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25 results on '"Safak, Okan"'

1. Correlation of intratumoral mast cell quantity with psychosocial distress in patients with pancreatic cancer: the PancStress study

Author

Sitte, Alicia, Goess, Ruediger, Tüfekçi, Tutku, Pergolini, Ilaria, Pfitzinger, Paulo Leonardo, Salvo-Romero, Eloísa, Mota Reyes, Carmen, Tokalov, Sergey, Safak, Okan, Steenfadt, Hendrik, Gürcinar, Ibrahim H., Yurteri, Ümmügülsüm, Goebel-Stengel, Miriam, Mazzuoli-Weber, Gemma, Stengel, Andreas, Erkan, Mert, Friess, Helmut, Istvanffy, Rouzanna, Ceyhan, Güralp Onur, Demir, Elke, and Demir, Ihsan Ekin

Published
2024
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6. Lymph node examination and survival in resected pancreatic ductal adenocarcinoma: retrospective study

Author

Goess, Ruediger, primary, Jäger, Carsten, additional, Perinel, Julie, additional, Pergolini, Ilaria, additional, Demir, Elke, additional, Safak, Okan, additional, Scheufele, Florian, additional, Schorn, Stephan, additional, Muckenhuber, Alexander, additional, Adham, Mustapha, additional, Novotny, Alexander, additional, Ceyhan, Güralp O, additional, Friess, Helmut, additional, and Demir, Ihsan Ekin, additional

Published
2024
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8. Inadequate lymph node examination leads to misclassification and affects survival in resected pancreatic ductal adenocarcinoma

Author

Goess, Ruediger, primary, Jäger, Carsten, additional, Perinel, Julie, additional, Pergolini, Ilaria, additional, Demir, Elke, additional, Safak, Okan, additional, Scheufele, Florian, additional, Schorn, Stephan, additional, Muckenhuber, Alexander, additional, Adham, Mustapha, additional, Novotny, Alexander, additional, Ceyhan, Güralp, additional, Friess, Helmut, additional, and Demir, Ihsan Ekin, additional

Published
2023
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9. A retrospective, multicentre, nationwide analysis of the impact of splenectomy on survival of pancreatic cancer patients

Author

Kießler, Maximilian, primary, Jäger, Carsten, additional, Reyes, Carmen Mota, additional, Pergolini, Ilaria, additional, Schorn, Stephan, additional, Göß, Rüdiger, additional, Safak, Okan, additional, Martignoni, Marc E., additional, Novotny, Alexander R., additional, Friess, Helmut, additional, Ceyhan, Güralp O., additional, and Demir, Ihsan Ekin, additional

Published
2023
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14. Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

Author

Safak, Okan, primary, Wang, Shenghan, additional, Mota Reyes, Carmen, additional, Gürcinar, Ibrahim Halil, additional, Tokalov, Sergey, additional, Cevik, Nedim Can, additional, Görgülü, Kivanc, additional, Yilmaz, Bengi Su, additional, Erdogan, Emre, additional, Ye, Linhan, additional, Li, Qiaolin, additional, Sever, Elif Arik, additional, Özer, Samed, additional, Süyen, Güldal, additional, Friess, Helmut, additional, Ceyhan, Güralp Onur, additional, Istvanffy, Rouzanna, additional, Algül, Hana, additional, and Demir, Ihsan Ekin, additional

Published
2023
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15. Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy.

Author

Safak, Okan, Wang, Shenghan, Mota Reyes, Carmen, Gürcinar, Ibrahim Halil, Tokalov, Sergey, Cevik, Nedim Can, Görgülü, Kivanc, Yilmaz, Bengi Su, Erdogan, Emre, Ye, Linhan, Li, Qiaolin, Sever, Elif Arik, Özer, Samed, Süyen, Güldal, Friess, Helmut, Ceyhan, Güralp Onur, Istvanffy, Rouzanna, Algül, Hana, and Demir, Ihsan Ekin

Published
2024
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18. Bacterial Content of the Human Pancreatic Duct: An Observational Study

Author

Demir, Elke, primary, Yilmaz, Bengi Su, additional, Jäger, Carsten, additional, Rothe, Kathrin, additional, Schorn, Stephan, additional, Pergolini, Ilaria, additional, Goess, Rüdiger, additional, Safak, Okan, additional, Wilhelm, Dirk, additional, Martignoni, Marc E., additional, Novotny, Alexander R., additional, Friess, Helmut, additional, Ceyhan, Güralp O., additional, and Demir, Ihsan Ekin, additional

Published
2022
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21. Patterns and Relevance of Langerhans Islet Invasion in Pancreatic Cancer

Author

Goess, Ruediger, primary, Mutgan, Ayse, additional, Çalışan, Umut, additional, Erdoğan, Yusuf, additional, Ren, Lei, additional, Jäger, Carsten, additional, Safak, Okan, additional, Stupakov, Pavel, additional, Istvanffy, Rouzanna, additional, Friess, Helmut, additional, Ceyhan, Güralp, additional, and Demir, Ihsan, additional

Published
2021
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22. The Effect of Celiac Neurolysis and Splanchnicectomy on Survival in Unresectable Pancreatic Cancer: A Systematic Review and Meta-Analysis.

Author

Ye, Linhan, Schorn, Stephan, Pergolini, Ilaria, Safak, Okan, Demir, Elke, Istvanffy, Rouzanna, Friess, Helmut, Ceyhan, Güralp O., and Demir, Ihsan Ekin

Subjects
PANCREATIC cancer, PANCREATIC intraepithelial neoplasia, FIXED effects model, RANDOM effects model, PANCREATIC duct, PAIN management
Abstract

Background: Intractable pancreatic pain is one of the most common symptoms of patients with pancreatic ductal adenocarcinoma (PDAC). Celiac neurolysis (CN) and splanchnicectomy were already described as effective methods to manage abdominal pain in unresectable PDAC, but their impact on overall survival (OS) has not yet been established. Objective: We aimed to investigate the impact of CN and splanchnicectomy on the survival of patients with unresectable pancreatic cancer. Methods: A systematic review of PubMed and Cochrane Library according to predefined searching terms was conducted in March 2020. Hazard ratios (HR) of OS data were calculated using the Mantel-Haenszel model for random effects or fixed effects. Result: Four randomized-controlled trials (RCTs) and 2 non-RCTs with a total of 2,507 patients were identified. The overall pooled HR did not reveal any relevant effect of CN and splanchnicectomy on OS (HR: 1.03; 95% CI: 0.81–1.32), which was also underlined by the sensitivity analysis of RCTs (HR: 1.0; 95% CI: 0.72–1.39) and non-RCTs (HR: 1.07; 95% CI: 0.71–1.63). However, subgroup analyses depending on tumor stage revealed that CN or splanchnicectomy was associated with a worsened OS in AJCC (American Joint Committee on Cancer) stage III patients with unresectable PDAC (HR: 1.22; 95% CI: 1.03–1.45), but nor for AJCC stage IV patients (HR: 1.27; 95% CI: 0.9–1.80). Conclusion: Although only few data are currently available, this systematic review with meta-analysis showed that in unresectable PDAC, CN or splanchnicectomy is associated with a worsened survival in stage III PDAC patients, with no effect on stage IV PDAC patients. These data call for caution in the usage of CN or splanchnicectomy in stage III PDAC and for further studies addressing this observation. [ABSTRACT FROM AUTHOR]

Published
2022
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