral blood between patients with extensive WMH (discovered due to transient ischemic attack; n = 29) and healthy elderly with minimal WMH (n = 25). The concentration of 12,13-DiHOME (a sEH-derived linoleic acid metabolite), and the ratio of 12,13-DiHOME to its sEH substrate, 12,13-EpOME, were elevated in the extensive WMH group (F1,53 = 5.9, p = 0.019), as was the 9,10-DiHOME/9,10-EpOME ratio (F1,53 = 5.4, p = 0.024). The 12,13-DiHOME/12,13-EpOME ratio was associated with poorer performance on a composite score derived from tests of psychomotor processing speed, attention, and executive function (β = - 0.473, p = 0.001, adjusted r2 = 0.213), but not with a composite verbal memory score. In a mediation model, periventricular WMH (but not deep WMH), explained 37% of the effect of the 12,13-DiHOME/12,13-EpOME ratio on the speed/attention/executive function composite score (indirect effect = - 0.50, 95% bootstrap confidence interval [- 0.99, - 0.17] Z-score units). Serum oxylipin changes consistent with higher sEH activity were markers of vascular cognitive impairment, and this association was partly explained by injury to the periventricular subcortical white matter.

Published
2019

10. Increased brain volumetric measurement precision from multi-site 3D T1-weighted 3 T magnetic resonance imaging by correcting geometric distortions

Author

Nanayakkara, Nuwan D., Arnott, Stephen R., Scott, Christopher J.M., Solovey, Igor, Liang, Shuai, Fonov, Vladimir S., Gee, Tom, Broberg, Dana N., Haddad, Seyyed M.H., Ramirez, Joel, Berezuk, Courtney, Holmes, Melissa, Adamo, Sabrina, Ozzoude, Miracle, Theyers, Athena, Sujanthan, Sujeevini, Zamyadi, Mojdeh, Casaubon, Leanne, Dowlatshahi, Dar, Mandzia, Jennifer, Sahlas, Demetrios, Saposnik, Gustavo, Hassan, Ayman, Swartz, Richard H., Strother, Stephen C., Szilagyi, Gregory M., Black, Sandra E., Symons, Sean, Investigators, O.N.D.R.I., and Bartha, Robert

Published
2022
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11. Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Kang, Min Su, Adamo, Sabrina, Scott, Christopher, Ramirez, Joel, Swardfager, Walter, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert Jr, Noseworthy, Michael D, Prato, Frank S, Sahlas, Demetrios J, Smith, Eric E, Kuo, Phillip H, Chad, Jordan A, Pasternak, Ofer, Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E, and Goubran, Maged

Published
2023
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12. Predicting Cognitive Impairment in Cerebrovascular Disease Using Spoken Discourse Production

Author

Roberts, Angela, Aveni, Katharine, Basque, Shalane, Orange, Joseph B., McLaughlin, Paula, Ramirez, Joel, Troyer, Angela K., Gutierrez, Stephanie, Chen, Angie, Bartha, Robert, Binns, Malcolm A., Black, Sandra E., Casaubon, Leanne K., Dowlatshahi, Dar, Hassan, Ayman, Kwan, Donna, Levine, Brian, Mandzia, Jennifer, Sahlas, Demetrios J., Scott, Christopher J. M., Strother, Stephen, Sunderland, Kelly M., Symons, Sean, and Swartz, Richard

Abstract

Purpose: Dementia due to cerebrovascular disease (CVD) is common. Detecting early cognitive decline in CVD is critical because addressing risk factors may slow or prevent dementia. This study used a multidomain discourse analysis approach to determine the spoken language signature of CVD-related cognitive impairment. Method: Spoken language and neuropsychological assessment data were collected prospectively from 157 participants with CVD as part of the Ontario Neurodegenerative Disease Research Initiative, a longitudinal, observational study of neurodegenerative disease. Participants were categorized as impaired (n = 92) or cognitively normal for age (n = 65) based on neuropsychology criteria. Spoken language samples were transcribed orthographically and annotated for 13 discourse features, across five domains. Discriminant function analyses were used to determine a minimum set of discourse variables, and their estimated weights, for maximizing diagnostic group separation. Results: The optimal discriminant function that included 10 of 13 discourse measures correctly classified 78.3% of original cases (69.4% cross-validated cases) with a sensitivity of 77.2% and specificity of 80.0%. Conclusion: Spoken discourse appears to be a sensitive measure for detecting cognitive impairment in CVD with measures of productivity, information content, and information efficiency heavily weighted in the final algorithm. [This article was written with ONDRI Investigators.]

Published
2021
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13. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Author

