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3. Men Who Have Sex with Both Men and Women in West Africa: Factors Associated with a High Behavioral Risk of Acquiring HIV from Male Partners and Transmission to Women (CohMSM ANRS 12324—Expertise France)

Author

Fiorentino, Marion, Coulibaly, Bakary, Couderc, Clotilde, Keita, Bintou Dembélé, Anoma, Camille, Dah, Elias, Mensah, Ephrem, Aka, Thomas Niamkey, Touré, Juste Rodrigue, Camara, Drissa, Kokouba, Anouwarsadat Rodolphe, Maradan, Gwenaëlle, Mora, Marion, Bourrelly, Michel, Riegel, Lucas, Rojas-Castro, Daniela, Spire, Bruno, Laurent, Christian, and Sagaon-Teyssier, Luis

Published
2024
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5. Socio-behavioral correlates of pre-exposure prophylaxis use and correct adherence in men who have sex with men in West Africa

Author

Eubanks, August, Coulibaly, Bakary, Dembélé Keita, Bintou, Anoma, Camille, Dah, Ter Tiero Elias, Mensah, Ephrem, Kaba, Sékou, Lokrou, Kpassou Julien, Ouedraogo, Faïçal Rodrigue, Badjassim, Alèda M. Fidèle, Maradan, Gwenaëlle, Bourrelly, Michel, Mora, Marion, Riegel, Lucas, Rojas Castro, Daniela, Yaya, Issifou, Spire, Bruno, Laurent, Christian, and Sagaon-Teyssier, Luis

Published
2022
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7. HIV pre-exposure prophylaxis for men who have sex with men in west Africa: a multicountry demonstration study

Author

Laurent, Christian, Yaya, Issifou, Ouedraogo, Sayouba, Granouillac, Bruno, Le Guicher, Gwenvael, Serrano, Laetitia, Peeters, Martine, Couderc, Clotilde, Spire, Bruno, Sagaon-Teyssier, Luis, Mora, Marion, Maradan, Gwenaëlle, Bourrelly, Michel, Mimi, Mohamed, Berenger, Cyril, Boyer, Sylvie, Rojas Castro, Daniela, Riegel, Lucas, Palvadeau, Paméla, Vuylsteke, Bea, De Baetselier, Irith, Reyniers, Thijs, Dembélé Keita, Bintou, Diallo, Fodié, Coulibaly, Alou, Maïga, Alassane Kader, Camara, Drissa, Diarra, Mahamadou, Ouologuem, Aly, Sangaré, Naboh, Keita, Abdoul Aziz, Cissé, Oumar, Traoré, Fodé, Ouary, Bréhima Abdrahamane, Kanta, Ibrahima, Anoma, Camille, Malan, Jean-Baptiste, Kotchi, Rachelle, Aka, Niamkey Thomas, Lokrou, Kpassou Julien, Coulibaly, Noufo Hamed, Koffi, Ekissi Jean Armel, N'guessan, Dibi Frédéric, Babo Yoro, Stéphane-Alain, Cissé, Adama, Dah, Ter Tiero Elias, Traoré, Issa, Rajaonarivelo, Camille, Ouedraogo, Fayçal Rodrique, Ouedraogo, Joseph, Coulibaly, Christian, Ouedraogo, Mamadou, Ilboudo, Ousseni, Traoré, Abdoulazziz, Comsiambo, Honoré, Mensah, Ephrem, Agboyibor, Mawuényégan Kouamivi, Attisso, Anani, Kokouba, Anouwarsadat, Badjassim, Aléda Mawuli, Agbomadji, Kouakou Kokouvi Selom, Attiogbe, Messan, Yaka, Kossi Jeff, Ekon, Agbégnigan Lorette, Bimba, Julien, Dagnra, Claver Anoumou, Tegueni, Kokou Dominique, Agboyibor, Mawuényégan K, Eubanks, August, Fayé-Ketté, Hortense, Koné, Amadou, Diandé, Souba, Dagnra, Claver A, and Dah, Ter Tiero E

Published
2021
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9. On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial

Author

Aboulker, Jean-Pierre, Bajos, Nathalie, Baril, Jean-Guy, Besnier, Michel, Binesse, Johan, Carette, Diane, Cattin, Grégoire, Chéret, Antoine, Chidiac, Christian, Choucair, Elias, Delfraissy, Jean-François, Demoulin, Baptiste, Diallo, Alpha, Durant-Zaleski, Isabelle, Doré, Véronique, Etien, Nicolas, Euphrasie, Françoise, Fonsart, Julien, Foubert, Valérie, Gibowski, Séverine, Girard, Gabriel, Guillon, Brigitte, Le Mestre, Soizic, Lert, France, Leturque, Nicolas, Lorente, Nicolas, Mennecier, Anaïs, Morin, Michel, Netzer, Emmanuelle, Otis, Joanne, Pasquet, Armelle, Peytavin, Gilles, Pialoux, Gilles, Préau, Marie, Rabian, Cécile, Rozenbaum, Willy, Sagaon-Teyssier, Luis, Saïdi, Yacine, Saouzanet, Marine, Simon, Marie-Christine, Suzan-Monti, Marie, Thompson, David, Timsit, Julie, Trottier, Benoît, Wainberg, Mark, Antoni, Guillemette, Tremblay, Cécile, Delaugerre, Constance, Charreau, Isabelle, Cua, Eric, Rojas Castro, Daniela, Raffi, François, Chas, Julie, Huleux, Thomas, Spire, Bruno, Capitant, Catherine, Cotte, Laurent, Meyer, Laurence, and Molina, Jean-Michel

Published
2020
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10. Differences in HIV cure clinical trial preferences of French people living with HIV and physicians in the ANRS-APSEC study: a discrete choice experiment

Author

Protiere, Christel, Arnold, Michael, Fiorentino, Marion, Fressard, Lisa, Lelievre, Jean D., Mimi, Mohamed, Raffi, Francois, Mora, Marion, Meyer, Laurence, Sagaon-Teyssier, Luis, Zucman, David, Preau, Marie, Lambotte, Olivier, Spire, Bruno, and Suzan-Monti, Marie

Subjects
Clinical trials -- Research -- Health aspects, Medical ethics -- Health aspects -- Research, AIDS vaccines -- Ethical aspects -- Product development -- Research, HIV -- Research, Immunotherapy -- Health aspects -- Research, Gastrointestinal diseases -- Research, Health
Abstract

