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437 results on '"Sahin, Ozgur"'

1. Polyol pathway-generated fructose is indispensable for growth and survival of non-small cell lung cancer

Author

Schwab, Annemarie, Siddiqui, Mohammad Aarif, Ramesh, Vignesh, Gollavilli, Paradesi Naidu, Turtos, Adriana Martinez, Møller, Sarah Søgaard, Pinna, Luisa, Havelund, Jesper F., Rømer, Anne Mette A., Ersan, Pelin Gülizar, Parma, Beatrice, Marschall, Sabine, Dettmer, Katja, Alhusayan, Mohammed, Bertoglio, Pietro, Querzoli, Giulia, Mielenz, Dirk, Sahin, Ozgur, Færgeman, Nils J., Asangani, Irfan A., and Ceppi, Paolo

Published
2024
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2. HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer

Author

Ferretti, Giulia D. S., Quaas, Colleen E., Bertolini, Irene, Zuccotti, Alessandro, Saatci, Ozge, Kashatus, Jennifer A., Sharmin, Salma, Lu, David Y., Poli, Adi Narayana Reddy, Quesnelle, Abigail F., Rodriguez-Blanco, Jezabel, de Cubas, Aguirre A., Hobbs, G. Aaron, Liu, Qin, O’Bryan, John P., Salvino, Joseph M., Kashatus, David F., Sahin, Ozgur, and Barnoud, Thibaut

Published
2024
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3. Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer

Author

Saatci, Ozge, Alam, Rashedul, Huynh-Dam, Kim-Tuyen, Isik, Aynur, Uner, Meral, Belder, Nevin, Ersan, Pelin Gulizar, Tokat, Unal Metin, Ulukan, Burge, Cetin, Metin, Calisir, Kubra, Gedik, Mustafa Emre, Bal, Hilal, Sener Sahin, Ozlem, Riazalhosseini, Yasser, Thieffry, Denis, Gautheret, Daniel, Ogretmen, Besim, Aksoy, Sercan, Uner, Aysegul, Akyol, Aytekin, and Sahin, Ozgur

Published
2024
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4. Continuously tracked, stable, large excursion trajectories of dipolar coupled nuclear spins

Author

Sahin, Ozgur, Asadi, Hawraa Al, Schindler, Paul, Pillai, Arjun, Sanchez, Erica, Markham, Matthew, Elo, Mark, McAllister, Maxwell, Druga, Emanuel, Fleckenstein, Christoph, Bukov, Marin, and Ajoy, Ashok

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Chemical Physics
Abstract

We report an experimental approach to excite, stabilize, and continuously track Bloch sphere orbits of dipolar-coupled nuclear spins in a solid. We demonstrate these results on a model system of hyperpolarized 13C nuclear spins in diamond. Without quantum control, inter-spin coupling leads to rapid spin decay in T2*=1.5ms. We elucidate a method to preserve trajectories for over T2'>27s at excursion solid angles up to 16 degrees, even in the presence of strong inter-spin coupling. This exploits a novel spin driving strategy that thermalizes the spins to a long-lived dipolar many-body state, while driving them in highly stable orbits. We show that motion of the spins can be quasi-continuously tracked for over 35s in three dimensions on the Bloch sphere. In this time the spins complete >68,000 closed precession orbits, demonstrating high stability and robustness against error. We experimentally probe the transient approach to such rigid motion, and thereby show the ability to engineer highly stable "designer" spin trajectories. Our results suggest new ways to stabilize and interrogate strongly-coupled quantum systems through periodic driving and portend powerful applications of rigid spin orbits in quantum sensing., Comment: 19 pages, 16 figures. SI: 4 pages, 7 figures. 1 anc movie file (also available on Youtube)

Published
2022

6. High-Field Magnetometry with Hyperpolarized Nuclear Spins

Author

Sahin, Ozgur, Sanchez, Erica de Leon, Conti, Sophie, Akkiraju, Amala, Reshetikhin, Paul, Druga, Emanuel, Aggarwal, Aakriti, Gilbert, Benjamin, Bhave, Sunil, and Ajoy, Ashok