Srivastava, Abhilekh, Aljammaz, Ahmed M, Akindotun, Akintomide Femi, Jin, Albert Y, Fraser, Alexander, Khaw, Alexander V, Lemnaru, Alexandru, Southwell, Alisia, Ramji, Alnar, Alvarado-Bolaños, Alonso, Mouminah, Amr, Lahlouh, Amro B, Yu, Amy Y, Alrohimi, Anas, Lavoie, Andre, Rogge, Andrea, Micieli, Andrew, Nguyen, Andrew Linh, Callaghan-Brown, Angelique, Florendo-Cumbermack, Anita, Wadhwa, Ankur, Beaudoin, Ann-Marie, Cayley, Anne, Liddy, Anne Marie, Trivedi, Anurag, Katsanos, Aristeidis H, Shuaib, Ashfaq, Butt, Asif Javed, Bereznyakova, Olena, Beauchamp, Beth, Mahlitz, Breane, Graham, Brett R, Dewar, Brian, Buck, Brian H, Durafourt, Bryce A, Holtby, Caitlin, Jackson-Tarlton, Caitlin S, Bockus, Caitlyn, Stephenson, Caroline, Galloway, Camille, Odier, Céline, Deacon, Charles, Zerna, Charlotte, Vekhande, Chetan C, Bocti, Christian, Stapf, Christian, Hawkes, Christine, Stables, Christine Anne, Bogiatzi, Chrysi, Rodriguez, Claudia, Candale-Radu, Claudia, Murphy, Colleen, Casserly, Courtney Sarah, Fok, Daniel, Boasquevisque, Danielle de Sa, Wile, Daryl, Volders, David, Sahlas, Demetrios J, Shand, Elaine, Cora, Elena Adela, Battista, Eliane Di, Stewart, Eileen, Junk, Emily, Harrison, Emma L, Frenette, Eric, Teleg, Ericka, Abdellah, Eslam, Ghrooda, Esseddeeg, Akthar, Farhana, Evoy, François, Klein, Gary M, Maclean, Genoveva, Jickling, Glen C, Hawthorne, Glenda, Boyd, Gordon, Walker, Gregory, Saposnik, Gustavo, Lau, H Lee, Badr, Hanan E, Toma, Hassanain, Kalashyan, Hayrapet, Marion-Moffet, Hugo, Grant, Ian, Fatakdawala, Idris, Beaulieu-Boire, Isabelle, Williams, Janice, Brar, Jaskiran, Rivest, Jean, Wang, Jeffrey Z, Dawe, Jessica, Stang, Jillian, Day, Joanne, Miller, Jodi, Gorman, Johnathon, Hopyan, Julia Jasmine, Lee, Julian, Kromm, Julie, Foster, Kaitlyn, Ratnayake, Kanchana, Perera, Kanjana S, Murray, Karina Villaluna, Ryckborst, Karla, Lin, Katie, Sage, Kayla, Sivakuma, Keithan, MacDonald, Kelly A, Ng, Kelvin Kuan, Merchant, Ketki, Khan, Khurshid, Ghavami, Kimia, Johnston, Kyra, Mai, Lauren M, White, Leah, Barratt, Lee, Longpre, Linda, Crellin, Lisa, Peeling, Lissa, Piquette, Lori, Lomax, Lysa Boissé, Sadeghi, Mahsa, Kamra, Maneesha, Lavoie-April, Manuel, Moores, Margaret, Bullrich, Maria Bres, McClelland, Marie, Salluzzi, Marina, Wilcox, Mark, Boulos, Mark I, Marko, Martha, Boyko, Matthew, Lantagne-Hurtubise, Maude, AlHamid, May Adel, Shawawrah, Mays, Kelly, Michael E, Thorne, Michael W D, Shamy, Michel, Bussiere, Miguel, Dominc Tse, Ming Yin, Benguzzi, Mowad, Sharma, Mukul, Horton, Myles, Newcommon, Nancy, Simon, Nandy-Shelwine, Parks, Natalie E, Sultan, Nazeem, Markovic, Nevena, Daneault, Nicole, Ishaque, Noman, Fairall, Paige, Kostyrko, Pawel B, Stys, Peter K, Teal, Philip, Couillard, Philippe, King-Azote, Princess, Collier, Quentin, Epp, Rachel, Nair, Radhika, Joundi, Raed A, Jassal, Rajive, Schneider, Raphael, Hosseini, Reza, Bouchard, Rosalie, Whelan, Ruth, Cooley, S Regan, Sujanthan, Sajeevan, Mansoor, Salman, Yip, Samuel, Wasyliw, Sanchea, Taylor, Sean W., Friedman, Sebastian, Mann, Sharan, Maley, Sharleen Weese, Chiasson, Sherry, Hu, Sherry Xueying, Althubait, Shorog, Himed, Shuhira, Chen, Shuo, Bal, Simerpreet S, Page, Stacey A, Beck, Stacey D, Woodroffe, Stephanie, Reiter, Stephanie D, Gaal, Stephen van, Peters, Steven Ray, Darvesh, Sultan, Save, Supriya, Alcock, Susan, Piercey, Susannah, Adam, Suzie, Gosselin, Sylvie, Fitzpatrick, Tess, Perron, Thomas-Louis, Stewart, Tim, Benstead, Timothy J, Naidoo, Vishaya, Wahab, Wasan Abd, Oczkowski, Wiesław, Kingston, William, Leduc, William, To, William T H, Yu, Yeyao Joe, Liu, Zhongyu A, Aljundi, Ziad Ezzat, Menon, Bijoy K, Singh, Nishita, Deschaintre, Yan, Almekhlafi, Mohammed A, Coutts, Shelagh B, Thirunavukkarasu, Sibi, Khosravani, Houman, Appireddy, Ramana, Moreau, Francois, Gubitz, Gord, Tkach, Aleksander, Catanese, Luciana, Dowlatshahi, Dar, Medvedev, George, Mandzia, Jennifer, Pikula, Aleksandra, Shankar, Jai, Williams, Heather, Field, Thalia S, Manosalva, Alejandro, Siddiqui, Muzaffar, Zafar, Atif, Imoukhuede, Oje, Hunter, Gary, Demchuk, Andrew M, Mishra, Sachin, Gioia, Laura C, Jalini, Shirin, Cayer, Caroline, Phillips, Stephen, Elamin, Elsadig, Shoamanesh, Ashkan, Subramaniam, Suresh, Kate, Mahesh, Jacquin, Gregory, Camden, Marie-Christine, Benali, Faysal, Alhabli, Ibrahim, Bala, Fouzi, Horn, MacKenzie, Stotts, Grant, Hill, Michael D, Gladstone, David J, Poppe, Alexandre, Sehgal, Arshia, Zhang, Qiao, Lethebe, Brendan Cord, Doram, Craig, Ademola, Ayoola, Kenney, Carol, Sajobi, Tolulope T, and Swartz, Richard H

Published
2022
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14. Prospective Validation of Computed Tomography to Identify Patients at High Risk for Stroke After Transient Ischemic Attack or Minor Stroke

Author

Ferguson, Emma, Yadav, Krishan, Sharma, Mukul, Sivilotti, Marco L.A., Émond, Marcel, Stiell, Ian G., Stotts, Grant, Lee, Jacques S., Worster, Andrew, Morris, Judy, Cheung, Ka Wai, Jin, Albert Y., Oczkowski, Wieslaw J., Sahlas, Demetrios J., Murray, Heather E., Mackey, Ariane, Verreault, Steve, Camden, Marie-Christine, Yip, Samuel, Teal, Philip, Gladstone, David J., Boulos, Mark I., Chagnon, Nicolas, Shouldice, Elizabeth, Atzema, Clare, Slaoui, Tarik, Teitelbaum, Jeanne, Nemnom, Marie-Joe, Wells, George A., Nath, Avik, and Perry, Jeffrey J.

Published
2023
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15. Time Course of Early Hematoma Expansion in Acute Spot-Sign Positive Intracerebral Hemorrhage: Prespecified Analysis of the SPOTLIGHT Randomized Clinical Trial