Introduction: Despite the advent of HIV cure-related clinical trials (HCRCT) for people living with HIV (PLWH), the risks and uncertainty involved raise ethical issues. Although research has provided insights into the levers and barriers to PLWH and physicians' participation in these trials, no information exists about stakeholders' preferences for HCRCT attributes, about the different ways PLWH and physicians value future HCRCT, or about how personal characteristics affect these preferences. The results from the present study will inform researchers' decisions about the most suitable HCRCT strategies to implement, and help them ensure ethical recruitment and well-designed informed consent. Methods: Between October 2016 and March 2017, a discrete choice experiment was conducted among 195 virally controlled PLWH and 160 physicians from 24 French HIV centres. Profiles within each group, based on individual characteristics, were obtained using hierarchical clustering. Trade-offs between five HCRCT attributes (trial duration, consultation frequency, moderate (digestive disorders, flu-type syndrome, fatigue) and severe (allergy, infections, risk of cancer) side effects (SE), outcomes) and utilities associated with four HCRCT candidates (latency reactivation, immunotherapy, gene therapy and a combination of atency reactivation and immunotherapy), were estimated using a mixed logit model. Results: Apart from severe SE--the most decisive attribute in both groups--PLWH and physicians made different trade-offs between HCRCT attributes, the latter being more concerned about outcomes, the former about the burden of participation (consultation frequency and moderate SE). These different trades-offs resulted in differences in preferences regarding the four candidate HCRCT. PLWH significantly preferred immunotherapy, whereas physicians preferred immunotherapy and combined therapy. Despite the heterogeneity of characteristics within the PLWH and physician profiles, results show some homogeneity in trade-offs and utilities regarding HCRCT. Conclusions: Severe SE, not outcomes, was the most decisive attribute determining future HCRCT participation. Particular attention should be paid to providing clear information, in particular on severe SE, to potential participants. Immunotherapy would appear to be the best HCRCT candidate for both PLWH and physicians. However, if the risk of cancer could be avoided, gene therapy would become the preferred strategy for the latter and the second choice for the former. Keywords: HIV eradication/remission; therapeutic HIV vaccine trial; social sciences; discrete choice experiment; preferences; ethics; clinical trial design recommendations; mixed logit mode, (1) | INTRODUCTION HIV cure research, a desired but risky and 'uncomfortable' innovation [1], raises several ethical questions [2-6]. More specifically, to test the effectiveness of new HIV cure-related clinical [...]

Published
2020
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12. Impact of the COVID-19 Health Crisis on Key Populations at Higher Risk for, or Living With, HIV or Hepatitis C Virus and People Working With These Populations: Multicountry Community-Based Research Study Protocol (EPIC Program)

Author

Delabre, Rosemary M, primary, Di Ciaccio, Marion, additional, Lorente, Nicolas, additional, Villes, Virginie, additional, Castro Avila, Juliana, additional, Yattassaye, Adam, additional, Bonifaz, César, additional, Ben Moussa, Amal, additional, Sikitu, Ingrid-Zaïre, additional, Khodabocus, Niloufer, additional, Freitas, Rosa, additional, Spire, Bruno, additional, Veras, Maria Amélia, additional, Sagaon-Teyssier, Luis, additional, Girard, Gabriel, additional, Roux, Perrine, additional, Velter, Annie, additional, Delpech, Valérie, additional, Ghosn, Jade, additional, Riegel, Lucas, additional, and Rojas Castro, Daniela, additional

Published
2023
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13. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial

Author

Pintado, C., Loze, B., Gatey, C., Ponscarme, D., Penot, P., Veron, R., Delgado, J., Dalle, E., Parlier, S., Madelaine, I., Danet, M., Mahjoub, N., Mezreb, N., Moudachirou, K., Morel, S., Conort, G., Lorho, F., Meunier, M., Rozenbaum, W., Monfort, C., Foucoin, J., Boissavy, B., Cousseau, S., Huon, S., Djessima, A., Berrebi, V., Adda, A., le Nagat, S., Zarka, L., Berdougo, J., Mzoughi, N., Clement, F., Decouty, A., Chapolard, C., Godinot, M., Adouard-groslafeige, C., Koffi, J., Pansu, A., Becker, A., Pailhes, S., Bonnet, F., Jeanblanc, F., Brochier, C., Teruin, X., Rouby, S., Gilly, L., Etienne, C., Tolonin, F., Breaud, S., Péchenot, V., Bagge, S., Cepitelli, T., Roger, PM., Rosenthal, E., Cheret, A., Cornavin, P., Vandamme, S., Lambec, J., Dumon, N., Leclanche, O., Huleux, T., Biekre, R., Melliez, H., Bazus, H., Pasquet, A., Bernaud, C., Besnier, M., Bonnet, B., Hall, N., Cavellec, M., Hue, H., Larmet, L., Colas, M., Choquet, R., Fouéré, S, Netzer, E., Leturque, N., Binesse, J., Foubert, V., Saouzanet, M., Euphrasie, F., Guillon, B., Saïdi, Y., Suzan, M., Cattin, G., Demoulin, B., Lorente, N., Molina, Jean-Michel, Charreau, Isabelle, Chidiac, Christian, Pialoux, Gilles, Cua, Eric, Delaugerre, Constance, Capitant, Catherine, Rojas-Castro, Daniela, Fonsart, Julien, Bercot, Béatrice, Bébéar, Cécile, Cotte, Laurent, Robineau, Olivier, Raffi, François, Charbonneau, Pierre, Aslan, Alexandre, Chas, Julie, Niedbalski, Laurence, Spire, Bruno, Sagaon-Teyssier, Luis, Carette, Diane, Mestre, Soizic Le, Doré, Veronique, and Meyer, Laurence

Published
2018
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15. Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study

Author

Meyer, L, Capitant, C, Charreau, I, Netzer, E, Leturque, N, Binesse, J, Foubert, V, Saouzanet, M, Euphrasie, F, Carette, D, Guillon, B, Saïdi, Y, Aboulker, J P, Spire, B, Suzan, M, Cattin, G, Demoulin, B, Sagaon-Teyssier, L, Lorente, N, Doré, V, Choucair, E, Le Mestre, S, Mennecier, A, Etien, N, Simon, M C, Diallo, A, Gibowski, S, Delfraissy, J F, Thompson, D, Sas, J, Pankovitch, J, Klein, M, Anis, A, Molina, Jean-Michel, Wainberg, Mark A, Trottier, Benoit, Tremblay, Cécile, Baril, Jean-Guy, Pialoux, Gilles, Cotte, Laurent, Chéret, Antoine, Pasquet, Armelle, Cua, Eric, Besnier, Michel, Rozenbaum, Willy, Chidiac, Christian, Delaugerre, Constance, Bajos, Nathalie, Timsit, Julie, Peytavin, Gilles, Fonsart, Julien, Durand-Zaleski, Isabelle, Meyer, Laurence, Aboulker, Jean-Pierre, Spire, Bruno, Suzan-Monti, Marie, Girard, Gabriel, Castro, Daniela Rojas, Préau, Marie, Morin, Michel, Thompson, David, Capitant, Catherine, Mennecier, Anaïs, Choucair, Elias, Doré, Véronique, Simon, Marie-Christine, Charreau, Isabelle, Otis, Joanne, Lert, France, Diallo, Alpha, Gibowski, Séverine, Rabian, Cecile, Chas, Julie, Tremblay, Cecile, Rojas-Castro, Daniela, Bernaud, Camille, Pintado, Claire, Sagaon-Teyssier, Luis, Mestre, Soizic Le, Ponscarme, Diane, and Doré, Veronique

