19 results on '"Sachs, Michele"'
Search Results
2. Unique immunological profile in patients with COVID-19
- Author
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Varchetta, Stefania, Mele, Dalila, Oliviero, Barbara, Mantovani, Stefania, Ludovisi, Serena, Cerino, Antonella, Bruno, Raffaele, Castelli, Alberto, Mosconi, Mario, Vecchia, Marco, Roda, Silvia, Sachs, Michele, Klersy, Catherine, and Mondelli, Mario U.
- Published
- 2021
- Full Text
- View/download PDF
3. Competing-risk analysis of coronavirus disease 2019 in-hospital mortality in a Northern Italian centre from SMAtteo COvid19 REgistry (SMACORE)
- Author
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Zuccaro, Valentina, Celsa, Ciro, Sambo, Margherita, Battaglia, Salvatore, Sacchi, Paolo, Biscarini, Simona, Valsecchi, Pietro, Pieri, Teresa Chiara, Gallazzi, Ilaria, Colaneri, Marta, Sachs, Michele, Roda, Silvia, Asperges, Erika, Lupi, Matteo, Di Filippo, Alessandro, Seminari, Elena, Di Matteo, Angela, Novati, Stefano, Maiocchi, Laura, Enea, Marco, Attanasio, Massimo, Cammà, Calogero, and Bruno, Raffaele
- Published
- 2021
- Full Text
- View/download PDF
4. Prevalence of chronic kidney disease among HIV-1-infected patients receiving a combination antiretroviral therapy
- Author
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Calza, Leonardo, Sachs, Michele, Colangeli, Vincenzo, Borderi, Marco, Granozzi, Bianca, Malosso, Pietro, Comai, Giorgia, Corradetti, Valeria, La Manna, Gaetano, and Viale, Pierluigi
- Published
- 2019
- Full Text
- View/download PDF
5. An atypical presentation of tuberculous gumma heralding a diagnosis of lymph node tuberculosis: Hindsight is 20/20
- Author
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Isoletta, Eugenio, primary, Ciolfi, Christian, additional, Bonometti, Arturo, additional, Sachs, Michele, additional, and Brazzelli, Valeria, additional
- Published
- 2022
- Full Text
- View/download PDF
6. High Frequencies of Functional Virus-Specific CD4+ T Cells in SARS-CoV-2 Subjects With Olfactory and Taste Disorders
- Author
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Mele, Dalila, primary, Calastri, Anna, additional, Maiorano, Eugenia, additional, Cerino, Antonella, additional, Sachs, Michele, additional, Oliviero, Barbara, additional, Mantovani, Stefania, additional, Baldanti, Fausto, additional, Bruno, Raffaele, additional, Benazzo, Marco, additional, Grifoni, Alba, additional, Sette, Alessandro, additional, Mondelli, Mario U., additional, and Varchetta, Stefania, additional
- Published
- 2021
- Full Text
- View/download PDF
7. Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy
- Author
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Melazzini, Federica, Colaneri, Marta, Fumoso, Federica, Freddi, Giulia, Lenti, Marco Vincenzo, Pieri, Teresa Chiara, Piloni, Davide, Noris, Patrizia, Pieresca, Carla, Preti, Paola Stefania, Russo, Mariaconcetta, Corsico, Angelo, Tavazzi, Guido, Baldanti, Fausto, Triarico, Antonio, Mojoli, Francesco, Bruno, Raffaele, Di Sabatino, Antonio, Aronico, Nicola, Bergamaschi, Gaetano, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Delliponti, Angela, Derosa, Giuseppe, Di Stefano, Michele, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mengoli, Caterina, Miceli, Emanuela, Mugellini, Amedeo, Muggia, Chiara, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Vjera, Francesca Torello, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Ballesio, Alessia, Banfi, Francesco, Barteselli, Chiara, Benedetti, Irene, de Andreis, Federica Borrelli, Brattoli, Michele, Calabretta, Francesca, Cambiè, Ginevra, Canta, Roberta, Conca, Federico, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Del Rio, Virginia, Di Terlizzi, Francesco, Ferrari, Maria Giovanna, Ferrari, Sara, Fiengo, Anna, Forni, Tommaso, Frigerio, Chiara, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gentile, Antonella, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lapia, Francesco, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Merli, Stefania, Mordà, Francesco, Nardone, Alba, Pace, Luca, Padovini, Lucia, Parodi, Alessandro, Pellegrino, Ivan, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Romito, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Santacroce, Giovanni, Savioli, Jessica, Soriano, Simone, Spataro, Carmine, Stefani, Debora, Aliberti, Anna