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2. Comparison of safety and effectiveness of antiretroviral therapy regimens among pregnant women living with HIV at preconception or during pregnancy: a systematic review and network meta-analysis of randomized trials.

Author

Mehrabi, Fatemeh, Karamouzian, Mohammad, Farhoudi, Behnam, Moradi Falah Langeroodi, Shahryar, Mehmandoost, Soheil, Abbaszadeh, Samaneh, Motaghi, Shahrzad, Mirzazadeh, Ali, Sadeghirad, Behnam, and Sharifi, Hamid

Subjects
Antiretroviral agents, HIV infection, Infant, Pregnant women, Vertical transmission, Female, Pregnancy, Infant, Newborn, Humans, Pregnancy Complications, Infectious, Pregnant Women, Stillbirth, Network Meta-Analysis, Premature Birth, Infectious Disease Transmission, Vertical, Randomized Controlled Trials as Topic, HIV Infections
Abstract

BACKGROUND: Mother-to-child transmission is the primary cause of HIV cases among children. Antiretroviral therapy (ART) plays a critical role in preventing mother-to-child transmission and reducing HIV progression, morbidity, and mortality among mothers. However, after more than two decades of ART during pregnancy, the comparative effectiveness and safety of ART medications during pregnancy are unclear, and existing evidence is contradictory. This study aimed to assess the effectiveness and safety of different ART regimens among pregnant women living with HIV at preconception or during pregnancy. METHODS: We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Web of Science. We included randomized trials that enrolled pregnant women living with HIV and randomized them to receive ART for at least four weeks. Pairs of reviewers independently completed screening for eligible studies, extracted data, and assessed the risk of bias using the Cochrane risk of bias tool. Our outcomes of interest included low birth weight, stillbirth, preterm birth, mother-to-child transmission of HIV, neonatal death, and congenital anomalies. Network meta-analysis was performed using a random-effects frequentist model, and the certainty of evidence was evaluated using the GRADE approach. RESULTS: We found 14 eligible randomized trials enrolling 9,561 pregnant women. The median duration of ART uptake ranged from 6.0 to 17.4 weeks. No treatment was statistically better than a placebo in reducing the rate of neonatal mortality, stillbirth, congenital defects, preterm birth, or low birth weight deliveries. Compared to placebo, zidovudine (ZDV)/lamivudine (3TC) and ZDV monotherapy likely reduce mother-to-child transmission (odds ratio (OR): 0.13; 95% CI: 0.05 to 0.31, high-certainty; and OR: 0.50; 95% CI: 0.33 to 0.74, moderate-certainty). Moderate-certainty evidence suggested that ZDV/3TC was associated with decreased odds of stillbirth (OR: 0.47; 95% CI: 0.09 to 2.60). CONCLUSIONS: Our analysis provides high- to moderate-certainty evidence that ZDV/3TC and ZDV are more effective in reducing the odds of mother-to-child transmission, with ZDV/3TC also demonstrating decreased odds of stillbirth. Notably, our findings suggest an elevated odds of stillbirth and preterm birth associated with all other ART regimens.

Published
2024

4. Management of Amphetamine and Methamphetamine Use Disorders: A Systematic Review and Network Meta-analysis of Randomized Trials

Author

Khalili, Malahat, Sadeghirad, Behnam, Bach, Paxton, Crabtree, Alexis, Javadi, Sara, Sadeghi, Erfan, Moradi, Sara, Mirzayeh Fashami, Fatemeh, Nakhaeizadeh, Mehran, Salehi, Sahar, Sofi-Mahmudi, Ahmad, Nasiri, Naser, Mehmandoost, Soheil, Moallef, Soroush, Langeroodi, Shahryar Moradi Falah, Moe, Jessica, Lysyshyn, Mark, Werb, Dan, Buxton, Jane A., and Karamouzian, Mohammad

Published
2024
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7. Therapist-guided remote versus in-person cognitive behavioural therapy: a systematic review and meta-analysis of randomized controlled trials

Author

Zandieh, Sara, Abdollahzadeh, Seyedeh Maryam, Sadeghirad, Behnam, Wang, Li, McCabe, Randi E., Yao, Liam, Inness, Briar E., Pathak, Ananya, Couban, Rachel J., Crandon, Holly, Torabiardakani, Kian, Bieling, Peter, and Busse, Jason W.

