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405 results on '"Sahaf, Bita"'

1. Engineered CD47 protects T cells for enhanced antitumour immunity

Author

Yamada-Hunter, Sean A., Theruvath, Johanna, McIntosh, Brianna J., Freitas, Katherine A., Lin, Frank, Radosevich, Molly T., Leruste, Amaury, Dhingra, Shaurya, Martinez-Velez, Naiara, Xu, Peng, Huang, Jing, Delaidelli, Alberto, Desai, Moksha H., Good, Zinaida, Polak, Roel, May, Audre, Labanieh, Louai, Bjelajac, Jeremy, Murty, Tara, Ehlinger, Zach, Mount, Christopher W., Chen, Yiyun, Heitzeneder, Sabine, Marjon, Kristopher D., Banuelos, Allison, Khan, Omair, Wasserman, Savannah L., Spiegel, Jay Y., Fernandez-Pol, Sebastian, Kuo, Calvin J., Sorensen, Poul H., Monje, Michelle, Majzner, Robbie G., Weissman, Irving L., Sahaf, Bita, Sotillo, Elena, Cochran, Jennifer R., and Mackall, Crystal L.

Published
2024
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2. CD22 CAR T cells demonstrate high response rates and safety in pediatric and adult B-ALL: Phase 1b results

Author

Schultz, Liora M., Jeyakumar, Nikeshan, Kramer, Anne Marijn, Sahaf, Bita, Srinagesh, Hrishi, Shiraz, Parveen, Agarwal, Neha, Hamilton, Mark, Erickson, Courtney, Jacobs, Ashley, Moon, Jennifer, Baggott, Christina, Arai, Sally, Bharadwaj, Sushma, Johnston, Laura J., Liedtke, Michaela, Lowsky, Robert, Meyer, Everett, Negrin, Robert, Rezvani, Andrew, Shizuru, Judy, Sidana, Surbhi, Egeler, Emily, Mavroukakis, Sharon, Tunuguntla, Ramya, Gkitsas-Long, Nikolaos, Retherford, Aidan, Brown, Annie Kathleen, Gramstrap-Petersen, Anne-Louise, Ibañez, Raquel Martin, Feldman, Steven A., Miklos, David B., Mackall, Crystal L., Davis, Kara L., Frank, Matthew, Ramakrishna, Sneha, and Muffly, Lori

Published
2024
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3. A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia

Author

Srinagesh, Hrishikesh, Jackson, Clayton, Shiraz, Parveen, Jeyakumar, Nikeshan, Hamilton, Mark, Egeler, Emily, Mavroukakis, Sharon, Kuo, Adam, Cancilla, Juancarlos, Sahaf, Bita, Agarwal, Neha, Kanegai, Alyssa, Kramer, Anne Marijn, Arai, Sally, Bharadwaj, Sushma, Dahiya, Saurabh, Hosoya, Hitomi, Johnston, Laura, Kennedy, Vanessa, Liedtke, Michaela, Lowsky, Robert, Mikkilineni, Lekha, Negrin, Robert, Rezvani, Andrew, Sidana, Surbhi, Shizuru, Judith, Smith, Melody, Weng, Wen-Kai, Feldman, Steven, Frank, Matthew J., Lee, Zachary, Tagliaferri, Mary, Marcondes, A. Mario, Miklos, David, Mackall, Crystal, and Muffly, Lori

Published
2024
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4. CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study

Author

Klysz, Dorota Danuta, Gkitsas-Long, Nikolaos, Bacigalupi, Juliana, Iglesias, Maria, Crawford, Emma, Nichols, Linnea, Cunanan, Kristen, Tamaresis, John, Spiegel, Jay Y., Ehlinger, Zachary, Kuo, Adam, Reynolds, Warren D., Arai, Sally, Johnston, Laura, Lowsky, Robert, Meyer, Everett, Negrin, Robert S., Rezvani, Andrew R., Shiraz, Parveen, Sidana, Surbhi, Weng, Wen Kai, Bharadwaj, Sushma, Dahiya, Saurabh, Smith, Melody, Schultz, Liora M., Ramakrishna, Sneha, Davis, Kara L., Tunuguntla, Ramya, Frank, Matthew J, Baird, John H, Kramer, Anne Marijn, Srinagesh, Hrishikesh K, Patel, Shabnum, Brown, Annie Kathleen, Oak, Jean S, Younes, Sheren F, Natkunam, Yasodha, Hamilton, Mark P, Su, Yi-Jiun, Agarwal, Neha, Chinnasamy, Harshini, Egeler, Emily, Mavroukakis, Sharon, Feldman, Steven A, Sahaf, Bita, Mackall, Crystal L, Muffly, Lori, and Miklos, David B

Published
2024
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5. CAR19 monitoring by peripheral blood immunophenotyping reveals histology-specific expansion and toxicity

Author

Hamilton, Mark P., Craig, Erin, Gentille Sanchez, Cesar, Mina, Alain, Tamaresis, John, Kirmani, Nadia, Ehlinger, Zachary, Syal, Shriya, Good, Zinaida, Sworder, Brian, Schroers-Martin, Joseph, Lu, Ying, Muffly, Lori, Negrin, Robert S., Arai, Sally, Lowsky, Robert, Meyer, Everett, Rezvani, Andrew R., Shizuru, Judith, Weng, Wen-Kai, Shiraz, Parveen, Sidana, Surbhi, Bharadwaj, Sushma, Smith, Melody, Dahiya, Saurabh, Sahaf, Bita, Kurtz, David M., Mackall, Crystal L., Tibshirani, Robert, Alizadeh, Ash A., Frank, Matthew J., and Miklos, David B.