Rita, Amatu, Alessandro, Anfossi, Laura, Arisi, Eric, Baldi, Chiara, Belliato, Mirko, Bellini, Lorenzo, Benzi, Alberto, Bichisao, Germana, Bolongaro, Antonia, Bottazzi, Andrea, Broglia, Federica, Bruschi, Giacomo, Caneva, Luca, Capaccio, Emanuele, Carboni, Valeria, Cavalloro, Fabrizio, Ciceri, Maria, Civardi, Luca, Delmonte, Maria Paola, Domenegati, Elisa Lucia, Ferrari, Federica, Ferrari, Fiorenza, Ferrari, Marta, Fuardo, Marinella, Gerletti, Maddalena Margherita, Gualdana, Simonetta, Ilardi, Marcella, Lo Coco, Claudia, Maggio, Giuseppe, Mascia, Maria Benedetta, Mencherini, Simonetta, Merati, Paola Maria, Mongodi, Silvia, Mori, Anna Maria, Morgante, Federica, Niebel, Thekla Larissa, Noli, Silvano, Orlando, Anita, Pagani, Michele, Passador, Debora, Pellicori, Simona, Perotti, Luciano, Picchioni, Raffaella, Poma, Silvia, Pozzi, Marco, Preti, Emanuela, Puce, Roberta, Radolovich, Danila Katia, Ragni, Gianluca, Repossi, Filippo, Riccardi, Francesca, Rizzardi, Roberto, Rodi, Giuseppe, Roldi, Emanuela, Rossi, Cristina, Sala Gallini, Giuseppe, Sciutti, Fabio, Sportiello, Debora, Ticozzelli, Giulia, Visconti, Federico, Zizzi, Silvia, Bagliani, Alessandro, Belotti, Corrado, Bossi, Chiara, Colombo, Andrea, Colombo, Costanza Natalia Julia, Cremascoli, Luca, Dammassa, Valentino, Discepoli, Roberto, Garlando, Maria Adelaide, Grandini, Filippo, Pellegrini, Andrea, Quaranta, Cecilia, Stella, Andrea, Torresani, Francesco, Mondelli, Mario, Brunetti, Enrico, Di Matteo, Angela, Seminari, Elena, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Asperges, Erika, Di Filippo, Alessandro, Sambo, Margherita, Biscarini, Simona, Lupi, Matteo, Roda, Silvia, Gallazzi, Ilaria, Sachs, Michele, Valsecchi, Pietro, Ferrari, Alessandra, Bosio, Matteo, Cascina, Alessandro, Conio, Valentina, Di Domenica, Rita, Donnetta, Anna, Fraolini, Elia, Gualtieri, Giuseppe, Mangiarotti, Patrizia, Mariani, Francesca, Meloni, Federica, Oggionni, Tiberio, Pasturenzi, Lidia, Ronzoni, Vanessa, Saracino, Laura, Stella, Giulia, Tomaselli, Stefano, Abbate, Tommaso, Accordino, Giulia, Bertuccio, Francesco, Burattini, Cecilia, Cacciatore, Elisa, Cattaneo, Elena, Chino, Vittorio, Coretti, Manuela, Della Zoppa, Matteo, Infusino, Cristina, Lettieri, Sara, Maccabruni, Valeria, Mancinelli, Silvia, Tirelli, Claudio, and Vertui, Valentina
- Subjects
medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,030204 cardiovascular system & hematology ,Single Center ,Tertiary referral hospital ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Internal Medicine ,Medicine ,cardiovascular diseases ,Mean platelet volume ,biology ,SARS-CoV-2 ,business.industry ,Pulmonary embolism ,C-reactive protein ,Anticoagulants ,Thrombosis ,equipment and supplies ,medicine.disease ,Im - Original ,030220 oncology & carcinogenesis ,biology.protein ,Emergency Medicine ,Observational study ,business - Abstract
Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, the magnitude of this association still needs to be defined. Furthermore, clinical predictors of thrombogenesis, and the relationship with the inflammatory status are currently unknown. On this basis, we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment. Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score > 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation between platelet count (PLT) and either C reactive protein (CRP) (p p = 0.0013), while a significant inverse correlation was observed between PLT and mean platelet volume (p p p = 0.002 and p = 0.005, respectively). No significant difference was found in d-dimer levels between VTE and non VTE patients, while significantly higher levels of LDH (p = 0.04) and IL-6 (p = 0.04) were observed in VTE patients in comparison to non-VTE patients. In conclusion, our findings showed a quite high prevalence of VTE in COVID-19 patients. Raised inflammatory indexes and increased serum levels of pro-inflammatory cytokines should raise the clinical suspicion of VTE.
