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8 results on '"Sadek, Michael"'

2. Editor's Choice – Management of Lower Extremity Venous Outflow Obstruction: Results of an International Delphi Consensus

Author

Abramowitz, Steve, Al-Hakim, Ramsey, Almeida, Jose, Avgerinos, Efthymios, Bashir, Riyaz, Binkert, Cristoph, Bismuth, Jean, Bjarnason, Haroldur, Black, Stephen, Chaer, Rabih, Comerota, Tony, Davies, Alun, de Graaf, Rick, DeRubertis, Brian, Desai, Kush, Dexter, David, Dillavou, Ellen, Dumantepe, Mert, Elias, Steve, Fastabend, Carl, Gagne, Paul, Garcia, Mark, Gasparis, Tony, George, Jon, Gibson, Kathy, Gillespie, David, Gohel, Manjit, Guimaraes, Marcelo, Henke, Peter, Hernandez, Diego, Hofmann, Lawrence, Hsu, Wan-hsien, Jalaie, Houman, Jolly, Michael, Kabnick, Lowell, Karunanithy, Narayan, Kaufmann, John, Khaja, Minhaj, Kokkosis, Angela, Kolli, Kanti, Kolluri, Raghu, Kuo, Will, Labropoulos, Nicos, Lessne, Mark, Leung, Daniel, Lichtenberg, Michael, Lim, Chung, Lohr, Joann, Lurie, Fedor, Machan, Lindsay, Malhotra, Rahul, Marston, William, McLafferty, Robert, Meissner, Mark, Mendes, Bobby, Muck, Pat, Murphy, Erin, O'Sullivan, Gerry, Ozsvath, Kathleen, Pappas, Peter, Patel, Parag, Pena, Consantino, Ramirez-Ortega, Marta, Razavi, Mahmood, Rooke, Thom, Ross, Charles, Rundback, John, Sadek, Michael, Saha, Prakash, Saleem, Taimur, Silver, Mitchell, Sista, Akhi, Spencer, Brooke, Sterling, Keith, Streif, Michael, Sudheendra, Deepak, Thorpe, Patti, Ting, Windsor, Tosenovsky, Patrik, Tripathi, Ramesh, van Laanen, Jorinde, Varcoe, Ramon, Villalba, Laurentia, Wang, Jeff, Weinberg, Mitchell, Wigham, Andrew, Wilton, Emma, Winokur, Ron, Yako, Hiroyoshi, Black, Stephen A., Fleck, Bruce, and Hofmann, Lawrence V.

Published
2024
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3. Glutamate Transporter 1 as a Novel Negative Regulator of Amyloid β.

Author

Sinha, Priyanka, Turchyna, Yuliia, Mitchell, Shane Patrick Clancy, Sadek, Michael, Armagan, Gokce, Perrin, Florian, Maesako, Masato, and Berezovska, Oksana

Subjects
GLUTAMATE transporters, ALZHEIMER'S disease, EPILEPTIFORM discharges, COGNITION disorders, AMYLOID
Abstract

Glutamate transporter-1 (GLT-1) dynamics are implicated in excitotoxicity and Alzheimer's disease (AD) progression. Early stages of AD are often marked by hyperactivity and increased epileptiform activity preceding cognitive decline. Previously, we identified a direct interaction between GLT-1 and Presenilin 1 (PS1) in the brain, highlighting GLT-1 as a promising target in AD research. This study reports the significance of this interaction and uncovers a novel role of GLT-1 in modulating amyloid-beta (Aβ) production. Overexpression of GLT-1 in cells reduces the levels of Aβ40 and Aβ42 by decreasing γ-secretase activity pertinent to APP processing and induces a more "open" PS1 conformation, resulting in decreased Aβ42/40 ratio. Inhibition of the GLT-1/PS1 interaction using cell-permeable peptides produced an opposing effect on Aβ, highlighting the pivotal role of this interaction in regulating Aβ levels. These findings emphasize the potential of targeting the GLT-1/PS1 interaction as a novel therapeutic strategy for AD. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Editor's Choice – Management of Lower Extremity Venous Outflow Obstruction: Results of an International Delphi Consensus