Published
2017
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22. Transitions in the labor market after cancer: a comparison of self-employed workers and salaried staff

Author

Tison, Aurélia, Sagaon-Teyssier, Luis, Sansonetti, Caroline, Blatier, Jean-François, Paraponaris, Alain, Aparicio, Thomas, Babin, Emmanuel, Beck, François, Benamouzig, Robert, Bendiane, Marc-Karim, Béranger, Cyril, Bessette, Dominique, Bouhnik, Anne-Déborah, Bousquet, Philippe-Jean, Cabanel-Gicquel, Marie-Claude, Cavallini-Lambert, Marianick, Chantry, Michèle, Chauvet, Claire, Cortaredona, Sébastien, Danguy, Véronique, Dorval, Michel, Herbet, Jean-Baptiste, Huiart, Laetitia, Joutard, Xavier, Le Corroller-Soriano, Anne-Gaëlle, Mancini, Julien, Morere, Jean-François, Nabi, Herman, Paraponaris, Alain, Peretti-Watel, Patrick, Préau, Marie, Protière, Christel, Retornaz, Frédérique, Rey, Dominique, Riandey, Benoit, Sagaon-Teyssier, Luis, Tison, Aurélia, Séror, Valérie, Singh-Manoux, Archana, Thiéblemont, Catherine, Verger, Pierre, and the VICAN 2 group

Published
2016
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24. Highly precarious general and sexual health conditions of young domestic servants: results from a qualitative exploratory study and perspectives for community-based research in Bamako, Mali.

Author

Fiorentino, Marion, Coulibaly, Abdouramane, Kamissoko, Aliou, Dramé, Souleymane, Koné, Aïchata, Traoré, Sokona, Koné, Mariam, Fofana, Sitan, Kanicomo, Fatoumata, Bagayoko, Gnamé, Cissé, Mamadou, Girard, Gabriel, Spire, Bruno, Dembélé Keita, Bintou, and Sagaon-Teyssier, Luis

Subjects
WORK environment, RESEARCH, VIOLENCE in the workplace, EMPLOYEE attitudes, DISCRIMINATION (Sociology), BLUE collar workers, MIGRANT labor, HYGIENE, MEDICAL care, QUALITATIVE research, PSYCHOSOCIAL factors, DESCRIPTIVE statistics, EMPLOYEES' workload, RESEARCH funding, THEMATIC analysis, SEXUAL health, INDUSTRIAL relations
Abstract

Most domestic servants (DS) in Mali are very young female migrants living in precarious conditions. We aimed to understand their living and working conditions in relation to their general and sexual health. Seven focus groups (53 participants) were conducted by the DS community-based organization ADDAD. Narratives were thematically analyzed using an inductive method. The dominant emerging theme was DS' strong dependence on their employers. Employers' attitudes regarding DS workload, the provision of food, water and hygiene products, housing conditions, and healthcare cover, appeared decisive for DS' physical and mental health, and the type of healthcare they used (self-medication, traditional care, healthcare facilities). Psychological, physical and sexual violence in employers' households was frequent. HIV/STI prevention knowledge was poor. These results highlight the serious risks for DS in terms of HIV/STI and unwanted pregnancies. DS were interested in receiving healthcare from ADDAD; this was motivated by the organization's trusting and understanding community-based environment, and DS' fear of discrimination in healthcare facilities. This study highlights the relevance of tackling the defense of rights and sexual health promotion for DS at the community level. Its findings can help identify research questions to evaluate the extent to which DS constitute a key HIV population. [ABSTRACT FROM AUTHOR]

Published
2023
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25. SARS-CoV-2 seroprevalence and living conditions in Bamako (Mali): a cross-sectional multistage household survey after the first epidemic wave, 2020

Author

Cissoko, Mady, primary, Landier, Jordi, additional, Kouriba, Bourema, additional, Sangare, Abdoul Karim, additional, Katilé, Abdoulaye, additional, Djimde, Abdoulaye A, additional, Berthé, Ibrahima, additional, Traore, Siriman, additional, Thera, Ismaila, additional, Hadiata, Maiga, additional, Sogodogo, Elisabeth, additional, Coulibaly, Karyn, additional, Guindo, Abdoulaye, additional, Dembele, Ousmane, additional, Sanogo, Souleymane, additional, Doumbia, Zoumana, additional, Dara, Charles, additional, Altmann, Mathias, additional, Bonnet, Emmanuel, additional, Balique, Hubert, additional, Sagaon-Teyssier, Luis, additional, Vidal, Laurent, additional, Sagara, Issaka, additional, Bendiane, Marc-Karim, additional, and Gaudart, Jean, additional

Published
2023
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26. Impact of the COVID-19 Health Crisis on Key Populations at Higher Risk for, or Living With, HIV or Hepatitis C Virus and People Working With These Populations: Multicountry Community-Based Research Study Protocol (EPIC Program) (Preprint)

Author

Delabre, Rosemary M, primary, Di Ciaccio, Marion, additional, Lorente, Nicolas, additional, Villes, Virginie, additional, Castro Avila, Juliana, additional, Yattassaye, Adam, additional, Bonifaz, César, additional, Ben Moussa, Amal, additional, Sikitu, Ingrid-Zaïre, additional, Khodabocus, Niloufer, additional, Freitas, Rosa, additional, Spire, Bruno, additional, Veras, Maria Amélia, additional, Sagaon-Teyssier, Luis, additional, Girard, Gabriel, additional, Roux, Perrine, additional, Velter, Annie, additional, Delpech, Valérie, additional, Ghosn, Jade, additional, Riegel, Lucas, additional, and Rojas Castro, Daniela, additional

Published
2022
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28. Treatment interruption in HIV‐positive patients followed up in Cameroonʼs antiretroviral treatment programme: individual and health care supply‐related factors (ANRS‐12288 EVOLCam survey)