- Published
- 2020
- Full Text
- View/download PDF
8. SARS Cov-2 infection in a renal-transplanted patient: A case report
- Author
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Seminari, Elena, Colaneri, Marta, Sambo, Margherita, Gallazzi, Ilaria, Di Matteo, Angela, Roda, Silvia, Bruno, Raffaele, Mondelli, Mario U., Brunetti, Enrico, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Sciarra, Marco, Asperges, Erika, Di Filippo, Alessandro, Biscarini, Simona, Lupi, Matteo, Pieri, Teresa C., Sachs, Michele, Valsecchi, Pietro, Perlini, Stefano, Alfano, Claudia, Bonzano, Marco, Briganti, Federica, Crescenzi, Giuseppe, Falchi, Anna G., Guarnone, Roberta, Guglielmana, Barbara, Maggi, Elena, Martino, Ilaria, Pettenazza, Pietro, Pioli di Marco, Serena, Quaglia, Federica, Sabena, Anna, Salinaro, Francesco, Speciale, Francesco, Zunino, Ilaria, De Lorenzo, Marzia, Secco, Gianmarco, Dimitry, Lorenzo, Cappa, Giovanni, Maisak, Igor, Chiodi, Benedetta, Sciarrini, Massimiliano, Barcella, Bruno, Resta, Flavia, Moroni, Luca, Vezzoni, Giulia, Scattaglia, Lorenzo, Boscolo, Elisa, Zattera, Caterina, Fidel, Tassi M., Vincenzo, Capozza, Vignaroli, Damiano, Bazzini, Marco, Iotti, Giorgio, Mojoli, Francesco, Belliato, Mirko, Perotti, Luciano, Mongodi, Silvia, Tavazzi, Guido, Marseglia, Gianluigi, Licari, Amelia, Brambilla, Ilaria, Daniela, Barbarini, Antonella, Bruno, Patrizia, Cambieri, Giulia, Campanini, Giuditta, Comolli, Marta, Corbella, Rossana, Daturi, Milena, Furione, Bianca, Mariani, Roberta, Maserati, Enza, Monzillo, Stefania, Paolucci, Maurizio, Parea, Elena, Percivalle, Antonio, Piralla, Francesca, Rovida, Antonella, Sarasini, Maurizio, Zavattoni, Guy, Adzasehoun, Laura, Bellotti, Ermanna, Cabano, Giuliana, Casali, Luca, Dossena, Gabriella, Frisco, Gabriella, Garbagnoli, Alessia, Girello, Viviana, Landini, Claudia, Lucchelli, Valentina, Maliardi, Simona, Pezzaia, Marta, Premoli, Alice, Bonetti, Giacomo, Caneva, Irene, Cassaniti, Alfonso, Corcione, Di Martino, Raffella, Di Napoli, Annapia, Alessandro, Ferrari, Guglielmo, Ferrari, Loretta, Fiorina, Federica, Giardina, Alessandra, Mercato, Federica, Novazzi, Giacomo, Ratano, Beatrice, Rossi, Maria, Sciabica I., Monica, Tallarita, Edoardo, Vecchio N., Cerino, Antonella, Varchetta, Stefania, Oliviero, Barbara, Mantovani, Stefania, Mele, Dalila, Calvi, Monica, Tizzonis, Michela, Nicora, Carlo, Triarico, Antonio, Petronella, Vincenzo, Marena, Carlo, Muzzi, Alba, Lago, Paolo, Comandatore, Francesco, Bissignandi, Gherard, Gaiarsa, Stefano, Rettani, Marco, and Band, Claudio
