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1. IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.

Author

Braz, Joao, Castellanos, Carlos, Salvatierra, Juan, Sadeghi, Mahsa, Schroeder, Andrew, Caston, Jaela, Munoz-Sandoval, Priscila, Roy, Suparna, Lazarevsky, Steven, Mar, Darryl, Zhou, Connie, Shin, Jeoung-Sook, Ansel, Karl, Basbaum, Allan, Yu, Xiaobing, and Fassett, Marlys

Subjects
Animals, Mice, Cytokines, Dermatitis, Atopic, Immunity, Neurogenic Inflammation, Pyroglyphidae, Skin, Interleukins
Abstract

Despite robust literature associating IL-31 with pruritic inflammatory skin diseases, its influence on cutaneous inflammation and the interplay between inflammatory and neurosensory pathways remain unmapped. Here, we examined the consequences of disrupting Il31 and its receptor Il31ra in a mouse model of house dust mite (HDM)-induced allergic dermatitis. Il31-deficient mice displayed a deficit in HDM dermatitis-associated scratching, consistent with its well-established role as a pruritogen. In contrast, Il31 deficiency increased the number and proportion of cutaneous type 2 cytokine-producing CD4+ T cells and serum IgE in response to HDM. Furthermore, Il4ra+ monocytes and macrophages capable of fueling a feedforward type 2 inflammatory loop were selectively enriched in Il31ra-deficient HDM dermatitis skin. Thus, IL-31 is not strictly a proinflammatory cytokine but rather an immunoregulatory factor that limits the magnitude of type 2 inflammatory responses in skin. Our data support a model wherein IL-31 activation of IL31RA+ pruritoceptors triggers release of calcitonin gene-related protein (CGRP), which can mediate neurogenic inflammation, inhibit CD4+ T cell proliferation, and reduce T cell production of the type 2 cytokine IL-13. Together, these results illustrate a previously unrecognized neuroimmune pathway that constrains type 2 tissue inflammation in the setting of chronic cutaneous allergen exposure and may explain paradoxical dermatitis flares in atopic patients treated with anti-IL31RA therapy.

Published
2023

8. Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity.

Author

Löken, Line S, Braz, Joao M, Etlin, Alexander, Sadeghi, Mahsa, Bernstein, Mollie, Jewell, Madison, Steyert, Marilyn, Kuhn, Julia, Hamel, Katherine, Llewellyn-Smith, Ida J, and Basbaum, Allan

Subjects
CGRP, interneurons, mechanical sensitivity, mouse, neuroscience, pain, spinal cord, touch, Biochemistry and Cell Biology
Abstract

Primary sensory neurons are generally considered the only source of dorsal horn calcitonin gene-related peptide (CGRP), a neuropeptide critical to the transmission of pain messages. Using a tamoxifen-inducible CalcaCreER transgenic mouse, here we identified a distinct population of CGRP-expressing excitatory interneurons in lamina III of the spinal cord dorsal horn and trigeminal nucleus caudalis. These interneurons have spine-laden, dorsally directed, dendrites, and ventrally directed axons. As under resting conditions, CGRP interneurons are under tonic inhibitory control, neither innocuous nor noxious stimulation provoked significant Fos expression in these neurons. However, synchronous, electrical non-nociceptive Aβ primary afferent stimulation of dorsal roots depolarized the CGRP interneurons, consistent with their receipt of a VGLUT1 innervation. On the other hand, chemogenetic activation of the neurons produced a mechanical hypersensitivity in response to von Frey stimulation, whereas their caspase-mediated ablation led to mechanical hyposensitivity. Finally, after partial peripheral nerve injury, innocuous stimulation (brush) induced significant Fos expression in the CGRP interneurons. These findings suggest that CGRP interneurons become hyperexcitable and contribute either to ascending circuits originating in deep dorsal horn or to the reflex circuits in baseline conditions, but not in the setting of nerve injury.