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Chemical Physics
Abstract

Quantum sensors have attracted broad interest in the quest towards sub-micronscale NMR spectroscopy. Such sensors predominantly operate at low magnetic fields. Instead, however, for high resolution spectroscopy, the high-field regime is naturally advantageous because it allows high absolute chemical shift discrimination. Here we propose and demonstrate a high-field spin magnetometer constructed from an ensemble of hyperpolarized ${}^{13}C$ nuclear spins in diamond. The ${}^{13}C$ nuclei are initialized via Nitrogen Vacancy (NV) centers and protected along a transverse Bloch sphere axis for minute-long periods. When exposed to a time-varying (AC) magnetic field, they undergo secondary precessions that carry an imprint of its frequency and amplitude. The method harnesses long rotating frame ${}^{13}C$ sensor lifetimes $T_2^{\prime}{>}$20s, and their ability to be continuously interrogated. For quantum sensing at 7T and a single crystal sample, we demonstrate spectral resolution better than 100 mHz (corresponding to a frequency precision ${<}$1ppm) and single-shot sensitivity better than 70pT. We discuss the advantages of nuclear spin magnetometers over conventional NV center sensors, including deployability in randomly-oriented diamond particles and in optically scattering media. Since our technique employs densely-packed ${}^{13}C$ nuclei as sensors, it demonstrates a new approach for magnetometry in the "coupled-sensor" limit. This work points to interesting opportunities for microscale NMR chemical sensors constructed from hyperpolarized nanodiamonds and suggests applications of dynamic nuclear polarization (DNP) in quantum sensing.

Published
2021
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8. High field magnetometry with hyperpolarized nuclear spins

Author

Sahin, Ozgur, de Leon Sanchez, Erica, Conti, Sophie, Akkiraju, Amala, Reshetikhin, Paul, Druga, Emanuel, Aggarwal, Aakriti, Gilbert, Benjamin, Bhave, Sunil, and Ajoy, Ashok

Subjects
Quantum Physics, Engineering, Electronics, Sensors and Digital Hardware, Physical Sciences, Bioengineering
Abstract

Quantum sensors have attracted broad interest in the quest towards sub-micronscale NMR spectroscopy. Such sensors predominantly operate at low magnetic fields. Instead, however, for high resolution spectroscopy, the high-field regime is naturally advantageous because it allows high absolute chemical shift discrimination. Here we demonstrate a high-field spin magnetometer constructed from an ensemble of hyperpolarized 13C nuclear spins in diamond. They are initialized by Nitrogen Vacancy (NV) centers and protected along a transverse Bloch sphere axis for minute-long periods. When exposed to a time-varying (AC) magnetic field, they undergo secondary precessions that carry an imprint of its frequency and amplitude. For quantum sensing at 7T, we demonstrate detection bandwidth up to 7 kHz, a spectral resolution

Published
2022

10. Hydration solids

Author

Harrellson, Steven G., DeLay, Michael S., Chen, Xi, Cavusoglu, Ahmet-Hamdi, Dworkin, Jonathan, Stone, Howard A., and Sahin, Ozgur

Published
2023
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12. High Resolution Dielectric Characterization of Single Cells and Microparticles Using Integrated Microfluidic Microwave Sensors

Author

Secme, Arda, Tefek, Uzay, Sari, Burak, Pisheh, Hadi Sedaghat, Uslu, H. Dilara, Akbulut, Ozge, Kucukoglu, Berk, Erdogan, R. Tufan, Alhmoud, Hashim, Sahin, Ozgur, and Hanay, M. Selim

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

Microwave sensors can probe intrinsic material properties of analytes in a microfluidic channel at physiologically relevant ion concentrations. While microwave sensors have been used to detect single cells and microparticles in earlier studies, the synergistic use and comparative analysis of microwave sensors with optical microscopy for material classification and size tracking applications have been scarcely investigated so far. Here we combined microwave and optical sensing to differentiate microscale objects based on their dielectric properties. We designed and fabricated two types of planar sensor: a Coplanar Waveguide Resonator (CPW) and a Split-Ring Resonator (SRR). Both sensors possessed sensing electrodes with a narrow gap to detect single cells passing through a microfluidic channel integrated on the same chip. We also show that standalone microwave sensors can track the relative changes in cellular size in real-time. In sensing single 20-micron diameter polystyrene particles, Signal-to-Noise ratio values of approximately 100 for CPW and 70 for SRR sensors were obtained. These findings demonstrate that microwave sensing technology can serve as a complementary technique for single-cell biophysical experiments and microscale pollutant screening.