Author

Al-Ajlan, Fahad S., Gladstone, David J., Song, Dongbeom, Thorpe, Kevin E., Swartz, Rick H., Butcher, Kenneth S., del Campo, Martin, Dowlatshahi, Dar, Gensicke, Henrik, Lee, Gloria Jooyoung, Flaherty, Matthew L., Hill, Michael D., Aviv, Richard I., Demchuk, Andrew M., Swartz, Richard H., Gladstone, David J., Boyle, Karl, Braganza, Maria, Fedasko, Nadia, Golob, Dolores, Bardi, Edith, Senyshyn, Samantha, Cayley, Megan, Colavecchia, Connie, Demchuk, Andrew M., Hill, Michael D., Coutts, Shelagh, Klein, Gary, Menon, Bijoy, Watson, Tim, Smith, Eric, Subramaniam, Suresh, Bal, Simerpreet, Barber, Philip, Camden, Marie-Christine, Horton, Myles, Mishra, Sachin, Nambiar, Vivek, Torres, Andres Venegas, Adatia, Sweta, Alseraya, Amjad, Desai, Jamsheed, Mandzia, Jennifer, Shamy, Michel, Trivedi, Anurag, Choi, Philip, Dubuc, Veronique, Klourfeld, Evgenia, Field, Thalia, Singh, Dilip, Musuka, Tapuwa, Bloujney, Sarah, Nikneshan, Davar, Imoukhuede, Oje, Yu, Amy, Appireddy, Ramana, Evans, Jamie, Ryckborst, Karla, Calvert, Carly, Dowlatshahi, Dariush, Stotts, Grant, Sharma, Mukul, Robert, Sohail, Mortensen, Melodie, Shamloul, Rany, Campo, Martin Del, Silver, Frank L., Casaubon, Leanne, Jaigobin, Cheryl, Perez, Yael, Kalman, Libby, Abraham, Jemini, Wiegner, Relu, Cayley, Anne, Riediger, Victoria, Butcher, Ken, Kate, Mahesh, Jeerakathil, Thomas, Shuaib, Ashfaq, Gaucher, Sylvia, Sivakumar, Leka, Yip, Samuel, Teal, Philip, Woolfenden, Andrew, Benavente, Oscar, Beckman, Jeff, Murphy, Colleen, Field, Thalia, Asdaghi, Negar, Villaluna-MurrVay, Karina, Sahlas, Demetrios J., Algird, Almunder, Knapman, Jordan, Macmillan, Sue, Sancan, Janice, Mehdiratta, Manu, Perez, Yael, John, Verity, Dhanani, AlNoor, Temple, Bryan, Douen, Andre, Selchen, Daniel, Saposnik, Gustavo, Kostyrko, Pawel, Chan, Richard, Young, Bryan, Kumar, Balagopal, Soros, Peter, Hesser, Kimberley, Wright, Mary, Frank, Connie, Amato-Marziali, Belinda, Deschaintre, Yan, Poppe, Alexandre, Lapierre, Marlene, Boulanger, Jean-Martin, Berger, Leo, Blais, Lise, Simard, Christel, Teitelbaum, Jeanne, Campbell, Natasha, Jin, Al, Breen, Adriana, and Bickford, Suzanne

Published
2023
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16. Predictors of neurologists confirming or overturning emergency physicians' diagnosis of TIA or stroke

Author

Cortel-LeBlanc, Miguel A., Sharma, Mukul, Cortel-LeBlanc, Achelle, Sivilotti, Marco L. A., Émond, Marcel, Stiell, Ian G., Stotts, Grant, Lee, Jacques, Worster, Andrew, Morris, Judy, Cheung, Ka Wai, Jin, Albert Y., Oczkowski, Wieslaw J., Sahlas, Demetrios J., Murray, Heather E., Mackey, Ariane, Verreault, Steve, Camden, Marie-Christine, Yip, Samuel, Teal, Philip, Gladstone, David J., Boulos, Mark I., Chagnon, Nicolas, Shouldice, Elizabeth, Atzema, Clare, Slaoui, Tarik, Teitelbaum, Jeanne, Abdulaziz, Kasim E., Wells, George A., Taljaard, Monica, and Perry, Jeffrey J.

Published
2021
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17. MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease

Author

Strong, Michael, Kleinstiver, Peter, Rashkovan, Natalie, Bronskill, Susan, Black, Sandra E., Borrie, Michael, Finger, Elizabeth, Fischer, Corinne, Frank, Andrew, Freedman, Morris, Kumar, Sanjeev, Pasternak, Stephen, Pollock, Bruce, Rajji, Tarek, Seitz, Dallas, Tang-Wai, David, Tartaglia, Carmela, Varriano, Brenda, Abrahao, Agessandro, Chum, Marvin, Shoesmith, Christen, Turnbull, John, Zinman, Lorne, Lawrence-Dewar, Jane, Kwan, Donna, Tan, Brian, Fraser, Julia, McIlroy, Bill, Cornish, Ben, Van Ooteghem, Karen, Faria, Frederico, Montero-Odasso, Manuel, Sarquis-Adamson, Yanina, Black, Alanna, Greenberg, Barry, Hatch, Wendy, Hudson, Chris, Leontieva, Elena, Margolin, Ed, Mandelcorn, Efrem, Tayyari, Faryan, Defrawy, Sherif, Brien, Don, Chen, Ying, Coe, Brian, Munoz, Doug, Bonnick, Alisia, Casaubon, Leanne, Dowlatshahi, Dar, Hassan, Ayman, Mandzia, Jennifer, Sahlas, Demetrios, Saposnik, Gustavo, Swartz, Richard H., Breen, David, Grimes, David, Jog, Mandar, Lang, Anthony, Marras, Connie, Masellis, Mario, Steeves, Tom, Bulman, Dennis, Dilliott, Allison Ann, Ghani, Mahdi, Hegele, Rob, Robinson, John, Rogaeva, Ekaterina, Farhan, Sali, Bartha, Rob, Haddad, Hassan, Nanayakkara, Nuwan, Ramirez, Joel, Scott, Christopher, Symons, Sean, Berezuk, Courtney, Holmes, Melissa, Adamo, Sabrina, Ozzoude, Miracle, Zamyadi, Mojdeh, Arnott, Stephen, Beaton, Derek, Binns, Malcolm, Lou, Wendy, Raamana, Pradeep, Strother, Stephen, Sunderland, Kelly, Theyers, Athena, Uthirakumaran, Abiramy, Zou, Guangyong (GY), Sujanthan, Sujeevini, Munoz, David, Dixon, Roger A., Woulfe, John, Levine, Brian, McLaughlin, Paula, Orange, J.B., Peltsch, Alicia, Roberts, Angela, Troyer, Angela, Holmes, Melissa F., Scott, Christopher J.M., Gao, Fuqiang, Yu, Di, Swardfager, Walter, Boulos, Mark I., Murray, Brian J., Bartha, Robert, and Lim, Andrew

Published
2021
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19. Neural Correlates of Mild Behavioral Impairment in older adults across the neurodegenerative spectrum

Author

Rashidi‐Ranjbar, Neda, primary, Churchill, Nathan W, additional, Black, Sandra E., additional, Kumar, Sanjeev, additional, Tartaglia, Carmela, additional, Freedman, Morris, additional, Lang, Anthony E, additional, Steeves, Thomas, additional, Swartz, Richard H., additional, Saposnik, Gustavo, additional, Kwan, Donna, additional, McLaughlin, Paula, additional, Troyer, Angela, additional, Symons, Sean, additional, Strother, Stephen C., additional, Borrie, Michael, additional, Frank, Andrew R, additional, Pasternak, Stephen H, additional, Pollock, Bruce G., additional, Rajji, Tarek K., additional, Seitz, Dallas, additional, Tang‐Wai, David F., additional, Casaubon, Leanne, additional, Mandzia, Jennifer, additional, Jog, Mandar, additional, Masellis, Mario, additional, Scott, Christopher J. M., additional, Adamo, Sabrina M., additional, Ozzoude, Miracle, additional, Ismail, Zahinoor, additional, Munoz, David G., additional, Dowlatshahi, Dar, additional, Hassan, Ayman, additional, Marras, Connie, additional, Bartha, Robert, additional, Ramirez, Joel, additional, Berezuk, Courtney, additional, Holmes, Melissa F., additional, Sahlas, Demetrios J., additional, Southwell, Alisia, additional, Arnott, Stephen R., additional, Grimes, David A., additional, Schweizer, Tom A., additional, and Fischer, Corinne E., additional

Published
2023
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21. Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology.