Published
2024
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7. Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy

Author

Kaczanowska, Sabina, Murty, Tara, Alimadadi, Ahmad, Contreras, Cristina F., Duault, Caroline, Subrahmanyam, Priyanka B., Reynolds, Warren, Gutierrez, Norma A., Baskar, Reema, Wu, Catherine J., Michor, Franziska, Altreuter, Jennifer, Liu, Yang, Jhaveri, Aashna, Duong, Vandon, Anbunathan, Hima, Ong, Claire, Zhang, Hua, Moravec, Radim, Yu, Joyce, Biswas, Roshni, Van Nostrand, Stephen, Lindsay, James, Pichavant, Mina, Sotillo, Elena, Bernstein, Donna, Carbonell, Amanda, Derdak, Joanne, Klicka-Skeels, Jacquelyn, Segal, Julia E., Dombi, Eva, Harmon, Stephanie A., Turkbey, Baris, Sahaf, Bita, Bendall, Sean, Maecker, Holden, Highfill, Steven L., Stroncek, David, Glod, John, Merchant, Melinda, Hedrick, Catherine C., Mackall, Crystal L., Ramakrishna, Sneha, and Kaplan, Rosandra N.

Published
2024
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8. Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy

Author

Good, Zinaida, Spiegel, Jay Y., Sahaf, Bita, Malipatlolla, Meena B., Ehlinger, Zach J., Kurra, Sreevidya, Desai, Moksha H., Reynolds, Warren D., Wong Lin, Anita, Vandris, Panayiotis, Wu, Fang, Prabhu, Snehit, Hamilton, Mark P., Tamaresis, John S., Hanson, Paul J., Patel, Shabnum, Feldman, Steven A., Frank, Matthew J., Baird, John H., Muffly, Lori, Claire, Gursharan K., Craig, Juliana, Kong, Katherine A., Wagh, Dhananjay, Coller, John, Bendall, Sean C., Tibshirani, Robert J., Plevritis, Sylvia K., Miklos, David B., and Mackall, Crystal L.

Published
2022
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9. Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy

Author

Hamilton, Mark P., primary, Sugio, Takeshi, additional, Noordenbos, Troy, additional, Shi, Shuyu, additional, Bulterys, Philip L., additional, Liu, Chih Long, additional, Kang, Xiaoman, additional, Olsen, Mari N., additional, Good, Zinaida, additional, Dahiya, Saurabh, additional, Frank, Matthew J., additional, Sahaf, Bita, additional, Mackall, Crystal L., additional, Gratzinger, Dita, additional, Diehn, Maximilian, additional, Alizadeh, Ash A., additional, and Miklos, David B., additional

Published
2024
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10. Early cytopenias and infections after standard of care idecabtagene vicleucel in relapsed or refractory multiple myeloma

Author

Logue, Jennifer M., Peres, Lauren C., Hashmi, Hamza, Colin-Leitzinger, Christelle M., Shrewsbury, Alexandria M., Hosoya, Hitomi, Gonzalez, Rebecca M., Copponex, Christina, Kottra, Krista H., Hovanky, Vanna, Sahaf, Bita, Patil, Sunita, Lazaryan, Aleksandr, Jain, Michael D., Baluch, Aliyah, Klinkova, Olga V., Bejanyan, Nelli, Faramand, Rawan G., Elmariah, Hany, Khimani, Farhad, Davila, Marco L., Mishra, Asmita, Blue, Brandon J., Grajales-Cruz, Ariel F., Castaneda Puglianini, Omar A., Liu, Hien D., Nishihori, Taiga, Freeman, Ciara L., Brayer, Jason B., Shain, Kenneth H., Baz, Rachid C., Locke, Frederick L., Alsina, Melissa, Sidana, Surbhi, and Hansen, Doris K.

Published
2022
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11. Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

Author

Hartmann, Felix J, Babdor, Joel, Gherardini, Pier Federico, Amir, El-Ad D, Jones, Kyle, Sahaf, Bita, Marquez, Diana M, Krutzik, Peter, O’Donnell, Erika, Sigal, Natalia, Maecker, Holden T, Meyer, Everett, Spitzer, Matthew H, and Bendall, Sean C

Subjects
Biological Sciences, Transplantation, Immunization, Clinical Research, Vaccine Related, Inflammatory and immune system, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Biomarkers, Clinical Trials as Topic, Female, Graft vs Host Disease, Humans, Immunophenotyping, Immunotherapy, Male, Middle Aged, Monitoring, Immunologic, Neoplasms, Reference Standards, CyTOF, biomarker, bone marrow transplantation, cancer, immunotherapy, mass cytometry, monitoring, phenotyping, Cancer, Phenotyping, Monitoring, Mass Cytometry, Biomarker, Bone Marrow Transplantation, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

The success of immunotherapy has led to a myriad of clinical trials accompanied by efforts to gain mechanistic insight and identify predictive signatures for personalization. However, many immune monitoring technologies face investigator bias, missing unanticipated cellular responses in limited clinical material. We present here a mass cytometry (CyTOF) workflow for standardized, systems-level biomarker discovery in immunotherapy trials. To broadly enumerate immune cell identity and activity, we established and extensively assessed a reference panel of 33 antibodies to cover major cell subsets, simultaneously quantifying activation and immune checkpoint molecules in a single assay. This assay enumerates ≥98% of peripheral immune cells with ≥4 positively identifying antigens. Robustness and reproducibility are demonstrated on multiple samples types, across two research centers and by orthogonal measurements. Using automated analysis, we identify stratifying immune signatures in bone marrow transplantation-associated graft-versus-host disease. Together, this validated workflow ensures comprehensive immunophenotypic analysis and data comparability and will accelerate biomarker discovery.

