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6. Building a tuberculosis-free world: The Lancet Commission on tuberculosis

Author

Reid, Michael J A, primary, Arinaminpathy, Nimalan, additional, Bloom, Amy, additional, Bloom, Barry R, additional, Boehme, Catharina, additional, Chaisson, Richard, additional, Chin, Daniel P, additional, Churchyard, Gavin, additional, Cox, Helen, additional, Ditiu, Lucica, additional, Dybul, Mark, additional, Farrar, Jeremy, additional, Fauci, Anthony S, additional, Fekadu, Endalkachew, additional, Fujiwara, Paula I, additional, Hallett, Timothy B, additional, Hanson, Christy L, additional, Harrington, Mark, additional, Herbert, Nick, additional, Hopewell, Philip C, additional, Ikeda, Chieko, additional, Jamison, Dean T, additional, Khan, Aamir J, additional, Koek, Irene, additional, Krishnan, Nalini, additional, Motsoaledi, Aaron, additional, Pai, Madhukar, additional, Raviglione, Mario C, additional, Sharman, Almaz, additional, Small, Peter M, additional, Swaminathan, Soumya, additional, Temesgen, Zelalem, additional, Vassall, Anna, additional, Venkatesan, Nandita, additional, van Weezenbeek, Kitty, additional, Yamey, Gavin, additional, Agins, Bruce D, additional, Alexandru, Sofia, additional, Andrews, Jason R, additional, Beyeler, Naomi, additional, Bivol, Stela, additional, Brigden, Grania, additional, Cattamanchi, Adithya, additional, Cazabon, Danielle, additional, Crudu, Valeriu, additional, Daftary, Amrita, additional, Dewan, Puneet, additional, Doepel, Laurie K, additional, Eisinger, Robert W, additional, Fan, Victoria, additional, Fewer, Sara, additional, Furin, Jennifer, additional, Goldhaber-Fiebert, Jeremy D, additional, Gomez, Gabriela B, additional, Graham, Stephen M, additional, Gupta, Devesh, additional, Kamene, Maureen, additional, Khaparde, Sunil, additional, Mailu, Eunice W, additional, Masini, Enos O, additional, McHugh, Lorrie, additional, Mitchell, Ellen, additional, Moon, Suerie, additional, Osberg, Michael, additional, Pande, Tripti, additional, Prince, Lea, additional, Rade, Kirankumar, additional, Rao, Raghuram, additional, Remme, Michelle, additional, Seddon, James A, additional, Selwyn, Casey, additional, Shete, Priya, additional, Sachdeva, Kuldeep S, additional, Stallworthy, Guy, additional, Vesga, Juan F, additional, Vilc, Valentina, additional, and Goosby, Eric P, additional

Published
2019
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7. Tuberculosis preventive treatment: the next chapter of tuberculosis elimination in India

Author

Moonan, Patrick K, primary, Nair, Sreenivas A, additional, Agarwal, Reshu, additional, Chadha, Vineet K, additional, Dewan, Puneet K, additional, Gupta, Umesh D, additional, Ho, Christine S, additional, Holtz, Timothy H, additional, Kumar, Ajay M, additional, Kumar, Nishant, additional, Kumar, Prahlad, additional, Maloney, Susan A, additional, Mase, Sundari R, additional, Oeltmann, John E, additional, Paramasivan, C N, additional, Parmar, Malik M, additional, Rade, Kiran K, additional, Ramachandran, Ranjani, additional, Rao, Raghuram, additional, Salhorta, Virendra S, additional, Sarin, Rohit, additional, Sarin, Sanjay, additional, Sachdeva, Kuldeep S, additional, Selvaraju, Sriram, additional, Singla, Rupak, additional, Surie, Diya, additional, Tonsing, Jamhoih, additional, Tripathy, Srikanth P, additional, and Khaparde, Sunil D, additional

Published
2018
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10. Direct Observation of Treatment Provided by a Family Member as Compared to Non-Family Member among Children with New Tuberculosis: A Pragmatic, Non-Inferiority, Cluster-Randomized Trial in Gujarat, India

Author

Dave, Paresh Vamanrao, primary, Shah, Amar Niranjan, additional, Nimavat, Pankaj B., additional, Modi, Bhavesh B., additional, Pujara, Kirit R., additional, Patel, Pradip, additional, Mehariya, Keshabhai, additional, Rade, Kiran Vaman, additional, Shekar, Soma, additional, Sachdeva, Kuldeep S., additional, Oeltmann, John E., additional, and Kumar, Ajay M. V., additional

Published
2016
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11. Building a tuberculosis-free world: The LancetCommission on tuberculosis

