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Your search keyword '"Safarzadeh Kozani, Pooria"' showing total 41 results
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41 results on '"Safarzadeh Kozani, Pooria"'

9. CAR-T cell therapy in triple-negative breast cancer: Hunting the invisible devil

Author

Nasiri, Fatemeh, primary, Kazemi, Mehrasa, additional, Mirarefin, Seyed Mohamad Javad, additional, Mahboubi Kancha, Maral, additional, Ahmadi Najafabadi, Milad, additional, Salem, Faeze, additional, Dashti Shokoohi, Setareh, additional, Evazi Bakhshi, Sahar, additional, Safarzadeh Kozani, Pouya, additional, and Safarzadeh Kozani, Pooria, additional

Published
2022
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10. ACE2 in SARS-CoV-2-Mediated COVID-19: A Brief Review

Author

Safarzadeh Kozani, Pooria, primary, Dashti Shokoohi, Setareh, additional, Baharifar, Narges, additional, Sheikhi, Sepideh, additional, Khalaf Shamsabadi, Fatemeh, additional, Chamaie Nejad, Forough, additional, Sheikhi, Mehdi, additional, Rabiee Valashedi, Mehdi, additional, Safarzadeh Kozani, Pouya, additional, Mirarefin, Seyed Mohamad Javad, additional, and Sheikhi, Abdolkarim, additional

Published
2022
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12. Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies.

Author

Dabiri, Hamed, Safarzadeh Kozani, Pooria, Habibi Anbouhi, Mahdi, Mirzaee Godarzee, Mohadeseh, Haddadi, Mohammad Hossein, Basiri, Mohsen, Ziaei, Vahab, Sadeghizadeh, Majid, and Hajizadeh Saffar, Ensiyeh

Subjects
CHIMERIC antigen receptors, CYTOTOXIC T cells, CELLULAR therapy, CELL transformation, CELL surface antigens, T cells, T cell receptors
Abstract

Chimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically engineered immune cells that can detect target antigens on the surface of target cells and eliminate them following adoptive transfer. Recent progress in CAR-based therapies has led to outstanding clinical success in certain patients with leukemias and lymphomas and offered therapeutic benefits to those resistant to conventional therapies. The universal approach to stable CAR transgene delivery into the T/NK cells is the use of viral particles. Such approaches mediate semi-random transgene insertions spanning the entire genome with a high preference for integration into sites surrounding highly-expressed genes and active loci. Regardless of the variable CAR expression level based on the integration site of the CAR transgene, foreign integrated DNA fragments may affect the neighboring endogenous genes and chromatin structure and potentially change a transduced T/NK cell behavior and function or even favor cellular transformation. In contrast, site-specific integration of CAR constructs using recent genome-editing technologies could overcome the limitations and disadvantages of universal random gene integration. Herein, we explain random and site-specific integration of CAR transgenes in CAR-T/NK cell therapies. Also, we tend to summarize the methods for site-specific integration as well as the clinical outcomes of certain gene disruptions or enhancements due to CAR transgene integration. Also, the advantages and limitations of using site-specific integration methods are discussed in this review. Ultimately, we will introduce the genomic safe harbor (GSH) standards and suggest some appropriate safety prospects for CAR integration in CAR-T/NK cell therapies. [ABSTRACT FROM AUTHOR]

Published
2023
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13. COVID-19 Vaccines Approved by the US Food and Drug Administration

Author

Safarzadeh Kozani, Pouya, primary, Safarzadeh Kozani, Pooria, additional, Dashti Shokoohi, Setareh, additional, Evazi Bakhshi, Sahar, additional, Narimani Kohnehshahri, Samira, additional, Sheikhi, Mehdi, additional, Khalaf Shamsabadi, Fatemeh, additional, Baharifar, Narges, additional, and Sheikhi, Abdolkarim, additional

Published
2022
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14. COVID-19 Vaccines in Iran

Author

Safarzadeh Kozani, Pouya, primary, Safarzadeh Kozani, Pooria, additional, Mirarefin, Seyed Mohamad Javad, additional, Sheikhi, Sara, additional, Baharifar, Narges, additional, Sheikhi, Mehdi, additional, Shams, Nasir, additional, Nikbakht, Mojtaba, additional, and Sheikhi, Abdolkarim, additional

Published
2022
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21. Polysaccharide-based hydrogels: properties, advantages, challenges, and optimization methods for applications in regenerative medicine.