Published
2019

12. Transplantation of donor grafts with defined ratio of conventional and regulatory T cells in HLA-matched recipients.

Author

Meyer, Everett, Laport, Ginna, Xie, Bryan, MacDonald, Kate, Sahaf, Bita, Tang, Sai-Wen, Baker, Jeanette, Armstrong, Randall, Tate, Keri, Tadisco, Cynthia, Arai, Sally, Johnston, Laura, Lowsky, Robert, Muffly, Lori, Rezvani, Andrew, Shizuru, Judith, Weng, Wen-Kai, Sheehan, Kevin, Miklos, David, Negrin, Robert, and Heydari, Kartoosh

Subjects
Bone marrow transplantation, Cellular immune response, Clinical Trials, Transplantation, Adult, Aged, Bone Marrow Transplantation, Female, Graft vs Host Disease, Hematologic Neoplasms, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, T-Lymphocytes, Regulatory, Tissue Donors, Young Adult
Abstract

BACKGROUNDIn preclinical murine and early clinical studies of hematopoietic cell transplantation, engineering of donor grafts with defined ratios of CD4+CD25+FoxP3+ Tregs to conventional T cells (Tcons) results in the prevention of graft-versus-host disease and improved immune reconstitution. The use of highly purified primary graft Tregs for direct cell infusion has potential advantages over impure immunomagnetic selection or culture expansion, but has not been tested clinically. We performed a phase I study of the timed addition of CD34-selected hematopoietic stem cells and Tregs, followed by Tcons for the treatment of patients with high-risk hematological malignancies.METHODSWe present interim evaluation of a single-center open phase I/II study of administration of human leukocyte-matched Tregs and CD34-selected hematopoietic cells, followed by infusion of an equal ratio of Tcons in adult patients undergoing myeloablative hematopoietic stem cell transplantation (HCT) for high-risk or active hematological malignancies. Tregs were purified by immunomagnetic selection and high-speed cell sorting.RESULTSHere we report results for the first 12 patients who received Tregs of between 91% and 96% purity. Greater than grade II GVHD was noted in 2 patients in the first cohort of 5 patients, who received cryopreserved Tregs, but neither acute nor chronic GVHD was noted in the second cohort of 7 patients, who received fresh Tregs and single-agent GVHD prophylaxis. Patients in the second cohort appeared to have normal immune reconstitution compared with patients who underwent transplantation and did not develop GVHD.CONCLUSIONOur study shows that the use of highly purified fresh Tregs is clinically feasible and supports continued investigation of the strategy.TRIAL REGISTRATIONClinicalTrials.gov NCT01660607.FUNDINGNIH NHBLI R01 HL114591 and K08HL119590.

Published
2019

13. Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells

Author

Good, Zinaida, Borges, Luciene, Vivanco Gonzalez, Nora, Sahaf, Bita, Samusik, Nikolay, Tibshirani, Robert, Nolan, Garry P, and Bendall, Sean C

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Stem Cell Research, Vaccine Related, Stem Cell Research - Nonembryonic - Non-Human, Infectious Diseases, Cancer, Regenerative Medicine, Stem Cell Research - Nonembryonic - Human, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Cell Differentiation, Cell Proliferation, Cell Tracking, Humans, Lymphocyte Activation, Multipotent Stem Cells, Single-Cell Analysis, T-Lymphocytes
Abstract

Selective differentiation of naive T cells into multipotent T cells is of great interest clinically for the generation of cell-based cancer immunotherapies. Cellular differentiation depends crucially on division state and time. Here we adapt a dye dilution assay for tracking cell proliferative history through mass cytometry and uncouple division, time and regulatory protein expression in single naive human T cells during their activation and expansion in a complex ex vivo milieu. Using 23 markers, we defined groups of proteins controlled predominantly by division state or time and found that undivided cells account for the majority of phenotypic diversity. We next built a map of cell state changes during naive T-cell expansion. By examining cell signaling on this map, we rationally selected ibrutinib, a BTK and ITK inhibitor, and administered it before T cell activation to direct differentiation toward a T stem cell memory (TSCM)-like phenotype. This method for tracing cell fate across division states and time can be broadly applied for directing cellular differentiation.

Published
2019

14. GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas

Author

Majzner, Robbie G., Ramakrishna, Sneha, Yeom, Kristen W., Patel, Shabnum, Chinnasamy, Harshini, Schultz, Liora M., Richards, Rebecca M., Jiang, Li, Barsan, Valentin, Mancusi, Rebecca, Geraghty, Anna C., Good, Zinaida, Mochizuki, Aaron Y., Gillespie, Shawn M., Toland, Angus Martin Shaw, Mahdi, Jasia, Reschke, Agnes, Nie, Esther H., Chau, Isabelle J., Rotiroti, Maria Caterina, Mount, Christopher W., Baggott, Christina, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Erickson, Courtney, Green, Sean, Kunicki, Michael, Fujimoto, Michelle, Ehlinger, Zach, Reynolds, Warren, Kurra, Sreevidya, Warren, Katherine E., Prabhu, Snehit, Vogel, Hannes, Rasmussen, Lindsey, Cornell, Timothy T., Partap, Sonia, Fisher, Paul G., Campen, Cynthia J., Filbin, Mariella G., Grant, Gerald, Sahaf, Bita, Davis, Kara L., Feldman, Steven A., Mackall, Crystal L., and Monje, Michelle

Published
2022
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17. CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

Author

Spiegel, Jay Y., Patel, Shabnum, Muffly, Lori, Hossain, Nasheed M., Oak, Jean, Baird, John H., Frank, Matthew J., Shiraz, Parveen, Sahaf, Bita, Craig, Juliana, Iglesias, Maria, Younes, Sheren, Natkunam, Yasodha, Ozawa, Michael G., Yang, Eric, Tamaresis, John, Chinnasamy, Harshini, Ehlinger, Zach, Reynolds, Warren, Lynn, Rachel, Rotiroti, Maria Caterina, Gkitsas, Nikolaos, Arai, Sally, Johnston, Laura, Lowsky, Robert, Majzner, Robbie G., Meyer, Everett, Negrin, Robert S., Rezvani, Andrew R., Sidana, Surbhi, Shizuru, Judith, Weng, Wen-Kai, Mullins, Chelsea, Jacob, Allison, Kirsch, Ilan, Bazzano, Magali, Zhou, Jing, Mackay, Sean, Bornheimer, Scott J., Schultz, Liora, Ramakrishna, Sneha, Davis, Kara L., Kong, Katherine A., Shah, Nirali N., Qin, Haiying, Fry, Terry, Feldman, Steven, Mackall, Crystal L., and Miklos, David B.