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Male ,medicine.medical_specialty ,ARDS ,medicine.medical_treatment ,infectious disease ,Disease ,030230 surgery ,clinical research/practice ,Asymptomatic ,Tacrolimus ,Kidney Failure ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,Glomerulonephritis ,medicine ,Extracorporeal membrane oxygenation ,Immunology and Allergy ,immunosuppressant – calcineurin inhibitor: tacrolimus ,infection and infectious agents – viral ,COVID-19 ,Ceftriaxone ,Coronavirus Infections ,Cytokines ,Glomerulonephritis, IGA ,Humans ,Immunosuppression Therapy ,Kidney Failure, Chronic ,Middle Aged ,Mycophenolic Acid ,Pandemics ,Pneumonia, Viral ,SARS-CoV-2 ,Treatment Outcome ,Kidney Transplantation ,Pharmacology (medical) ,Viral ,Chronic ,Intensive care medicine ,Kidney transplantation ,IGA ,Mechanical ventilation ,Transplantation ,business.industry ,Immunosuppression ,Pneumonia ,medicine.disease ,medicine.symptom ,Cytokine storm ,business - Abstract
The clinical manifestation of COVID-19 can vary from an asymptomatic course to ARDS requiring invasive mechanical ventilation and extracorporeal membrane oxygenation. A kidney transplanted patient infected with SARS CoV-2 infection showed a mild disease despite immune suppression. It is possible that Immunosuppression can "be protective" as the cytokine storm is an important factor in the disease story. Despite the good outcome reported in the present case report, is remains of vital importance the solid organ transplant patients use precautions in order to avoid the infection.
- Published
- 2020
9. Unique immunological profile in patients with COVID-19
- Author
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Varchetta, Stefania, primary, Mele, Dalila, additional, Oliviero, Barbara, additional, Mantovani, Stefania, additional, Ludovisi, Serena, additional, Cerino, Antonella, additional, Bruno, Raffaele, additional, Castelli, Alberto, additional, Mosconi, Mario, additional, Vecchia, Marco, additional, Roda, Silvia, additional, Sachs, Michele, additional, Klersy, Catherine, additional, and Mondelli, Mario U., additional
- Published
- 2020
- Full Text
- View/download PDF
10. In-hospital mortality from Coronavirus Disease 2019 in a northern Italian centre:results of a competing risk analysis from SMAtteo COvid19 REgistry (SMACORE)
- Author
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Zuccaro, Valentina, primary, Celsa, Ciro, additional, Sambo, Margherita, additional, Battaglia, Salvatore, additional, Sacchi, Paolo, additional, Biscarini, Simona, additional, Valsecchi, Pietro, additional, Pieri, Teresa Chiara, additional, Gallazzi, Ilaria, additional, Colaneri, Marta, additional, Sachs, Michele, additional, Roda, Silvia, additional, Asperges, Erika, additional, Lupi, Matteo, additional, Filippo, Alessandro Di, additional, Seminari, Elena, additional, Matteo, Angela Di, additional, Novati, Stefano, additional, Maiocchi, Laura, additional, Enea, Marco, additional, Attanasio, Massimo, additional, Cammà, Calogero, additional, and Bruno, Raffaele, additional
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- 2020
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11. High Frequencies of Functional Virus-Specific CD4+ T Cells in SARS-CoV-2 Subjects With Olfactory and Taste Disorders.