Author

Safarzadeh Kozani, Pooria, Safarzadeh Kozani, Pouya, Hamidi, Masoud, Valentine Okoro, Oseweuba, Eskandani, Morteza, and Jaymand, Mehdi

Subjects
*REGENERATIVE medicine, *HYDROGELS, *BIOPOLYMERS, *BIOMATERIALS, *POLYSACCHARIDES
Abstract

In the past few years, research has focused on design and development of natural polymers-based hydrogels owing to their inherent features as well as numerous application ranges. In this context, polysaccharide-based hydrogels have attracted significant interest mainly due to their superior physicochemical and biological characteristics. However, these types of biomaterials 'suffer' from some problems. This review aims to give an update of diverse optimization strategies used to improve the physicochemical and biological properties of hydrogels based on natural polysaccharides as biomaterials for regenerative medicine applications. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Addressing the obstacles of CAR T cell migration in solid tumors: wishing a heavy traffic.

Author

Safarzadeh Kozani, Pooria, Safarzadeh Kozani, Pouya, and Rahbarizadeh, Fatemeh

Subjects
*CHIMERIC antigen receptors, *CELL migration
Abstract

Chimeric antigen receptor T cell (CAR-T) therapy has been recognized as one of the most prosperous treatment options against certain blood-based malignancies. However, the same clinical and commercial success have been out of range in the case of solid tumors. The main contributing factor in this regard is the hostile environment the tumor cells impose that results in the exhaustion of immune effector cells alongside the abrogation of their infiltration capacity. The discovery of the underlying mechanisms and the development of reliable counterstrategies to overcome the inaccessibility of CAR-Ts to their target cells might correlate with encouraging clinical outcomes in advanced solid tumors. Here, we highlight the successive physical and metabolic barriers that systemically administered CAR-Ts face on their journey toward their target cells. Moreover, we propose meticulously-devised countertactics and combination therapies that can be applied to maximize the therapeutic benefits of CAR-T therapies against solid tumors. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Polysaccharide-based hydrogels: properties, advantages, challenges, and optimization methods for applications in regenerative medicine

Author

Safarzadeh Kozani, Pooria, Safarzadeh Kozani, Pouya, Hamidi, Masoud, Okoro, Oseweuba, Eskandani, Morteza, Jaymand, Mehdi, Safarzadeh Kozani, Pooria, Safarzadeh Kozani, Pouya, Hamidi, Masoud, Okoro, Oseweuba, Eskandani, Morteza, and Jaymand, Mehdi

Abstract

In the past few years, research has focused on design and development of natural polymers-based hydrogels owing to their inherent features as well as numerous application ranges. In this context, polysaccharide-based hydrogels have attracted significant interest mainly due to their superior physicochemical and biological characteristics. However, these types of biomaterials ‘suffer’ from some problems. This review aims to give an update of diverse optimization strategies used to improve the physicochemical and biological properties of hydrogels based on natural polysaccharides as biomaterials for regenerative medicine applications., SCOPUS: re.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2021

40. Production, characterization and biological activities of exopolysaccharides from a new cold-adapted yeast: Rhodotorula mucilaginosa sp. GUMS16

Author

Hamidi, Masoud, primary, Gholipour, Amir Reza, additional, Delattre, Cédric, additional, Sesdighi, Faezeh, additional, Mirzaei Seveiri, Rasool, additional, Pasdaran, Ardalan, additional, Kheirandish, Setareh, additional, Pierre, Guillaume, additional, Safarzadeh Kozani, Pouya, additional, Safarzadeh Kozani, Pooria, additional, and Karimitabar, Fatemeh, additional

Published
2020
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41. Strategies for Dodging the Obstacles in CAR T Cell Therapy.

Author

Safarzadeh Kozani, Pooria, Safarzadeh Kozani, Pouya, Rahbarizadeh, Fatemeh, and Khoshtinat Nikkhoi, Shahryar

Subjects
CHIMERIC antigen receptors, CYTOKINE release syndrome, TUMOR treatment, GRAFT rejection, LYMPHOBLASTIC leukemia, HAND-foot syndrome
Abstract

Chimeric antigen receptor (CAR) T cell therapy has offered cancer patients a new alternative therapeutic choice in recent years. This novel type of therapy holds tremendous promise for the treatment of various hematologic malignancies including B-cell acute lymphoblastic leukemia (B-ALL) and lymphoma. However, CAR T cell therapy has experienced its ups and downs in terms of toxicities and efficacy shortcomings. Adverse events such as cytokine release syndrome (CRS), neurotoxicity, graft rejection, on-target off-tumor toxicities, and tumor relapse have tied the rescuing hands of CAR T cell therapies. Moreover, in the case of solid tumor treatment, CAR T cell therapies have not yielded encouraging results mainly due to challenges such as the formidable network of the tumor microenvironments (TME) that operates in a suppressive fashion resulting in CAR T cell dysfunction. In this review, we tend to shine a light on emerging strategies and solutions for addressing the mentioned barriers. These solutions might dramatically help shorten the gap between a successful clinical outcome and the hope for it. [ABSTRACT FROM AUTHOR]

Published
2021
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