Published
2021
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18. Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma

Author

Baird, John H., Epstein, David J., Tamaresis, John S., Ehlinger, Zachary, Spiegel, Jay Y., Craig, Juliana, Claire, Gursharan K., Frank, Matthew J., Muffly, Lori, Shiraz, Parveen, Meyer, Everett, Arai, Sally, Brown, Janice (Wes), Johnston, Laura, Lowsky, Robert, Negrin, Robert S., Rezvani, Andrew R., Weng, Wen-Kai, Latchford, Theresa, Sahaf, Bita, Mackall, Crystal L., Miklos, David B., and Sidana, Surbhi

Published
2021
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19. Pharmacology, Formulations, and Adverse Effects

Author

Frye, Richard Eugene, Andrus, James P., Lemley, Kevin V., De Rosa, Stephen C., Ghezzi, Pietro, Holmgren, Arne, Jones, Dean, Jahoor, Farook, Kopke, Richard, Cotgreave, Ian, Bottiglieri, Teodoro, Kaplowitz, Neil, Nakamura, Hajime, Staal, Frank, Ela, Stephen W., Atkuri, Kondala R., Tirouvanziam, Rabindra, Heydari, Kartoosh, Sahaf, Bita, Zolopa, Andrew, Mantovani, John J., Herzenberg, Leonard A., Herzenberg, Leonore A., Frye, Richard Eugene, editor, and Berk, Michael, editor

Published
2019
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20. Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease

Author

Ghezzi, Pietro, Lemley, Kevin V., Andrus, James P., De Rosa, Stephen C., Holmgren, Arne, Jones, Dean, Jahoor, Farook, Kopke, Richard, Cotgreave, Ian, Bottiglieri, Teodoro, Kaplowitz, Neil, Nakamura, Hajime, Staal, Frank, Ela, Stephen W., Atkuri, Kondala R., Tirouvanziam, Rabindra, Heydari, Kartoosh, Sahaf, Bita, Zolopa, Andrew, Frye, Richard Eugene, Mantovani, John J., Herzenberg, Leonard A., Herzenberg, Leonore A., Frye, Richard Eugene, editor, and Berk, Michael, editor

Published
2019
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21. CD22 CAR T-Cells Manufactured in Prodigy System and in Bag Culture Yield Equivalent Responses for B-ALL

Author

Dreyzin, Alexandra, primary, Kramer, Anne Marijn, additional, Yates, Bonnie, additional, Wang, Hao-Wei, additional, Sahaf, Bita, additional, Yuan, Constance, additional, Ehlinger, Zachary, additional, Patil, Sunita, additional, Martin, Kathryn, additional, Muffly, Lori S, additional, Shalabi, Haneen, additional, Davis, Kara L, additional, Frank, Matthew J., additional, Schultz, Liora Michal, additional, Altan-Bonnet, Gregoire, additional, Mackall, Crystal L., additional, Taylor, Naomi, additional, Highfill, Steven, additional, Feldman, Steven, additional, Stroncek, David F., additional, Ramakrishna, Sneha, additional, and Shah, Nirali N., additional

Published
2024
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22. CAR19 Therapy Drives Expansion of Clonal Hematopoiesis and Associated Cytopenias

Author

Hamilton, Mark P., primary, Sworder, Brian, additional, Alig, Stefan, additional, Good, Zinaida, additional, Boegeholz, Jan, additional, Schroers-Martin, Joseph, additional, Tamaresis, John, additional, Esfahani, Mohammad, additional, Lu, Ying, additional, Olsen, Mari, additional, Liu, Chih Long, additional, Ehlinger, Zachary, additional, Desai, Moksha, additional, Liu-Fei, Felicia, additional, Muffly, Lori S, additional, Negrin, Robert S., additional, Arai, Sally, additional, Johnston, Laura, additional, Lowsky, Robert, additional, Meyer, Everett H., additional, Rezvani, Andrew R., additional, Shizuru, Judith A., additional, Weng, Wen-Kai, additional, Shiraz, Parveen, additional, Sidana, Surbhi, additional, Bharadwaj, Sushma, additional, Smith, Melody, additional, Dahiya, Saurabh, additional, Sahaf, Bita, additional, Diehn, Max, additional, Frank, Matthew J., additional, Mackall, Crystal L., additional, Kurtz, David, additional, Miklos, David B., additional, and Alizadeh, Ash A., additional

Published
2024
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23. Effective Prevention of Steroid-Requiring Chronic Gvhd with B Cell Depletion: A Randomized, Placebo-Controlled Trial

Author

Cutler, Corey, primary, Kim, Haesook T, additional, Banna, Hassan El, additional, Halloran, Elizabeth, additional, Matozel, Emily, additional, Ho, Vincent, additional, Koreth, John, additional, Gooptu, Mahasweta, additional, Shapiro, Roman M., additional, Kelkar, Amar H., additional, Gibson, Chris J., additional, Reynolds, Carol, additional, Ansuinelli, Michela, additional, Tamada, Rayuko, additional, Au, Chloe, additional, DeFilipp, Zachariah, additional, El-Jawahri, Areej, additional, Chen, Dr. Yi-Bin, additional, Jurdi, Najla El, additional, Weisdorf, Daniel J., additional, Couriel, Daniel R., additional, Lee, Catherine J., additional, Sahaf, Bita, additional, Craig, Juliana, additional, Ji, Kathleen, additional, Soiffer, Robert, additional, Antin, Joseph H., additional, Miklos, David B., additional, and Ritz, Jerome, additional