- Author
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Mele, Dalila, Calastri, Anna, Maiorano, Eugenia, Cerino, Antonella, Sachs, Michele, Oliviero, Barbara, Mantovani, Stefania, Baldanti, Fausto, Bruno, Raffaele, Benazzo, Marco, Grifoni, Alba, Sette, Alessandro, Mondelli, Mario U., and Varchetta, Stefania
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SARS-CoV-2 ,T cells ,TASTE disorders ,SMELL disorders ,ACUTE phase proteins ,IMMUNOLOGIC diseases - Abstract
Olfactory and taste disorders (OTD) are commonly found as presenting symptoms of SARS-CoV-2 infection in patients with clinically mild COVID-19. Virus-specific T cells are thought to play an important role in the clearance of SARS-CoV-2; therefore the study of T cell specific immune responses in patients with mild symptoms may help to understand their possible role in protection from severe disease. We evaluated SARS-CoV-2-specific T cell responses to four different peptide megapools covering all SARS-CoV-2 proteins during the acute phase of the disease in 33 individuals with mild or no other symptom beside OTD and in 22 age-matched patients with severe infection. A control group of 15 outpatients with OTD and consistently negative nasopharyngeal SARS-CoV-2 RNA swabs and virus-specific IgG serology was included in the study. Increased frequencies of virus-specific CD4
+ and CD8+ T cells were found in SARS-CoV-2 positive patients with OTD compared with those with severe COVID-19 and with SARS-CoV-2 negative OTD individuals. Moreover, enhanced CD4+ and CD8+ T-cell activation induced by SARS-CoV-2 peptides was associated with higher interferon (IFN)γ production. Increased frequencies of Spike (S1/S2)-specific CD4+ T cells showing enhanced IFNγ secretion and granzyme B content were associated with serum spike-specific IgG in the OTD group. In conclusion, patients with SARS-CoV-2 induced OTD develop highly functional virus-specific CD4+ and CD8+ T cells during the symptomatic phase of the disease, suggesting that robust and coordinated T-cell responses provide protection against extension of COVID-19 to the lower respiratory tract. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
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12. Correction to: Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy
- Author
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Melazzini, Federica, Colaneri, Marta, Fumoso, Federica, Freddi, Giulia, Lenti, Marco Vincenzo, Pieri, Teresa Chiara, Piloni, Davide, Noris, Patrizia, Pieresca, Carla, Preti, Paola Stefania, Russo, Mariaconcetta, Corsico, Angelo, Tavazzi, Guido, Baldanti, Fausto, Triarico, Antonio, Mojoli, Francesco, Bruno, Raffaele, Di Sabatino, Antonio, Aronico, Nicola, Bergamaschi, Gaetano, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Delliponti, Angela, Derosa, Giuseppe, Di Stefano, Michele, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mengoli, Caterina, Miceli, Emanuela, Mugellini, Amedeo, Muggia, Chiara, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Vjera, Francesca Torello, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Ballesio, Alessia, Banfi, Francesco, Barteselli, Chiara, Benedetti, Irene, Borrelli de Andreis, Federica, Brattoli, Michele, Calabretta, Francesca, Cambiè, Ginevra, Canta, Roberta, Conca, Federico, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Del Rio, Virginia, Di Terlizzi, Francesco, Ferrari, Maria Giovanna, Ferrari, Sara, Fiengo, Anna, Forni, Tommaso, Frigerio, Chiara, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gentile, Antonella, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lapia, Francesco, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Merli, Stefania, Mordà, Francesco, Nardone, Alba, Pace, Luca, Padovini, Lucia, Parodi, Alessandro, Pellegrino, Ivan, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Romito, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Santacroce, Giovanni, Savioli, Jessica, Soriano, Simone, Spataro, Carmine, Stefani, Debora, Aliberti, Anna