Published
2021

9. IL-31 uncouples skin inflammation from itch sensation in allergic dermatitis

Author

Fassett, Marlys S, Braz, Joao M, Castellanos, Carlos A, Schroeder, Andrew W, Sadeghi, Mahsa, Mar, Darryl J, Zhou, Connie J, Shin, Jeoung-Sook, Basbaum, Allan I, and Ansel, K Mark

Subjects
2.1 Biological and endogenous factors, Skin, Inflammatory and immune system
Abstract

ABSTRACTDespite a robust literature associating IL-31 with pruritic inflammatory skin diseases, its influence on cutaneous inflammation and on the interplay between inflammatory and neurosensory pathways remain unmapped. Here, we examined the effects of IL-31 and its receptor IL31RA on both inflammation and pruritus in mouse models of dermatitis, including chronic topical house dust mite (HDM) exposure. Unexpectedly, Il31 deficiency increased cutaneous adaptive type 2 cytokine-producing cells and serum IgE. In addition, M2-like macrophages capable of fueling feedforward pro-inflammatory loops were selectively enriched in Il31ra-deficient skin. Thus, IL-31 is not strictly a pro-inflammatory cytokine, but rather an immunoregulatory factor that limits the magnitude of allergic skin inflammation. In contrast, Il31-deficient mice displayed a deficit in HDM-induced scratching. Itch reduction occurred despite intact – and in some cases increased – responsiveness of sensory neurons to other pruritogens released during HDM challenge, highlighting the non-redundant contribution of IL-31-receptive sensory afferents to pruritus in environmental allergen-induced dermatitis. When present, therefore, IL-31 uncouples circuits driven by sensory neurons and immune cells that converge in inflamed skin.

Published
2021

10. IL-31 uncouples skin inflammation from itch sensation in allergic dermatitis

Author

Fassett, Marlys, Braz, Joao, Castellanos, Carlos, Schroeder, Andrew, Sadeghi, Mahsa, Mar, Darryl, Zhou, Connie, Shin, Jeoung-Sook, Basbaum, Allan, and Ansel, Mark

Subjects
Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Skin
Abstract

ABSTRACT Despite a robust literature associating IL-31 with pruritic inflammatory skin diseases, its influence on cutaneous inflammation and on the interplay between inflammatory and neurosensory pathways remain unmapped. Here, we examined the effects of IL-31 and its receptor IL31RA on both inflammation and pruritus in mouse models of dermatitis, including chronic topical house dust mite (HDM) exposure. Unexpectedly, Il31 deficiency increased cutaneous adaptive type 2 cytokine-producing cells and serum IgE. In addition, M2-like macrophages capable of fueling feedforward pro-inflammatory loops were selectively enriched in Il31ra -deficient skin. Thus, IL-31 is not strictly a pro-inflammatory cytokine, but rather an immunoregulatory factor that limits the magnitude of allergic skin inflammation. In contrast, Il31 -deficient mice displayed a deficit in HDM-induced scratching. Itch reduction occurred despite intact – and in some cases increased – responsiveness of sensory neurons to other pruritogens released during HDM challenge, highlighting the non-redundant contribution of IL-31-receptive sensory afferents to pruritus in environmental allergen-induced dermatitis. When present, therefore, IL-31 uncouples circuits driven by sensory neurons and immune cells that converge in inflamed skin.

