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9. Protein turnover in the human kidney

Author

Garibotto, Giacomo, Tessari, P, Zanetti, M, Robaudo, C, Saffioti, S, Sala, Mr, Inchiostro, S, Vettore, M, Deferrari, G., TESSARI P, SOETERS PB, PITTONI G, TIENGO A, Garibotto, G., Tessari, P., Zanetti, Michela, Robaudo, C., Saffioti, S., Sala, M., Inchiostro, S., Vettore, M., and Deferrari, G.

Subjects
kidnay, protein metabolism, amino acids, kidney, protein turnover, protein turnover, amino acids, kidney
Published
1997

10. Leucine metabolism and protein dynamics in the human kidney

Author

Garibotto, G., Tessari, P., Robaudo, C., Vettore, M., Saffioti, S., Zanetti, Michela, Sofia, A., Deferrari, G., Tizianello, A., Garibotto, G., Tessari, P., Robaudo, C., Vettore, M., Saffioti, S., Zanetti, Michela, Sofia, A., Deferrari, G., and Tizianello, A.

Subjects
Adult, Male, kidney, Carbon Isotopes, Nitrogen Isotopes, Proteins, Kidney, Keto Acids, Bicarbonates, Kinetics, protein metabolism, Leucine, Humans, Female, Oxidation-Reduction
Published
1997

21. [Acute effects of peritoneal dialysis on muscle protein turnover]

Author

Sofia A, Russo R, Saffioti S, Sacco P, Dertenois L, Pastorino N, Verzola D, Ravera F, Deferrari G, and GIACOMO GARIBOTTO

Subjects
Brachial Artery, Phenylalanine, Muscle Proteins, Proteins, Tritium, Protein-Energy Malnutrition, Forearm, Glucose, Dialysis Solutions, Hyperinsulinism, Humans, Infusions, Intra-Arterial, Insulin, Kidney Failure, Chronic, Amino Acids, Peritoneal Dialysis
Abstract

Despite continuing glucose absorption and stimulation of insulin secretion, wasting is common in patients with chronic renal failure (CRF) treated with peritoneal dialysis.To evaluate if peritoneal dialysis per se has any effect(s) on muscle protein turnover we employed the forearm perfusion method associated with the kinetics of 3H-phenylalanine in seventeen patients with CRF in the basal state and: a) during the systemic hyperinsulinemia associated with peritoneal dialysis (6 patients) (200-240 min); b) during locally-induced hyperinsulinemia, without systemic effects on aminoacid (AA) availability (6 patients) (80-120 min); c) in time-controls (5 patients) (80-240 min).Peritoneal dialysis and local infusion of insulin in the brachial artery (0.01 mU/min/kg) induced a similar degree of systemic or local, moderate hyperinsulinemia (19+/-4 e 21+/-3 microU/ml, respectively). During both protocols an insulin-related inhibition of muscle protein degradation occurred; however peritoneal dialysis caused a 20% decrease in forearm phenylalanine rate of disposal (an index of muscle protein synthesis), which correlated with the decline of arterial BCAA and potassium, which were removed via the peritoneal fluid. Furthermore, a persistent negative net phenylalanine and AA balance across the forearm was observed during peritoneal dialysis, while the negative basal net phenylalanine and AA balance was reversed to a positive or neutral one during local hyperinsulinemia.We conclude that in CRF patients even a modest elevation in local insulin levels is followed by an anabolic muscle response, while the same effect is not observed during the systemic hyperinsulinemia associated with substrate removal which occurs during peritoneal dialysis. In this setting the antiproteolytic effect of hyperinsulinemia is offset by a decrease in muscle protein synthesis which is accounted for by a decrease in AA availability. Our data indicate that protein metabolism during peritoneal dialysis is characterized not only by decreased, but also less efficient, turnover rates.

Published
2002

24. A peritoneal dialysis solution prepared from a three-compartment bag: biological and clinical effects

Author

Cappelli, G, Amore, A, Bandiani, G, Cancarini, Giovanni, Coppo, R, Feriani, M, Dell'Aquila, R, Saffioti, S, Spisni, C, Stingone, A, Orazi, E, Ballocchi, S, and Renaux, J. L.