Subjects
Medical research -- Analysis, Medicine, Experimental -- Analysis, Chronic pain -- Analysis, Cognitive therapy -- Analysis, Patient compliance -- Analysis, Behavioral health care -- Analysis, Behavior modification -- Analysis, Anxiety -- Analysis, Evidence-based medicine -- Analysis, Health
Abstract

Background: Cognitive behavioural therapy (CBT) has been shown to be effective for several psychiatric and somatic conditions; however, most randomized controlled trials (RCTs) have administered treatment in person and whether remote delivery is similarly effective remains uncertain. We sought to compare the effectiveness of therapist-guided remote CBT and in-person CBT. Methods: We systematically searched MEDLINE, Embase, PsycINFO, CINAHL, and the Cochrane Central Register of Controlled Trials from inception to July 4, 2023, for RCTs that enrolled adults (aged [greater than or equal to] 18 yr) presenting with any clinical condition and that randomized participants to either therapist-guided remote CBT (e.g., teleconference, videoconference) or in-person CBT. Paired reviewers assessed risk of bias and extracted data independently and in duplicate. We performed random-effects model meta-analyses to pool patient-important primary outcomes across eligible RCTs as standardized mean differences (SMDs). We used Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidance to assess the certainty of evidence and used the Instrument to Assess the Credibility of Effect Modification Analyses (ICEMAN) to rate the credibility of subgroup effects. Results: We included 54 RCTs that enrolled a total of 5463 patients. Seventeen studies focused on treatment of anxiety and related disorders, 14 on depressive symptoms, 7 on insomnia, 6 on chronic pain or fatigue syndromes, 5 on body image or eating disorders, 3 on tinnitus, 1 on alcohol use disorder, and 1 on mood and anxiety disorders. Moderate-certainty evidence showed little to no difference in the effectiveness of therapist-guided remote and in-person CBT on primary outcomes (SMD -0.02, 95% confidence interval -0.12 to 0.07). Interpretation: Moderate-certainty evidence showed little to no difference in the effectiveness of in-person and therapist-guided remote CBT across a range of mental health and somatic disorders, suggesting potential for the use of therapist-guided remote CBT to facilitate greater access to evidence-based care. Systematic review registration: Open Science Framework (https://osf.io/7asrc), Cognitive behavioural therapy (CBT) is a form of psychotherapy that focuses on the identification and modification of unhelpful thoughts and behaviour patterns and has been shown to be effective for [...]

Published
2024
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12. Pharmacological agents for procedural sedation and analgesia in the emergency department and intensive care unit: a systematic review and network meta-analysis of randomised trials

Author

Sharif, Sameer, Kang, Jasmine, Sadeghirad, Behnam, Rizvi, Fayyaz, Forestell, Ben, Greer, Alisha, Hewitt, Mark, Fernando, Shannon M., Mehta, Sangeeta, Eltorki, Mohamed, Siemieniuk, Reed, Duffett, Mark, Bhatt, Maala, Burry, Lisa, Perry, Jeffrey J., Petrosoniak, Andrew, Pandharipande, Pratik, Welsford, Michelle, and Rochwerg, Bram

Published
2024
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13. Topical treatments for atopic dermatitis (eczema): Systematic review and network meta-analysis of randomized trials

Author

Chu, Derek K., Chu, Alexandro W.L., Rayner, Daniel G., Guyatt, Gordon H., Yepes-Nuñez, Juan José, Gomez-Escobar, Luis, Pérez-Herrera, Lucia C., Díaz Martinez, Juan Pablo, Brignardello-Petersen, Romina, Sadeghirad, Behnam, Wong, Melanie M., Ceccacci, Renata, Zhao, Irene X., Basmaji, John, MacDonald, Margaret, Chu, Xiajing, Islam, Nazmul, Gao, Ya, Izcovich, Ariel, Asiniwasis, Rachel N., Boguniewicz, Mark, De Benedetto, Anna, Capozza, Korey, Chen, Lina, Ellison, Kathy, Frazier, Winfred T., Greenhawt, Matthew, Huynh, Joey, LeBovidge, Jennifer, Lio, Peter A., Martin, Stephen A., O’Brien, Monica, Ong, Peck Y., Silverberg, Jonathan I., Spergel, Jonathan M., Smith Begolka, Wendy, Wang, Julie, Wheeler, Kathryn E., Gardner, Donna D., and Schneider, Lynda

Published
2023
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14. American Society for Gastrointestinal Endoscopy guideline on endoscopic submucosal dissection for the management of early esophageal and gastric cancers: methodology and review of evidence

Author

Al-Haddad, Mohammad A., Elhanafi, Sherif E., Forbes, Nauzer, Thosani, Nirav C., Draganov, Peter V., Othman, Mohamed O., Ceppa, Eugene P., Kaul, Vivek, Feely, Michael M., Sahin, Ilyas, Ruan, Yibing, Sadeghirad, Behnam, Morgan, Rebecca L., Buxbaum, James L., Calderwood, Audrey H., Chalhoub, Jean M., Coelho-Prabhu, Nayantara, Desai, Madhav, Fujii-Lau, Larissa L., Kohli, Divyanshoo R., Kwon, Richard S., Machicado, Jorge D., Marya, Neil B., Pawa, Swati, Ruan, Wenly, Sheth, Sunil G., Storm, Andrew C., Thiruvengadam, Nikhil R., and Qumseya, Bashar J.