Published
2024
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24. Real Time, Point-of-Need Measurement of Blood CD19 CAR-T Vector Load Is Concordant with Standard Ddpcr Method

Author

Bharadwaj, Sushma, primary, Smith, Courtney J, additional, Nater, Jenny, additional, Vardhanabhuti, Saran, additional, Mallampet, Jayasindhu, additional, Elkordy, Sarah, additional, Fang, Jing, additional, Twoy, Abigail, additional, Syal, Shriya, additional, Broos, Katrijn, additional, Wuyts, Jan, additional, Braem, Gorik, additional, Adriany, Tom, additional, Metsu, Sofie, additional, Maertens, Geert, additional, Mattie, Mike, additional, Sahaf, Bita, additional, Kong, Katherine A., additional, Smith, Melody, additional, Frank, Matthew J., additional, Dahiya, Saurabh, additional, Shen, Rhine R., additional, and Miklos, David B., additional

Published
2024
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25. Analysis of PET-CT Derived Radiomic Biomarkers with Efficacy, Safety, and Expansion of Axicabtagene Ciloleucel (Axi-Cel) in Patients with Relapsed or Refractory Large B-Cell Lymphoma (LBCL)

Author

Bharadwaj, Sushma, primary, Lau, Eric, additional, Hashmi, Ayesha, additional, Hamilton, Mark P., additional, Jensen, Alexandria, additional, Goyal, Anmol, additional, Marar, Mallika, additional, Lee, Caroline, additional, Ananth, Snegha, additional, Sahaf, Bita, additional, Mallampet, Jayasindhu, additional, Ehlinger, Zachary, additional, Syal, Shriya, additional, Patil, Sunita, additional, Guo, Henry, additional, Smith, Melody, additional, Weng, Wen-Kai, additional, Frank, Matthew J., additional, Binkley, Michael S, additional, Miklos, David B., additional, and Dahiya, Saurabh, additional

Published
2024
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26. Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy

Author

Kaczanowska, Sabina, primary, Murty, Tara, additional, Alimadadi, Ahmad, additional, Contreras, Cristina F., additional, Duault, Caroline, additional, Subrahmanyam, Priyanka B., additional, Reynolds, Warren, additional, Gutierrez, Norma A., additional, Baskar, Reema, additional, Wu, Catherine J., additional, Michor, Franziska, additional, Altreuter, Jennifer, additional, Liu, Yang, additional, Jhaveri, Aashna, additional, Duong, Vandon, additional, Anbunathan, Hima, additional, Ong, Claire, additional, Zhang, Hua, additional, Moravec, Radim, additional, Yu, Joyce, additional, Biswas, Roshni, additional, Van Nostrand, Stephen, additional, Lindsay, James, additional, Pichavant, Mina, additional, Sotillo, Elena, additional, Bernstein, Donna, additional, Carbonell, Amanda, additional, Derdak, Joanne, additional, Klicka-Skeels, Jacquelyn, additional, Segal, Julia E., additional, Dombi, Eva, additional, Harmon, Stephanie A., additional, Turkbey, Baris, additional, Sahaf, Bita, additional, Bendall, Sean, additional, Maecker, Holden, additional, Highfill, Steven L., additional, Stroncek, David, additional, Glod, John, additional, Merchant, Melinda, additional, Hedrick, Catherine C., additional, Mackall, Crystal L., additional, Ramakrishna, Sneha, additional, and Kaplan, Rosandra N., additional

Published
2023
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28. CD22-directed CAR T-cell therapy for large B-cell lymphomas progressing after CD19-directed CAR T-cell therapy: a dose-finding phase 1 study

Author

Frank, Matthew J, Baird, John H, Kramer, Anne Marijn, Srinagesh, Hrishikesh K, Patel, Shabnum, Brown, Annie Kathleen, Oak, Jean S, Younes, Sheren F, Natkunam, Yasodha, Hamilton, Mark P, Su, Yi-Jiun, Agarwal, Neha, Chinnasamy, Harshini, Egeler, Emily, Mavroukakis, Sharon, Feldman, Steven A, Sahaf, Bita, Mackall, Crystal L, Muffly, Lori, Miklos, David B, Klysz, Dorota Danuta, Gkitsas-Long, Nikolaos, Bacigalupi, Juliana, Iglesias, Maria, Crawford, Emma, Nichols, Linnea, Cunanan, Kristen, Tamaresis, John, Spiegel, Jay Y., Ehlinger, Zachary, Kuo, Adam, Reynolds, Warren D., Arai, Sally, Johnston, Laura, Lowsky, Robert, Meyer, Everett, Negrin, Robert S., Rezvani, Andrew R., Shiraz, Parveen, Sidana, Surbhi, Weng, Wen Kai, Bharadwaj, Sushma, Dahiya, Saurabh, Smith, Melody, Schultz, Liora M., Ramakrishna, Sneha, Davis, Kara L., and Tunuguntla, Ramya

Abstract

Outcomes are poor for patients with large B-cell lymphoma who relapse after CD19-directed chimeric antigen receptor (CAR) T-cell therapy (CAR19). CD22 is a nearly universally expressed B-cell surface antigen and the efficacy of a CD22-directed CAR T-cell therapy (CAR22) in large B-cell lymphoma is unknown, which was what we aimed to examine in this study.