Published
2021

15. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Author

Srivastava, Abhilekh, Aljammaz, Ahmed M, Akindotun, Akintomide Femi, Jin, Albert Y, Fraser, Alexander, Khaw, Alexander V, Lemnaru, Alexandru, Southwell, Alisia, Ramji, Alnar, Alvarado-Bolaños, Alonso, Mouminah, Amr, Lahlouh, Amro B, Yu, Amy Y, Alrohimi, Anas, Lavoie, Andre, Rogge, Andrea, Micieli, Andrew, Nguyen, Andrew Linh, Callaghan-Brown, Angelique, Florendo-Cumbermack, Anita, Wadhwa, Ankur, Beaudoin, Ann-Marie, Cayley, Anne, Liddy, Anne Marie, Trivedi, Anurag, Katsanos, Aristeidis H, Shuaib, Ashfaq, Butt, Asif Javed, Bereznyakova, Olena, Beauchamp, Beth, Mahlitz, Breane, Graham, Brett R, Dewar, Brian, Buck, Brian H, Durafourt, Bryce A, Holtby, Caitlin, Jackson-Tarlton, Caitlin S, Bockus, Caitlyn, Stephenson, Caroline, Galloway, Camille, Odier, Céline, Deacon, Charles, Zerna, Charlotte, Vekhande, Chetan C, Bocti, Christian, Stapf, Christian, Hawkes, Christine, Stables, Christine Anne, Bogiatzi, Chrysi, Rodriguez, Claudia, Candale-Radu, Claudia, Murphy, Colleen, Casserly, Courtney Sarah, Fok, Daniel, Boasquevisque, Danielle de Sa, Wile, Daryl, Volders, David, Sahlas, Demetrios J, Shand, Elaine, Cora, Elena Adela, Battista, Eliane Di, Stewart, Eileen, Junk, Emily, Harrison, Emma L, Frenette, Eric, Teleg, Ericka, Abdellah, Eslam, Ghrooda, Esseddeeg, Akthar, Farhana, Evoy, François, Klein, Gary M, Maclean, Genoveva, Jickling, Glen C, Hawthorne, Glenda, Boyd, Gordon, Walker, Gregory, Saposnik, Gustavo, Lau, H Lee, Badr, Hanan E, Toma, Hassanain, Kalashyan, Hayrapet, Marion-Moffet, Hugo, Grant, Ian, Fatakdawala, Idris, Beaulieu-Boire, Isabelle, Williams, Janice, Brar, Jaskiran, Rivest, Jean, Wang, Jeffrey Z, Dawe, Jessica, Stang, Jillian, Day, Joanne, Miller, Jodi, Gorman, Johnathon, Hopyan, Julia Jasmine, Lee, Julian, Kromm, Julie, Foster, Kaitlyn, Ratnayake, Kanchana, Perera, Kanjana S, Murray, Karina Villaluna, Ryckborst, Karla, Lin, Katie, Sage, Kayla, Sivakuma, Keithan, MacDonald, Kelly A, Ng, Kelvin Kuan, Merchant, Ketki, Khan, Khurshid, Ghavami, Kimia, Johnston, Kyra, Mai, Lauren M, White, Leah, Barratt, Lee, Longpre, Linda, Crellin, Lisa, Peeling, Lissa, Piquette, Lori, Lomax, Lysa Boissé, Sadeghi, Mahsa, Kamra, Maneesha, Lavoie-April, Manuel, Moores, Margaret, Bullrich, Maria Bres, McClelland, Marie, Salluzzi, Marina, Wilcox, Mark, Boulos, Mark I, Marko, Martha, Boyko, Matthew, Lantagne-Hurtubise, Maude, AlHamid, May Adel, Shawawrah, Mays, Kelly, Michael E, Thorne, Michael W D, Shamy, Michel, Bussiere, Miguel, Dominc Tse, Ming Yin, Benguzzi, Mowad, Sharma, Mukul, Horton, Myles, Newcommon, Nancy, Simon, Nandy-Shelwine, Parks, Natalie E, Sultan, Nazeem, Markovic, Nevena, Daneault, Nicole, Ishaque, Noman, Fairall, Paige, Kostyrko, Pawel B, Stys, Peter K, Teal, Philip, Couillard, Philippe, King-Azote, Princess, Collier, Quentin, Epp, Rachel, Nair, Radhika, Joundi, Raed A, Jassal, Rajive, Schneider, Raphael, Hosseini, Reza, Bouchard, Rosalie, Whelan, Ruth, Cooley, S Regan, Sujanthan, Sajeevan, Mansoor, Salman, Yip, Samuel, Wasyliw, Sanchea, Taylor, Sean W., Friedman, Sebastian, Mann, Sharan, Maley, Sharleen Weese, Chiasson, Sherry, Hu, Sherry Xueying, Althubait, Shorog, Himed, Shuhira, Chen, Shuo, Bal, Simerpreet S, Page, Stacey A, Beck, Stacey D, Woodroffe, Stephanie, Reiter, Stephanie D, Gaal, Stephen van, Peters, Steven Ray, Darvesh, Sultan, Save, Supriya, Alcock, Susan, Piercey, Susannah, Adam, Suzie, Gosselin, Sylvie, Fitzpatrick, Tess, Perron, Thomas-Louis, Stewart, Tim, Benstead, Timothy J, Naidoo, Vishaya, Wahab, Wasan Abd, Oczkowski, Wiesław, Kingston, William, Leduc, William, To, William T H, Yu, Yeyao Joe, Liu, Zhongyu A, Aljundi, Ziad Ezzat, Menon, Bijoy K, Singh, Nishita, Deschaintre, Yan, Almekhlafi, Mohammed A, Coutts, Shelagh B, Thirunavukkarasu, Sibi, Khosravani, Houman, Appireddy, Ramana, Moreau, Francois, Gubitz, Gord, Tkach, Aleksander, Catanese, Luciana, Dowlatshahi, Dar, Medvedev, George, Mandzia, Jennifer, Pikula, Aleksandra, Shankar, Jai, Williams, Heather, Field, Thalia S, Manosalva, Alejandro, Siddiqui, Muzaffar, Zafar, Atif, Imoukhuede, Oje, Hunter, Gary, Demchuk, Andrew M, Mishra, Sachin, Gioia, Laura C, Jalini, Shirin, Cayer, Caroline, Phillips, Stephen, Elamin, Elsadig, Shoamanesh, Ashkan, Subramaniam, Suresh, Kate, Mahesh, Jacquin, Gregory, Camden, Marie-Christine, Benali, Faysal, Alhabli, Ibrahim, Bala, Fouzi, Horn, MacKenzie, Stotts, Grant, Hill, Michael D, Gladstone, David J, Poppe, Alexandre, Sehgal, Arshia, Zhang, Qiao, Lethebe, Brendan Cord, Doram, Craig, Ademola, Ayoola, Kenney, Carol, Sajobi, Tolulope T, and Swartz, Richard H