Published
2023
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15. Epinephrine in Out-of-Hospital Cardiac Arrest: A Network Meta-analysis and Subgroup Analyses of Shockable and Nonshockable Rhythms

Author

Fernando, Shannon M., Mathew, Rebecca, Sadeghirad, Behnam, Rochwerg, Bram, Hibbert, Benjamin, Munshi, Laveena, Fan, Eddy, Brodie, Daniel, Di Santo, Pietro, Tran, Alexandre, McLeod, Shelley L., Vaillancourt, Christian, Cheskes, Sheldon, Ferguson, Niall D., Scales, Damon C., Lin, Steve, Sandroni, Claudio, Soar, Jasmeet, Dorian, Paul, Perkins, Gavin D., and Nolan, Jerry P.

Published
2023
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16. Inotropes, vasopressors, and mechanical circulatory support for treatment of cardiogenic shock complicating myocardial infarction: a systematic review and network meta-analysis

Author

Fernando, Shannon M., Mathew, Rebecca, Sadeghirad, Behnam, Brodie, Daniel, Belley-Côté, Emilie P., Thiele, Holger, van Diepen, Sean, Fan, Eddy, Di Santo, Pietro, Simard, Trevor, Russo, Juan J., Tran, Alexandre, Lévy, Bruno, Combes, Alain, Hibbert, Benjamin, and Rochwerg, Bram

Published
2022
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18. Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis

Author

Fernando, Shannon M., Tran, Alexandre, Sadeghirad, Behnam, Burns, Karen E. A., Fan, Eddy, Brodie, Daniel, and Munshi, Laveena

Subjects
Fresenius Medical Care AG & Company KGaA, Health care industry -- Comparative analysis, Adults -- Comparative analysis, Health care industry
Abstract

Purpose Systematic review and network meta-analysis to investigate the efficacy of noninvasive respiratory strategies, including noninvasive positive pressure ventilation (NIPPV) and high-flow nasal cannula (HFNC), in reducing extubation failure among critically ill adults. Methods We searched databases from inception through October 2021 for randomized controlled trials (RCTs) evaluating noninvasive respiratory support therapies (NIPPV, HFNC, conventional oxygen therapy, or a combination of these) following extubation in critically ill adults. Two reviewers performed screening, full text review, and extraction independently. The primary outcome of interest was reintubation. We used GRADE to rate the certainty of our findings. Results We included 36 RCTs (6806 patients). Compared to conventional oxygen therapy, NIPPV (OR 0.65 [95% CI 0.52-0.82]) and HFNC (OR 0.63 [95% CI 0.45-0.87]) reduced reintubation (both moderate certainty). Sensitivity analyses showed that the magnitude of the effect was highest in patients with increased baseline risk of reintubation. As compared to HFNC, no difference in incidence of reintubation was seen with NIPPV (OR 1.04 [95% CI 0.78-1.38], low certainty). Compared to conventional oxygen therapy, neither NIPPV (OR 0.8 [95% CI 0.61-1.04], moderate certainty) or HFNC (OR 0.9 [95% CI 0.66-1.24], low certainty) reduced short-term mortality. Consistent findings were demonstrated across multiple subgroups, including high- and low-risk patients. These results were replicated when evaluating noninvasive strategies for prevention (prophylaxis), but not in rescue (application only after evidence of deterioration) situations. Conclusions Our findings suggest that both NIPPV and HFNC reduced reintubation in critically ill adults, compared to conventional oxygen therapy. NIPPV did not reduce incidence of reintubation when compared to HFNC. These findings support the preventative application of noninvasive respiratory support strategies to mitigate extubation failure in critically ill adults, but not in rescue conditions., Author(s): Shannon M. Fernando [sup.1] [sup.2], Alexandre Tran [sup.1] [sup.3] [sup.4], Behnam Sadeghirad [sup.5] [sup.6], Karen E. A. Burns [sup.6] [sup.7] [sup.8], Eddy Fan [sup.7] [sup.9] [sup.10] [sup.11], Daniel Brodie [...]

Published
2022
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21. Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets

Author

Fernando, Shannon M., Di Santo, Pietro, Sadeghirad, Behnam, Lascarrou, Jean-Baptiste, Rochwerg, Bram, Mathew, Rebecca, and Sekhon, Mypinder S.