Published
2020

14. Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis

Author

Janneh, Alhaji H., Kassir, Mohamed Faisal, Atilgan, F. Cansu, Lee, Han Gyul, Sheridan, Megan, Oleinik, Natalia, Szulc, Zdzislaw, Voelkel-Johnson, Christina, Nguyen, Hung, Li, Hong, Peterson, Yuri K., Marangoni, Elisabetta, Saatci, Ozge, Sahin, Ozgur, Lilly, Michael, Atkinson, Carl, Tomlinson, Stephen, Mehrotra, Shikhar, and Ogretmen, Besim

Published
2022
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16. HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin

Author

Biondini, Marco, Kiepas, Alex, El-Houjeiri, Leeanna, Annis, Matthew G., Hsu, Brian E., Fortier, Anne-Marie, Morin, Geneviève, Martina, José A., Sirois, Isabelle, Aguilar-Mahecha, Adriana, Gruosso, Tina, McGuirk, Shawn, Rose, April A. N., Tokat, Unal M., Johnson, Radia M., Sahin, Ozgur, Bareke, Eric, St-Pierre, Julie, Park, Morag, Basik, Mark, Majewski, Jacek, Puertollano, Rosa, Pause, Arnim, Huang, Sidong, Keler, Tibor, and Siegel, Peter M.

Published
2022
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22. Abstract A008: Toxic PARP trapping upon cAMP-induced DNA damage reinstates the efficacy of endocrine therapy and CDK4/6 inhibitors in treatment-refractory ER+ breast cancer

Author

Saatci, Ozge, primary, Cetin, Mein, additional, Uner, Meral, additional, Tokat, Unal Metin, additional, Chatzistamou, Ioulia, additional, Ersan, Pelin Gulizar, additional, Montaudon, Elodie, additional, Akyol, Aytekin, additional, Aksoy, Sercan, additional, Uner, Aysegul, additional, Marangoni, Elisabetta, additional, Sajish, Mathew, additional, and Sahin, Ozgur, additional

Published
2024
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24. Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer

Author

Saatci, Ozge, primary, Alam, Rashed, additional, Huynh-Dam, Kim-Tuyen, additional, Isik, Aynur, additional, Uner, Meral, additional, Belder, Nevin, additional, Ersan, Pelin Gulizar, additional, Cetin, Metin, additional, Tokat, Unal Metin, additional, Gedik, Mustafa Emre, additional, Bal, Hilal, additional, Sahin, Ozlem Sener, additional, Riazalhosseini, Yasser, additional, Thieffry, Denis, additional, Gautheret, Daniel, additional, Ogretmen, Besim, additional, Aksoy, Sercan, additional, Uner, Aysegul, additional, Akyol, Aytekin, additional, and Sahin, Ozgur, additional

Published
2023
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25. Time-varying tip-sample force measurements confirm steady-state dynamics in tapping-mode atomic force microscopy

Author

Sahin, Ozgur

Subjects
Physics - Instrumentation and Detectors
Abstract

Direct time-varying tip-sample force measurements by torsional harmonic cantilevers facilitate detailed investigations of the cantilever dynamics in tapping-mode atomic force microscopy. Here we report experimental evidence that the mathematical relationships describing the steady state dynamics are quantitatively satisfied by the independent measurements of tip-sample forces over a broad range of experimental conditions. These results confirm the existing understanding of the tapping-mode atomic force microscopy and build confidence on the reliability of time-varying tip-sample force measurements by the torsional harmonic cantilevers., Comment: 16 pages including 3 figures

Published
2007
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26. Harnessing bifurcations in tapping-mode atomic force microscopy to calibrate time-varying tip-sample force measurements

Author

Sahin, Ozgur

Subjects
Physics - Instrumentation and Detectors
Abstract

Torsional harmonic cantilevers allow measurement of time varying tip-sample forces in tapping-mode atomic force microscopy. Accuracy of these force measurements is important for quantitative nanomechanical measurements. Here we demonstrate a method to convert the torsional deflection signals into a calibrated force waveform with the use of non-linear dynamical response of the tapping cantilever. Specifically the transitions between steady oscillation regimes are used to calibrate the torsional deflection signals., Comment: 13 pages

Published
2007
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30. Cholesterol biogenesis is a PTEN‐dependent actionable node for the treatment of endocrine therapy‐refractory cancers