Published
2022
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18. Effect of vitamin D on clinical outcomes in patients with thermal injury

Author

Pirdastan, Sepide, primary, Mahdavi Roshan, Marjan, additional, Mobayen, Mohammadreza, additional, Asadzadegan, Reza, additional, Ebrahim Ghafari, Mohammad, additional, Mazhari, Seyed Amirhossein, additional, Sadeghi, Mahsa, additional, Bagheri Toolaroud, Parissa, additional, and Alizadeh Otaghvar, Hamidreza, additional

Published
2024
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21. Bifidobacterium exopolysaccharides: new insights into engineering strategies, physicochemical functions, and immunomodulatory effects on host health.

Author

Sadeghi, Mahsa, Haghshenas, Babak, and Nami, Yousef

Subjects
BIFIDOBACTERIUM, IMMUNOMODULATORS, LACTIC acid bacteria, RESEARCH personnel, IMMUNE system
Abstract

Bifidobacteria are a prominent type of bacteria that have garnered significant research attention for their exceptional probiotic properties and capacity to produce exopolysaccharides (EPSs). These compounds exhibit diverse physical, chemical, and biological characteristics, prompting numerous investigations into their potential applications. Researchers have noted their beneficial effects as immune modulators within the host's body across various industries. Extensive research has been conducted on the immunomodulatory effects of bifidobacteria-derived EPSs, with emerging engineering strategies aimed at enhancing their immune-modulating capabilities. Understanding the structure, physicochemical properties, and biological activities of these compounds is crucial for their effective utilization across different industries. Our review encompassed numerous studies exploring Bifidobacterium and its metabolites, including EPSs, across various sectors, drawing from diverse databases. The distinctive properties of EPSs have spurred investigations into their applications, revealing their potential to bolster the immune system, combat inflammation, and treat various ailments. Additionally, these compounds possess antioxidant and antimicrobial properties, making them suitable for incorporation into a range of products spanning food, health, and medicine. [ABSTRACT FROM AUTHOR]