Subjects
Fresenius Medical Care AG & Company KGaA, Hypothermia -- Analysis, Health care industry -- Analysis, Cardiac arrest -- Analysis, Health care industry
Abstract

Purpose Targeted temperature management (TTM) may improve survival and functional outcome in comatose survivors of out-of-hospital cardiac arrest (OHCA), though the optimal target temperature remains unknown. We conducted a systematic review and network meta-analysis to investigate the efficacy and safety of deep hypothermia (31-32 °C), moderate hypothermia (33-34 °C), mild hypothermia (35-36 °C), and normothermia (37-37.8 °C) during TTM. Methods We searched six databases from inception to June 2021 for randomized controlled trials (RCTs) evaluating TTM in comatose OHCA survivors. Two reviewers performed screening, full text review, and extraction independently. The primary outcome of interest was survival with good functional outcome. We used GRADE to rate our certainty in estimates. Results We included 10 RCTs (4218 patients). Compared with normothermia, deep hypothermia (odds ratio [OR] 1.30, 95% confidence interval [CI] 0.73-2.30), moderate hypothermia (OR 1.34, 95% CI 0.92-1.94) and mild hypothermia (OR 1.44, 95% CI 0.74-2.80) may have no effect on survival with good functional outcome (all low certainty). Deep hypothermia may not improve survival with good functional outcome, as compared to moderate hypothermia (OR 0.97, 95% CI 0.61-1.54, low certainty). Moderate hypothermia (OR 1.23, 95% CI 0.86-1.77) and deep hypothermia (OR 1.27, 95% CI 0.70-2.32) may have no effect on survival, as compared to normothermia. Finally, incidence of arrhythmia was higher with moderate hypothermia (OR 1.45, 95% CI 1.08-1.94) and deep hypothermia (OR 3.58, 95% CI 1.77-7.26), compared to normothermia (both high certainty). Conclusions Mild, moderate, or deep hypothermia may not improve survival or functional outcome after OHCA, as compared to normothermia. Moderate and deep hypothermia were associated with higher incidence of arrhythmia. Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit., Author(s): Shannon M. Fernando [sup.1] [sup.2], Pietro Di Santo [sup.3] [sup.4], Behnam Sadeghirad [sup.5] [sup.6], Jean-Baptiste Lascarrou [sup.7], Bram Rochwerg [sup.6] [sup.8], Rebecca Mathew [sup.1] [sup.3], Mypinder S. Sekhon [sup.9], [...]

Published
2021
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22. Drug treatments for covid-19 : living systematic review and network meta-analysis

Author

Siemieniuk, Reed AC, Bartoszko, Jessica J, Ge, Long, Zeraatkar, Dena, Izcovich, Ariel, Kum, Elena, Pardo-Hernandez, Hector, Rochwerg, Bram, Lamontagne, Francois, Han, Mi Ah, Liu, Qin, Agarwal, Arnav, Agoritsas, Thomas, Chu, Derek K, Couban, Rachel, Darzi, Andrea, Devji, Tahira, Fang, Bo, Fang, Carmen, Flottorp, Signe Agnes, Foroutan, Farid, Ghadimi, Maryam, Heels-Ansdell, Diane, Honarmand, Kimia, Hou, Liangying, Hou, Xiaorong, Ibrahim, Quazi, Khamis, Assem, Lam, Bonnie, Loeb, Mark, Marcucci, Maura, McLeod, Shelley L, Motaghi, Sharhzad, Murthy, Srinivas, Mustafa, Reem A, Neary, John D, Qasim, Anila, Rada, Gabriel, Riaz, Irbaz Bin, Sadeghirad, Behnam, Sekercioglu, Nigar, Sheng, Lulu, Sreekanta, Ashwini, Switzer, Charlotte, Tendal, Britta, Thabane, Lehana, Tomlinson, George, Turner, Tari, Vandvik, Per O, Vernooij, RobinWM, Viteri-García, Andrés, Wang, Ying, Yao, Liang, Ye, Zhikang, Guyatt, Gordon H, and Brignardello-Petersen, Romina

Published
2020

23. Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults : systematic review and network meta-analysis of randomised trials

Author

Ge, Long, Sadeghirad, Behnam, Ball, Geoff D C, da Costa, Bruno R, Hitchcock, Christine L, Svendrovski, Anton, Kiflen, Ruhi, Quadri, Kalimullah, Kwon, Henry Y, Karamouzian, Mohammad, Adams-Webber, Thomasin, Ahmed, Waleed, Damanhoury, Samah, Zeraatkar, Dena, Nikolakopoulou, Adriani, Tsuyuki, Ross T, Tian, Jinhui, Yang, Kehu, Guyatt, Gordon H, and Johnston, Bradley C