Author

Tong, Christelle, Suzan‐Monti, Marie, Sagaon‐Teyssier, Luis, Mimi, Mohamed, Laurent, Christian, Maradan, Gwenaëlle, Mengue, Marie‐Thérèse, Spire, Bruno, Kuaban, Christopher, Vidal, Laurent, Boyer, Sylvie, Ambani, A, Ndalle, O, Momo, P, Boyer, V, March, L, Mora, M, de Sèze, M, Liégeois, F, Delaporte, E, Boyer, V, Eymard‐Duvernay, S, Chabrol, F, Kouakam, E, Ossanga, O, Essama Owona, H, Biloa, C, Mpoudi‐Ngolé, E, Fouda, P.J, Kouanfack, C, Abessolo, H, Noumssi, N, Defo, M, Meli, H, Nanga, Z, Perfura, Y, Ngo Tonye, M, Kouambo, O, Olinga, U, Soh, E, Ejangue, C, Njom Nlend, E, Simo Ndongo, A, Abeng Mbozoʼo, E, Mpoudi Ngole, M, Manga, N, Danwe, C, Ayangma, L, Taman, B, Njitoyap Ndam, E.C, Fangam Molu, B, Meli, J, Hadja, H, Lindou, J, Bob Oyono, J.M, Beke, S, Eloundou, D, Touko, G, Ze, J.J, Fokoua, M, Ngum, L, Ewolo, C, Bondze, C, Ngan Bilong, J.D, Maninzou, D.S, Nono Toche, A, Tsoungi Akoa, M, Ateba, P, Abia, S, Guterrez, A, Garcia, R, Thumerel, P, Belley Priso, E, Mapoure, Y, Malongue, A, Meledie Ndjong, A.P, Mbatchou, B, Hachu, J, Ngwane, S, Dissongo, J, Mbangue, M, Penda, Ida, Mossi, H, Tchatchoua, G, Ngongang, Yoyo, Nouboue, C, Wandji, I, Ndalle, L, Djene, J, Gomez, M.J, Mafuta, A, Mgantcha, M, Moby, E.H, Kuitcheu, M.C, Mawe, A.L, Engonwei, Ngam, Bitang, L.J, Ndam, M, Pallawo, R.B, Adamou, Issiakou, Temgoua, G, Ndjie Essaga, C, Tchimou, C, Yeffou, A, Ngo, I, Fokam, H, Nyemb, H, Njock, L.R, Omgnesseck, S, Kamto, E, Takou, B, Buffeteau, L.J.‐G, Ndoumbe, F, Noah, J.‐D., and Seyep, I

Published
2018
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29. Human Immunodeficiency Virus Seroconversion Among Men Who Have Sex With Men Who Use Event-Driven or Daily Oral Pre-Exposure Prophylaxis (CohMSM-PrEP): A Multi-Country Demonstration Study From West Africa.

Author

Laurent, Christian, Yaya, Issifou, Cuer, Benjamin, Sagaon-Teyssier, Luis, Mensah, Ephrem, Dah, Ter Tiero Elias, Coulibaly, Alou, Kouamé, Malan Jean-Baptiste, Peytavin, Gilles, Serrano, Laetitia, Eubanks, August, Traoré, Issa, Diallo, Fodié, Riegel, Lucas, Castro, Daniela Rojas, Dagnra, Claver A, Anoma, Camille, Vuylsteke, Bea, Keita, Bintou Dembélé, and Spire, Bruno

Subjects
HIV infection epidemiology, SOCIAL determinants of health, CONFIDENCE intervals, ORAL drug administration, MULTIVARIATE analysis, SEROCONVERSION, REGRESSION analysis, DISEASE incidence, PRE-exposure prophylaxis, DESCRIPTIVE statistics, RESEARCH funding, MEN who have sex with men, SOCIODEMOGRAPHIC factors, DATA analysis software, HIV, LONGITUDINAL method, POISSON distribution
Abstract

Background Data on human immunodeficiency virus (HIV) seroconversion among men who have sex with men (MSM) using pre-exposure prophylaxis (PrEP) in West Africa are needed. This study aimed to document HIV seroconversion and associated determinants, PrEP adherence, plasma drug concentrations, and HIV drug resistance in MSM using event-driven or daily PrEP in Burkina Faso, Côte d'Ivoire, Mali, and Togo. Methods A prospective cohort study was conducted in 2017–2021 among HIV-seronegative MSM aged 18 or over who were at high risk of HIV infection. Participants could choose between event-driven and daily PrEP, switch regimens, and discontinue or restart PrEP. The determinants of HIV incidence were investigated using a multivariate mixed-effects Poisson regression analysis. Results A total of 647 participants were followed for a total time of 1229.3 person-years. Of 5371 visits, event-driven PrEP was chosen in 3873 (72.1%), and daily PrEP in 1400 (26.1%). HIV incidence was 2.4 per 100 person-years (95% confidence interval [CI] 1.5–3.6) for event-driven PrEP, and 0.6 per 100 person-years (95% CI.1–2.3) for daily PrEP (adjusted incidence rate ratio 4.40, 95% CI 1.00–19.36, P =.050). Adequate adherence was lower with event-driven than daily PrEP (44.3% vs 74.9%, P <.001). Plasma drug concentrations were undetectable in 92 (97.9%) of the 94 measures taken for 23 participants who seroconverted. Only 1 participant had resistance to PrEP drugs. Conclusions HIV seroconversions mainly occurred in participants who chose event-driven PrEP. The study's data highlighted major difficulties with adherence to this regimen. Improving adherence to event-driven PrEP constitutes a major research and public health priority in this context. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Disclosure of HIV Status Beyond Sexual Partners by People Living with HIV in France: A Call for Help? Results from the National Cross-Sectional Survey ANRS-VESPA2

Author

Marcellin, Fabienne, Suzan-Monti, Marie, Vilotitch, Antoine, Sagaon-Teyssier, Luis, Mora, Marion, Dray-Spira, Rosemary, Préau, Marie, Lert, France, Spire, Bruno, Lert, France, Spire, Bruno, Carrieri, Maria Patrizia, Dray-Spira, Rosemary, Hamelin, Christine, Lorente, Nicolas, Préau, Marie, Suzan-Monti, Marie, Marcellin, Fabienne, Duracinsky, Martin, The ANRS VESPA2 Study Group, and with the collaboration of Marion Mora

Published
2017
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31. What can lead to late diagnosis of HIV in an illegal gold mining environment? A qualitative study at the French Guiana’s border with Brazil

Author

Floersheim, Charlotte, Musso, Sandrine, Eubanks, August, Douine, Maylis, Spire, Bruno, Sagaon-Teyssier, Luis, Parriault, Marie, Girard, Gabriel, Mosnier, Emilie, Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Centre Norbert Elias (CNELIAS), École des hautes études en sciences sociales (EHESS)-Avignon Université (AU)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des sciences de la santé publique [Marseille] (ISSPAM), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and Service des maladies infectieuses et tropicales [Cayenne, Guyane Française]