Author

Xhima, Kristiana, Ottoy, Julie, Gibson, Erin, Zukotynski, Katherine, Scott, Christopher, Feliciano, Ginelle J., Adamo, Sabrina, Kuo, Phillip H., Borrie, Michael J., Chertkow, Howard, Frayne, Richard, Laforce, Robert, Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Sossi, Vesna, Thiel, Alexander, Soucy, Jean‐Paul, and Tardif, Jean‐Claude

Abstract

INTRODUCTION: Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co‐exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood. METHODS: In a unique cohort of mixed Alzheimer's disease and moderate–severe SVD, we examined whether total and regional neuroimaging measures of SVD, white matter hyperintensities (WMH), and Aβ, as assessed by 18F‐AV45 positron emission tomography, exert additive or synergistic effects on hippocampal volume and shape. RESULTS: Frontal WMH, occipital WMH, and Aβ were independently associated with smaller hippocampal volume. Frontal WMH had a spatially distinct impact on hippocampal shape relative to Aβ. In contrast, hippocampal shape alterations associated with occipital WMH spatially overlapped with Aβ‐vulnerable subregions. DISCUSSION: Hippocampal degeneration is differentially sensitive to SVD and Aβ pathology. The pattern of hippocampal atrophy could serve as a disease‐specific biomarker, and thus guide clinical diagnosis and individualized treatment strategies for mixed dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Transcranial Doppler ultrasound to evaluate the risk of hyperperfusion after endovascular stroke thrombectomy

Author

Katsanos, Aristeidis H., primary, Srivastava, Abhilekh, additional, Sahlas, Demetrios J., additional, Perera, Kanjana, additional, Ng, Kelvin K. H., additional, Joundi, Raed A., additional, Van Adel, Brian, additional, Larrazabal, Ramiro, additional, Ratnayake, Kanchana, additional, Tsivgoulis, Georgios, additional, Benavente, Oscar, additional, Hart, Robert, additional, Sharma, Mukul, additional, Shoamanesh, Ashkan, additional, and Catanese, Luciana, additional

Published
2023
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25. Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI

Author

Pieruccini-Faria, Frederico, primary, Cornish, Benjamin, additional, Binns, Malcolm, additional, Fraser, Julia, additional, Haddad, Seyyed M. H., additional, Sunderland, Kelly, additional, Ramirez, Joel, additional, Beaton, Derek, additional, Kwan, Donna, additional, Dilliott, Allison A., additional, Scott, Christopher, additional, Sarquis-Adamson, Yanina, additional, Black, Alanna, additional, Van Ooteghem, Karen, additional, Casaubon, Leanne, additional, Dowlatshahi, Dar, additional, Hassan, Ayman, additional, Mandzia, Jennifer, additional, Sahlas, Demetrios, additional, Saposnik, Gustavo, additional, Tan, Brian, additional, Hegele, Robert, additional, Bulman, Dennis, additional, Ghani, Mahdi, additional, Robinson, John, additional, Rogaeva, Ekaterina, additional, Farhan, Sali, additional, Symons, Sean, additional, Nanayakkara, Nuwan, additional, Arnott, Stephen R., additional, Berezuk, Courtney, additional, Holmes, Melissa, additional, Adamo, Sabrina, additional, Ozzoude, Miracle, additional, Zamyadi, Mojdeh, additional, Lou, Wendy, additional, Sujanthan, Sujeevini, additional, Bartha, Robert, additional, Black, Sandra E., additional, Swartz, Richard H., additional, McIlroy, William, additional, and Montero-Odasso, Manuel, additional

Published
2023
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26. Peripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel disease

Author

Swardfager, Walter, Yu, Di, Scola, Gustavo, Cogo-Moreira, Hugo, Chan, Parco, Zou, Yi, Herrmann, Nathan, Lanctôt, Krista L., Ramirez, Joel, Gao, Fuqiang, Masellis, Mario, Swartz, Richard H., Sahlas, Demetrios J., Chan, Pak Cheung, Ojeda-Lopez, Carmen, Milan-Tomas, Angela, Pettersen, Jacqueline A., Andreazza, Ana C., and Black, Sandra E.

Published
2017
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29. Transcranial Doppler ultrasound to evaluate the risk of hyperperfusion after endovascular stroke thrombectomy.

Author

Katsanos, Aristeidis H., Srivastava, Abhilekh, Sahlas, Demetrios J., Perera, Kanjana, Ng, Kelvin K. H., Joundi, Raed A., Van Adel, Brian, Larrazabal, Ramiro, Ratnayake, Kanchana, Tsivgoulis, Georgios, Benavente, Oscar, Hart, Robert, Sharma, Mukul, Shoamanesh, Ashkan, and Catanese, Luciana

Subjects
TRANSCRANIAL Doppler ultrasonography, ENDOVASCULAR surgery, HYPERPERFUSION, ISCHEMIC stroke, FLOW velocity, CEREBRAL arteries, BLOOD pressure
Abstract

Background and Purpose: Hemorrhagic transformation (HT) has been reported in up to 50% of acute ischemic stroke (AIS) patients with a large vessel occlusion (LVO) treated with endovascular thrombectomy (EVT). HT may be driven by postrecanalization hyperperfusion injury and is independently associated with worse functional outcomes. Strategies to identify patients at risk for HT may assist in developing preventive therapies. Methods: We prospectively included adult AIS patients with an anterior circulation LVO achieving successful recanalization after EVT. Consenting participants received transcranial Doppler ultrasound (TCD) within 18 hours of procedure completion. We compared flow velocities according to the presence of HT on the computed tomography scan performed within the first 24±12 hours from the end of EVT. We also evaluated the association of flow velocities with systemic blood pressure (BP) readings at the time of insonation. Results: A total of 48 patients consented to participate in the study. Six (12%) were excluded due to the absence of temporal windows. HT was detected in 20 participants (48%). Those with HT had higher peak systolic velocities on the middle cerebral arteries compared to those without HT for both the symptomatic (107±42 vs. 82±25 cm/second, p =.024) and asymptomatic (97±21 vs. 81±25 cm/second, p =.040) sides. No correlation of flow velocities on either the symptomatic or asymptomatic side and BP measurements at the time of insonation was detected. Conclusion: TCD can identify patients at risk of HT following successful EVT. TCD could serve as an inexpensive ancillary test to guide participant selection for clinical trials targeting postprocedural reperfusion injury. [ABSTRACT FROM AUTHOR]