Published
2020

27. Topical Treatments for Atopic Dermatitis: Systematic Review and Network Meta-Analysis of Randomized Trials

Author

Chu, Derek, primary, Chu, Alexandro, additional, Rayner, Daniel, additional, Guyatt, Gordon, additional, Yepes-Nuñez, Juan José, additional, Gomez-Escobar, Luis, additional, Pérez-Herrera, Lucia, additional, Díaz Martinez, Juan Pablo, additional, Brignardello-Petersen, Romina, additional, Sadeghirad, Behnam, additional, Wong, Melanie, additional, Ceccacci, Renata, additional, Zhao, Irene, additional, Basmaji, John, additional, Macdonald, Margaret, additional, Chu, Xiajing, additional, Islam, Nazmul, additional, Gao, Ya, additional, Izcovich, Ariel, additional, Asiniwasis, Rachel, additional, Boguniewicz, Mark, additional, De Benedetto, Anna, additional, Capozza, Korey, additional, Chen, Lina, additional, Ellison, Kathy, additional, Frazier, Winfred, additional, Greenhawt, Matthew, additional, Huynh, Joey, additional, Lebovidge, Jennifer, additional, Lio, Peter, additional, Martin, Stephen, additional, O'Brien, Monica, additional, Ong, Peck, additional, Silverberg, Jonathan, additional, Spergel, Jonathan, additional, Begolka, Wendy Smith, additional, Wang, Julie, additional, Wheeler, Kathryn, additional, Gardner, Donna, additional, and Schneider, Lynda, additional

Published
2024
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32. Management of chronic pain associated with temporomandibular disorders: a clinical practice guideline

Author

Busse, Jason W, primary, Casassus, Rodrigo, additional, Carrasco-Labra, Alonso, additional, Durham, Justin, additional, Mock, David, additional, Zakrzewska, Joanna M, additional, Palmer, Carolyn, additional, Samer, Caroline F, additional, Coen, Matteo, additional, Guevremont, Bruno, additional, Hoppe, Thomas, additional, Guyatt, Gordon H, additional, Crandon, Holly N, additional, Yao, Liang, additional, Sadeghirad, Behnam, additional, Vandvik, Per O, additional, Siemieniuk, Reed A C, additional, Lytvyn, Lyuba, additional, Hunskaar, Birk Stokke, additional, and Agoritsas, Thomas, additional

Published
2023
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34. Probiotics, Prebiotics, Lactoferrin, and Combination Products for Prevention of Mortality and Morbidity in Preterm Infants

Author

Wang, Yuting, primary, Florez, Ivan D., additional, Morgan, Rebecca L., additional, Foroutan, Farid, additional, Chang, Yaping, additional, Crandon, Holly N., additional, Zeraatkar, Dena, additional, Bala, Malgorzata M., additional, Mao, Randi Q., additional, Tao, Brendan, additional, Shahid, Shaneela, additional, Wang, Xiaoqin, additional, Beyene, Joseph, additional, Offringa, Martin, additional, Sherman, Philip M., additional, El Gouhary, Enas, additional, Guyatt, Gordon H., additional, and Sadeghirad, Behnam, additional

Published
2023
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35. Perioperative Factors Associated With Postoperative Delirium in Patients Undergoing Noncardiac Surgery

Author

Sadeghirad, Behnam, primary, Dodsworth, Benjamin T., additional, Schmutz Gelsomino, Nayeli, additional, Goettel, Nicolai, additional, Spence, Jessica, additional, Buchan, Tayler A., additional, Crandon, Holly N., additional, Baneshi, Mohammad R., additional, Pol, Robert A., additional, Brattinga, Baukje, additional, Park, Ui Jun, additional, Terashima, Masanori, additional, Banning, Louise B. D., additional, Van Leeuwen, Barbara L., additional, Neerland, Bjørn E., additional, Chuan, Alwin, additional, Martinez, Felipe T., additional, Van Vugt, Jeroen L. A., additional, Rampersaud, Y. Raja, additional, Hatakeyama, Shingo, additional, Di Stasio, Enrico, additional, Milisen, Koen, additional, Van Grootven, Bastiaan, additional, van der Laan, Lijckle, additional, Thomson Mangnall, Linda, additional, Goodlin, Sarah J., additional, Lungeanu, Diana, additional, Denhaerynck, Kris, additional, Dhakharia, Vibhawari, additional, Sampson, Elizabeth L., additional, Zywiel, Michael G., additional, Falco, Lisa, additional, Nguyen, Anna-Lisa V., additional, Moss, Stephana J., additional, Krewulak, Karla D., additional, Jaworska, Natalia, additional, Plotnikoff, Kara, additional, Kotteduwa-Jayawarden, Supun, additional, Sandarage, Ryan, additional, Busse, Jason W., additional, and Mbuagbaw, Lawrence, additional

Published
2023
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38. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines—2016 revision

