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Your search keyword '"Sagara, Seiji"' showing total 17 results
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17 results on '"Sagara, Seiji"'

4. Efficacy of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the activity of the advanced glycation end product (AGE) - receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes

Author

Sakata, Koji, Hayakawa, Manabu, Yano, Yuichiro, Tamaki, Noboru, Yokota, Naoto, Eto, Takuma, Watanabe, Reiko, Hirayama, Naoteru, Matsuo, Takeshi, Kuroki, Kazuo, Sagara, Seiji, Mishima, Osamu, Koga, Masahiro, Nagata, Naoto, Nishino, Yuri, Kitamura, Kazuo, Kario, Kazuomi, Takeuchi, Masayoshi, and Yamagishi, Sho-ichi

Published
2013
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10. Tu1183 The Combined Use of Narrow-Band Imaging With Magnifying Endoscopy and Lugol Chromoendoscopy May Be Helpful in Detecting Metachronous Lesions Following Endoscopic Resection for Esophageal Squamous Cell Carcinoma

Author

Akimoto, Teppei, primary, Goto, Osamu, additional, Sasaki, Motoki, additional, Sagara, Seiji, additional, Fujimoto, Ai, additional, Ochiai, Yasutoshi, additional, Maehata, Tadateru, additional, Nishizawa, Toshihiro, additional, Nakamura, Rieko, additional, Hosoe, Naoki, additional, Kawakubo, Hirofumi, additional, Uraoka, Toshio, additional, Ogata, Haruhiko, additional, and Yahagi, Naohisa, additional

Published
2016
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15. Prevention of esophageal stricture after endoscopic submucosal dissection using RNA-based silencing of carbohydrate sulfotransferase 15 in a porcine model.

Author

Hiroki Sato, Seiji Sagara, Nao Nakajima, Teppei Akimoto, Kenji Suzuki, Hiroyuki Yoneyama, Shuji Terai, Naohisa Yahagi, Sato, Hiroki, Sagara, Seiji, Nakajima, Nao, Akimoto, Teppei, Suzuki, Kenji, Yoneyama, Hiroyuki, Terai, Shuji, and Yahagi, Naohisa

Subjects
RNA interference, ENDOSCOPY, DISSECTION, RNA metabolism, ANIMAL experimentation, COLLAGEN, ESOPHAGOSCOPY, ESOPHAGEAL stenosis, FIBROBLASTS, GENES, GROWTH factors, INJECTIONS, RNA, SWINE, TRANSFERASES, ULCERS, FIBROSIS, METABOLISM, PREVENTION, THERAPEUTICS
Abstract

Background and study aims Endoscopic submucosal dissection (ESD) for esophageal carcinoma frequently causes fibrotic strictures that require treatment. A possible preventive effect of small interfering RNA (siRNA) targeting carbohydrate sulfotransferase 15 (CHST15) on esophageal stricture formation after ESD was investigated in 3 pigs. Materials and methods Two half-circumferential ESD ulcers were created in the oral and anal ends of the esophagus. CHST15 siRNA was injected submucosally in one of the two ESD ulcers. Endoscopic, macroscopic, histological, and polymerase chain reaction analyses were performed. Results On post-operative day 14, the non-treated ulcers were found to show histological fibrosis and increased expression of the CHST15 messenger RNA. A single endoscopic injection of CHST15 siRNA alleviated stricture development in post-ESD ulcers with significant reduction in the mucosal contraction rate. The deposition of collagen and accumulation of fibroblasts and myofibroblasts were diminished in ulcers treated with CHST15 siRNA, where significant suppression of CHST15, transforming growth factor-beta (TGF-β), and collagen-1 messenger RNAs was also seen. Conclusion CHST15 siRNA alleviated esophageal post-ESD stricture formation via repression of fibrosis, revealing a novel therapeutic role for antifibrotic agents in the prevention of post-ESD strictures. [ABSTRACT FROM AUTHOR]

Published
2017
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17. Independent association of cognitive dysfunction with cardiac hypertrophy irrespective of 24-h or sleep blood pressure in older hypertensives

Author

Hayakawa, Manabu, primary, Yano, Yuichiro, additional, Kuroki, Kazuo, additional, Inoue, Ryuji, additional, Nakanishi, Chihiro, additional, Sagara, Seiji, additional, Koga, Masahiro, additional, Kubo, Hirohide, additional, Imakiire, Satoru, additional, Aoyagi, Zyuntaro, additional, Kitani, Michitaka, additional, Kanemaru, Katsuhiro, additional, Hidehito, Shirao, additional, Shimada, Kazuyuki, additional, and Kario, Kazuomi, additional

Published
2012
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