Published
2024
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30. EFFECTS OF VASCULAR BURDEN ON COGNITION ARE MEDIATED BY ATROPHY, AMYLOID, AND GLUCOSE METABOLISM: A MULTI-CENTRE MIXED COHORT OF SMALL VESSEL DISEASE AND ALZHEIMER'S PATHOLOGY

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Adamo, Sabrina, Scott, Christopher, Gaudet, Vincent, Ramirez, Joel, Swardfager, Walter, Cogo-Moreira, Hugo, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kang, Min Su, Rabin, Jennifer, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert, Jr., Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Kuo, Phillip H., Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E., and Goubran, Maged

Published
2024
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31. Association of apolipoprotein E variation with cognitive impairment across multiple neurodegenerative diagnoses

Author

Dilliott, Allison A., Sunderland, Kelly M., McLaughlin, Paula M., Roberts, Angela C., Evans, Emily C., Abrahao, Agessandro, Binns, Malcolm A., Black, Sandra E., Borrie, Michael, Casaubon, Leanne.K., Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne.E., Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kumar, Sanjeev, Kwan, Donna, Lang, Anthony E., Mandzia, Jennifer, Marras, Connie, Masellis, Mario, McIntyre, Adam D., Pasternak, Stephen, Pollock, Bruce G., Rajji, Tarek K., Robinson, John F., Rogaeva, Ekaterina, Sahlas, Demetrios J., Saposnik, Gustavo, Sato, Christine, Seitz, Dallas, Shoesmith, Christen, Steeves, Thomas, Strother, Stephen C., Swartz, Richard H., Tan, Brian, Tang-Wai, David, Tartaglia, Maria C., Troyer, Angela K., Turnbull, John, Zinman, Lorne, and Hegele, Robert A.

Published
2021
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32. Rare neurovascular genetic and imaging markers across neurodegenerative diseases

Author

Dilliott, Allison A, Berberian, Stephanie A, Sunderland, Kelly M, Binns, Malcolm A, Zimmer, Julia, Ozzoude, Miracle, Scott, Christopher J M, Gao, Fuqiang, Lang, Anthony E, Breen, David P, Tartaglia, Maria C, Tan, Brian, Swartz, Richard H, Rogaeva, Ekaterina, Borrie, Michael, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Kumar, Sanjeev, Pasternak, Stephen, Pollock, Bruce G, Rajji, Tarek K, Tang-Wai, David F, Abrahao, Agessandro, Turnbull, John, Zinman, Lorne, Casaubon, Leanne, Dowlatshahi, Dar, Hassan, Ayman, Mandzia, Jennifer, Sahlas, Demetrios, Saposnik, Gustavo, Grimes, David, Marras, Connie, Steeves, Thomas, Masellis, Mario, Farhan, Sali M K, Bartha, Robert, Symons, Sean, Hegele, Robert A, Black, Sandra E, and Ramirez, Joel

Abstract

INTRODUCTION: Cerebral small vessel disease (SVD) is common in patients with cognitive impairment and neurodegenerative diseases such as Alzheimer's and Parkinson's. This study investigated the burden of magnetic resonance imaging (MRI)-based markers of SVD in patients with neurodegenerative diseases as a function of rare genetic variant carrier status.METHODS: The Ontario Neurodegenerative Disease Research Initiative study included 520 participants, recruited from 14 tertiary care centers, diagnosed with various neurodegenerative diseases and determined the carrier status of rare non-synonymous variants in five genes (ABCC6, COL4A1/COL4A2, NOTCH3/HTRA1).RESULTS: NOTCH3/HTRA1 were found to significantly influence SVD neuroimaging outcomes; however, the mechanisms by which these variants contribute to disease progression or worsen clinical correlates are not yet understood.DISCUSSION: Further studies are needed to develop genetic and imaging neurovascular markers to enhance our understanding of their potential contribution to neurodegenerative diseases.

Published
2023

33. Men Are at Higher Risk of Screening Positive for Vascular Cognitive Impairment Compared to Women after Stroke and Transient Ischemic Attack

Author

Zinman, Julia, primary, Kapoor, Arunima, additional, Si, Kevin, additional, Sujanthan, Sajeevan, additional, Southwell, Alisia, additional, Cayley, Megan L., additional, Sicard, Michelle N., additional, Lien, Karen, additional, Murray, Brian J., additional, Lanctôt, Krista, additional, Herrmann, Nathan, additional, Dowlatshahi, Dar, additional, Sahlas, Demetrios J., additional, Saposnik, Gustavo, additional, Mandzia, Jennifer L., additional, Casaubon, Leanne K., additional, Hassan, Ayman, additional, Perez, Yael, additional, and Swartz, Richard H., additional

Published
2023
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34. Ninety‐Day Stroke or Transient Ischemic Attack Recurrence in Patients Prescribed Anticoagulation in the Emergency Department With Atrial Fibrillation and a New Transient Ischemic Attack or Minor Stroke

Author

Wilson, Graham, primary, Sharma, Mukul, additional, Eagles, Debra, additional, Nemnom, Marie‐Joe, additional, Sivilotti, Marco L. A., additional, Émond, Marcel, additional, Stiell, Ian G., additional, Stotts, Grant, additional, Lee, Jacques, additional, Worster, Andrew, additional, Morris, Judy, additional, Cheung, Ka Wai, additional, Jin, Albert Y., additional, Oczkowski, Wieslaw J., additional, Sahlas, Demetrios J., additional, Murray, Heather E., additional, Mackey, Ariane, additional, Verreault, Steve, additional, Camden, Marie Christine, additional, Yip, Samuel, additional, Teal, Philip, additional, Gladstone, David J., additional, Boulos, Mark I., additional, Chagnon, Nicolas, additional, Shouldice, Elizabeth, additional, Atzema, Clare, additional, Slaoui, Tarik, additional, Teitlebaum, Jeanne, additional, Wells, George A., additional, Nath, Avik, additional, and Perry, Jeffrey J., additional

Published
2023
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35. Quantitative Lipidomic Analysis of Serum Phospholipids Reveals Dissociable Markers of Alzheimer’s Disease and Subcortical Cerebrovascular Disease

Author

Otoki, Yurika, primary, Yu, Di, additional, Shen, Qing, additional, Sahlas, Demetrios J., additional, Ramirez, Joel, additional, Gao, Fuqiang, additional, Masellis, Mario, additional, Swartz, Richard H., additional, Chan, Pak Cheung, additional, Pettersen, Jacqueline A., additional, Kato, Shunji, additional, Nakagawa, Kiyotaka, additional, Black, Sandra E., additional, Swardfager, Walter, additional, and Taha, Ameer Y., additional

Published
2023
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36. The Use of Random Forests to Classify Amyloid Brain PET

Author

Zukotynski, Katherine, Gaudet, Vincent, Kuo, Phillip H., Adamo, Sabrina, Goubran, Maged, Scott, Christopher, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert, Jr, Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, and Black, Sandra E.