Author

Brożek, Jan L., Bousquet, Jean, Agache, Ioana, Agarwal, Arnav, Bachert, Claus, Bosnic-Anticevich, Sinthia, Brignardello-Petersen, Romina, Canonica, G. Walter, Casale, Thomas, Chavannes, Niels H., Correia de Sousa, Jaime, Cruz, Alvaro A., Cuello-Garcia, Carlos A., Demoly, Pascal, Dykewicz, Mark, Etxeandia-Ikobaltzeta, Itziar, Florez, Ivan D., Fokkens, Wytske, Fonseca, Joao, Hellings, Peter W., Klimek, Ludger, Kowalski, Sergio, Kuna, Piotr, Laisaar, Kaja-Triin, Larenas-Linnemann, Désirée E., Lødrup Carlsen, Karin C., Manning, Peter J., Meltzer, Eli, Mullol, Joaquim, Muraro, Antonella, O'Hehir, Robyn, Ohta, Ken, Panzner, Petr, Papadopoulos, Nikolaos, Park, Hae-Sim, Passalacqua, Gianni, Pawankar, Ruby, Price, David, Riva, John J., Roldán, Yetiani, Ryan, Dermot, Sadeghirad, Behnam, Samolinski, Boleslaw, Schmid-Grendelmeier, Peter, Sheikh, Aziz, Togias, Alkis, Valero, Antonio, Valiulis, Arunas, Valovirta, Erkka, Ventresca, Matthew, Wallace, Dana, Waserman, Susan, Wickman, Magnus, Wiercioch, Wojtek, Yepes-Nuñez, Juan José, Zhang, Luo, Zhang, Yuan, Zidarn, Mihaela, Zuberbier, Torsten, and Schünemann, Holger J.

Published
2017
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39. A systematic survey of the methods literature on the reporting quality and optimal methods of handling participants with missing outcome data for continuous outcomes in randomized controlled trials

Author

Zhang, Yuqing, Alyass, Akram, Vanniyasingam, Thuva, Sadeghirad, Behnam, Flórez, Iván D., Pichika, Sathish Chandra, Kennedy, Sean Alexander, Abdulkarimova, Ulviya, Zhang, Yuan, Iljon, Tzvia, Morgano, Gian Paolo, Colunga Lozano, Luis E., Aloweni, Fazila Abu Bakar, Lopes, Luciane C., Yepes-Nuñez, Juan José, Fei, Yutong, Wang, Li, Kahale, Lara A., Meyre, David, Akl, Elie A., Thabane, Lehana, and Guyatt, Gordon H.

Published
2017
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40. Systematic survey of randomized trials evaluating the impact of alternative diagnostic strategies on patient-important outcomes

Author

El Dib, Regina, Tikkinen, Kari A.O., Akl, Elie A., Gomaa, Huda A., Mustafa, Reem A., Agarwal, Arnav, Carpenter, Christopher R., Zhang, Yuchen, Jorge, Eliane C., Almeida, Ricardo A.M.B., do Nascimento Junior, Paulo, Doles, Joao Vitor P., Mustafa, Ahmad A., Sadeghirad, Behnam, Lopes, Luciane C., Bergamaschi, Cristiane C., Suzumura, Erica A., Cardoso, Marília M.A., Corrente, José Eduardo, Stone, Samuel B., Schunemann, Holger J., and Guyatt, Gordon H.

Published
2017
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42. Failure of scabies treatment: a systematic review and meta-analysis.

Author

Mbuagbaw, Lawrence, Sadeghirad, Behnam, Morgan, Rebecca L, Mertz, Dominik, Motaghi, Shahrzad, Ghadimi, Maryam, Babatunde, Ifeoluwa, Zani, Babalwa, Pasumarthi, Tejanth, Derby, McKenzie, Kothapudi, Venkata N, Palmer, Nicole R, Aebischer, Anton, Harder, Thomas, and Reichert, Felix

Subjects
*SCABIES, *TREATMENT failure, *IVERMECTIN, *CINAHL database, *FACTOR analysis
Abstract