Author

Reid, Michael J A, Arinaminpathy, Nimalan, Bloom, Amy, Bloom, Barry R, Boehme, Catharina, Chaisson, Richard, Chin, Daniel P, Churchyard, Gavin, Cox, Helen, Ditiu, Lucica, Dybul, Mark, Farrar, Jeremy, Fauci, Anthony S, Fekadu, Endalkachew, Fujiwara, Paula I, Hallett, Timothy B, Hanson, Christy L, Harrington, Mark, Herbert, Nick, Hopewell, Philip C, Ikeda, Chieko, Jamison, Dean T, Khan, Aamir J, Koek, Irene, Krishnan, Nalini, Motsoaledi, Aaron, Pai, Madhukar, Raviglione, Mario C, Sharman, Almaz, Small, Peter M, Swaminathan, Soumya, Temesgen, Zelalem, Vassall, Anna, Venkatesan, Nandita, van Weezenbeek, Kitty, Yamey, Gavin, Agins, Bruce D, Alexandru, Sofia, Andrews, Jason R, Beyeler, Naomi, Bivol, Stela, Brigden, Grania, Cattamanchi, Adithya, Cazabon, Danielle, Crudu, Valeriu, Daftary, Amrita, Dewan, Puneet, Doepel, Laurie K, Eisinger, Robert W, Fan, Victoria, Fewer, Sara, Furin, Jennifer, Goldhaber-Fiebert, Jeremy D, Gomez, Gabriela B, Graham, Stephen M, Gupta, Devesh, Kamene, Maureen, Khaparde, Sunil, Mailu, Eunice W, Masini, Enos O, McHugh, Lorrie, Mitchell, Ellen, Moon, Suerie, Osberg, Michael, Pande, Tripti, Prince, Lea, Rade, Kirankumar, Rao, Raghuram, Remme, Michelle, Seddon, James A, Selwyn, Casey, Shete, Priya, Sachdeva, Kuldeep S, Stallworthy, Guy, Vesga, Juan F, Vilc, Valentina, and Goosby, Eric P

Published
2019
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12. Correction: Comparative Evaluation of GenoType MTBDRplus Line Probe Assay with Solid Culture Method in Early Diagnosis of Multidrug Resistant Tuberculosis (MDR-TB) at a Tertiary Care Centre in India

Author

Yadav, Raj N., primary, Singh, Binit K., additional, Sharma, Surendra K., additional, Sharma, Rohini, additional, Soneja, Manish, additional, Sreenivas, Vishnubhatla, additional, Myneedu, Vithal P., additional, Hanif, Mahmud, additional, Kumar, Ashok, additional, Sachdeva, Kuldeep S., additional, Paramasivan, Chinnambedu N., additional, Vollepore, Balasangameshwra, additional, Thakur, Rahul, additional, Raizada, Neeraj, additional, Arora, Suresh K., additional, and Sinha, Sanjeev, additional

Published
2013
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13. Comparative Evaluation of GenoType MTBDRplus Line Probe Assay with Solid Culture Method in Early Diagnosis of Multidrug Resistant Tuberculosis (MDR-TB) at a Tertiary Care Centre in India

Author

Yadav, Raj N., primary, Singh, Binit K., additional, Sharma, Surendra K., additional, Sharma, Rohini, additional, Soneja, Manish, additional, Sreenivas, Vishnubhatla, additional, Myneedu, Vithal P., additional, Hanif, Mahmud, additional, Kumar, Ashok, additional, Sachdeva, Kuldeep S., additional, Paramasivan, Chinnambedu N., additional, Vollepore, Balasangameshwra, additional, Thakur, Rahul, additional, Raizada, Neeraj, additional, Arora, Suresh K., additional, and Sinha, Sanjeev, additional

Published
2013
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14. Comparative Evaluation of GenoType MTBDRplus Line Probe Assay with Solid Culture Method in Early Diagnosis of Multidrug Resistant Tuberculosis (MDR-TB) at a Tertiary Care Centre in India.

Author

Yadav, Raj N., Singh, Binit K., Sharma, Surendra K., Sharma, Rohini, Soneja, Manish, Sreenivas, Vishnubhatla, Myneedu, Vithal P., Hanif, Mahmud, Kumar, Ashok, Sachdeva, Kuldeep S., Paramasivan, Chinnambedu N., Vollepore, Balasangameshwra, Thakur, Rahul, Raizada, Neeraj, Arora, Suresh K., and Sinha, Sanjeev

Subjects
TUBERCULOSIS diagnosis, EARLY diagnosis, MULTIDRUG resistance, GENOTYPE-environment interaction, DRUG resistance, GENETIC mutation
Abstract