Subjects
MESH: Aged, Public health, MESH: Humans, MESH: Middle Aged, Epidemiology, [SDV]Life Sciences [q-bio], HIV & AIDS, MESH: Adult, MESH: HIV Infections, MESH: Mining, MESH: Male, MESH: Delayed Diagnosis, MESH: French Guiana, MESH: Gold, MESH: Brazil, MESH: Female
Abstract

International audience; Objective The present study aimed to understand what factors can lead to late HIV diagnosis of illegal gold miners at French Guiana's border with Brazil. Design An exploratory qualitative study with in-depth interviews and observations was conducted between November 2019 and February 2020. Setting The study was conducted in the main medical healthcare service and two non-governmental organisation premises in the Oyapock border region, which is a supply area for illegal gold mining sites. Participants Fifteen people living with HIV diagnosed with CD4 count

Published
2022
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33. SARS-CoV-2 seroprevalence and living conditions in Bamako (Mali): a cross-sectional multistage household survey after the first epidemic wave, 2020

Author

Cissoko, Mady, primary, Landier, Jordi, additional, Kouriba, Bourema, additional, Sangare, Abdoul Karim, additional, Katile, Abdoulaye, additional, Djimdé, Abdoulaye, additional, Berthé, Ibrahima, additional, Traoré, Siriman, additional, Thera, Ismaïla, additional, Maiga, Hadiata, additional, Sogodogo, Elisabeth, additional, Coulibaly, Karyn, additional, Guindo, Abdoulaye, additional, Dembelé, Ousmane, additional, Sanogo, Souleymane, additional, Doumbia, Zoumana, additional, Dara, Charles, additional, Altmann, Mathias, additional, Bonnet, Emmanuel, additional, Balique, Hubert, additional, Sagaon-Teyssier, Luis, additional, Vidal, Laurent, additional, Sagara, Issaka, additional, Bendiane, Marc-Karim, additional, and Gaudart, Jean, additional

Published
2022
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37. Individual and healthcare supply-related HIV transmission factors in HIV-positive patients enrolled in the antiretroviral treatment access program in the Centre and Littoral regions in Cameroon (ANRS-12288 EVOLCam survey)

Author

Coulaud, Pierre-Julien, Sow, Abdourahmane, Sagaon-Teyssier, Luis, Ndiaye, Khadim, Maradan, Gwenaëlle, Laurent, Christian, Spire, Bruno, Vidal, Laurent, Kuaban, Christopher, Boyer, Sylvie, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des sciences de la santé publique [Marseille] (ISSPAM), Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Faculté des Sciences - Yaoundé I, Université de Yaoundé I, and This study was funded by the French National Agency for Research on HIV/AIDS and viral hepatitis (ANRS, grant 12288, PIs: LV and KB, https://www.anrs.fr/fr). PJC was the recipient of a doctoral fellowship from ANRS (B7-ANRS 12324, https://www.anrs.fr/fr) and Sidaction (17-2-FJC- 11561, https://www.sidaction.org/).

Subjects
Adult, Sexual Partners, Anti-Retroviral Agents, [SDV]Life Sciences [q-bio], Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, HIV Infections, Cameroon, Delivery of Health Care
Abstract

International audience; Background: Despite great progress in antiretroviral treatment (ART) access in recent decades, HIV incidence remains high in sub-Saharan Africa. We investigated the role of individual and healthcare supply-related factors in HIV transmission risk in HIV-positive adults enrolled in 19 HIV services in the Centre and Littoral regions of Cameroon.Methods: Factors associated with HIV transmission risk (defined as both unstable aviremia and inconsistent condom use with HIV-negative or unknown status partners) were identified using a multi-level logistic regression model. Besides socio-demographic and behavioral individual variables, the following four HIV-service profiles, identified using cluster analysis, were used in regression analyses as healthcare supply-related variables: 1) district services with large numbers of patients, almost all practicing task-shifting and not experiencing antiretroviral drugs (ARV) stock-outs (n = 4); 2) experienced and well-equipped national reference services, most practicing task-shifting and not experiencing ARV stock-outs (n = 5); 3) small district services with limited resources and activities, almost all experiencing ARV stock-outs (n = 6); 4) small district services with a wide range of activities and half not experiencing ARV stock-outs (n = 4).Results: Of the 1372 patients (women 67%, median age [Interquartile]: 39 [33-44] years) reporting sexual activity in the previous 12 months, 39% [min-max across HIV services: 25%-63%] were at risk of transmitting HIV. The final model showed that being a woman (adjusted Odd Ratio [95% Confidence Interval], p-value: 2.13 [1.60-2.82], p

Published
2021
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38. Loss to Follow-Up from HIV Pre-Exposure Prophylaxis Care in Men Who Have Sex with Men in West Africa.

Author

Eubanks, August, Coulibaly, Bakary, Keita, Bintou Dembélé, Anoma, Camille, Dah, Ter Tiero Elias, Mensah, Ephrem, Maradan, Gwenaëlle, Bourrelly, Michel, Mora, Marion, Riegel, Lucas, Rojas Castro, Daniela, Yaya, Issifou, Spire, Bruno, Laurent, Christian, and Sagaon-Teyssier, Luis

Subjects
HIV, PRE-exposure prophylaxis, HIV infections
Abstract

Loss to follow-up (LTFU) from HIV pre-exposure prophylaxis (PrEP) care compromises the goal of HIV elimination. We investigated the proportion of LTFU and associated risk factors among men who have sex with men (MSM) enrolled in a PrEP demonstration project in Burkina Faso, Côte d'Ivoire, Mali, and Togo. CohMSM-PrEP, a prospective cohort study, was conducted between November 2017 and June 2021 in community-based clinics. MSM aged 18 years or older at substantial risk of HIV infection received a comprehensive prevention package, including PrEP and peer education. LTFU was defined as not returning to the clinic for six months. Associated risk factors were investigated using a time-varying Cox's model. Of 647 participants followed up for a median time of 15 months, 372 were LTFU (57.5%). LTFU was associated with younger age (adjusted hazard ratio [95% Confidence Interval]; 1.50 [1.17–1.94]), unemployment (1.33 [1.03–1.71]), depression (1.63 [1.12–2.38]), and perceiving no HIV risk with stable male partners (1.61 [1.23–2.10]). Contacting peer educators outside of scheduled visits was protective (0.74 [0.56–0.97]). Our findings show that LTFU from PrEP care in West African MSM is a major challenge to achieving HIV elimination, but that the involvement of peer educators in PrEP delivery helps to limit LTFU by providing users with adequate support. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Intimate partner violence by men living with HIV in Cameroon: Prevalence, associated factors and implications for HIV transmission risk (ANRS-12288 EVOLCAM)