Background Treatment failure is considered to be an important factor in relation to the increase in scabies incidence over the last decade. However, the regional and temporal differences, in addition to the predictors of therapy failure, are unclear. Objectives We aimed to conduct a systematic review of the prevalence of treatment failure in patients with scabies and investigation of associated factors. Methods We searched MEDLINE, EMBASE, CINAHL, Web of Science, Scopus, Global Health and the Cochrane Central Register of Controlled Trials from inception to August 2021 for randomized and quasi-randomized trials, in addition to observational studies that enrolled children or adults diagnosed with confirmed or clinical scabies treated with permethrin, ivermectin, crotamiton, benzyl benzoate, malathion, sulfur or lindane, and measured treatment failure or factors associated with treatment failure. We performed a random effects meta-analysis for all outcomes reported by at least two studies. Results A total of 147 studies were eligible for inclusion in the systematic review. The overall prevalence of treatment failure was 15.2% [95% confidence interval (CI) 12.9–17.6; I 2 = 95.3%, moderate-certainty evidence] with regional differences between World Health Organization regions (P = 0.003) being highest in the Western Pacific region (26.9%, 95% CI 14.5–41.2). Oral ivermectin (11.8%, 95% CI 8.4–15.4), topical ivermectin (9.3%, 95% CI 5.1–14.3) and permethrin (10.8%, 95% CI 7.5–14.5) had relatively lower failure prevalence compared with the overall prevalence. Failure prevalence was lower in patients treated with two doses of oral ivermectin (7.1%, 95% CI 3.1–12.3) compared with those treated with one dose (15.2%, 95% CI 10.8–20.2; P = 0.021). Overall and permethrin treatment failure prevalence in the included studies (1983–2021) increased by 0.27% and 0.58% per year, respectively. Only three studies conducted a multivariable risk factor analysis; no studies assessed resistance. Conclusions A second dose of ivermectin showed lower failure prevalence than single-dose ivermectin, which should be considered in all guidelines. The increase in treatment failure over time hints at decreasing mite susceptibility for several drugs, but reasons for failure are rarely assessed. Ideally, scabicide susceptibility testing should be implemented in future studies. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Management of chronic pain associated with temporomandibular disorders: a clinical practice guideline.

Author

Busse, Jason W., Casassus, Rodrigo, Carrasco-Labra, Alonso, Durham, Justin, Mock, David, Zakrzewska, Joanna M., Palmer, Carolyn, Samer, Caroline F., Coen, Matteo, Guevremont, Bruno, Hoppe, Thomas, Guyatt, Gordon H., Crandon, Holly N., Liang Yao, Sadeghirad, Behnam, Vandvik, Per O., Siemieniuk, Reed A. C., Lytvyn, Lyuba, Hunskaar, Birk Stokke, and Agoritsas, Thomas

Subjects
CHRONIC pain treatment, NARCOTICS, HEALTH services accessibility, NONSTEROIDAL anti-inflammatory agents, MEDICAL care costs, MEDICAL protocols, RISK assessment, HEALTH care teams, TEMPOROMANDIBULAR disorders, RELAXATION techniques, PAIN management, COGNITIVE therapy, DISEASE complications
Published
2024
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44. Management of chronic pain secondary to temporomandibular disorders: a systematic review and network meta-analysis of randomised trials.

Author

Liang Yao, Sadeghirad, Behnam, Meixuan Li, Jing Li, Qi Wang, Crandon, Holly N., Martin, Grace, Morgan, Rebecca, Florez, Ivan D., Hunskaar, Birk Stokke, Wells, Jeff, Moradi, Sara, Ying Zhu, Ahmed, Muhammad Muneeb, Ya Gao, Liujiao Cao, Kehu Yang, Jinhui Tian, Jialing Li, and Zhong, Linda

Subjects
CHRONIC pain treatment, CINAHL database, SLEEP quality, STRETCH (Physiology), META-analysis, MEDICAL information storage & retrieval systems, RANGE of motion of joints, SYSTEMATIC reviews, PHYSICAL therapy, PSYCHOSOCIAL functioning, BIOFEEDBACK training, TREATMENT effectiveness, MANIPULATION therapy, RESEARCH funding, TEMPOROMANDIBULAR disorders, MEDLINE, ADVERSE health care events, RELAXATION techniques, PAIN management, COGNITIVE therapy, EXERCISE therapy, DISEASE complications
Published
2024
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46. Perioperative Factors Associated with Postoperative Delirium in Patients Undergoing Noncardiac Surgery:An Individual Patient Data Meta-Analysis