Subjects
Glycation End Products, Advanced, Male, Glycosylation, Drug Storage, Apoptosis, Epithelium, Electrolytes, Peritoneal Dialysis, Continuous Ambulatory, Dialysis Solutions, In Situ Nick-End Labeling, Humans, solution, Cells, Cultured, Drug Packaging, Aged, Uremia, peritoneal dialysis, Membrane Proteins, Equipment Design, Middle Aged, No abstract available, Caspase 9, Glucose, Caspases, Female, Peritoneum, Tumor Suppressor Protein p53, Peritoneal Dialysis
Published
2000

28. Cell signalling / Pathophysiology

Author

Cerini, C., primary, Gondouin, B., additional, Dou, L., additional, Duval-Sabatier, A., additional, Brunet, P., additional, Dignat- George, F., additional, Burtey, S., additional, Okano, K., additional, Iwasaki, T., additional, Jinnai, H., additional, Hibi, A., additional, Miwa, N., additional, Kimata, N., additional, Nitta, K., additional, Akiba, T., additional, Dolley-Hitze, T., additional, Verhoest, G., additional, Jouan, F., additional, Arlot-Bonnemains, Y., additional, Lavenu, A., additional, Belaud-Rotureau, M.-A., additional, Rioux-Leclercq, N., additional, Vigneau, C., additional, Cox, S. N., additional, Sallustio, F., additional, Serino, G., additional, Loverre, A., additional, Pesce, F., additional, Gigante, M., additional, Zaza, G., additional, Stifanelli, P., additional, Ancona, N., additional, Schena, F. P., additional, Marc, P., additional, Jacques, T., additional, Green, J. M., additional, Mortensen, R. B., additional, Verma, R., additional, Leu, K., additional, Schatz, P. J., additional, Wojchowski, D. M., additional, Ihoriya, C., additional, Satoh, M., additional, Sasaki, T., additional, Kashihara, N., additional, Jung, Y. J., additional, Kang, K. P., additional, Lee, A. S., additional, Lee, J. E., additional, Lee, S., additional, Park, S. K., additional, Kim, W., additional, Florian, T., additional, Tepel, M., additional, Ying, L., additional, Katharina, K., additional, Nora, F., additional, Antje, W., additional, Alexandra, S., additional, Chiu, Y.-T., additional, Wu, M.-J., additional, Liu, Z.-H., additional, Liang, Y., additional, Zheng, C.-X., additional, Chen, Z.-H., additional, Zeng, C.-H., additional, Ranzinger, J., additional, Rustom, A., additional, Kihm, L., additional, Heide, D., additional, Scheurich, P., additional, Zeier, M., additional, Schwenger, V., additional, Liu, J., additional, Zhong, F., additional, Xu, L., additional, Zhou, Q., additional, Hao, X., additional, Wang, W., additional, Chen, N., additional, Liu, X., additional, Lu, Y., additional, Guo, S., additional, Lin, D., additional, Vilasi, A., additional, Deplano, S., additional, Cutillas, P., additional, Unwin, R., additional, Tam, F. W. K., additional, Medrano-Andres, D., additional, Lopez-Martinez, V., additional, Martinez-Miguel, P., additional, Cano, J. L., additional, Arribas, I., additional, Rodiguez-Puyol, M., additional, Lopez-Ongil, S., additional, Kadoya, H., additional, Nagasu, H., additional, Lindeberg, E., additional, Grundstrom, G., additional, Alexandra, M., additional, Ghosh, C. C., additional, David, S., additional, Mukherjee, A., additional, John, S. G., additional, Mcintyre, C. W., additional, Haller, H., additional, Parikh, S. M., additional, Troyano, N., additional, Del Nogal, M., additional, Olmos, G., additional, Mora, I., additional, DE Frutos, S., additional, Rodriguez-Puyol, M., additional, Ruiz, M. P., additional, Rothe, H., additional, Shapiro, W., additional, Ketteler, M., additional, Ramakrishnan, S. K., additional, Loupy, A., additional, Houillier, P., additional, Guilhermino Pereira, L., additional, Boim, M., additional, Aragao, D., additional, Casarini, D., additional, Jin, Y., additional, Moon, J.-Y., additional, Kim, Y.-G., additional, Lee, S.-H., additional, Lee, T.-W., additional, Ihm, C.-G., additional, Kim, E.-Y., additional, Lee, H.-J., additional, Wi, J.-G., additional, Jeong, K.-H., additional, Ruan, X. Z., additional, LI, L.-C., additional, Varghese, Z., additional, Chen, J.-B., additional, Lee, C.-T., additional, Moorhead, J., additional, Cerini, C., additional, Poitevin, S., additional, Dignat-George, F., additional, Stephane, B., additional, Bonanni, A., additional, Verzola, D., additional, Maggi, D., additional, Brunori, G., additional, Sofia, A., additional, Mannucci, I., additional, Maffioli, S., additional, Salani, B., additional, D'amato, E., additional, Saffioti, S., additional, Laudon, A., additional, Cordera, R., additional, Garibotto, G., additional, Maquigussa, E., additional, and Arnoni, C., additional

Published
2012
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38. Reply (Letter to the Editor)

Author

Musso, N. R., Deferrari, G., Pende, Aldo, Vergassola, C., Saffioti, S., Gurreri, G., and Lotti, G.

Published
1990

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