Published
2024
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29. Transcriptional Profiling Associated with CD22 CAR T Cell Clinical Response in LBCL

Author

Kramer, Anne Marijn, primary, Hamilton, Mark P., additional, Prabhu, Snehit, additional, Desai, Moksha, additional, Kuo, Adam, additional, Ehlinger, Zachary, additional, Agarwal, Neha, additional, Su, Yi-Jiun, additional, Gkitsas, Nikolaos, additional, Fowler, Carley, additional, Keerthi, Vimal, additional, Retherford, Aidan, additional, Klysz, Dorota, additional, Tunuguntla, Ramya, additional, Feldman, Steven, additional, Sahaf, Bita, additional, Baird, John H., additional, Muffly, Lori S., additional, Mackall, Crystal L., additional, Miklos, David B., additional, Good, Zinaida, additional, and Frank, Matthew J., additional

Published
2023
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30. S230: CD22 CAR T CELL THERAPY IS SAFE AND EFFECTIVE IN PATIENTS WITH LARGE B CELL LYMPHOMA WHO HAVE RELAPSED AFTER CD19 CAR T CELL THERAPY.

Author

Frank, Matthew J., primary, Baird, John, additional, Kramer, Anne, additional, Patel, Shabnum, additional, Sahaf, Bita, additional, Craig, Juliana, additional, Crawford, Emma, additional, Younes, Sheren, additional, Oak, Jean, additional, Natkunan, Yasodha, additional, Spiegel, Jay, additional, Ehlinger, Zachary, additional, Chinnasamy, Harshini, additional, Reynolds, Warren, additional, Srinagesh, Hrishi, additional, Su, Yi-Jiun, additional, Egeler, Emily, additional, Feldman, Steven, additional, Mackall, Crystal, additional, Muffly, Lori, additional, and Miklos, David, additional

Published
2023
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32. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial

Author

Andermann, Tessa M., Fouladi, Farnaz, Tamburini, Fiona B., Sahaf, Bita, Tkachenko, Ekaterina, Greene, Courtney, Buckley, Matthew T., Brooks, Erin F., Hedlin, Haley, Arai, Sally, Mackall, Crystal L., Miklos, David, Negrin, Robert S., Fodor, Anthony A., Rezvani, Andrew R., and Bhatt, Ami S.

Published
2021
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35. Abstract 2142: Immune determinants of CAR-T expansion in solid tumor patients receiving GD2 CAR-T cell therapy

Author

Murty, Tara, primary, Kaczanowska, Sabina, additional, Alimadadi, Ahmad, additional, Contreras, Cristina, additional, Duault, Caroline, additional, Balasubrahmanyan, Priyanka, additional, Reynolds, Warren, additional, Gutierrez, Norma, additional, Baskar, Reema, additional, Wu, Catherine, additional, Michor, Franziska, additional, Altreuter, Jennifer, additional, Liu, Yang, additional, Jhaveri, Aashna, additional, Duong, Vandon, additional, Anbunathan, Hima, additional, Moravec, Radim, additional, Hong, Joyce, additional, Biswas, Roshni, additional, Van Nostrand, Stephen, additional, Lindsay, James, additional, Pichavant, Mina, additional, Sotillo, Elena, additional, Sahaf, Bita, additional, Bendall, Sean, additional, Maecker, Holden, additional, Highfill, Steven, additional, Stroncek, David, additional, Merchant, Melinda, additional, Glod, John, additional, Hedrick, Catherine, additional, Mackall, Crystal, additional, Ramakrishna, Sneha, additional, and Kaplan, Rosandra, additional

Published
2023
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36. Abstract 5741: Harnessing macrophages, while protecting T cells, enhances anti-tumor efficacy

Author

Yamada-Hunter, Sean A., primary, Theruvath, Johanna, additional, Radosevich, Molly T., additional, McIntosh, Brianna J., additional, Freitas, Katherine A., additional, Martinez-Velez, Naiara, additional, Sotillo, Elena, additional, Leruste, Amaury, additional, Xu, Peng, additional, Desai, Moksha H., additional, Sahaf, Bita, additional, Banuelos, Allison, additional, Wasserman, Savannah L., additional, Weissman, Irving L., additional, Cochran, Jennifer R., additional, and Mackall, Crystal L., additional

Published
2023
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37. Abstract 959: Immune signatures of GD2 CAR T cell activity in H3K27M+ diffuse midline glioma patients

Author

Ramakrishna, Sneha, primary, Good, Zinaida, additional, Desai, Moksha, additional, Zamler, Daniel, additional, Mancusi, Rebecca, additional, Mahdi, Jasia, additional, Majzner, Robbie, additional, Schultz, Liora, additional, Richards, Rebecca, additional, Kamens, Jennifer, additional, Barsan, Valentin, additional, Campen, Cynthia, additional, Partap, Sonia, additional, Ehlinger, Zachary, additional, Reynolds, Warren, additional, Chen, Yiyun, additional, Hamilton, Mark P., additional, Moon, Jennifer, additional, Baggott, Christina, additional, Kunicki, Michael, additional, Fujimoto, Michelle, additional, Li, Amy, additional, Jariwala, Sneha, additional, Mavroukakis, Sharon, additional, Egeler, Emily, additional, Jacobs, Ashley, additional, Erickson, Courtney, additional, Yamabe-Kwong, Karen, additional, Prabhu, Snehit, additional, Davis, Kara, additional, Feldman, Steve, additional, Sahaf, Bita, additional, Mackall, Crystal L., additional, and Monje, Michelle, additional

Published
2023
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38. Abstract 1128: Lineage tracing of CAR T cells in patients with B cell malignancies

Author

Good, Zinaida, primary, Hamilton, Mark P., additional, Spiegel, Jay Y., additional, Kurra, Sreevidya, additional, Desai, Moksha H., additional, Prabhu, Snehit, additional, Chiou, Shin-Heng, additional, Yeh, Christine Y., additional, Chen, Yiyun, additional, Yang, Eric, additional, Ozawa, Michael G., additional, Wu, Fang, additional, Frank, Matthew J., additional, Muffly, Lori, additional, Claire, Gursharan K., additional, Craig, Juliana, additional, Iglesias, Maria I., additional, Bharadwaj, Sushma, additional, Kong, Katherine A., additional, Wagh, Dhananjay, additional, Coller, John, additional, Davis, Mark M., additional, Plevritis, Sylvia K., additional, Sahaf, Bita, additional, Miklos, David B., additional, and Mackall, Crystal L., additional