Author

Sadeghirad, Behnam, Dodsworth, Benjamin T., Schmutz Gelsomino, Nayeli, Goettel, Nicolai, Spence, Jessica, Buchan, Tayler A., Crandon, Holly N., Baneshi, Mohammad R., Pol, Robert A., Brattinga, Baukje, Park, Ui Jun, Terashima, Masanori, Banning, Louise B.D., Van Leeuwen, Barbara L., Neerland, Bjørn E., Chuan, Alwin, Martinez, Felipe T., Van Vugt, Jeroen L.A., Rampersaud, Y. Raja, Hatakeyama, Shingo, Di Stasio, Enrico, Milisen, Koen, Van Grootven, Bastiaan, Van Der Laan, Lijckle, Thomson Mangnall, Linda, Goodlin, Sarah J., Lungeanu, Diana, Denhaerynck, Kris, Dhakharia, Vibhawari, Sampson, Elizabeth L., Zywiel, Michael G., Falco, Lisa, Nguyen, Anna Lisa V., Moss, Stephana J., Krewulak, Karla D., Jaworska, Natalia, Plotnikoff, Kara, Kotteduwa-Jayawarden, Supun, Sandarage, Ryan, Busse, Jason W., Mbuagbaw, Lawrence, Sadeghirad, Behnam, Dodsworth, Benjamin T., Schmutz Gelsomino, Nayeli, Goettel, Nicolai, Spence, Jessica, Buchan, Tayler A., Crandon, Holly N., Baneshi, Mohammad R., Pol, Robert A., Brattinga, Baukje, Park, Ui Jun, Terashima, Masanori, Banning, Louise B.D., Van Leeuwen, Barbara L., Neerland, Bjørn E., Chuan, Alwin, Martinez, Felipe T., Van Vugt, Jeroen L.A., Rampersaud, Y. Raja, Hatakeyama, Shingo, Di Stasio, Enrico, Milisen, Koen, Van Grootven, Bastiaan, Van Der Laan, Lijckle, Thomson Mangnall, Linda, Goodlin, Sarah J., Lungeanu, Diana, Denhaerynck, Kris, Dhakharia, Vibhawari, Sampson, Elizabeth L., Zywiel, Michael G., Falco, Lisa, Nguyen, Anna Lisa V., Moss, Stephana J., Krewulak, Karla D., Jaworska, Natalia, Plotnikoff, Kara, Kotteduwa-Jayawarden, Supun, Sandarage, Ryan, Busse, Jason W., and Mbuagbaw, Lawrence

Abstract

Importance: Postoperative delirium (POD) is a common and serious complication after surgery. Various predisposing factors are associated with POD, but their magnitude and importance using an individual patient data (IPD) meta-analysis have not been assessed. Objective:To identify perioperative factors associated with POD and assess their relative prognostic value among adults undergoing noncardiac surgery. Data Sources: MEDLINE, EMBASE, and CINAHL from inception to May 2020. Study Selection:Studies were included that (1) enrolled adult patients undergoing noncardiac surgery, (2) assessed perioperative risk factors for POD, and (3) measured the incidence of delirium (measured using a validated approach). Data were analyzed in 2020. Data Extraction and Synthesis: Individual patient data were pooled from 21 studies and 1-stage meta-analysis was performed using multilevel mixed-effects logistic regression after a multivariable imputation via chained equations model to impute missing data. Main Outcomes and Measures: The end point of interest was POD diagnosed up to 10 days after a procedure. A wide range of perioperative risk factors was considered as potentially associated with POD. Results: A total of 192 studies met the eligibility criteria, and IPD were acquired from 21 studies that enrolled 8382 patients. Almost 1 in 5 patients developed POD (18%), and an increased risk of POD was associated with American Society of Anesthesiologists (ASA) status 4 (odds ratio [OR], 2.43; 95% CI, 1.42-4.14), older age (OR for 65-85 years, 2.67; 95% CI, 2.16-3.29; OR for >85 years, 6.24; 95% CI, 4.65-8.37), low body mass index (OR for body mass index <18.5, 2.25; 95% CI, 1.64-3.09), history of delirium (OR, 3.9; 95% CI, 2.69-5.66), preoperative cognitive impairment (OR, 3.99; 95% CI, 2.94-5.43), and preoperative C-reactive protein level

Published
2023

47. Limited responsiveness related to the minimal important difference of patient-reported outcomes in rare diseases

Author

Johnston, Bradley C., Miller, Patricia A., Agarwal, Arnav, Mulla, Sohail, Khokhar, Rabia, De Oliveira, Kyle, Hitchcock, Christine L., Sadeghirad, Behnam, Mohiuddin, Mukarram, Sekercioglu, Nigar, Seweryn, Michal, Koperny, Magdalena, Bala, Malgorzata M., Adams-Webber, Thomasin, Granados, Alicia, Hamed, Alaa, Crawford, Mark W., van der Ploeg, Ans T., and Guyatt, Gordon H.

Published
2016
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50. Comparison of seven popular structured dietary programmes and risk of mortality and major cardiovascular events in patients at increased cardiovascular risk: systematic review and network meta-analysis

Author

Karam, Giorgio, primary, Agarwal, Arnav, additional, Sadeghirad, Behnam, additional, Jalink, Matthew, additional, Hitchcock, Christine L, additional, Ge, Long, additional, Kiflen, Ruhi, additional, Ahmed, Waleed, additional, Zea, Adriana M, additional, Milenkovic, Jovana, additional, Chedrawe, Matthew AJ, additional, Rabassa, Montserrat, additional, El Dib, Regina, additional, Goldenberg, Joshua Z, additional, Guyatt, Gordon H, additional, Boyce, Erin, additional, and Johnston, Bradley C, additional

Published
2023
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