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153 results on '"Sagrado, Salvador"'

24. Tarjeta para configuración y comunicación con una FPGA Spartan 6 usando el controlador USB TF2232H

Author

Sagrado Salvador, Guillermo, Pablo Gómez, Santiago de, and Universidad de Valladolid. Escuela de Ingenierías Industriales

Subjects
Diseño, 3325 Tecnología de las Telecomunicaciones, Configuración JTAG, Spartan 6
Abstract

El actual proyecto presenta una solución referida a la necesidad de configurar y comunicarse con una FPGA del modelo Spartan 6 del fabricante Xilinx a través de un dispositivo intermedio como es un controlador USB. Se diseña una tarjeta que contenga las conexiones entre ambos dispositivos y que se conecta al host a través de USB. El trabajo abarca desde la búsqueda de las conexiones entre dispositivos hasta la fabricación de la tarjeta. Se desarrollará también el interfaz de configuración JTAG para la FPGA Spartan 6 haciendo pruebas con el fichero de código tanto a través de cableado como con la tarjeta de este trabajo ya fabricada., Departamento de Tecnología Electrónica, Grado en Ingeniería en Tecnologías Industriales

Published
2019

25. Quantitative retention-structure and retention-activity relationship studies of local anesthetics by micellar liquid chromatography

Author

Escuder-Gilabert, Laura, Sagrado, Salvador, Villanueva-Camanas, Rosa Maria, and Medina-Hernandez, Maria Jose

Subjects
Liquid chromatography -- Usage, Local anesthesia -- Research, Toxicology -- Analysis, Chemistry
Abstract

The retention of compounds in micellar liquid chromatography (MLC) is governed by hydrophobic and electrostatic forces. For ionic compounds, both interactions should be considered. The present report offers a novel retention model that includes the hydrophobicity of compounds and the molar fraction of the charged form of compounds and compares it with other previously reported models. High correlations between the logarithm of capacity factors and these structural parameters were obtained for local anesthetics with different degrees of ionization using a nonionic surfactant solution as mobile phase. Modeling the retention of compounds as a function of physicochemical parameters and experimental variables is established by means of multiple linear regression. In addition, a predictive model for estimating the hydrophobicity of local anesthetics is proposed. Finally, quantitative and qualitative retention - activity relationships in MLC are also investigated for these compounds. An excellent correlation between the capacity factors in MLC and the anesthetic potency of local anesthetics was obtained.

Published
1998

28. Trimeprazine is enantioselectively degraded by an activated sludge in ready biodegradability test conditions

Author

Ministerio de Economía y Competitividad, Escuder-Gilabert, Laura, Martin-Biosca, Y., Perez-Baeza, Mireia, Sagrado, Salvador, Medina-Hernandez, Maria Jose, Ministerio de Economía y Competitividad, Escuder-Gilabert, Laura, Martin-Biosca, Y., Perez-Baeza, Mireia, Sagrado, Salvador, and Medina-Hernandez, Maria Jose

Abstract

[EN] A great number of available pharmaceuticals are chiral compounds. Although they are usually manufactured as racemic mixtures, they can be enantioselectively biodegraded as a result of microbial processes. In this paper, a biodegradability assay in similar conditions to those recommended in OECD tests of enantiomers of trimeprazine (a phenothiazine employed as a racemate) is carried out. Experiments were performed in batch mode using a minimal salts medium inoculated with an activated sludge (collected from a Valencian Waste Water Treatment Plant, WWTP) and supplemented with the racemate. The concentration of the enantiomers of trimeprazine were monitored by means of a chiral HPLC method using a cellulose-based chiral stationary phase and 0.5 M NaClO4/acetonitrile (60:40, v/v) mobile phases. Experiments were performed at three concentration levels of the racemate. In parallel, the optical density at 600 nm (OD600) was measured to control the biomass growth and to connect it with enantioselectivity. The calculated enantiomeric fractions (EF) offer the first evidence of enantioselective biodegradation of trimeprazine. A simplified Monod equation was used as a curve fitting approach for concentration (S), biodegradation (BD), and for the first time, EF experimental data in order to expand the usefulness of the results. Precision studies on S (repeatability conditions) and, for the first time, EF (intermediate precision conditions) were also performed.

Published
2018

33. Evaluation of the enantioselective binding of imazalil to human serum albumin by capillary electrophoresis.

Author

Asensi‐Bernardi, Lucía, Martín‐Biosca, Yolanda, Escuder‐Gilabert, Laura, Sagrado, Salvador, and Medina‐Hernández, María José

Abstract

In this work, a methodology for the evaluation of enantioselective binding of imazalil (IMA) enantiomers to human serum albumin (HSA) that does not require the separation of free and bound to HSA fractions is developed. This methodology comprises the incubation of IMA-HSA designed mixtures for 30 min directly in the capillary electrophoresis system and the subsequent direct injection and chiral separation of IMA employing highly sulfated β-cyclodextrin as chiral selector and the complete filling technique. Two mathematical approaches were used to estimate apparent affinity constants ( K1), protein binding and enantioselectivity ( ES) for both enantiomers of IMA. Moderate enantioselective binding of IMA enantiomers to HSA ( ES = 2.0) was shown by the 1:1 stoichiometry and log K1 values of 3.4 ± 0.4 and 3.1 ± 0.3 for the first and second eluted enantiomers, respectively. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2015
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