Author

Kaysudu, Irmak, primary, Gungul, Taha Bugra, additional, Atici, Sena, additional, Yilmaz, Sevval, additional, Bayram, Engin, additional, Guven, Gozde, additional, Cizmecioglu, Nihal Terzi, additional, Sahin, Ozgur, additional, Yesiloz, Gurkan, additional, Haznedaroglu, Berat Zeki, additional, and Cizmecioglu, Onur, additional

Published
2023
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31. Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer

Author

Gedik, Mustafa Emre, primary, Saatci, Ozge, additional, Oberholtzer, Nathaniel, additional, Uner, Meral, additional, Akbulut, Ozge, additional, Cetin, Metin, additional, Aras, Mertkaya, additional, Ibis, Kubra, additional, Caliskan, Burcu, additional, Banoglu, Erden, additional, Wiemann, Stefan, additional, Uner, Aysegul, additional, Aksoy, Sercan, additional, Mehrotra, Shikhar, additional, and Sahin, Ozgur, additional

Published
2023
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33. Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer

Author

Saatci, Ozge, Kaymak, Aysegul, Raza, Umar, Ersan, Pelin G., Akbulut, Ozge, Banister, Carolyn E., Sikirzhytski, Vitali, Tokat, Unal Metin, Aykut, Gamze, Ansari, Suhail A., Dogan, Hayriye Tatli, Dogan, Mehmet, Jandaghi, Pouria, Isik, Aynur, Gundogdu, Fatma, Kosemehmetoglu, Kemal, Dizdar, Omer, Aksoy, Sercan, Akyol, Aytekin, Uner, Aysegul, Buckhaults, Phillip J., Riazalhosseini, Yasser, and Sahin, Ozgur

Published
2020
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38. Abstract 3883: Overcoming tamoxifen resistance by re-activating cAMP-Ca2+−ROS-ferroptosis axis in ER+ breast cancer

Author

Alam, Rashedul, primary, Saatci, Ozge, additional, Uner, Meral Bugadyci, additional, Huynh-Dam, Kim-Tuyen, additional, Cetin, Metin, additional, Gedik, Mustafa Emre, additional, Belder, Nevin, additional, Bal, Hilal, additional, Tokat, Unal Metin, additional, Marangoni, Elisabetta, additional, Aksoy, Sercan, additional, Uner, Aysegul, additional, Akyol, Aytekin, additional, and Sahin, Ozgur, additional

Published
2023
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39. Abstract 578: Novel bi-thiazole LOX inhibitors to overcome chemotherapy resistance in triple negative breast cancer

Author

Cetin, Metin, primary, Saatci, Ozge, additional, Rezaeian, Abdol-Hossein, additional, Akbulut, Ozge, additional, Chintada, Nageswara Rao, additional, Taylor, Harrison, additional, Pederson, Breanna, additional, Chatzistamou, Ioulia, additional, Najafabadi, Hamed Shateri, additional, Lessner, Susan, additional, Angel, Peggi, additional, McInnes, Campbell, additional, and Sahin, Ozgur, additional

Published
2023
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43. Table S2 from Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors

Author

Wang, Lin, primary, Londono, Luz M., primary, Cowell, Jessica, primary, Saatci, Ozge, primary, Aras, Mertkaya, primary, Ersan, Pelin G., primary, Serra, Sara, primary, Pei, Hong, primary, Clift, Renee, primary, Zhao, Qiping, primary, Phan, Kim B., primary, Huang, Lei, primary, LaBarre, Michael J., primary, Li, Xiaoming, primary, Shepard, H. Michael, primary, Deaglio, Silvia, primary, Linden, Joel, primary, Thanos, Christopher D., primary, Sahin, Ozgur, primary, and Cekic, Caglar, primary

Published
2023
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44. Supplementary Figures from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells

Author

Schwab, Annemarie, primary, Siddiqui, Aarif, primary, Vazakidou, Maria Eleni, primary, Napoli, Francesca, primary, Böttcher, Martin, primary, Menchicchi, Bianca, primary, Raza, Umar, primary, Saatci, Özge, primary, Krebs, Angela M., primary, Ferrazzi, Fulvia, primary, Rapa, Ida, primary, Dettmer-Wilde, Katja, primary, Waldner, Maximilian J., primary, Ekici, Arif B., primary, Rasheed, Suhail Ahmed Kabeer, primary, Mougiakakos, Dimitrios, primary, Oefner, Peter J., primary, Sahin, Ozgur, primary, Volante, Marco, primary, Greten, Florian R., primary, Brabletz, Thomas, primary, and Ceppi, Paolo, primary