Published
2019
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38. DOC screen completion time reflects executive function, speed of processing and fluency in an observational cohort study

Author

Southwell, Alisia, primary, Sujanthan, Sajeevan, additional, Armel, Tera, additional, Xing, Elaine, additional, Kapoor, Arunima, additional, Eileen Liu, Xiao Yu, additional, Lanctot, Krista L., additional, Herrmann, Nathan, additional, Murray, Brian J., additional, Thorpe, Kevin E., additional, Cayley, Megan L., additional, Sicard, Michelle N., additional, Lien, Karen, additional, Sahlas, Demetrios J., additional, and Swartz, Richard H., additional

Published
2023
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39. Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A, McLaughlin, Paula M, Abrahao, Agessandro, Black, Sandra E, Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B, Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G, Rajji, Tarek K, Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D L, Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F, Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
Psychiatry and Mental health
Abstract

Objective Neuropsychiatric symptoms (NPS) are prevalent in neurodegenerative disorders, however, their frequency and impact on function across different disorders is not well understood. We compared the frequency and severity of NPS across Alzheimer's disease (AD) (either with mild cognitive impairment or dementia), Cerebrovascular disease (CVD), Parkinson's disease (PD), frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS), and explored the association between NPS burden and function. Methods We obtained data from Ontario Neurodegenerative Disease Research Initiative (ONDRI) that included following cohorts: AD ( N = 111), CVD ( N = 148), PD ( N = 136), FTD ( N = 50) and ALS ( N = 36). We compared the frequency and severity of individual NPS (assessed by the neuropsychiatric inventory questionnaire) across cohorts using generalized estimating equations and analysis of variance. Second, we assessed the relationship of NPS burden with instrumental (iADLs) and basic (ADLs) activities of living across cohorts using multivariate linear regression while adjusting for relevant demographic and clinical covariates. Results Frequency of NPS varied across cohorts (χ2(4) = 34.4, p < .001), with post-hoc tests showing that FTD had the greatest frequency as compared to all other cohorts. The FTD cohort also had the greatest severity of NPS ( H(4) = 34.5, p < .001). Further, there were differences among cohorts in terms of the association between NPS burden and ADLs ( F(4,461) = 3.1, p = 0.02). Post-hoc comparisons suggested that this finding was driven by the FTD group, however, the differences did not remain significant following Bonferroni correction. There were no differences among cohorts in terms of the association between NPS burden and IADLs. Conclusions NPS frequency and severity are markedly greater in FTD as compared to other neurodegenerative diseases. Further, NPS burden appears to be associated differently with function across neurodegenerative disorders, highlighting the need for individualized clinical interventions.

Published
2023

40. sj-docx-1-nnr-10.1177_15459683231177606 – Supplemental material for Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI

Author

Pieruccini-Faria, Frederico, Cornish, Benjamin, Binns, Malcolm, Fraser, Julia, Haddad, Seyyed M. H., Sunderland, Kelly, Ramirez, Joel, Beaton, Derek, Kwan, Donna, Dilliott, Allison A., Scott, Christopher, Sarquis-Adamson, Yanina, Black, Alanna, Van Ooteghem, Karen, Casaubon, Leanne, Dowlatshahi, Dar, Hassan, Ayman, Mandzia, Jennifer, Sahlas, Demetrios, Saposnik, Gustavo, Tan, Brian, Hegele, Robert, Bulman, Dennis, Ghani, Mahdi, Robinson, John, Rogaeva, Ekaterina, Farhan, Sali, Symons, Sean, Nanayakkara, Nuwan, Arnott, Stephen R., Berezuk, Courtney, Holmes, Melissa, Adamo, Sabrina, Ozzoude, Miracle, Zamyadi, Mojdeh, Lou, Wendy, Sujanthan, Sujeevini, Bartha, Robert, Black, Sandra E., Swartz, Richard H., McIlroy, William, and Montero-Odasso, Manuel

Subjects
FOS: Clinical medicine, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-docx-1-nnr-10.1177_15459683231177606 for Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI by Frederico Pieruccini-Faria, Benjamin Cornish, Malcolm Binns, Julia Fraser, Seyyed M. H. Haddad, Kelly Sunderland, Joel Ramirez, Derek Beaton, Donna Kwan, Allison A. Dilliott, Christopher Scott, Yanina Sarquis-Adamson, Alanna Black, Karen Van Ooteghem, Leanne Casaubon, Dar Dowlatshahi, Ayman Hassan, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Brian Tan, Robert Hegele, Dennis Bulman, Mahdi Ghani, John Robinson, Ekaterina Rogaeva, Sali Farhan, Sean Symons, Nuwan Nanayakkara, Stephen R. Arnott, Courtney Berezuk, Melissa Holmes, Sabrina Adamo, Miracle Ozzoude, Mojdeh Zamyadi, Wendy Lou, Sujeevini Sujanthan, Robert Bartha, Sandra E. Black, Richard H. Swartz, William McIlroy and Manuel Montero-Odasso in Neurorehabilitation and Neural Repair

Published
2023
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41. sj-pdf-1-jcb-10.1177_0271678X231152001 - Supplemental material for Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Kang, Min Su, Adamo, Sabrina, Scott, Christopher, Ramirez, Joel, Swardfager, Walter, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert Jr, Noseworthy, Michael D, Prato, Frank S, Sahlas, Demetrios J, Smith, Eric E, Kuo, Phillip H, Chad, Jordan A, Pasternak, Ofer, Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E, and Goubran, Maged

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231152001 for Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease by Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Min Su Kang, Sabrina Adamo, Christopher Scott, Joel Ramirez, Walter Swardfager, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Jr Laforce, Michael D Noseworthy, Frank S Prato, Demetrios J Sahlas, Eric E Smith, Phillip H Kuo, Jordan A Chad, Ofer Pasternak, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E Black, Maged Goubran in Journal of Cerebral Blood Flow & Metabolism

Published
2023
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42. sj-docx-2-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-2-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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43. sj-pdf-1-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-pdf-1-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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44. sj-docx-3-cpa-10.1177_07067437221147443 - Supplemental material for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function

Author

Kapustin, Daniel, Zarei, Shadi, Wang, Wei, Binns, Malcolm A., McLaughlin, Paula M., Abrahao, Agessandro, Black, Sandra E., Borrie, Michael, Breen, David, Casaubon, Leanna, Dowlatshahi, Dar, Finger, Elizabeth, Fischer, Corinne E, Frank, Andrew, Freedman, Morris, Grimes, David, Hassan, Ayman, Jog, Mandar, Kwan, Donna, Lang, Anthony, Levine, Brian, Mandzia, Jennifer, Marras, Connie, Masellis, Mario, Orange, Joseph B., Pasternak, Stephen, Peltsch, Alicia, Pollock, Bruce G., Rajji, Tarek K., Roberts, Angela, Sahlas, Demetrios, Saposnik, Gustavo, Seitz, Dallas, Shoesmith, Christen, Southwell, Alisia, Steeves, Thomas D.L., Sunderland, Kelly, Swartz, Richard H, Tan, Brian, Tang-Wai, David F., Tartaglia, Maria Carmela, Troyer, Angela, Turnbull, John, Zinman, Lorne, and Kumar, Sanjeev