Rita, Amatu, Alessandro, Anfossi, Laura, Arisi, Eric, Baldi, Chiara, Belliato, Mirko, Bellini, Lorenzo, Benzi, Alberto, Bichisao, Germana, Bolongaro, Antonia, Bottazzi, Andrea, Broglia, Federica, Bruschi, Giacomo, Caneva, Luca, Capaccio, Emanuele, Carboni, Valeria, Cavalloro, Fabrizio, Ciceri, Maria, Civardi, Luca, Delmonte, Maria Paola, Domenegati, Elisa Lucia, Ferrari, Federica, Ferrari, Fiorenza, Ferrari, Marta, Fuardo, Marinella, Gerletti, Maddalena Margherita, Gualdana, Simonetta, Ilardi, Marcella, Lo Coco, Claudia, Maggio, Giuseppe, Mascia, Maria Benedetta, Mencherini, Simonetta, Merati, Paola Maria, Mongodi, Silvia, Mori, Anna Maria, Morgante, Federica, Niebel, Thekla Larissa, Noli, Silvano, Orlando, Anita, Pagani, Michele, Passador, Debora, Pellicori, Simona, Perotti, Luciano, Picchioni, Raffaella, Poma, Silvia, Pozzi, Marco, Preti, Emanuela, Puce, Roberta, Radolovich, Danila Katia, Ragni, Gianluca, Repossi, Filippo, Riccardi, Francesca, Rizzardi, Roberto, Rodi, Giuseppe, Roldi, Emanuela, Rossi, Cristina, Sala Gallini, Giuseppe, Sciutti, Fabio, Sportiello, Debora, Ticozzelli, Giulia, Visconti, Federico, Zizzi, Silvia, Bagliani, Alessandro, Belotti, Corrado, Bossi, Chiara, Colombo, Andrea, Colombo, Costanza Natalia Julia, Cremascoli, Luca, Dammassa, Valentino, Discepoli, Roberto, Garlando, Maria Adelaide, Grandini, Filippo, Pellegrini, Andrea, Quaranta, Cecilia, Stella, Andrea, Torresani, Francesco, Mondelli, Mario, Brunetti, Enrico, Di Matteo, Angela, Seminari, Elena, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Asperges, Erika, Di Filippo, Alessandro, Sambo, Margherita, Biscarini, Simona, Lupi, Matteo, Roda, Silvia, Gallazzi, Ilaria, Sachs, Michele, Valsecchi, Pietro, Ferrari, Alessandra, Bosio, Matteo, Cascina, Alessandro, Conio, Valentina, Di Domenica, Rita, Donnetta, Anna, Fraolini, Elia, Gualtieri, Giuseppe, Mangiarotti, Patrizia, Mariani, Francesca, Meloni, Federica, Oggionni, Tiberio, Pasturenzi, Lidia, Ronzoni, Vanessa, Saracino, Laura, Stella, Giulia, Tomaselli, Stefano, Abbate, Tommaso, Accordino, Giulia, Bertuccio, Francesco, Burattini, Cecilia, Cacciatore, Elisa, Cattaneo, Elena, Chino, Vittorio, Coretti, Manuela, Della Zoppa, Matteo, Infusino, Cristina, Lettieri, Sara, Maccabruni, Valeria, Mancinelli, Silvia, Tirelli, Claudio, and Vertui, Valentina
- Subjects
Adult ,Male ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,MEDLINE ,Tertiary referral hospital ,Single Center ,Statistics, Nonparametric ,Tertiary Care Centers ,Prevalence ,Internal Medicine ,medicine ,Humans ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,Aged ,Retrospective Studies ,Aged, 80 and over ,Academic Medical Centers ,Task force ,business.industry ,Correction ,COVID-19 ,Venous Thromboembolism ,Middle Aged ,Northern italy ,Italy ,Emergency medicine ,Emergency Medicine ,Female ,business ,Venous thromboembolism - Abstract
Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, the magnitude of this association still needs to be defined. Furthermore, clinical predictors of thrombogenesis, and the relationship with the inflammatory status are currently unknown. On this basis, we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment. Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation between platelet count (PLT) and either C reactive protein (CRP) (p 0.0001) or lactate dehydrogenase (LDH) (p = 0.0013), while a significant inverse correlation was observed between PLT and mean platelet volume (p 0.0001). Platelet-to-lymphocyte ratio significantly correlated with CRP (p 0.0001). The majority of VTE patients was male and younger compared to non-VTE patients (p = 0.002 and p = 0.005, respectively). No significant difference was found in D-dimer levels between VTE and non VTE patients, while significantly higher levels of LDH (p = 0.04) and IL-6 (p = 0.04) were observed in VTE patients in comparison to non-VTE patients. In conclusion, our findings showed a quite high prevalence of VTE in COVID-19 patients. Raised inflammatory indexes and increased serum levels of pro-inflammatory cytokines should raise the clinical suspicion of VTE.
