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Your search keyword '"Saeedi, Mohsen"' showing total 175 results
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175 results on '"Saeedi, Mohsen"'

7. Depletion of CNOT4 modulates the DNA damage responses following ionizing radiation (IR)

Author

Eskandarian, Samira, Grand, Roger, Irani, Shiva, Saeedi, Mohsen, and Mirfakhraie, Reza

Subjects
DNA repair, DNA, Radiation, DNA damage, Cells, Health
Abstract

Byline: Samira. Eskandarian, Roger. Grand, Shiva. Irani, Mohsen. Saeedi, Reza. Mirfakhraie Background: The Ccr4-Not complex (CNOT complex in mammals) is a unique and highly conserved complex with numerous cellular functions. [...]

Published
2024

26. Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs); where do they stand in tumorigenesis and how they can change the face of cancer therapy?

Author

Tajaldini, Mahboubeh, primary, Saeedi, Mohsen, additional, Amiriani, Taghi, additional, Amiriani, Amir Hossein, additional, Sedighi, Sima, additional, Mohammad zadeh, Fatemeh, additional, Dehghan, Mohammad, additional, Jahanshahi, Mehrdad, additional, Zanjan Ghandian, Maziar, additional, Khalili, Pedram, additional, poorkhani, Amir houshang, additional, Alizadeh, Ali Mohammad, additional, and Khori, Vahid, additional

Published
2022
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39. Simultaneous Desorption and Desorption Kinetics of Phenanthrene, Anthracene, and Heavy Metals from Kaolinite with Different Organic Matter Content

Author

Mollahoseini Afsaneh, Saeedi Mohsen, and Mohammadi Amir

Subjects
chemistry.chemical_classification, 021110 strategic, defence & security studies, Anthracene, Health, Toxicology and Mutagenesis, 0211 other engineering and technologies, Soil Science, Heavy metals, 02 engineering and technology, 010501 environmental sciences, Phenanthrene, Contamination, complex mixtures, 01 natural sciences, Pollution, chemistry.chemical_compound, chemistry, Desorption, Environmental chemistry, Soil water, Environmental Chemistry, Kaolinite, Organic matter, 0105 earth and related environmental sciences
Abstract

Soils contaminated simultaneously with polycyclic aromatic hydrocarbons (PAHs) and heavy metals pose major threat to human health and environment by getting released from soil into water environmen...

Published
2018

48. Role of heavy metals and organic matter on sorption and mobility of polycyclic aromatic hydrocarbons in soil : implications for remediation

Author

Saeedi, Mohsen

Subjects
complex mixtures
Abstract

Polycyclic aromatic hydrocarbons (PAHs) are a group of abundant contaminants in contaminated sites having many adverse effects on human health and the ecosystem. Due to the many common sources of PAHs and heavy metals, many sites are contaminated by both groups. Co-presence of these contaminants can affect their sorption/desorption in the soil environment, affecting their fate, transport, and remediation processes. This research project advanced the understanding of sorption behavior of PAHs co-existing with heavy metals in soil. Three types of artificially blended clay and clay minerals (kaolinite, kaolinite+sand, kaolinite+sand+bentonite) and a real spiked clayey soil sample were investigated. The synergistic effect of organic matter (humic acid) with heavy metals on enhancing the sorption of PAHs was tested and confirmed for the first time. Different single and combined solutions were used to enhance the desorption of PAHs from the soil. Two non-ionic surfactants (Triton X-100 and Tween 80) with EDTA showed the capability to simultaneously remove these PAHs (acenaphthene, fluorene and fluoranthene) and these prominent heavy metals (Ni, Pb, and Zn) from the soil sample. Results also showed that the co-presence of metal contaminants and soil organic matter can decrease the mobility and desorption of PAHs with the results that the efficiency of soil washing/flushing remediation could decrease in such cases. Our findings also show that the rate of desorption of PAHs is reduced by the co-presence of organic matter and heavy metals in soil. This affects the cost and time of remediation of sites contaminated by mixed heavy metals and PAHs. Our findings were confirmed through column soil flushing of a real natural soil sample by combined enhancing solutions.

Published
2019
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50. Importance of CNOT8 Deadenylase Subunit in DNA Damage Responses Following Ionizing Radiation (IR).

Author

Eskandarian, Samira, Grand, Roger, Irani, Shiva, Saeedi, Mohsen, and Mirfakhraie, Reza

Subjects
DNA damage, IONIZING radiation, WESTERN immunoblotting, EUKARYOTIC cells, HELA cells, REGULATOR genes
Abstract

Background: The Ccr4-Not protein complex (CNOT complex) is a key regulator of gene expression in eukaryotic cells. Ccr4-Not Complex is composed of at least nine conserved subunits in mammalian cells with two main enzymatic activities. CNOT8 is a subunit of the complex with deadenylase activity that interacts transiently with the CNOT6 or CNOT6L subunits. Here, we focused on the role of the human CNOT8 subunit in the DNA damage response (DDR). Methods: Cell viability was assessed to measure ATP level using a Cell Titer-Glo Luminescence reagent up to 4 days' post CNOT8 siRNA transfection. In addition, expression level of phosphorylated proteins in signalling pathways were detected by western blotting and immunofluorescence microscopy. CNOT8- depleted Hela cells post- 3 Gy ionizing radiation (IR) treatment were considered as a control. Results: Our results from cell viability assays indicated a significant reduction at 72-hour post CNOT8 siRNA transfection (p= 0.04). Western blot analysis showed slightly alteration in the phosphorylation of DNA damage response (DDR) proteins in CNOT8-depleted HeLa cells following treatment with ionizing radiation (IR). Increased foci formation of H2AX, RPA, 53BP1, and RAD51 foci was observed after IR in CNOT8-depleted cells compared to the control cells. Conclusions: We conclude that CNOT8 deadenylase subunit is involved in the cellular response to DNA damage. [ABSTRACT FROM AUTHOR]

Published
2020
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