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-3-cpa-10.1177_07067437221147443 for Neuropsychiatric Symptom Burden across Neurodegenerative Disorders and its Association with Function by Daniel Kapustin, Shadi Zarei, Wei Wang, Malcolm A. Binns, Paula M. McLaughlin, Agessandro Abrahao, Sandra E. Black, Michael Borrie, David Breen, Leanna Casaubon, Dar Dowlatshahi, Elizabeth Finger, Corinne E Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Donna Kwan, Anthony Lang, Brian Levine, Jennifer Mandzia, Connie Marras, Mario Masellis, Joseph B. Orange, Stephen Pasternak, Alicia Peltsch, Bruce G. Pollock, Tarek K. Rajji, Angela Roberts, Demetrios Sahlas, Gustavo Saposnik, Dallas Seitz, Christen Shoesmith, Alisia Southwell, Thomas D.L. Steeves, Kelly Sunderland, Richard H Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, Angela Troyer, John Turnbull, Lorne Zinman, and Sanjeev Kumar in The Canadian Journal of Psychiatry

Published
2023
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45. Vascular Brain Lesions, Cognitive Reserve, and Their Association with Cognitive Profile in Persons with Early-Stage Cognitive Decline

Author

Durrani, Romella, primary, Badhwar, Amanpreet, additional, Bhangu, Jaspreet, additional, Ganesh, Aravind, additional, Black, Sandra E., additional, Barber, Philip A., additional, Frayne, Richard, additional, Field, Thalia S., additional, Hachinski, Vladimir, additional, Sahlas, Demetrios, additional, Mai, Lauren M., additional, Sharma, Mukul, additional, Swartz, Richard H., additional, and Smith, Eric E., additional

Published
2022
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46. White Matter Hyperintensities and Cortical Atrophy are associated with Neuropsychiatric Symptoms in Neurodegenerative and Cerebrovascular Diseases

Author

Ozzoude, Miracle, primary, Varriano, Brenda, additional, Beaton, Derek, additional, Ramirez, Joel, additional, Adamo, Sabrina, additional, Holmes, Melissa F., additional, Scott, Christopher J.M., additional, Gao, Fuqiang, additional, Sunderland, Kelly M., additional, McLaughlin, Paula, additional, Goubran, Maged, additional, Kwan, Donna, additional, Roberts, Angela, additional, Bartha, Robert, additional, Symons, Sean, additional, Tan, Brian, additional, Swartz, Richard H., additional, Abrahao, Agessandro, additional, Saposnik, Gustavo, additional, Masellis, Mario, additional, Lang, Anthony E., additional, Marras, Connie, additional, Zinman, Lorne, additional, Shoesmith, Christen, additional, Borrie, Michael, additional, Fischer, Corinne E., additional, Frank, Andrew, additional, Freedman, Morris, additional, Montero-Odasso, Manuel, additional, Kumar, Sanjeev, additional, Pasternak, Stephen, additional, Strother, Stephen C., additional, Pollock, Bruce G., additional, Rajji, Tarek K., additional, Seitz, Dallas, additional, Tang-Wai, David F., additional, Turnbull, John, additional, Dowlatshahi, Dar, additional, Hassan, Ayman, additional, Casaubon, Leanne, additional, Mandzia, Jennifer, additional, Sahlas, Demetrios, additional, Breen, David P., additional, Grimes, David, additional, Jog, Mandar, additional, Steeves, Thomas D.L., additional, Arnott, Stephen R., additional, Black, Sandra E., additional, Finger, Elizabeth, additional, Rabin, Jennifer, additional, Investigators, ONDRI, additional, and Tartaglia, Maria Carmela, additional

Published
2022
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48. The effect of white matter hyperintensities on verbal memory: Mediation by temporal lobe atrophy

Author

Swardfager, Walter, Cogo-Moreira, Hugo, Masellis, Mario, Ramirez, Joel, Herrmann, Nathan, Edwards, Jodi D., Saleem, Mahwesh, Chan, Parco, Yu, Di, Nestor, Sean M., Scott, Christopher J.M., Holmes, Melissa F., Sahlas, Demetrios J., Kiss, Alexander, Oh, Paul I., Strother, Stephen C., Gao, Fuqiang, Stefanovic, Bojana, Keith, Julia, Symons, Sean, Swartz, Richard H., Lanctôt, Krista L., Stuss, Donald T., and Black, Sandra E.

Published
2018
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49. Cost-free pharmacotherapy in smokers with TIA or stroke: QUIT-MED randomised controlled trial

Author

Reid, Robert, primary, Papadakis, Sophia, additional, Gocan, Sophia, additional, Bourgoin, Aline, additional, Laplante, Mary Ann, additional, Armstrong, Ashley, additional, Aitken, Debbie, additional, Sahlas, Demetrios, additional, Stotts, Grant, additional, Cotie, Lisa, additional, Mullen, Kerri-Anne, additional, Pipe, Andrew, additional, Mir, Hassan, additional, and Sharma, Mukul, additional

Published
2022
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50. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Author