Published
2024
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24. IL-31–dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis

Author

Fassett, Marlys S., primary, Braz, Joao M., additional, Castellanos, Carlos A., additional, Salvatierra, Juan J., additional, Sadeghi, Mahsa, additional, Yu, Xiaobing, additional, Schroeder, Andrew W., additional, Caston, Jaela, additional, Munoz-Sandoval, Priscila, additional, Roy, Suparna, additional, Lazarevsky, Steven, additional, Mar, Darryl J., additional, Zhou, Connie J., additional, Shin, Jeoung-Sook, additional, Basbaum, Allan I., additional, and Ansel, K. Mark, additional

Published
2023
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30. Predictive value of serum albumin and calcium levels in burn patients with Pseudomonas aeruginosa infection: A comprehensive analysis of clinical outcomes.

Author

Haghighi Bardineh, Seyed Ashkan, Balou, Heydar Ali, Sedigh Ebrahim‐Saraie, Hadi, Mobayen, Mohammadreza, Esmailzadeh, Mojdeh, Haghighi, Samane, Haghighi, Arezoo, and Sadeghi, Mahsa

Subjects
PREDICTIVE tests, HOSPITAL care, CALCIUM, BURN patients, PSEUDOMONAS diseases, INTENSIVE care units, DATA analysis software, LENGTH of stay in hospitals, VITAMIN D, SERUM albumin
Abstract

In the ongoing challenge to reduce burn‐associated mortality rates, this study explores the predictive capacity of clinical factors in burn patients, focusing on vitamin D, calcium, and serum albumin levels during hospitalisation in cases with Pseudomonas aeruginosa infection. Our research involves a comprehensive analysis of 100 burn patients, encompassing crucial clinical parameters such as the burn severity index, serum albumin, vitamin D, and calcium levels at admission. Data were meticulously entered into IBM Statistics SPSS software version 28 and subjected to statistical analysis. The study reveals an average patient age of 39.75 years and a notable 34% mortality rate. Additionally, the average lengths of hospital and intensive care unit (ICU) stays are determined to be 11.33 and 7.79 days, respectively. Significantly, a correlation between calcium and albumin variables and treatment outcomes is established, showcasing their potential to predict variable changes in patient mortality rates. Furthermore, a noteworthy association is observed between serum calcium levels and the duration of ICU hospitalisation. In conclusion, albumin and calcium variables emerge as sensitive and specific indicators for predicting outcomes in burn patients. Importantly, the independence of these factors from the physician's experience and diagnosis reduces human error and thus increases the accuracy of mortality prediction in this patient population. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Knowledge, attitude, and sources of information towards burn first aid among people referred to a burn centre in the north of Iran.

Author

Tolouei, Mohammad, Pirooz, Amir, Ashoobi, Mohammad Taghi, Davoudpour, Ravak, Zarei, Reza, Sadeghi, Mahsa, Mehdipour, Fatemeh, and Bagheri Toolaroud, Parissa

Subjects
TREATMENT for burns & scalds, RESEARCH methodology, CROSS-sectional method, AGE distribution, FIRST aid in illness & injury, HEALTH literacy, SEX distribution, MEDICAL referrals, BURN care units, HEALTH attitudes, INFORMATION resources, DESCRIPTIVE statistics, RESEARCH funding, STATISTICAL sampling, SOCIODEMOGRAPHIC factors, MARITAL status, DATA analysis software, EDUCATIONAL attainment
Abstract