Author

Black, Stephen A., primary, Gohel, Manjit, additional, de Graaf, Rick, additional, Gagne, Paul, additional, Silver, Mitchell, additional, Fleck, Bruce, additional, Hofmann, Lawrence V., additional, Abramowitz, Steve, additional, Al-Hakim, Ramsey, additional, Almeida, Jose, additional, Avgerinos, Efthymios, additional, Bashir, Riyaz, additional, Binkert, Cristoph, additional, Bismuth, Jean, additional, Bjarnason, Haroldur, additional, Black, Stephen, additional, Chaer, Rabih, additional, Comerota, Tony, additional, Davies, Alun, additional, DeRubertis, Brian, additional, Desai, Kush, additional, Dexter, David, additional, Dillavou, Ellen, additional, Dumantepe, Mert, additional, Elias, Steve, additional, Fastabend, Carl, additional, Garcia, Mark, additional, Gasparis, Tony, additional, George, Jon, additional, Gibson, Kathy, additional, Gillespie, David, additional, Guimaraes, Marcelo, additional, Henke, Peter, additional, Hernandez, Diego, additional, Hofmann, Lawrence, additional, Hsu, Wan-hsien, additional, Jalaie, Houman, additional, Jolly, Michael, additional, Kabnick, Lowell, additional, Karunanithy, Narayan, additional, Kaufmann, John, additional, Khaja, Minhaj, additional, Kokkosis, Angela, additional, Kolli, Kanti, additional, Kolluri, Raghu, additional, Kuo, Will, additional, Labropoulos, Nicos, additional, Lessne, Mark, additional, Leung, Daniel, additional, Lichtenberg, Michael, additional, Lim, Chung, additional, Lohr, Joann, additional, Lurie, Fedor, additional, Machan, Lindsay, additional, Malhotra, Rahul, additional, Marston, William, additional, McLafferty, Robert, additional, Meissner, Mark, additional, Mendes, Bobby, additional, Muck, Pat, additional, Murphy, Erin, additional, O'Sullivan, Gerry, additional, Ozsvath, Kathleen, additional, Pappas, Peter, additional, Patel, Parag, additional, Pena, Consantino, additional, Ramirez-Ortega, Marta, additional, Razavi, Mahmood, additional, Rooke, Thom, additional, Ross, Charles, additional, Rundback, John, additional, Sadek, Michael, additional, Saha, Prakash, additional, Saleem, Taimur, additional, Sista, Akhi, additional, Spencer, Brooke, additional, Sterling, Keith, additional, Streif, Michael, additional, Sudheendra, Deepak, additional, Thorpe, Patti, additional, Ting, Windsor, additional, Tosenovsky, Patrik, additional, Tripathi, Ramesh, additional, van Laanen, Jorinde, additional, Varcoe, Ramon, additional, Villalba, Laurentia, additional, Wang, Jeff, additional, Weinberg, Mitchell, additional, Wigham, Andrew, additional, Wilton, Emma, additional, Winokur, Ron, additional, and Yako, Hiroyoshi, additional

Published
2024
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6. The Role of IL-13, IL-15 and Granulysin in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Author

Sadek, Michael, primary, Iqbal, Omer, additional, Siddiqui, Fakiha, additional, Till, Sean, additional, Mazariegos, Melissa, additional, Campbell, Edward, additional, Mudaliar, Kumaran, additional, Speiser, Jodi, additional, Bontekoe, Emily, additional, Kouta, Ahmed, additional, Farooqui, Ambar, additional, Daravath, Bharathi, additional, Qneibi, Dalia, additional, Sadek, Ramy, additional, Hoppensteadt, Debra, additional, Fareed, Jawed, additional, and Bouchard, Charles, additional

Published
2021
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