Menon, Bijoy K, primary, Buck, Brian H, additional, Singh, Nishita, additional, Deschaintre, Yan, additional, Almekhlafi, Mohammed A, additional, Coutts, Shelagh B, additional, Thirunavukkarasu, Sibi, additional, Khosravani, Houman, additional, Appireddy, Ramana, additional, Moreau, Francois, additional, Gubitz, Gord, additional, Tkach, Aleksander, additional, Catanese, Luciana, additional, Dowlatshahi, Dar, additional, Medvedev, George, additional, Mandzia, Jennifer, additional, Pikula, Aleksandra, additional, Shankar, Jai, additional, Williams, Heather, additional, Field, Thalia S, additional, Manosalva, Alejandro, additional, Siddiqui, Muzaffar, additional, Zafar, Atif, additional, Imoukhuede, Oje, additional, Hunter, Gary, additional, Demchuk, Andrew M, additional, Mishra, Sachin, additional, Gioia, Laura C, additional, Jalini, Shirin, additional, Cayer, Caroline, additional, Phillips, Stephen, additional, Elamin, Elsadig, additional, Shoamanesh, Ashkan, additional, Subramaniam, Suresh, additional, Kate, Mahesh, additional, Jacquin, Gregory, additional, Camden, Marie-Christine, additional, Benali, Faysal, additional, Alhabli, Ibrahim, additional, Bala, Fouzi, additional, Horn, MacKenzie, additional, Stotts, Grant, additional, Hill, Michael D, additional, Gladstone, David J, additional, Poppe, Alexandre, additional, Sehgal, Arshia, additional, Zhang, Qiao, additional, Lethebe, Brendan Cord, additional, Doram, Craig, additional, Ademola, Ayoola, additional, Shamy, Michel, additional, Kenney, Carol, additional, Sajobi, Tolulope T, additional, Swartz, Richard H, additional, Srivastava, Abhilekh, additional, Aljammaz, Ahmed M, additional, Akindotun, Akintomide Femi, additional, Jin, Albert Y, additional, Fraser, Alexander, additional, Khaw, Alexander V, additional, Lemnaru, Alexandru, additional, Southwell, Alisia, additional, Ramji, Alnar, additional, Alvarado-Bolaños, Alonso, additional, Mouminah, Amr, additional, Lahlouh, Amro B, additional, Yu, Amy Y, additional, Alrohimi, Anas, additional, Lavoie, Andre, additional, Rogge, Andrea, additional, Micieli, Andrew, additional, Nguyen, Andrew Linh, additional, Callaghan-Brown, Angelique, additional, Florendo-Cumbermack, Anita, additional, Wadhwa, Ankur, additional, Beaudoin, Ann-Marie, additional, Cayley, Anne, additional, Liddy, Anne Marie, additional, Trivedi, Anurag, additional, Katsanos, Aristeidis H, additional, Shuaib, Ashfaq, additional, Butt, Asif Javed, additional, Bereznyakova, Olena, additional, Beauchamp, Beth, additional, Mahlitz, Breane, additional, Graham, Brett R, additional, Dewar, Brian, additional, Durafourt, Bryce A, additional, Holtby, Caitlin, additional, Jackson-Tarlton, Caitlin S, additional, Bockus, Caitlyn, additional, Stephenson, Caroline, additional, Galloway, Camille, additional, Odier, Céline, additional, Deacon, Charles, additional, Zerna, Charlotte, additional, Vekhande, Chetan C, additional, Bocti, Christian, additional, Stapf, Christian, additional, Hawkes, Christine, additional, Stables, Christine Anne, additional, Bogiatzi, Chrysi, additional, Rodriguez, Claudia, additional, Candale-Radu, Claudia, additional, Murphy, Colleen, additional, Casserly, Courtney Sarah, additional, Fok, Daniel, additional, Boasquevisque, Danielle de Sa, additional, Wile, Daryl, additional, Volders, David, additional, Sahlas, Demetrios J, additional, Shand, Elaine, additional, Cora, Elena Adela, additional, Battista, Eliane Di, additional, Stewart, Eileen, additional, Junk, Emily, additional, Harrison, Emma L, additional, Frenette, Eric, additional, Teleg, Ericka, additional, Abdellah, Eslam, additional, Ghrooda, Esseddeeg, additional, Akthar, Farhana, additional, Evoy, François, additional, Klein, Gary M, additional, Maclean, Genoveva, additional, Jickling, Glen C, additional, Hawthorne, Glenda, additional, Boyd, Gordon, additional, Walker, Gregory, additional, Saposnik, Gustavo, additional, Lau, H Lee, additional, Badr, Hanan E, additional, Toma, Hassanain, additional, Kalashyan, Hayrapet, additional, Marion-Moffet, Hugo, additional, Grant, Ian, additional, Fatakdawala, Idris, additional, Beaulieu-Boire, Isabelle, additional, Williams, Janice, additional, Brar, Jaskiran, additional, Rivest, Jean, additional, Wang, Jeffrey Z, additional, Dawe, Jessica, additional, Stang, Jillian, additional, Day, Joanne, additional, Miller, Jodi, additional, Gorman, Johnathon, additional, Hopyan, Julia Jasmine, additional, Lee, Julian, additional, Kromm, Julie, additional, Foster, Kaitlyn, additional, Ratnayake, Kanchana, additional, Perera, Kanjana S, additional, Murray, Karina Villaluna, additional, Ryckborst, Karla, additional, Lin, Katie, additional, Sage, Kayla, additional, Sivakuma, Keithan, additional, MacDonald, Kelly A, additional, Ng, Kelvin Kuan, additional, Merchant, Ketki, additional, Khan, Khurshid, additional, Ghavami, Kimia, additional, Johnston, Kyra, additional, Mai, Lauren M, additional, White, Leah, additional, Barratt, Lee, additional, Longpre, Linda, additional, Crellin, Lisa, additional, Peeling, Lissa, additional, Piquette, Lori, additional, Lomax, Lysa Boissé, additional, Sadeghi, Mahsa, additional, Kamra, Maneesha, additional, Lavoie-April, Manuel, additional, Moores, Margaret, additional, Bullrich, Maria Bres, additional, McClelland, Marie, additional, Salluzzi, Marina, additional, Wilcox, Mark, additional, Boulos, Mark I, additional, Marko, Martha, additional, Boyko, Matthew, additional, Lantagne-Hurtubise, Maude, additional, AlHamid, May Adel, additional, Shawawrah, Mays, additional, Kelly, Michael E, additional, Thorne, Michael W D, additional, Bussiere, Miguel, additional, Dominc Tse, Ming Yin, additional, Benguzzi, Mowad, additional, Sharma, Mukul, additional, Horton, Myles, additional, Newcommon, Nancy, additional, Simon, Nandy-Shelwine, additional, Parks, Natalie E, additional, Sultan, Nazeem, additional, Markovic, Nevena, additional, Daneault, Nicole, additional, Ishaque, Noman, additional, Fairall, Paige, additional, Kostyrko, Pawel B, additional, Stys, Peter K, additional, Teal, Philip, additional, Couillard, Philippe, additional, King-Azote, Princess, additional, Collier, Quentin, additional, Epp, Rachel, additional, Nair, Radhika, additional, Joundi, Raed A, additional, Jassal, Rajive, additional, Schneider, Raphael, additional, Hosseini, Reza, additional, Bouchard, Rosalie, additional, Whelan, Ruth, additional, Cooley, S Regan, additional, Sujanthan, Sajeevan, additional, Mansoor, Salman, additional, Yip,, Samuel, additional, Wasyliw, Sanchea, additional, Taylor, Sean W., additional, Friedman, Sebastian, additional, Mann, Sharan, additional, Maley, Sharleen Weese, additional, Chiasson, Sherry, additional, Hu, Sherry Xueying, additional, Althubait, Shorog, additional, Himed, Shuhira, additional, Chen, Shuo, additional, Bal, Simerpreet S, additional, Page, Stacey A, additional, Beck, Stacey D, additional, Woodroffe, Stephanie, additional, Reiter, Stephanie D, additional, Gaal, Stephen van, additional, Peters, Steven Ray, additional, Darvesh, Sultan, additional, Save, Supriya, additional, Alcock, Susan, additional, Piercey, Susannah, additional, Adam, Suzie, additional, Gosselin, Sylvie, additional, Fitzpatrick, Tess, additional, Perron, Thomas-Louis, additional, Stewart, Tim, additional, Benstead, Timothy J, additional, Naidoo, Vishaya, additional, Wahab, Wasan Abd, additional, Oczkowski, Wiesław, additional, Kingston, William, additional, Leduc, William, additional, To, William T H, additional, Yu, Yeyao Joe, additional, Liu, Zhongyu A, additional, and Aljundi, Ziad Ezzat, additional

Published
2022
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