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3 results on '"Saez-Castresana, Javier"'

1. Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01

Author

Vera, Beatriz, Martínez-Vélez, Naiara, Xipell, Enric, Acanda de la Rocha, Arlet, Patiño-García, Ana, Saez-Castresana, Javier, Gonzalez-Huarriz, Marisol, Cascallo, Manel, Alemany, Ramón, and Alonso, Marta M.

Subjects
0301 basic medicine, Adenoviruses, Genes, Viral, Cell Lines, Cancer Treatment, lcsh:Medicine, Disease, Injections, Intralesional, Virus Replication, Mice, 0302 clinical medicine, Cytopathogenic Effect, Viral, Animal Cells, Medicine and Health Sciences, Genes, Synthetic, Blastomas, Cytotoxic T cell, Adenovirus, Gliomas, lcsh:Science, Neurological Tumors, Cultured Tumor Cells, Oncolytic Virotherapy, Multidisciplinary, Brain Neoplasms, Stem Cells, Animal Models, Glioma, Oncolytic Viruses, Oncology, Neurology, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Biological Cultures, Adenovirus E1A Proteins, Cellular Types, Oligopeptides, Research Article, Oncolytic adenovirus, Hyaluronoglucosaminidase, Mouse Models, Biology, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Model Organisms, In vivo, Virology, Cell Line, Tumor, medicine, Animals, Humans, neoplasms, Organisms, Genetically Modified, Adenoviruses, Human, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Correction, Cell Biology, Cell Cultures, Glioma Cells, medicine.disease, Xenograft Model Antitumor Assays, Viral Replication, Oncolytic virus, 030104 developmental biology, Viral replication, Cell culture, Immunology, Cancer research, lcsh:Q, Stem Cell Lines, Glioblastoma Multiforme, E2F1 Transcription Factor
Abstract

Despite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal. Therapy with tumor-selective viruses is emerging as a treatment option for this devastating disease. In this study we characterize the anti-glioma effect of VCN-01, an improved hyaluronidase-armed pRB-pathway-selective oncolytic adenovirus that has proven safe and effective in the treatment of several solid tumors. VCN-01 displayed a significant cytotoxic effect on glioma cells in vitro. In vivo, in two different orthotopic glioma models, a single intra-tumoral administration of VCN-01 increased overall survival significantly and led to long-term survivors free of disease.

Published
2015

3. Molecular analysis of chromosomh 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors

Author

Bello, M. Josefa, Saez-Castresana, Javier, Pestaña, Ángel, Rey, Juan A., Bello, M. Josefa, Saez-Castresana, Javier, Pestaña, Ángel, and Rey, Juan A.

Abstract

Alterations of the short arm of chromosome I are recurrently found in cytogenetic analysis of malignant gliomas, and deletions of Ip36-p32 region characterize at least the higher-grade tumors, glioblastoma multiforme. Molecular analysis of tumor-derived and normal genomic DNA from 57 cases of gliomas, using a panel of chromosome I-specific DNA probes showed LOH in 16 tumors. Allelic losses on I p were primarily restricted to glioblastoma multiforme (2/11) and to tumors with a major oligodendroglial component: grade 11 oligodendrogliomas (6/6), grade 111 anaplastic oligodendrogliomas (5/6) and grade II-III mixed oligo-astrocytomas (2/3). Losses for Iq markers were detected in only I tumor (glioblastoma multiforme). Our data suggest that anomalies of Ip primarily characterize oligodendrogliomas, whereas they are rare events in astrocytic tumors and indicate that a tumor-suppressor gene on Ip36-p32 is involved in the development of brain tumors with oligodendroglial differentiation.

Published
1994

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