- Published
- 2021
13. Performance of VivaDiag COVID‐19 IgM/IgG Rapid Test is inadequate for diagnosis of COVID‐19 in acute patients referring to emergency room department.
- Author
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Cassaniti, Irene, Novazzi, Federica, Giardina, Federica, Salinaro, Francesco, Sachs, Michele, Perlini, Stefano, Bruno, Raffaele, Mojoli, Francesco, and Baldanti, Fausto
- Subjects
COVID-19 ,SARS-CoV-2 ,HOSPITAL emergency services ,MEDICAL virology ,RNA replicase - Published
- 2020
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- View/download PDF
14. Clinical characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia, North Italy, 21 to 28 February 2020.
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Colaneri, Marta, Sacchi, Paolo, Zuccaro, Valentina, Biscarini, Simona, Sachs, Michele, Roda, Silvia, Pieri, Teresa Chiara, Valsecchi, Pietro, Piralla, Antonio, Seminari, Elena, Di Matteo, Angela, Novati, Stefano, Maiocchi, Laura, Pagnucco, Layla, Tirani, Marcello, Baldanti, Fausto, Mojoli, Francesco, Perlini, Stefano, and Bruno, Raffaele
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- 2020
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15. A challenging case of SARS-CoV-2- AIDS and Nocardiosis coinfection from the SMatteo COVID-19 Registry (SMACORE)
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marta colaneri, Lupi, Matteo, Sachs, Michele, Ludovisi, Serena, Di Matteo, Angela, Pagnucco, Layla, Gulminetti, Roberto, Mariani, Bianca, Fabbiani, Massimiliano, and Bruno, Raffaele
16. Sars-Cov 2 versus Flu: ECMO-associated bloodstream infections.
- Author
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Roda S, Seminari E, Pieri TC, Sachs M, Di Matteo AM, Belliato M, Corbella M, Degani A, Piralla A, and Bruno R
- Subjects
- Humans, Middle Aged, Retrospective Studies, SARS-CoV-2, COVID-19, Extracorporeal Membrane Oxygenation, Sepsis
- Abstract
SARS-CoV-2 and flu may lead to severe acute respiratory distress syndrome (ARDS) requiring extracorporeal membrane oxygenation (ECMO). The aim of the present study is to compare the incidence of bloodstream infections (BSIs) and outcome in patients with flu and SARS-CoV-2 infection hospitalized in ICU and undergoing ECMO. This study is a retrospective analysis of the San Matteo COVID-19 Registry (SMACORE) cohort. The study was conducted from January 2018 to April 2020. Demographic data and microbiological data were recorded during hospitalization. BSIs occurring during ECMO were analyzed. Eighteen patients treated with ECMO, 22 subjects with SARS-CoV-2 infection and 7 with flu, median age 61years for SARS-CoV-2 and 50 for flu (p=NS). Median ECMO duration was similar in the two pathologies. Median time to bloodstream infection from ECMO initiation was similar. Bloodstream infection incidence rate was 2.65 per 100 patients/days for flu and 2.2 per 100 patients/days for SARS-CoV-2. Global infection rate was 5 per 100 patients/days for SARS-CoV-2 patients and 5.3 per 100 patients/days for flu. Mortality during ECMO was 40.9% (5 out of 22 patients) for SARS-CoV-2 infection while none died among flu patients. ECMO-associated mortality was higher in SARS-CoV-2 infection compared with flu infection.
- Published
- 2022
17. High Frequencies of Functional Virus-Specific CD4 + T Cells in SARS-CoV-2 Subjects With Olfactory and Taste Disorders.