Optimal management of burns begins with first aid from the first hours of injury. Adequate knowledge of how to perform first aid for burns can reduce the consequences of injury. Therefore, this study aims to determine the knowledge, attitude, and sources of information assessment towards burn First aid among people referred to a burn centre in the north of Iran. A questionnaire‐based survey was conducted to assess knowledge, attitude, and sources of information towards burn first aid among people referred to a burn centre in the north of Iran in 2023. In this survey, a convenience sampling method was adopted. The variables consisted of four items on socio‐demographic information, 15 items on knowledge, ten items on attitude, and one item on sources of information related to burn First aid. A total of 371 individuals responded to the survey. The mean age of participants was 31.90 ± 8.49 years old. The mean score of the total knowledge of the participants in the research was 6.04 ± 3.05. There was a statistically significant relationship between the variables of age, sex, marital status, place of residence, level of education, and history of receiving first aid training with the participants' knowledge level. The average score of the total attitude of the participants was 44.08 ± 3.88. Out of 371 participants, 214 people (57.7%) had an average attitude, and 157 people (42.3%) had a good attitude towards burn first aid. There was a statistically significant relationship between place of residence, level of education, and history of receiving first aid training with the participants' attitudes in the research. In addition, the level of knowledge had a statistically significant relationship with the participants' attitude level in the research (p‐value <0.001). The majority of participants have limited knowledge of burn first aid. This lack of knowledge could lead to severe consequences. Therefore, healthcare organizations should review and promote consistent guidelines for burn first aid to tackle and minimize the effect of this grave injury. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Sensing Systems Using Large Area Printed Organic Electronics

Author

Sadeghi, Mahsa

Subjects
Electrical engineering, Materials Science, Computer science, Circuits, Organic Phototransistors, Organic Thin Film Transistors, Sensing Systems
Abstract

Organic electronics is an emerging technology with advantages of mechanical flexibility,solution-processability, and high-throughput manufacturing at low temperatures on inexpensiveand light-weight substrates such as plastic, paper, and fiber in large-scales not possiblewith high-temperature processing techniques. While the performance of devices cannot rivalthe silicon counterpart, the performance should be tuned to meet the required specificationsof the application in mind. This thesis will overview the performance of the organic thintransistors (OTFTs) and organic phototransistors (OPTs) optimized and used for circuitsand large area sensing applications. The work first covers the printing techniques employedfor the fabrication of organic devices on the flexible substrate. There have been device-leveloptimizations for scale ratio tuning and power improvement by using a bilayer gate dielectricstructure. We also introduce a novel technique for rapid and digital modulation of the scaleratios. Interconnection is done with the screen printing method for the fabrication of printedflexible logic circuits and an OTFT weak classifier for data classification. The OPTs, witha good dual performance as both transistor and photodetector, are capable of merging thesensing and function generation in one substrate, which can reduce system complexity.

Published
2020

43. Adopting distributed ledger technology for the sustainable construction industry: evaluating the barriers using Ordinal Priority Approach

Author

Sadeghi, Mahsa, Mahmoudi, Amin, and Deng, Xiaopeng

Subjects
Technology, Process management, Emerging technologies, Health, Toxicology and Mutagenesis, Supply chain, Social sustainability, Blockchain, Engineering, Procurement, Environmental Chemistry, Distributed ledger technology (DLT), Supply chain management, business.industry, Construction Industry, Commerce, Building information modeling (BIM), General Medicine, Pollution, Sustainability, Building information modeling, Ordinal Priority Approach (OPA), Transparency (graphic), Construction 4.0, business, Research Article, Multiple attributes decision-making (MADM)
Abstract

Construction 4.0 has become a buzzword since the penetration of building information modeling (BIM), cyber-physical systems, and digital and computing technologies into the construction industry. Among emerging technologies, distributed ledger technology (DLT), or blockchain, is a powerful business enhancer whose potential can disrupt projects, AEC (architecture, engineering, and construction) firms, and construction supply chain, and in a broader sense, the whole construction industry. This technology has not reached the plateau of productivity due to several barriers and challenges. Previous studies have started to investigate the barriers to implementing DLT in various sectors and segmentations. However, we still need further surveys in the construction industry. This study evaluates the applicability of identified challenges and barriers based on a sustainability perspective. Precisely, we will answer which challenges need to be addressed for the sustainability of the construction industry. To meet the research objective, the ordinal priority approach (OPA) in multiple attributes decision-making (MADM) was utilized. This novel method determines the weight of sustainability attributes and barriers simultaneously. The results show that DLT implementation needs (i) infrastructure for data management, (ii) advanced applications and archetypes, and (iii) customers' demand, interest, and tendency, and (iv) taxation and reporting. Solving high-ranked challenges is the key to social sustainability from the aspects of "supply chain management and procurement"; "transparency, anti-corruption, and anti-counterfeiting"; and "fair operation and honest competition."