Published
2023
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39. Abstract 5707: Tumor and immune determinants of response to anti-BCMA CAR T-cell therapy in multiple myeloma using cell-free DNA

Author

Carleton, Mia, primary, Hosoya, Hitomi, additional, Tanaka, Kailee L., additional, Sworder, Brian, additional, Hovanky, Vanna, additional, Sahaf, Bita, additional, Frank, Matthew J., additional, Duran, George E., additional, Zhang, Tian Y., additional, Arai, Sally, additional, Iberri, David, additional, Liedtke, Michaela, additional, Miklos, David B., additional, Khodadoust, Michael S., additional, Sidana, Surbhi, additional, and Kurtz, David M., additional

Published
2023
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40. Higher Rates of Severe Infection and Persistent Cytopenias in Long-Term CAR19 Responders Than after Autologous HCT: A Single Institution Study of 139 Subjects

Author

Hamilton, Mark P, Liu-Fei, Felicia C, Alig, Stefan K., Tamaresis, John, Esfahani, Mohammad Shahrokh, Good, Zinaida, Sworder, Brian, Schroers-Martin, Joseph, Liu, Chih Long, Severinsen, Freja Tang, Hanson, Paul J, Lu, Ying, Lowsky, Robert, Negrin, Robert S., Meyer, Everett H, Smith, Melody, Bharadwaj, Sushma, Shizuru, Judith A, Sidana, Surbhi, Shiraz, Parveen, Rezvani, Andrew R., Johnston, Laura J., Weng, Wen-Kai, Arai, Sally, Muffly, Lori, Dahiya, Saurabh, Diehn, Maximilian, Kurtz, David M., Sahaf, Bita, Mackall, Crystal L., Frank, Matthew J, Miklos, David B., and Alizadeh, Ash A.

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

41. Pharmacology, Formulations, and Adverse Effects

Author

Frye, Richard Eugene, primary, Andrus, James P., additional, Lemley, Kevin V., additional, De Rosa, Stephen C., additional, Ghezzi, Pietro, additional, Holmgren, Arne, additional, Jones, Dean, additional, Jahoor, Farook, additional, Kopke, Richard, additional, Cotgreave, Ian, additional, Bottiglieri, Teodoro, additional, Kaplowitz, Neil, additional, Nakamura, Hajime, additional, Staal, Frank, additional, Ela, Stephen W., additional, Atkuri, Kondala R., additional, Tirouvanziam, Rabindra, additional, Heydari, Kartoosh, additional, Sahaf, Bita, additional, Zolopa, Andrew, additional, Mantovani, John J., additional, Herzenberg, Leonard A., additional, and Herzenberg, Leonore A., additional

Published
2018
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42. Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease

Author

Ghezzi, Pietro, primary, Lemley, Kevin V., additional, Andrus, James P., additional, De Rosa, Stephen C., additional, Holmgren, Arne, additional, Jones, Dean, additional, Jahoor, Farook, additional, Kopke, Richard, additional, Cotgreave, Ian, additional, Bottiglieri, Teodoro, additional, Kaplowitz, Neil, additional, Nakamura, Hajime, additional, Staal, Frank, additional, Ela, Stephen W., additional, Atkuri, Kondala R., additional, Tirouvanziam, Rabindra, additional, Heydari, Kartoosh, additional, Sahaf, Bita, additional, Zolopa, Andrew, additional, Frye, Richard Eugene, additional, Mantovani, John J., additional, Herzenberg, Leonard A., additional, and Herzenberg, Leonore A., additional

Published
2018
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43. Immune Phenotypic Quantification of Axicabtagene Ciloleucel and Brexucabtagene Autoleucel Demonstrates Lymphoma Histology Specific Differences in CAR19 Expansion and Toxicity

Author

Hamilton, Mark P., primary, Gentille, Cesar, additional, Mina, Alain, additional, Good, Zinaida, additional, Tamaresis, John, additional, Ehlinger, Zachary, additional, Syal, Shriya, additional, Sworder, Brian, additional, Schroers-Martin, Joseph, additional, Lu, Ying, additional, Muffly, Lori, additional, Negrin, Robert S., additional, Arai, Sally, additional, Johnston, Laura, additional, Lowsky, Robert, additional, Meyer, Everett H., additional, Rezvani, Andrew R., additional, Shizuru, Judith A., additional, Weng, Wen-Kai, additional, Shiraz, Parveen, additional, Sidana, Surbhi, additional, Bharadwaj, Sushma, additional, Smith, Melody, additional, Dahiya, Saurabh, additional, Sahaf, Bita, additional, Kurtz, David M., additional, Mackall, Crystal, additional, Alizadeh, Ash A., additional, Frank, Matthew J., additional, and Miklos, David B., additional

Published
2023
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44. CD22 CAR T Cell Therapy Induces Durable Remissions in Patients with Large B Cell Lymphoma Who Relapse after CD19 CAR T Cell Therapy

Author

Frank, Matthew J., primary, Sahaf, Bita, additional, Baird, John, additional, Patel, Shabnum, additional, Craig, Juliana, additional, Iglesias, Maria, additional, Crawford, Emma, additional, Oak, Jean S., additional, Younes, Sheren F., additional, Natkunam, Yasodha, additional, Srinagesh, Hrishikesh K., additional, Spiegel, Jay, additional, Ehlinger, Zachary, additional, Chinnasamy, Harshini, additional, Reynolds, Warren D., additional, Egeler, Emily, additional, Arai, Sally, additional, Johnston, Laura, additional, Lowsky, Robert, additional, Negrin, Robert S., additional, Rezvani, Andrew R., additional, Shiraz, Parveen, additional, Sidana, Surbhi, additional, Weng, Wen-Kai, additional, Dahiya, Saurabh, additional, Smith, Melody, additional, Schultz, Liora Michal, additional, Ramakrishna, Sneha, additional, Davis, Kara L, additional, Feldman, Steven, additional, Mackall, Crystal, additional, Muffly, Lori, additional, and Miklos, David B., additional

