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10. Germline mutations in the von Hippel-Lindau (VHL) gene in patients from Poland: disease presentation in patients with deletions of the entire VHL gene

Author

Cybulski, C, Krzystolik, K, Murgia, A, Górski, B, Dębniak, T, Jakubowska, A, Martella, M, Kurzawski, G, Prost, M, Kojder, I, Limon, J, Nowacki, P, Sagan, L, Białas, B, Kałuża, J, Zdunek, M, Omulecka, A, Jaskólski, D, Kostyk, E, Koraszewska-Matuszewska, B, Haus, O, Janiszewska, H, Pecold, K, Starzycka, M, Słomski, R, Ćwirko, M, Sikorski, A, Gliniewicz, B, Cyryłowski, L, Fiszer-Maliszewska, Ł, Gronwald, J, Tołoczko-Grabarek, A, Zajączek, S, and Lubiński, J

Published
2002

16. +Gz tolerance in man after 14-day bedrest periods with isometric and isotonic exercise conditioning

Author

Greenleaf, J. E, Haines, R. F, Sandler, H, Bernauer, E. M, Morse, J. T, Armbruster, R, Sagan, L, and Van Beaumont, W

Subjects
Aerospace Medicine
Abstract

The effects of isometric and isotonic exercise training on post-bedrest +Gz tolerance were determined. In general, 14-day bedrest resulted in a significant loss of Gz tolerance, as previously discovered. At 2.1 Gz, neither the isometric nor the isotonic exercises regimens resulted in a significant increase in post-bedrest Gz tolerance. However, following isometric exercise, restoration of about half the tolerance decrement occurred at 3.2 Gz and 3.8 Gz. Possible reasons for this partial restoration of tolerance are put forward.

Published
1975

21. Intermittent Light Exposures in Humans: A Case for Dual Entrainment in the Treatment of Alzheimer's Disease

Author

Mariana G. Figueiro and Sagan Leggett

Subjects
Alzheimer's disease, circadian entrainment, flashing light, gamma entrainment, memory, sleep, Neurology. Diseases of the nervous system, RC346-429
Abstract

Circadian sleep disorders are common among American adults and can become especially acute among older adults, especially those living with Alzheimer's disease (AD) and mild cognitive impairment (MCI), leading to the exacerbation of symptoms and contributing to the development and advancement of the diseases. This review explores the connections between circadian sleep disorders, cognition, and neurodegenerative disease, offering insights on rapidly developing therapeutic interventions employing intermittent light stimuli for improving sleep and cognition in persons with AD and MCI. Light therapy has the potential to affect sleep and cognition via at least two pathways: (1) a regular and robust light-dark pattern reaching the retina that promotes circadian phase shifting, which can promote entrainment and (2) 40 Hz flickering light that promotes gamma-wave entrainment. While this is a new area of research, preliminary evidence shows the potential of dual circadian and gamma-wave entrainment as an important therapy not only for those with AD, but for others with cognitive impairment.

Published
2021
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29. The effect of stem cell mobilisation with granulocyte clony-stimulating factor on the morphology of the haematopoietic organs in mice

Author

Barcew, K., Paczkowska, E., Dabkowska, E., Baskiewcz-Masiuk, M., Marchlewicz, M., Domański, L., Sagan, L., Barbara Wiszniewska, and Machaliński, B.

Subjects
Mice, Inbred BALB C, Dose-Response Relationship, Drug, Injections, Subcutaneous, Apoptosis, Bone Marrow Cells, Cell Count, Hematopoietic Stem Cells, Hematopoietic Stem Cell Mobilization, Mice, Liver, Cell Movement, Granulocyte Colony-Stimulating Factor, Animals, Female, Spleen
Abstract

The cellular mobilisation of mice with granulocyte colony-stimulating factor (G-CSF) results in an egress of haematopoietic stem/progenitor cells from the bone marrow and an increase in their level in the peripheral blood. While the mobilisation process with different agents is widely studied, little is known about the morphology of the murine haematopoietic organs during the mobilisation. The purpose of this study was to examine the morphology of the bone marrow, spleen and liver in mice mobilised with G-CSF. To address this issue mice were injected subcutaneously with G-CSF for 6 consecutive days. Morphological analysis revealed an increase in the number of mature neutrophils close to the wall of sinusoids in the bone marrow as well as hypertrophy of the red pulp in the spleen. At the same time no morphological changes were noticed in the livers of G-CSF-mobilised mice. In conclusion, G-CSF induces discrete ultrastructural changes in the bone marrow, which intensify the transendothelial traverse of haematopoietic stem and progenitor cells from it. The changes in the spleen are related to repopulation of this organ by mobilised early haematopoietic cells circulating in the peripheral blood. We also noticed that the process of migration of haematopoietic cells from the bone marrow into the peripheral blood began on day 2 and was most pronounced on day 4 after stimulation with G-CSF.

43. New biological books: Human biology & health.

Author

Sagan, L.

Subjects
SICKNESS, Recovery & Death: A History & Forecast of Ill Health (Book)
Abstract

Reviews the book `Sickness, Recovery and Death: A History and Forecast of Ill Health,` by James C. Riley.

Published
1990

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