Published
2021

44. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Author

Menon, Bijoy K, primary, Buck, Brian H, additional, Singh, Nishita, additional, Deschaintre, Yan, additional, Almekhlafi, Mohammed A, additional, Coutts, Shelagh B, additional, Thirunavukkarasu, Sibi, additional, Khosravani, Houman, additional, Appireddy, Ramana, additional, Moreau, Francois, additional, Gubitz, Gord, additional, Tkach, Aleksander, additional, Catanese, Luciana, additional, Dowlatshahi, Dar, additional, Medvedev, George, additional, Mandzia, Jennifer, additional, Pikula, Aleksandra, additional, Shankar, Jai, additional, Williams, Heather, additional, Field, Thalia S, additional, Manosalva, Alejandro, additional, Siddiqui, Muzaffar, additional, Zafar, Atif, additional, Imoukhuede, Oje, additional, Hunter, Gary, additional, Demchuk, Andrew M, additional, Mishra, Sachin, additional, Gioia, Laura C, additional, Jalini, Shirin, additional, Cayer, Caroline, additional, Phillips, Stephen, additional, Elamin, Elsadig, additional, Shoamanesh, Ashkan, additional, Subramaniam, Suresh, additional, Kate, Mahesh, additional, Jacquin, Gregory, additional, Camden, Marie-Christine, additional, Benali, Faysal, additional, Alhabli, Ibrahim, additional, Bala, Fouzi, additional, Horn, MacKenzie, additional, Stotts, Grant, additional, Hill, Michael D, additional, Gladstone, David J, additional, Poppe, Alexandre, additional, Sehgal, Arshia, additional, Zhang, Qiao, additional, Lethebe, Brendan Cord, additional, Doram, Craig, additional, Ademola, Ayoola, additional, Shamy, Michel, additional, Kenney, Carol, additional, Sajobi, Tolulope T, additional, Swartz, Richard H, additional, Srivastava, Abhilekh, additional, Aljammaz, Ahmed M, additional, Akindotun, Akintomide Femi, additional, Jin, Albert Y, additional, Fraser, Alexander, additional, Khaw, Alexander V, additional, Lemnaru, Alexandru, additional, Southwell, Alisia, additional, Ramji, Alnar, additional, Alvarado-Bolaños, Alonso, additional, Mouminah, Amr, additional, Lahlouh, Amro B, additional, Yu, Amy Y, additional, Alrohimi, Anas, additional, Lavoie, Andre, additional, Rogge, Andrea, additional, Micieli, Andrew, additional, Nguyen, Andrew Linh, additional, Callaghan-Brown, Angelique, additional, Florendo-Cumbermack, Anita, additional, Wadhwa, Ankur, additional, Beaudoin, Ann-Marie, additional, Cayley, Anne, additional, Liddy, Anne Marie, additional, Trivedi, Anurag, additional, Katsanos, Aristeidis H, additional, Shuaib, Ashfaq, additional, Butt, Asif Javed, additional, Bereznyakova, Olena, additional, Beauchamp, Beth, additional, Mahlitz, Breane, additional, Graham, Brett R, additional, Dewar, Brian, additional, Durafourt, Bryce A, additional, Holtby, Caitlin, additional, Jackson-Tarlton, Caitlin S, additional, Bockus, Caitlyn, additional, Stephenson, Caroline, additional, Galloway, Camille, additional, Odier, Céline, additional, Deacon, Charles, additional, Zerna, Charlotte, additional, Vekhande, Chetan C, additional, Bocti, Christian, additional, Stapf, Christian, additional, Hawkes, Christine, additional, Stables, Christine Anne, additional, Bogiatzi, Chrysi, additional, Rodriguez, Claudia, additional, Candale-Radu, Claudia, additional, Murphy, Colleen, additional, Casserly, Courtney Sarah, additional, Fok, Daniel, additional, Boasquevisque, Danielle de Sa, additional, Wile, Daryl, additional, Volders, David, additional, Sahlas, Demetrios