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5. Disparities in health utilities among hepatitis C patients receiving care in different settings

Author

Saeed, Yasmin A, Mason, Kate, Mitsakakis, Nicholas, Feld, Jordan J, Bremner, Karen E, Phoon, Arcturus, Fried, Alice, Wong, Josephine F, Powis, Jeff, Krahn, Murray D, and Wong, William WL

Subjects
Hepatology, Original Research
Abstract

BACKGROUND: Although chronic hepatitis C (CHC) disproportionately affects marginalized individuals, most health utility studies are conducted in hospital settings which are difficult for marginalized patients to access. We compared health utilities in CHC patients receiving care at hospital-based clinics and socio-economically marginalized CHC patients receiving care through a community-based program. METHODS: We recruited CHC patients from hospital-based clinics at the University Health Network and community-based sites of the Toronto Community Hep C Program, which provides treatment, support, and education to patients who have difficulty accessing mainstream health care. We elicited utilities using six standardized instruments (EuroQol-5D-3L [EQ-5D], Health Utilities Index Mark 2/Mark 3 [HUI2/HUI3], Short Form-6D [SF-6D], time trade-off [TTO], and Visual Analogue Scale [VAS]). Multivariable regression analysis was performed to examine factors associated with differences in health utility. RESULTS: Compared with patients recruited from the hospital setting ( n = 190), patients recruited from the community setting ( n = 101) had higher unemployment (87% versus 67%), history of injection drug use (88% versus 42%), and history of mental health issue(s) (79% versus 46%). Unadjusted health utilities were lower in community than hospital patients (e.g., EQ-5D: 0.722 [SD 0.209] versus 0.806 [SD 0.195]). Unemployment and a history of mental health issue(s) were significant predictors of low health utility. CONCLUSIONS: Socio-economically marginalized CHC patients have lower health utilities than patients typically represented in the CHC utility literature. Their utilities should be incorporated into future cost-utility analyses to better represent the population living with CHC in health policy decisions.

Published
2023

6. Apelin Receptor Dimerization and Oligomerization

Author

Yeganeh-Hajahmadi, Mahboobeh, Moosavi-Saeed, Yasmin, and Rostamzadeh, Farzaneh

Abstract

Apelin and its receptor are expressed in many tissues and play an important role in maintaining the homeostasis of the cardiovascular system and body fluids. Also, the association of this system with many diseases, such as diabetes, hypertension, obesity, cancer, diabetic retinopathy, etc., has been determined. This system is considered a therapeutic goal in many mentioned diseases. G protein-coupled receptors (GPCRs) have the ability to form oligomers and dimers with themselves and other receptors. The formation of these oligomers is associated with a change in the signaling pathways of the receptors. Research on the oligo and dimers of these receptors can revolutionize the principles of pharmacology. The apelin receptor (APJ) is also a GPCR and has been shown to have the ability to form dimers and oligomers. This article discusses the dimerization and oligomerization of this receptor with its own receptor and other receptors, as well as the signaling pathways.

Published
2024
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8. Impact of direct‐acting antiviral treatment on health utility in patients with chronic hepatitis C in hospital and community settings

Author

Wong, William W. L., primary, Wong, Josephine, additional, Bremner, Karen E., additional, Saeed, Yasmin, additional, Mason, Kate, additional, Phoon, Arcturus, additional, Martel‐Laferrière, Valérie, additional, Bruneau, Julie, additional, Feld, Jordan J., additional, Feng, Zeny, additional, Baguley, Elizabeth, additional, Lee, Samuel S., additional, Powis, Jeff, additional, and Krahn, Murray D., additional

Published
2023
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9. Striving toward hepatitis C elimination in the era of COVID-19