Author

Fiorentino, Marion, Sow, Abdourahmane, Sagaon-Teyssier, Luis, Mora, Marion, Mengue, Marie-Thérèse, Vidal, Laurent, Kuaban, Christopher, March, Laura, Laurent, Christian, Spire, Bruno, Boyer, Sylvie, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Catholique d'Afrique Centrale - Institut Catholique de Yaoundé (UCAC), University of Yaoundé [Cameroun], Infectious and Tropical Diseases Department [Montpellier], Institut de Recherche pour le Développement (IRD)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM), EVOLCam study Group, Centre de Recherche et de Documentation sur l'Océanie (CREDO), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Malbec, Odile

Subjects
RNA viruses, Male, Epidemiology, [SDV]Life Sciences [q-bio], Intimate Partner Violence, Social Sciences, HIV Infections, Criminology, Pathology and Laboratory Medicine, Sociology, Immunodeficiency Viruses, Risk Factors, Surveys and Questionnaires, Medicine and Health Sciences, Psychology, Public and Occupational Health, Cameroon, Traumatic Injury Risk Factors, HIV diagnosis and management, Vaccination and Immunization, [SDV] Life Sciences [q-bio], Medical Microbiology, HIV epidemiology, Viral Pathogens, Viruses, population characteristics, Female, Crime, Pathogens, Research Article, Adult, HIV prevention, Immunology, education, Antiretroviral Therapy, Microbiology, behavioral disciplines and activities, Antiviral Therapy, Retroviruses, mental disorders, Humans, Violent Crime, Microbial Pathogens, Preventive medicine, Behavior, Lentivirus, Organisms, Biology and Life Sciences, HIV, social sciences, Diagnostic medicine, Cross-Sectional Studies, Logistic Models, Socioeconomic Factors, Medical Risk Factors, Human Sexual Behavior
Abstract

International audience; Objectives: Intimate partner violence (IPV) against women is frequent in Central Africa and may be a HIV infection risk factor. More data on HIV-positive men (MLHIV) committing IPV are needed to develop perpetrator-focused IPV and HIV prevention interventions. We investigated the relationship between IPV and HIV transmission risk and IPV-associated factors.Methods: We used data from the cross-sectional survey EVOLCam which was conducted in Cameroonian outpatient HIV structures in 2014. The study population comprised MLHIV declaring at least one sexual partner in the previous year. Using principal component analysis, we built three variables measuring, respectively, self-reported MLHIV-perpetrated psychological and physical IPV (PPV), severe physical IPV (SPV), and sexual IPV (SV). Ordinal logistic regressions helped investigate: i) the relationship between HIV transmission risk (defined as unstable aviremia and inconsistent condom use) and IPV variables, ii) factors associated with each IPV variable.Results: PPV, SPV and SV were self-reported by 28, 15 and 11% of the 406 study participants, respectively. IPV perpetrators had a significantly higher risk of transmitting HIV than non-IPV perpetrators. Factors independently associated with IPV variables were: i) socio-demographic, economic and dyadic factors, including younger age (PPV and SPV), lower income (PPV), not being the household head (SPV and SV), living with a main partner (SPV), and having a younger main partner (SPV); ii) sexual behaviors, including ≥2 partners in the previous year (PPV and SPV), lifetime sex with another man (SPV), inconsistent condom use (SV), and >20 partners during lifetime (SV); iii) HIV-related stigma (PPV and SV).Conclusion: IPV perpetrators had a higher risk of transmitting HIV and having lifetime and recent risky sexual behaviors. Perpetrating IPV was more frequent in those with socioeconomic vulnerability and self-perceived HIV-related stigma. These findings highlight the need for interventions to prevent IPV by MLHIV and related HIV transmission to their(s) partner(s).

Published
2021
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41. Homonegativity, sexual violence and condom use with women in men who have sex with men and women in West Africa

Author

Fiorentino, Marion, primary, Eubanks, August, additional, Coulaud, Pierre-Julien, additional, Couderc, Clotilde, additional, Keita, Bintou D., additional, Anoma, Camille, additional, Dah, Elias, additional, Mensah, Ephrem, additional, Maradan, Gwenaëlle, additional, Bourrelly, Michel, additional, Riegel, Lucas, additional, Rojas-Castro, Daniela, additional, Yaya, Issifou, additional, Spire, Bruno, additional, Laurent, Christian, additional, and Sagaon-Teyssier, Luis, additional

Published
2020
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42. Loss to follow-up among female sex workers in Zambia: findings from a five-year HIV-incidence cohort

Author

Malama, Kalonde, primary, Sagaon-Teyssier, Luis, additional, Gosset, Andréa, additional, Parker, Rachel, additional, Wall, Kristin M, additional, Tichacek, Amanda, additional, Sharkey, Tyronza, additional, Kilembe, William, additional, Inambao, Mubiana, additional, Price, Matt A, additional, Spire, Bruno, additional, and Allen, Susan, additional

Published
2020
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43. Adherence to quarterly HIV prevention services and its impact on HIV incidence in men who have sex with men in West Africa (CohMSM ANRS 12324 – Expertise France)

Author

DAH, Ter Tiero Elias, primary, Yaya, Issifou, additional, Sagaon-Teyssier, Luis, additional, Coulibaly, Alou, additional, Kouamé, Malan Jean-Baptiste, additional, Agboyibor, Mawuényégan Kouamivi, additional, Maiga, Kader, additional, Traoré, Issa, additional, Mora, Marion, additional, Palvadeau, Paméla, additional, Rojas-Castro, Daniela, additional, Diallo, Fodié, additional, Mensah, Ephrem, additional, Anoma, Camille, additional, Keita, Bintou Dembélé, additional, Spire, Bruno, additional, and Laurent, Christian, additional

Published
2020
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45. On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial

Author

Antoni, Guillemette, primary, Tremblay, Cécile, additional, Delaugerre, Constance, additional, Charreau, Isabelle, additional, Cua, Eric, additional, Rojas Castro, Daniela, additional, Raffi, François, additional, Chas, Julie, additional, Huleux, Thomas, additional, Spire, Bruno, additional, Capitant, Catherine, additional, Cotte, Laurent, additional, Meyer, Laurence, additional, Molina, Jean-Michel, additional, Aboulker, Jean-Pierre, additional, Bajos, Nathalie, additional, Baril, Jean-Guy, additional, Besnier, Michel, additional, Binesse, Johan, additional, Carette, Diane, additional, Cattin, Grégoire, additional, Chéret, Antoine, additional, Chidiac, Christian, additional, Choucair, Elias, additional, Delfraissy, Jean-François, additional, Demoulin, Baptiste, additional, Diallo, Alpha, additional, Durant-Zaleski, Isabelle, additional, Doré, Véronique, additional, Etien, Nicolas, additional, Euphrasie, Françoise, additional, Fonsart, Julien, additional, Foubert, Valérie, additional, Gibowski, Séverine, additional, Girard, Gabriel, additional, Guillon, Brigitte, additional, Le Mestre, Soizic, additional, Lert, France, additional, Leturque, Nicolas, additional, Lorente, Nicolas, additional, Mennecier, Anaïs, additional, Morin, Michel, additional, Netzer, Emmanuelle, additional, Otis, Joanne, additional, Pasquet, Armelle, additional, Peytavin, Gilles, additional, Pialoux, Gilles, additional, Préau, Marie, additional, Rabian, Cécile, additional, Rozenbaum, Willy, additional, Sagaon-Teyssier, Luis, additional, Saïdi, Yacine, additional, Saouzanet, Marine, additional, Simon, Marie-Christine, additional, Suzan-Monti, Marie, additional, Thompson, David, additional, Timsit, Julie, additional, Trottier, Benoît, additional, and Wainberg, Mark, additional

Published
2020
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46. Individual and healthcare supply-related HIV transmission factors in HIV-positive patients enrolled in the antiretroviral treatment access program in the Centre and Littoral regions in Cameroon (ANRS-12288 EVOLCam survey).

Author

Coulaud, Pierre-julien, Sow, Abdourahmane, Sagaon-Teyssier, Luis, Ndiaye, Khadim, Maradan, Gwenaëlle, Laurent, Christian, Spire, Bruno, Vidal, Laurent, Kuaban, Christopher, and Boyer, Sylvie

Subjects
HIV infection transmission, HEALTH services accessibility, ANTIRETROVIRAL agents, HIV testing kits, HIV-positive persons, REPORTING of diseases
Abstract

Background: Despite great progress in antiretroviral treatment (ART) access in recent decades, HIV incidence remains high in sub-Saharan Africa. We investigated the role of individual and healthcare supply-related factors in HIV transmission risk in HIV-positive adults enrolled in 19 HIV services in the Centre and Littoral regions of Cameroon. Methods: Factors associated with HIV transmission risk (defined as both unstable aviremia and inconsistent condom use with HIV-negative or unknown status partners) were identified using a multi-level logistic regression model. Besides socio-demographic and behavioral individual variables, the following four HIV-service profiles, identified using cluster analysis, were used in regression analyses as healthcare supply-related variables: 1) district services with large numbers of patients, almost all practicing task-shifting and not experiencing antiretroviral drugs (ARV) stock-outs (n = 4); 2) experienced and well-equipped national reference services, most practicing task-shifting and not experiencing ARV stock-outs (n = 5); 3) small district services with limited resources and activities, almost all experiencing ARV stock-outs (n = 6); 4) small district services with a wide range of activities and half not experiencing ARV stock-outs (n = 4). Results: Of the 1372 patients (women 67%, median age [Interquartile]: 39 [33–44] years) reporting sexual activity in the previous 12 months, 39% [min-max across HIV services: 25%-63%] were at risk of transmitting HIV. The final model showed that being a woman (adjusted Odd Ratio [95% Confidence Interval], p-value: 2.13 [1.60–2.82], p<0.001), not having an economic activity (1.34 [1.05–1.72], p = 0.019), having at least two sexual partners (2.45 [1.83–3.29], p<0.001), reporting disease symptoms at HIV diagnosis (1.38 [1.08–1.75], p = 0.011), delayed ART initiation (1.32 [1.02–1.71], p = 0.034) and not being ART treated (2.28 [1.48–3.49], p<0.001) were all associated with HIV transmission risk. Conversely, longer time since HIV diagnosis was associated with a lower risk of transmitting HIV (0.96 [0.92–0.99] per one-year increase, p = 0.024). Patients followed in the third profile had a higher risk of transmitting HIV (1.71 [1.05–2.79], p = 0.031) than those in the first profile. Conclusions: Healthcare supply constraints, including limited resources and ARV supply chain deficiency may impact HIV transmission risk. To reduce HIV incidence, HIV services need adequate resources to relieve healthcare supply-related barriers and provide suitable support activities throughout the continuum of care. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Evolution of Condom Use Among a 5-Year Cohort of Female Sex Workers in Zambia.

Author

Malama, Kalonde, Price, Matt A., Sagaon-Teyssier, Luis, Parker, Rachel, Wall, Kristin M., Tichacek, Amanda, Sharkey, Tyronza, Kilembe, William, Inambao, Mubiana, Spire, Bruno, and Allen, Susan

Subjects
RISK-taking behavior, SEX work, CONDOMS, WOMEN'S health, BEHAVIOR modification, LONGITUDINAL method
Abstract

Observing sexual behaviour change over time could help develop behavioural HIV prevention interventions for female sex workers in Zambia, where these interventions are lacking. We investigated the evolution of consistent condom use among female sex workers and their clients and steady partners. Participants were recruited into an HIV incidence cohort from 2012 to 2017. At each visit, women received HIV counselling and testing, screening for sexually transmitted infections (STIs) and free condoms. Our outcome was reported consistent (100%) condom use in the previous month with steady partners, repeat clients, and non-repeat clients. Consistent condom use at baseline was highest with non-repeat clients (36%) followed by repeat clients (27%) and steady partners (17%). Consistent condom use between baseline and Month 42 increased by 35% with steady partners, 39% with repeat clients and 41% with non-repeat clients. Access to condoms, HIV/STI counselling and testing promoted positive sexual behaviour change. [ABSTRACT FROM AUTHOR]

Published
2022
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48. On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse : a post-hoc analysis of the ANRS IPERGAY trial

Author

Antoni, G., Tremblay, C., Delaugerre, C., Charreau, I., Cua, E., Castro, D. R., Raffi, F., Chas, J., Huleux, T., Spire, B., Capitant, C., Cotte, L., Meyer, L., Molina, J. M., Sagaon Teyssier, Luis (collab.), and ANRS Ipergay Study Group