Published
2023
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45. Early Results of a Phase I Study of CAR-T Cells + NKTR-255 (PEG-IL-15) in Adults with R/R ALL

Author

Jackson, Clayton, primary, Shiraz, Parveen, additional, Iglesias, Maria, additional, Egeler, Emily, additional, Sahaf, Bita, additional, Arai, Sally, additional, Bharadwaj, Sushma, additional, Johnston, Laura, additional, Lowsky, Robert, additional, Meyer, Everett H., additional, Negrin, Robert S., additional, Rezvani, Andrew R., additional, Weng, Wen-Kai, additional, Shizuru, Judith A., additional, Marcondes, Mario Q., additional, Tagliaferri, Mary A., additional, Sidana, Surbhi, additional, Frank, Matthew J., additional, Smith, Melody, additional, Feldman, Steven, additional, Miklos, David B., additional, Mackall, Crystal, additional, Syal, Shriya, additional, Patil, Sunita, additional, Reynolds, Warren D., additional, and Muffly, Lori, additional

Published
2023
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46. Analysis of Bendamustine Lymphodepletion, CD19 CART Expansion, Safety and Efficacy in Patients with Rel/Ref Non-Hodgkin Lymphoma

Author

Bharadwaj, Sushma, primary, Hamilton, Mark P., additional, Sahaf, Bita, additional, Tamaresis, John, additional, Latchford, Theresa M., additional, Arai, Sally, additional, Johnston, Laura, additional, Lowsky, Robert, additional, Negrin, Robert S., additional, Rezvani, Andrew R., additional, Shizuru, Judith A., additional, Meyer, Everett H., additional, Shiraz, Parveen, additional, Sidana, Surbhi, additional, Smith, Melody, additional, Weng, Wen-Kai, additional, Muffly, Lori, additional, Mackall, Crystal, additional, Frank, Matthew J., additional, Miklos, David B., additional, and Dahiya, Saurabh, additional

Published
2023
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47. Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomas

Author

Sworder, Brian J., primary, Kurtz, David M., additional, Alig, Stefan K., additional, Frank, Matthew J., additional, Shukla, Navika, additional, Garofalo, Andrea, additional, Macaulay, Charles W., additional, Shahrokh Esfahani, Mohammad, additional, Olsen, Mari N., additional, Hamilton, James, additional, Hosoya, Hitomi, additional, Hamilton, Mark, additional, Spiegel, Jay Y., additional, Baird, John H., additional, Sugio, Takeshi, additional, Carleton, Mia, additional, Craig, Alexander F.M., additional, Younes, Sheren F., additional, Sahaf, Bita, additional, Sheybani, Natasha D., additional, Schroers-Martin, Joseph G., additional, Liu, Chih Long, additional, Oak, Jean S., additional, Jin, Michael C., additional, Beygi, Sara, additional, Hüttmann, Andreas, additional, Hanoun, Christine, additional, Dührsen, Ulrich, additional, Westin, Jason R., additional, Khodadoust, Michael S., additional, Natkunam, Yasodha, additional, Majzner, Robbie G., additional, Mackall, Crystal L., additional, Diehn, Maximilian, additional, Miklos, David B., additional, and Alizadeh, Ash A., additional

Published
2023
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49. Determinants of Resistance to Engineered T-Cell Therapies Targeting CD19 in Large B-Cell Lymphomas

Author

Sworder, Brian, primary, Kurtz, David M., additional, Alig, Stefan K., additional, Frank, Matthew J, additional, Shukla, Navika D., additional, Garofalo, Andrea, additional, Macaulay, Charles, additional, Shahrokh Esfahani, Mohammad, additional, Olsen, Mari, additional, Hamilton, James, additional, Hosoya, Hitomi, additional, Hamilton, Mark P, additional, Spiegel, Jay Y., additional, Baird, John H., additional, Carleton, Mia, additional, Craig, Alexander F.M., additional, Younes, Sheren F., additional, Sahaf, Bita, additional, Sheybani, Natasha, additional, Schroers-Martin, Joseph, additional, Liu, Chih Long, additional, Oak, Jean S, additional, Jin, Michael C., additional, Beygi, Sara, additional, Hüttmann, Andreas, additional, Hanoun, Christine, additional, Dührsen, Ulrich, additional, Westin, Jason, additional, Khodadoust, Michael S., additional, Natkunam, Yasodha, additional, Majzner, Robbie G., additional, Mackall, Crystal L., additional, Diehn, Maximilian, additional, Miklos, David B., additional, and Alizadeh, Ash A., additional

Published
2022
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50. Analysis of Bendamustine Lymphodepletion, CD19 CART Expansion, Safety and Efficacy in Patients with Rel/Ref Non-Hodgkin Lymphoma

Author

Bharadwaj, Sushma, primary, Hamilton, Mark P, additional, Sahaf, Bita, additional, Tamaresis, John, additional, Patil, Sunita, additional, Hanson, Paul J, additional, Latchford, Theresa, additional, Arai, Sally, additional, Johnston, Laura J., additional, Lowsky, Robert, additional, Negrin, Robert S., additional, Rezvani, Andrew R., additional, Shizuru, Judith A, additional, Meyer, Everett H, additional, Shiraz, Parveen, additional, Sidana, Surbhi, additional, Smith, Melody, additional, Weng, Wen-Kai, additional, Muffly, Lori, additional, Mackall, Crystal L., additional, Frank, Matthew J, additional, Miklos, David B., additional, and Dahiya, Saurabh, additional

Published
2022
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