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Background The periorbital region is one of the areas showing the earliest signs of aging and is especially prone to skin wrinkles and discoloration. Both fractional carbon dioxide (CO2) laser and intense pulsed light (IPL) have been evaluated in treatment of periorbital wrinkles. Objective The objective of this study was to evaluate and compare the efficacy of fractional CO2 laser and IPL in the treatment of periorbital wrinkles. Patients and Methods The present study is a prospective comparative split face study which included 20 adult female patients with mild to moderate periorbital wrinkles. Their age ranged from 30 to 40 years. Each patient received four treatment sessions with three weeks intervals on each side of the periorbital region, one with IPL and one with fractional CO2 laser. Evaluation was done before each treatment session and two months after last session with ordinary photographs and by wrinkles indentation index as calculated by the Antera 3D camera. Results There was a highly statistically difference between the mean percentage of improvement of the wrinkles indentation index by fractional CO2 laser as compared to IPL. Conclusion Both IPL and fractional CO2 laser are promising effective modalities of treatment of periorbital wrinkles which are easy and safe to use. However, fractional CO2 laser is more effective and leads to more improvement in wrinkles indentation index by Antera camera score.

Background Psoriasis is known as chronic immune-mediated inflammatory skin disease affecting about 3% of the world’s population. Cytokine gene polymorphism attracted considerable interest as they have been found to alter gene transcription thereby influencing inflammatory processes in response to various diseases. Subjects A total of 50 psoraitic patients and 50 controls were genotyped for TNF–α −238G/A polymorphism by using polymerase chain reaction. ECG and lipid profile were done to assess cardiovascular risk. Results Polymorphism of TNF–α −238 was not found to be associated with an increased risk for psoriasis (p value 0.98). There is significant difference between cases and controls as regard systolic and diastolic blood pressure . Conclusion Our findings suggest that there is no association between TNF alpha polymorphism and risk of psoriasis in Egyptian psoraitic patients.

Background: Acne is the most common skin disease affecting adolescents and young adults, with associated scarring and its sequelae. Treatment options are either lifting procedures raising scar base closer to normal skin surface, or resurfacing ones injuring epidermis and superficial dermis with neocollagenesis and epidermal repair. Punch elevation (PE) method is better for improving deep atrophic acne scars, that can be combined with depth resurfacing. CO2 laser stimulates new collagen formation, tightens skin and raises scar to surface. Aim of the Work: to assess efficacy and safety of combination of PE technique and fractional co2 laser (Fr co2 L) compared to fr co2 L alone. Subjects and Methods: 20 atrophic post acne scars patients were subjected to history taking, general and dermatological examinations, identifying scars types and grades. Treatment response at start, before each fr. co2 L session and 4 weeks after last laser session was clinically evaluated by Goodman and Baron scale, and recording patients’ photographs, satisfaction, and complications. Histopathological examination of scar skin biopsies before and 4 weeks after the last fr. co2 L session was done using H&E, Mallory trichome, sliver stain and immunohistochemical VEGF. Results: combined treatment with fr co2 L and PE was more effective in improving post acne scars than fr. co2 L resurfacing alone. Histopathological examination before combined fr. co2 L and PE treatment and 1 month after the last fr. co2 L session showed high significant increase in epidermal thickness (H&E), increase in collagen fiber type III (Mallory trichrome stain), decrease in collagen fiber type I (sliver stain) and increase in fibroblasts’ activity (VEGF). Conclusion: both PE technique and fr. co2 L resurfacing show promising efficacy and safety in treating atrophic post acne scars, complementing each other to improve skin texture and appearance, with excellent cosmetic outcomes.