Background: The objectives of the study were to compare the performance of line probe assay (GenoType MTBDRplus) with solid culture method for an early diagnosis of multidrug resistant tuberculosis (MDR-TB), and to study the mutation patterns associated with rpoB, katG and inhA genes at a tertiary care centre in north India. Methods: In this cross-sectional study, 269 previously treated sputum-smear acid-fast bacilli (AFB) positive MDR-TB suspects were enrolled from January to September 2012 at the All India Institute of Medical Sciences hospital, New Delhi. Line probe assay (LPA) was performed directly on the sputum specimens and the results were compared with that of conventional drug susceptibility testing (DST) on solid media [Lowenstein Jensen (LJ) method]. Results: DST results by LPA and LJ methods were compared in 242 MDR-TB suspects. The LPA detected rifampicin (RIF) resistance in 70 of 71 cases, isoniazid (INH) resistance in 86 of 93 cases, and MDR-TB in 66 of 68 cases as compared to the conventional method. Overall (rifampicin, isoniazid and MDR-TB) concordance of the LPA with the conventional DST was 96%. Sensitivity and specificity were 98% and 99% respectively for detection of RIF resistance; 92% and 99% respectively for detection of INH resistance; 97% and 100% respectively for detection of MDR-TB. Frequencies of katG gene, inhA gene and combined katG and inhA gene mutations conferring all INH resistance were 72/87 (83%), 10/87 (11%) and 5/87 (6%) respectively. The turnaround time of the LPA test was 48 hours. Conclusion: The LPA test provides an early diagnosis of monoresistance to isoniazid and rifampicin and is highly sensitive and specific for an early diagnosis of MDR-TB. Based on these findings, it is concluded that the LPA test can be useful in early diagnosis of drug resistant TB in high TB burden countries. [ABSTRACT FROM AUTHOR]

Published
2013
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15. Effect of delamanid on interim outcomes of bacteriological conversion amongst pediatric drug resistant tuberculosis cases in India.

Author

Kalawadia D, Gandhi D, Dirkhipa TY, Jaiswal A, Shah D, Salve J, Parmar M, Sachdeva KS, Bodhanwala M, and Shah I

Abstract

Aim: To determine the bacteriological conversion rate after 6 months of Delamanid (DLM) based treatment in children with drug-resistant tuberculosis (DR-TB) and determine factors associated with bacteriological conversion., Methods: This is a descriptive retrospective study done in children between the age of 6-17 years with DR-TB who received DLM-based therapy from October 2018 to May 2021. The drug resistance pattern of TB was detected using Xpert RIF/MTB and phenotypic drug sensitivity testing (DST) on TB-MGIT culture reports. Follow-up sputum TB MGIT culture was carried out monthly after DLM initiation for 6 months. Factors associated with sputum bacteriological conversion such as age, gender, pulmonary TB (PTB) versus disseminated TB, unilateral or bilateral lung involvement, type of DR-TB, prior treatment failure, and type of DR-TB regimen were analyzed., Results: Sixty patients received DLM of which two had extrapulmonary TB (EPTB) and sputum conversion could not be assessed. The mean age at presentation was 12.69 ± 3.03 years. Five patients (8.3%) died while on DLM treatment. On follow-up, 8 (13.7%) out of 58 patients had no sputum bacteriological conversion after 6 months of DLM initiation of which three patients were on salvage therapy; 46 (79.3%) had sputum bacteriological conversion within 6 months of DLM initiation., Conclusion: Sputum bacteriological conversion rate was almost 80% at the end of 6 months of DLM-based treatment., (Copyright © 2024 Copyright: © 2024 Indian Chest Society.)

Published
2024
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16. Promoting tobacco cessation by integrating 'brief advice' in tuberculosis control programme.

Author

Kaur J, Sachdeva KS, Modi B, Jain DC, Chauhan LS, Dave P, Singh RJ, and Wilson N

Abstract

Background: There is an enormous health burden caused by the co-prevalence of tuberculosis (TB) and tobacco use in India. This intervention study was undertaken in district Vadodara, Gujarat, India to promote tobacco cessation by integrating 'brief advice' for tobacco cessation in TB patients who were tobacco users and registered for treatment under TB control programme, based on the tested strategies advocated by World Health Organization (WHO) and the International Union against Tuberculosis and Lung Diseases (The Union)., Materials and Methods: Brief advice for tobacco cessation based on five A's, advocated by the WHO and the UNION was incorporated into the on-going TB Control programme in India in the year 2010. The tools were developed for education, training and capturing data. All the registered TB patients receiving directly observed treatment short-course (DOTS) who used tobacco in any form were offered brief advice during routine interaction for treatment., Results: A total of 46.3% of TB patients, predominantly males (89.6% males and 10.3% females) were current users of tobacco; 39.1% used smokeless tobacco, 35.9% were smokers and 25% were dual users, that is, smoked as well as used smokeless tobacco. At the end of treatment, of the 67.3% patients who were offered brief advice, quit tobacco use, 18.2% re-lapsed while 14.5% were lost to follow-up., Conclusion: A significant numbers of TB patients use tobacco with adverse impact on TB control programmes. Our study shows that it is feasible to introduce 'brief advice' strategy as a cost effective intervention for tobacco cessation among TB patients with careful monitoring.

Published
2013
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