Published
2023
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45. Figure S1-11 from Targeting Adenosine with Adenosine Deaminase 2 to Inhibit Growth of Solid Tumors

Author

Wang, Lin, primary, Londono, Luz M., primary, Cowell, Jessica, primary, Saatci, Ozge, primary, Aras, Mertkaya, primary, Ersan, Pelin G., primary, Serra, Sara, primary, Pei, Hong, primary, Clift, Renee, primary, Zhao, Qiping, primary, Phan, Kim B., primary, Huang, Lei, primary, LaBarre, Michael J., primary, Li, Xiaoming, primary, Shepard, H. Michael, primary, Deaglio, Silvia, primary, Linden, Joel, primary, Thanos, Christopher D., primary, Sahin, Ozgur, primary, and Cekic, Caglar, primary

Published
2023
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46. Supplementary Table from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells

Author

Schwab, Annemarie, primary, Siddiqui, Aarif, primary, Vazakidou, Maria Eleni, primary, Napoli, Francesca, primary, Böttcher, Martin, primary, Menchicchi, Bianca, primary, Raza, Umar, primary, Saatci, Özge, primary, Krebs, Angela M., primary, Ferrazzi, Fulvia, primary, Rapa, Ida, primary, Dettmer-Wilde, Katja, primary, Waldner, Maximilian J., primary, Ekici, Arif B., primary, Rasheed, Suhail Ahmed Kabeer, primary, Mougiakakos, Dimitrios, primary, Oefner, Peter J., primary, Sahin, Ozgur, primary, Volante, Marco, primary, Greten, Florian R., primary, Brabletz, Thomas, primary, and Ceppi, Paolo, primary

Published
2023
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47. Data from Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells

Author

Schwab, Annemarie, primary, Siddiqui, Aarif, primary, Vazakidou, Maria Eleni, primary, Napoli, Francesca, primary, Böttcher, Martin, primary, Menchicchi, Bianca, primary, Raza, Umar, primary, Saatci, Özge, primary, Krebs, Angela M., primary, Ferrazzi, Fulvia, primary, Rapa, Ida, primary, Dettmer-Wilde, Katja, primary, Waldner, Maximilian J., primary, Ekici, Arif B., primary, Rasheed, Suhail Ahmed Kabeer, primary, Mougiakakos, Dimitrios, primary, Oefner, Peter J., primary, Sahin, Ozgur, primary, Volante, Marco, primary, Greten, Florian R., primary, Brabletz, Thomas, primary, and Ceppi, Paolo, primary

Published
2023
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48. Data from 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation

Author

Rehman, Sumaiyah K., primary, Li, Shau-Hsuan, primary, Wyszomierski, Shannon L., primary, Wang, Qingfei, primary, Li, Ping, primary, Sahin, Ozgur, primary, Xiao, Yi, primary, Zhang, Siyuan, primary, Xiong, Yan, primary, Yang, Jun, primary, Wang, Hai, primary, Guo, Hua, primary, Zhang, Jitao D., primary, Medina, Daniel, primary, Muller, William J., primary, and Yu, Dihua, primary

Published
2023
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49. Supplementary Figure 2 from Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer

Author

Wang, Qingfei, primary, Li, Shau-Hsuan, primary, Wang, Hai, primary, Xiao, Yi, primary, Sahin, Ozgur, primary, Brady, Samuel W., primary, Li, Ping, primary, Ge, Hailiang, primary, Jaffee, Elizabeth M., primary, Muller, William J., primary, Hortobagyi, Gabriel N., primary, and Yu, Dihua, primary

Published
2023
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50. Supplementary Figure 7 from Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer

Author

Wang, Qingfei, primary, Li, Shau-Hsuan, primary, Wang, Hai, primary, Xiao, Yi, primary, Sahin, Ozgur, primary, Brady, Samuel W., primary, Li, Ping, primary, Ge, Hailiang, primary, Jaffee, Elizabeth M., primary, Muller, William J., primary, Hortobagyi, Gabriel N., primary, and Yu, Dihua, primary

Published
2023
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