- Author
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Mele D, Calastri A, Maiorano E, Cerino A, Sachs M, Oliviero B, Mantovani S, Baldanti F, Bruno R, Benazzo M, Grifoni A, Sette A, Mondelli MU, and Varchetta S
- Subjects
- Antibodies, Viral immunology, CD4 Lymphocyte Count, COVID-19 immunology, COVID-19 pathology, Cytokines blood, Humans, Interferon-gamma blood, Interferon-gamma immunology, Spike Glycoprotein, Coronavirus immunology, Ageusia pathology, Anosmia pathology, Antibodies, Viral blood, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, SARS-CoV-2 immunology
- Abstract
Olfactory and taste disorders (OTD) are commonly found as presenting symptoms of SARS-CoV-2 infection in patients with clinically mild COVID-19. Virus-specific T cells are thought to play an important role in the clearance of SARS-CoV-2; therefore the study of T cell specific immune responses in patients with mild symptoms may help to understand their possible role in protection from severe disease. We evaluated SARS-CoV-2-specific T cell responses to four different peptide megapools covering all SARS-CoV-2 proteins during the acute phase of the disease in 33 individuals with mild or no other symptom beside OTD and in 22 age-matched patients with severe infection. A control group of 15 outpatients with OTD and consistently negative nasopharyngeal SARS-CoV-2 RNA swabs and virus-specific IgG serology was included in the study. Increased frequencies of virus-specific CD4
+ and CD8+ T cells were found in SARS-CoV-2 positive patients with OTD compared with those with severe COVID-19 and with SARS-CoV-2 negative OTD individuals. Moreover, enhanced CD4+ and CD8+ T-cell activation induced by SARS-CoV-2 peptides was associated with higher interferon (IFN)γ production. Increased frequencies of Spike (S1/S2)-specific CD4+ T cells showing enhanced IFNγ secretion and granzyme B content were associated with serum spike-specific IgG in the OTD group. In conclusion, patients with SARS-CoV-2 induced OTD develop highly functional virus-specific CD4+ and CD8+ T cells during the symptomatic phase of the disease, suggesting that robust and coordinated T-cell responses provide protection against extension of COVID-19 to the lower respiratory tract., Competing Interests: AS is a consultant for Gritstone, Flow Pharma, Arcturus, Immunoscape, 20 CellCarta, OxfordImmunotech and Avalia. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Mele, Calastri, Maiorano, Cerino, Sachs, Oliviero, Mantovani, Baldanti, Bruno, Benazzo, Grifoni, Sette, Mondelli and Varchetta.)- Published
- 2021
- Full Text
- View/download PDF
18. A challenging case of SARS-CoV-2- AIDS and Nocardiosis coinfection from the SMatteo COvid19 REgistry (SMACORE).
- Author
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Colaneri M, Lupi M, Sachs M, Ludovisi S, Di Matteo A, Pagnucco L, Gulminetti R, Mariani B, Fabbiani M, and Bruno R
- Subjects
- Humans, Pandemics, Registries, SARS-CoV-2, Acquired Immunodeficiency Syndrome, COVID-19, Coinfection, Nocardia Infections diagnosis
- Abstract
The COVID-19 pandemic is posing an unprecedented threat worldwide. One issue that has faltered, though, concerns the underestimated risk to trade all for COVID-19, misdiagnosing other potentially life-threatening diseases. Further still, the presence of respiratory symptoms in AIDS patients should stimulate more vigilant efforts to uncover other or additional infections. This case report highlights the pitfalls of diagnosing a rare pulmonary infection during the COVID-19 pandemic.
- Published
- 2021
19. Clinical characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia, North Italy, 21 to 28 February 2020.
- Author
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Colaneri M, Sacchi P, Zuccaro V, Biscarini S, Sachs M, Roda S, Pieri TC, Valsecchi P, Piralla A, Seminari E, Di Matteo A, Novati S, Maiocchi L, Pagnucco L, Tirani M, Baldanti F, Mojoli F, Perlini S, and Bruno R
- Subjects
- Betacoronavirus, COVID-19, Coronavirus Infections, Europe, Hospitals, Teaching, Humans, Italy, Pandemics, Pneumonia, Viral, Reverse Transcriptase Polymerase Chain Reaction, SARS-CoV-2, Coronavirus
- Abstract
We describe clinical characteristics, treatments and outcomes of 44 Caucasian patients with coronavirus disease (COVID-19) at a single hospital in Pavia, Italy, from 21-28 February 2020, at the beginning of the outbreak in Europe. Seventeen patients developed severe disease, two died. After a median of 6 days, 14 patients were discharged from hospital. Predictors of lower odds of discharge were age > 65 years, antiviral treatment and for severe disease, lactate dehydrogenase > 300 mg/dL.
- Published
- 2020
- Full Text
- View/download PDF
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