1. Acute Liver Failure Induced by Carthamus tinctorius Oil: Case Reports and Literature Review.
- Author
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de Ataide EC, Reges Perales S, de Oliveira Peres MA, Bastos Eloy da Costa L, Quarella F, Valerini FG, Chueiri Neto F, Silveira Bello Stucchi R, and de Fátima Santana Ferreira Boin I
- Subjects
- Adult, Carthamus tinctorius toxicity, Female, Humans, Liver Failure, Acute surgery, Liver Transplantation, Male, Middle Aged, Dietary Supplements poisoning, Liver Failure, Acute chemically induced, Safflower Oil poisoning
- Abstract
Background: Acute liver failure (ALF) is a clinical syndrome that results from the abrupt loss of liver function in a patient without previous liver disease. The most frequent causes are viral hepatitis, drug induced, and autoimmune disease, but in 20% of cases no cause is identified. Carthamus tinctorius (safflower) oil is used as a dietary supplement for weight loss and antioxidant. There are 4 cases described in the literature of ALF induced by the use of this substance. The objective of this study was to report 3 cases of ALF treated at the Clinical Hospital of the State University of Campinas that suggest the use of C tinctorius oil as a probable etiologic factor., Case Reports: The 3 patients had a diagnosis of ALF according to the King's College criteria. All had a history of ingestion of this oil for weight loss. During etiologic evaluation, viral hepatitis, autoimmune diseases, or any other drug cause were excluded, thus pointing to C tinctorius oil as the triggering factor. All 3 patients underwent liver transplantation: 2 had good postoperative evolution, and 1 died 12 days after the procedure., Conclusions: Two cases are described in which the hepatic insufficiency induced by C tinctorius oil was successfully treated through liver transplantation. This highlights the risk of misuse of this substance for weight loss., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
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