J, additional, Shand, Elaine, additional, Cora, Elena Adela, additional, Battista, Eliane Di, additional, Stewart, Eileen, additional, Junk, Emily, additional, Harrison, Emma L, additional, Frenette, Eric, additional, Teleg, Ericka, additional, Abdellah, Eslam, additional, Ghrooda, Esseddeeg, additional, Akthar, Farhana, additional, Evoy, François, additional, Klein, Gary M, additional, Maclean, Genoveva, additional, Jickling, Glen C, additional, Hawthorne, Glenda, additional, Boyd, Gordon, additional, Walker, Gregory, additional, Saposnik, Gustavo, additional, Lau, H Lee, additional, Badr, Hanan E, additional, Toma, Hassanain, additional, Kalashyan, Hayrapet, additional, Marion-Moffet, Hugo, additional, Grant, Ian, additional, Fatakdawala, Idris, additional, Beaulieu-Boire, Isabelle, additional, Williams, Janice, additional, Brar, Jaskiran, additional, Rivest, Jean, additional, Wang, Jeffrey Z, additional, Dawe, Jessica, additional, Stang, Jillian, additional, Day, Joanne, additional, Miller, Jodi, additional, Gorman, Johnathon, additional, Hopyan, Julia Jasmine, additional, Lee, Julian, additional, Kromm, Julie, additional, Foster, Kaitlyn, additional, Ratnayake, Kanchana, additional, Perera, Kanjana S, additional, Murray, Karina Villaluna, additional, Ryckborst, Karla, additional, Lin, Katie, additional, Sage, Kayla, additional, Sivakuma, Keithan, additional, MacDonald, Kelly A, additional, Ng, Kelvin Kuan, additional, Merchant, Ketki, additional, Khan, Khurshid, additional, Ghavami, Kimia, additional, Johnston, Kyra, additional, Mai, Lauren M, additional, White, Leah, additional, Barratt, Lee, additional, Longpre, Linda, additional, Crellin, Lisa, additional, Peeling, Lissa, additional, Piquette, Lori, additional, Lomax, Lysa Boissé, additional, Sadeghi, Mahsa, additional, Kamra, Maneesha, additional, Lavoie-April, Manuel, additional, Moores, Margaret, additional, Bullrich, Maria Bres, additional, McClelland, Marie, additional, Salluzzi, Marina, additional, Wilcox, Mark, additional, Boulos, Mark I, additional, Marko, Martha, additional, Boyko, Matthew, additional, Lantagne-Hurtubise, Maude, additional, AlHamid, May Adel, additional, Shawawrah, Mays, additional, Kelly, Michael E, additional, Thorne, Michael W D, additional, Bussiere, Miguel, additional, Dominc Tse, Ming Yin, additional, Benguzzi, Mowad, additional, Sharma, Mukul, additional, Horton, Myles, additional, Newcommon, Nancy, additional, Simon, Nandy-Shelwine, additional, Parks, Natalie E, additional, Sultan, Nazeem, additional, Markovic, Nevena, additional, Daneault, Nicole, additional, Ishaque, Noman, additional, 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additional, Gaal, Stephen van, additional, Peters, Steven Ray, additional, Darvesh, Sultan, additional, Save, Supriya, additional, Alcock, Susan, additional, Piercey, Susannah, additional, Adam, Suzie, additional, Gosselin, Sylvie, additional, Fitzpatrick, Tess, additional, Perron, Thomas-Louis, additional, Stewart, Tim, additional, Benstead, Timothy J, additional, Naidoo, Vishaya, additional, Wahab, Wasan Abd, additional, Oczkowski, Wiesław, additional, Kingston, William, additional, Leduc, William, additional, To, William T H, additional, Yu, Yeyao Joe, additional, Liu, Zhongyu A, additional, and Aljundi, Ziad Ezzat, additional

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2022
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