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EVIDENC-BASED ANSWER A / NO. In general, nonoral estrogen use for menopausal symptoms is associated with a lower cardiovascular (CV) risk profile than oral estrogen use (strength of recommendation [SOR], [...]

Our growing understanding about the impact of light on health has recently been transferred to building certification programs, with some including recommendations for indoor light exposure that supports physiology, sleep [...]

Q/How does gender-affirming hormone therapy affect QOL in transgender patients? EVIDENCE-BASED ANSWER A/THERE ARE MODEST EFFECTS ON DEPRESSION BUT NOT ANXIETY. Gender-affirming hormone therapy (GAHT) is associated with modest improvements [...]

EVIDENCE-BASED ANSWER A / probably, although there are o head-to-head trials comparing the 2 dosing regimens. Event-driven pre-exposure prophylaxis (PrEP) dosing reduces HIV conversion by 86% compared to placebo (strength [...]

EVIDENCE-BASED ANSWER A / It depends. A diagnosis of chronic obstrucdve pulmonary disease (COPD) made using screening spirometry in patients without symptoms does not change the course of the disease [...]

EVIDENCE-BASED ANSWER A/ No. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet medications such as clopidogrel for acute coronary syndrome (ACS) doesn't increase the composite risk of cardiovascular [...]

How accurate is transcutaneous bilirubin testing in newborns with darker skin tones? Brandi Boden, DO; Brittany Buescher, MD; Amanda Kim, MD; Jon 0. Neher, MD; Sarah Safranek, [...]

EVIDENCE-BASED ANSWER AI It's unclear if there are any I highly effective medications for gastroparesis (TABLE (1-10)). Metoclopramide improves the sense of fullness by about 40% for as long as [...]

EVIDENCE-BASED ANSWER A / FECAL MICROBIAL TRANSPLANT (FMT) IS REASONABLY SAFE AND EFFECTIVE. In patients who have had multiple Clostridium difficile infections (CDIs), fecal microbial transplant (FMT) results in a [...]

EVIDENCE-BASED ANSWER A / QUITE WELL, for cardiopulmonary resuscitation (CPR). Most patients (91%-100%) who select 'do not resuscitate' (DNR) on their physician's orders for life-sustaining treatment (POLST) forms are allowed [...]

EVIDENCE-BASED ANSWER A / likely yes. Point-of-care ultrasound (POCUS) screening for abdominal aortic aneurysm (AAA) by nonradiologist physicians is 98% sensitive and 99% specific, compared with imaging performed by radiologists [...]

EVIDENCE-BASED ANSWER A/ Yes, to some degree--but it is of I uncertain clinical significance. Over a period of 6 months, metformin modestly reduced weight (-2.1 kg) and body fat mass [...]

Q / Do electronic reminder systems help patients with T2DM to lose weight? A / PROBABLY NOT--but they may I augment self-management. Four-component telehealth systems--including electronic reminders, measuring devices, patient-driven [...]

EVIDENCE-BASED ANSWER A / PATIENTS AT HIGHEST RISK for progression to diabetes benefit from metformin. In patients with metabolic syndrome who are in the highest-risk quartile for progression to diabetes [...]

EVIDENCE-BASED ANSWER A / We don't know which selective serotonin reuptake inhibitors (SSRIs) are the most effective and safe because no studies have compared these antidepressants with each other. Three [...]