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3. Lesion segmentation using U-Net network

Author

Motsch, Adrien, Motsch, Sebastien, and Saguet, Thibaut

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Statistics - Machine Learning, 62P10
Abstract

This paper explains the method used in the segmentation challenge (Task 1) in the International Skin Imaging Collaboration's (ISIC) Skin Lesion Analysis Towards Melanoma Detection challenge held in 2018. We have trained a U-Net network to perform the segmentation. The key elements for the training were first to adjust the loss function to incorporate unbalanced proportion of background and second to perform post-processing operation to adjust the contour of the prediction., Comment: 4 pages, ISIC 2018

Published
2018

4. Randomized double‐blind placebo‐controlled cosmetic trial of a topical first‐in‐class Neutraligand targeting the chemokine TARC/CCL17 in mild‐to‐moderate atopic dermatitis.

Author

Frossard, Nelly, Coïc, Alexandra, Saguet, Thibaut, Coïc, Alain, Himbert, Franck, Do, Quoc Tuan, Galzi, Jean‐Luc, Suehs, Carey, Guillaumet, Gerald, Bonnet, Pascal, and Bernard, Philippe

Subjects
ATOPIC dermatitis, FILAGGRIN, CHEMOKINE receptors, OINTMENTS, TOPICAL drug administration, SKIN physiology, QUALITY of life
Abstract

Copyright of International Journal of Cosmetic Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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7. Comparison of ultraviolet B-induced imbalance of antioxidant status in foreskin- and abdominal skin-derived human fibroblasts

Author

Saguet, Thibaut, Robin, Sophie, Nicod, Laurence, Delphine Binda, Viennet, Céline, Aubin, François, Coulomb, Bernard, Humbert, Philippe, Laboratoire d'Ingénierie et Biologie Cutanées ( LIBC ), IFR33-Université de Franche-Comté ( UFC ), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) ( HOTE GREFFON ), Université de Franche-Comté ( UFC ) -Etablissement français du sang [Bourgogne-France-Comté] ( EFS [Bourgogne-France-Comté] ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), BioExigence, BioExigence SARL, Sciences séparatives et biopharmaceutiques, Université de Franche-Comté ( UFC ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté [COMUE] ( UBFC ) -Université de Franche-Comté ( UFC ), Réparation et remodelage oro-fasciaux, Université Paris Descartes - Paris 5 ( UPD5 ), Département de dermatologie, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Saint-Jacques-Université de Franche-Comté ( UFC ), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC ( HOTE GREFFON ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Etablissement français du sang [Bourgogne-France-Comté] ( EFS [Bourgogne-France-Comté] ) -Université de Franche-Comté ( UFC ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Laboratoire d'Ingénierie et Biologie Cutanées (LIBC), IFR33-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Université de Franche-Comté (UFC), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Université Paris Descartes - Paris 5 (UPD5), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques-Université de Franche-Comté (UFC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Hôpital Saint-Jacques-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), and Saas, Philippe

Subjects
MESH: Oxidation-Reduction, Adult, Male, [SDV.IMM] Life Sciences [q-bio]/Immunology, Ultraviolet Rays, MESH : Male, Foreskin, MESH : Abdomen, MESH : Foreskin, MESH : Child, Preschool, MESH: Abdomen, MESH: Skin, MESH : Child, MESH: Child, MESH : Cells, Cultured, MESH : Fibroblasts, Abdomen, MESH : Skin, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, Humans, Child, MESH: Foreskin, Cells, Cultured, Skin, MESH : Oxidation-Reduction, MESH: Humans, integumentary system, MESH: Child, Preschool, MESH : Humans, MESH: Adult, MESH : Adult, Fibroblasts, MESH: Male, MESH: Fibroblasts, MESH : Ultraviolet Rays, Child, Preschool, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Ultraviolet Rays, Oxidation-Reduction, MESH: Cells, Cultured
Abstract

International audience; Ultraviolet B radiation (UVB) is involved in the development of deleterious cutaneous damage. Several changes could be attributed to UVB-induced reactive oxygen species attacks in fibroblasts. However dermal cells from young and adult skin could respond differently to oxidative stress. So antioxidant status and its consequences on cytotoxicity and apoptosis were compared in child foreskin fibroblasts (FF) and adult abdominal skin fibroblasts (AF) in response to UVB. Basal levels of lipid peroxidation tended to be higher in AF than in FF, which could be related to a reshaping of antioxidant defences (higher catalase and lower superoxide dismutase activities). AF and FF appeared to react similarly to high UVB doses as regards cytotoxicity and apoptosis which increased significantly 24h after exposure. The enhancement of cell death could be due to the inherent oxidative stress: glutathione appeared significantly decreased in both cell populations. As a consequence AF, but not FF, presented significantly increased levels of lipid peroxidation, which could be explained by the pre-cited differences of basal antioxidant defences. These results suggest that AF and FF do not respond to UVB by the same pathway.

Published
2006

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