Abstract

Background ANRS IPERGAY found that on-demand pre-exposure prophylaxis (PrEP) with oral tenofovir disoproxil fumarate plus emtricitabine was associated with an 86% relative reduction of HIV-1 incidence compared with placebo among men who have sex with men at high risk of HIV. We aimed to investigate whether on-demand PrEP was similarly effective among individuals with lower exposure to HIV risk. Methods Participants in the ANRS IPERGAY trial were randomly assigned to receive PrEP (fixed-dose combination of 300 mg tenofovir disoproxil fumarate and 200 mg emtricitabine per pill) or placebo. The primary endpoint was the diagnosis of HIV-1 infection. Pill uptake was assessed by counting returned pills at each follow-up and by estimating tenofovir concentration from frozen plasma samples. Participants were interviewed at each visit to assess the pattern of PrEP use. All participants enrolled in the modified intention-to-treat population of the double-blind phase of the ANRS IPERGAY trial were eligible for this post-hoc analysis. We calculated the total follow-up time for periods of less frequent sexual intercourse with high PrEP adherence (15 pills or fewer per month taken systematically or often during sexual intercourse). To estimate the time of HIV acquisition, fourth-generation HIV-1/2 ELISA assays, plasma HIV-1 RNA assays, and western blot analyses were done with use of frozen samples, and the stage of HIV infection was defined according to Fiebig staging. HIV incidence was compared between the two treatment groups among individuals who had less frequent sexual intercourse with high PrEP adherence. The ANRS IPERGAY trial is registered with ClinicalTrials.gov, NCT01473472. Findings 400 participants who were randomly assigned to receive PrEP (n=199) or placebo (n=201) between Feb 22, 2012, and Oct 17, 2014, were included in this analysis. 270 participants had at least one period of less frequent sexual intercourse with high PrEP adherence during the study, representing 134 person-years of follow-up and 31% of the total study follow-up. During these periods, participants in both groups reported a median of 5.0 (IQR 2.0-10.0) episodes of sexual intercourse per month and used a median of 9.5 (6.0-13.0) pills per month. Six HIV-1 infections were diagnosed in the placebo group (HIV incidence of 9.2 per 100 person-years; 95% CI 3.4-20.1) and none were diagnosed in the tenofovir disoproxil fumarate plus emtricitabine arm (HIV incidence of 0 per 100 person-years; 0-5.4; p=0.013), with a relative reduction of HIV incidence of 100% (95% CI 39-100). Interpretation A choice between daily or on-demand PrEP regimens could be offered to men who have sex with men who have less frequent sexual intercourse.

Published
2020

49. Combined sexual behavioral profiles in HIV-seronegative men who have sex with men in West Africa (CohMSM ANRS 12324-Expertise France)

Author

Coulaud, P. J., Sagaon Teyssier, Luis, Mrenda, B. M., Maradan, G., Mora, M., Bourrelly, M., Keita, B. D., Keita, A. A., Anoma, C., Yoro, S. A. B., Dah, T. T. E., Coulibaly, C., Mensah, E., Agbomadji, S., Bernier, A., Couderc, C., Laurent, Christian, Spire, B., Granouillac, Bruno (collab.), Izard, Suzanne (collab.), Laurent, Christian (collab.), March, Laura (collab.), Peeters, Martine (collab.), and CohMSM ANRS 12324 Study Group

Subjects
Sexual behavior, Identity, HIV risk, West Africa, virus diseases, Sexual orientation, MSM
Abstract

Understanding the dynamics of HIV infection in men who have sex with men (MSM) can help improve efficiency in existing prevention strategies. We aimed to identify and describe the sexual behaviors of MSM most at risk of HIV infection in West Africa. HIV-negative MSM were provided a quarterly preventive follow-up package in the community-based cohort CohMSM. They completed face-to-face sociobehavioral questionnaires every 6 months. This sub-study on 520 participants used a baseline, 6-, 12- and 18-month data cluster analysis to categorize two profiles (high risk [HRE] and moderate risk [MRE] of exposure to HIV) based on three risky sexual practices over the previous 6 months. HRE-MSM (61%) were more engaged in receptive practices, had a higher proportion of inconsistent condom use during anal sex, and reported more sexual partners than MRE-MSM (39%). The proportion of HIV seroconversions observed during the first 18 months of follow-up using sexual behavioral profiles (92% are HRE-MSM) was higher than using the three risky sexual practices separately. Factors associated with the HRE-MSM profile were being younger (18-21 years), reporting stigma, and having had no female partner while being attracted only to men. Our findings suggest that in order to identify MSM most at risk of HIV infection, several risky sexual practices need to be evaluated in a combined approach. Prevention programs should pay particular attention to younger MSM, and implement activities addressing questions of MSM identity and stigma in order to reduce the dynamic of HIV infection in Western African MSM.

Published
2020

50. Differences in HIV cure clinical trial preferences of French people living with HIV and physicians in the ANRS-APSEC study : a discrete choice experiment

Author

Protiere, C., Arnold, M., Fiorentino, Marion, Fressard, L., Lelievre, J. D., Mimi, M., Raffi, F., Mora, M., Meyer, L., Sagaon Teyssier, Luis, Zucman, D., Preau, M., Lambotte, O., Spire, B., Suzan-Monti, M., and ANRS-APSEC Study Group

Subjects
remission, trial design recommendations, therapeutic HIV vaccine trial, discrete choice experiment, mixed logit model, HIV eradication, social sciences, ethics, preferences, clinical
Abstract

Introduction Despite the advent of HIV cure-related clinical trials (HCRCT) for people living with HIV (PLWH), the risks and uncertainty involved raise ethical issues. Although research has provided insights into the levers and barriers to PLWH and physicians' participation in these trials, no information exists about stakeholders' preferences for HCRCT attributes, about the different ways PLWH and physicians value future HCRCT, or about how personal characteristics affect these preferences. The results from the present study will inform researchers' decisions about the most suitable HCRCT strategies to implement, and help them ensure ethical recruitment and well-designed informed consent. Methods Between October 2016 and March 2017, a discrete choice experiment was conducted among 195 virally controlled PLWH and 160 physicians from 24 French HIV centres. Profiles within each group, based on individual characteristics, were obtained using hierarchical clustering. Trade-offs between five HCRCT attributes (trial duration, consultation frequency, moderate (digestive disorders, flu-type syndrome, fatigue) and severe (allergy, infections, risk of cancer) side effects (SE), outcomes) and utilities associated with four HCRCT candidates (latency reactivation, immunotherapy, gene therapy and a combination of latency reactivation and immunotherapy), were estimated using a mixed logit model. Results Apart from severe SE - the most decisive attribute in both groups - PLWH and physicians made different trade-offs between HCRCT attributes, the latter being more concerned about outcomes, the former about the burden of participation (consultation frequency and moderate SE). These different trades-offs resulted in differences in preferences regarding the four candidate HCRCT. PLWH significantly preferred immunotherapy, whereas physicians preferred immunotherapy and combined therapy. Despite the heterogeneity of characteristics within the PLWH and physician profiles, results show some homogeneity in trade-offs and utilities regarding HCRCT. Conclusions Severe SE, not outcomes, was the most decisive attribute determining future HCRCT participation. Particular attention should be paid to providing clear information, in particular on severe SE, to potential participants. Immunotherapy would appear to be the best HCRCT candidate for both PLWH and physicians. However, if the risk of cancer could be avoided, gene therapy would become the preferred strategy for the latter and the second choice for the former.

Published
2020

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