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10 results on '"Safaei, Sadegh"'

6. Overexpression of cytoplasmic dynamin 2 is associated with worse outcomes in patients with clear cell renal cell carcinoma

Author

Safaei, Sadegh, primary, Sajed, Roya, additional, Saeednejad Zanjani, Leili, additional, Rahimi, Mandana, additional, Fattahi, Fahimeh, additional, Ensieh Kazemi-Sefat, Golnaz, additional, Razmi, Mahdieh, additional, Dorafshan, Shima, additional, Eini, Leila, additional, Madjd, Zahra, additional, and Ghods, Roya, additional

Published
2022
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8. A Security Model Based on Block Chain Smart Contracts for Improving Authentication on the Internet of Things

Author

Mohammad Saeid Safaei Sadegh and Shamsollah Ghanbari

Subjects
IoT, Security, Block Chain, Smart contract distributed ledger
Abstract

The internet has been developed for the first time in 1999 by Kevin Ashton, based on statistics published by research and research institute IDC as one of the highest - earning projects since 2006. One of the most important issues on the internet research indicates that the architecture of the internet has a three - layer model.This study presents a five - layer model for the internet by analyzing the proposed model, and by analyzing and examining the proposed model, the proposed model will provide a secure authentication service relative to the three layer models in order to improve the resistance against external intervention as well as Distributed confidentiality. The results of this study show that the blockchain - based method for increasing privacy security and capability of control will be a practical solution to the issue of internet security.

Published
2020
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10. Clinical Significance of Talin-1 and HER-2 Status in Different Types of Gastric Carcinoma.

Author

Hashemi, Farideh, Tajik, Fatemeh, Saeednejad Zanjani, Leili, Dehghan Manshadi, Masoumeh, Safaei, Sadegh, Babaheidarian, Pegah, Fattahi, Fahimeh, Ghods, Roya, and Madjd, Zahra

Subjects
*EPIDERMAL growth factor receptors, *EPIDERMAL growth factor, *RECEIVER operating characteristic curves, *CANCER invasiveness, *STOMACH cancer
Abstract

AbstractBackgroundMethodsResultsConclusionsTalin-1 (TLN1) is crucial in cell migration, metastasis, and cancer development. This study evaluated Talin-1 expression and its clinical significance in gastric cancer (GC), along with human epidermal growth factor receptor-2 (HER-2) expression and its correlation with Talin-1.Bioinformatics analysis assessed the potential prognostic value of Talin-1 and HER-2 in GC patients. The study included 223 GC patients (Signet Ring Cells and Intestinal subtypes) and 29 non-malignant tissue samples. Immunohistochemistry (IHC) on tissue microarray slides evaluated Talin-1 and HER-2 expression and clinical significance. Receiver operating characteristic (ROC) curves assessed their diagnostic value.Bioinformatics identified Talin-1 as a potential prognostic factor and HER-2 as an oncogene in GC. Talin-1 and HER-2 expression increased in SRC-type GC samples compared to non-malignant tissues. High cytoplasmic Talin-1 expression inversely correlated with tumor expansion and invasion in SRC-type GC. Increased HER-2 expression positively correlated with metastasis. ROC curves showed significant diagnostic values for both proteins.Higher cytoplasmic Talin-1 expression is associated with less invasive tumor behavior, while increased membranous HER-2 expression is associated with metastasis in SRC-type GC. These findings suggest potential use in assessing diagnosis and screening high-risk cancer patients, particularly those with SRC-type GC. [ABSTRACT FROM AUTHOR]

Published
2024
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