Author

Lanièce Delaunay, Charlotte, primary, Greenwald, Zoë R, additional, Minoyan, Nanor, additional, Artenie, Andreea Adelina, additional, Jeong, Dahn, additional, Marathe, Gayatri, additional, Saeed, Yasmin A, additional, Kolla, Gillian, additional, Kunden, Rasika D, additional, Okwor, Chisom Ifeoma Adaeze, additional, Wallace, Hannah L, additional, Mendlowitz, Andrew, additional, Liu, Ching-Hsuan, additional, Mazouz, Sabrina, additional, D’souza, Simmone, additional, Perciani, Catia Taniela, additional, Rheault, Marylin, additional, Palmer, Michael A, additional, Palayew, Adam, additional, Abdelnabi, Mohamed N, additional, and Cunningham, Evan B, additional

Published
2021
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11. Additional file 3: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Subjects
body regions, nervous system, fungi
Abstract

Characteristics of included randomized controlled trials. (PDF 358 kb)

Published
2019
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12. Additional file 1: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Abstract

PRISMA flow diagram and full search strategy for Ovid MEDLINE. (PDF 623 kb)

Published
2019
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13. Additional file 4: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Subjects
body regions, nervous system, fungi
Abstract

Participant baseline characteristics of included randomized controlled trials. (PDF 398 kb)

Published
2019
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14. Additional file 5: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

Network inconsistency evaluation. (PDF 59 kb)

Published
2019
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15. Additional file 6: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Abstract

Relative effects on outcomes of all pairs of interventions in Odds Ratios (95% credible intervals) as calculated from the network meta-analyses using fixed effects models. (PDF 122 kb)

Published
2019
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16. Additional file 2: of Antiviral treatment for treatment-naĂŻve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials

Author

Wong, William, Pechivanoglou, Petros, Wong, Josephine, Bielecki, Joanna, Haines, Alex, Aysegul Erman, Saeed, Yasmin, Arcturus Phoon, Tadrous, Mina, Younis, Mona, Rayad, Noha, Rac, Valeria, Janssen, Harry, and Krahn, Murray

Subjects
body regions, nervous system, fungi, education
Abstract

Cochrane risk of bias assessment results. (PDF 375 kb)

Published
2019
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17. Striving toward hepatitis C elimination in the era of COVID-19.

Author

Delaunay, Charlotte Lanièce, Greenwald, Zoë R., Minoyan, Nanor, Artenie, Andreea Adelina, Jeong, Dahn, Marathe, Gayatri, Saeed, Yasmin A., Kolla, Gillian, Kunden, Rasika D., Adaeze Okwor, Chisom Ifeoma, Wallace, Hannah L., Mendlowitz, Andrew, Ching-Hsuan Liu, Mazouz, Sabrina, D'souza, Simmone, Perciani, Catia Taniela, Rheault, Marylin, Palmer, Michael A., Palayew, Adam, and Abdelnabi, Mohamed N.

Published
2021
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20. Assessment of the Efficacy of Second Life, a Virtual Learning Environment, in Dental Education.

Author

Tantawi, Maha M. A. El, Kashlan, Mona K. EI, and Saeed, Yasmin M.

Abstract

This study assessed the efficacy of Second Life (SL) in delivering lectures and demonstrating clinical procedures. Six-teen students in a dental school in Alexandria, Egypt, volunteered to participate in SL to learn about topical fluoride through lec-tures and YouTube videos demonstrating the application of fluoride gel. This was followed by face to face (F2F) sessions about pits and fissures sealant including lectures and F2F demonstration. Knowledge improvement was assessed by pre- and posttests; practical skills were assessed by a checklist; and percent scores were calculated. The relation between these scores and some background variables was assessed. Students' satisfaction with and perceptions of SL were also assessed. Knowledge improved significantly after both SL and F2F experiences (pO.OOOl for both). There were no significant differences between SL and F2F in knowledge improvement or skills percent scores (p=0.16 and 0.26, respectively). Knowledge improvement was significantly related to previous experience with SL and previous year grade (p=0.02 and 0.007, respectively) but not to gender. Practical skills scores were not related to any of these three variables. Satisfaction with SL experience was high and not affected by any of the three variables, and the experience was perceived positively. This study suggests that SL can complement traditional F2F teach-ing, especially for underachieving students and in higher education institutions with problems of increasing numbers of students and limited space. [ABSTRACT FROM AUTHOR]

Published
2013

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