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1. Marsupialization: A conservative approach for treating dentigerous cyst in children in the mixed dentition

Author

Kirtaniya B, Sachdev V, Singla A, and Sharma A

Subjects
Dentigerous cyst, enucleation, marsupialization, mixed dentition, Dentistry, RK1-715
Abstract

Dentigerous cysts are usually encountered in the practice of pediatric dentistry. The treatment modalities range from marsupialization to enucleation of the lesion and are based on the involvement of the lesion with the adjacent structures. However, loss of a permanent tooth in the management of a dentigerous cyst can be devastating to a child who has already a congenitally missing tooth. The first case describes the technique of marsupialization in which we extracted the grossly carious deciduous 1st molar and created a window through the extracted socket to decompress the lesion. In this case the 2nd premolars were congenitally missing on both sides of the mandible for which we had not gone for enucleation of the dentigerous cyst along with the developing 1st premolar. The second case is a developmental type of a big dentigerous cyst where marsupialization was followed by enucleation of the cystic lining but without removal of the affected tooth. Both the teeth erupted in the oral cavity.

Published
2010

2. Natural prevalence of antibody titers to Glucostltransferase of Streptococcus mutans in serum in high and low caries active children

Author

Kirtaniya B, Chawla H, Tiwari A, Ganguly N, and Sachdev V

Subjects
Antigen, GTF, immunoglobulins, serum, Streptococcus mutans, vaccine, Dentistry, RK1-715
Abstract

In this investigation, serum immunoglobulin G (IgG) and immunoglobulin A (IgA) titers, as well as total immunoglobulin concentration (IgG + IgA + IgM), were found to be raised with the increase in the number of dental caries. Only the total serum antibody titer in high dental caries (HDC) group was found to be significantly raised as compared to no dental carries (NDC) group. Although the IgG and IgA titers were raised in blood with the increased number of caries, the results were not statistically significant. However, we could not find any correlation between serum antibodies and dental caries except that there was an increased trend of serum antibodies to GTF with the increased number of carious lesions.

Published
2010

3. Natural prevalence of antibody titres to GTF of S. mutans in saliva in high and low caries active children

Author

Kirtaniya B, Chawla H, Tiwari A, Ganguly N, and Sachdev V

Subjects
Antigen, glucosyltransferase, immunoglobulins, polysaccharides, saliva, S. mutans, Dentistry, RK1-715
Abstract

The present study was conducted to find out the role of natural immunity against dental caries. Whole stimulated saliva of various caries from active children was collected. Antigen glucosyltransferase (GTF) was prepared from Streptococcus mutans serotype C and the antibody titre was estimated using ELISA. Salivary IgG, s-IgA and total immunoglobulins (IgG + s-IgA+ IgM) concentration were assayed. The result showed an increased level of salivary IgG concentration with the increased number of dental caries, which was not statistically significant. But there were significant decrease of s-IgA titre as well as total immunoglobulin concentration in saliva with the increased number of dental caries. This study showed that because of lack of local immunity the children are more prone to dental caries.

Published
2009

6. New constraints on oscillation parameters from $\nu_e$ appearance and $\nu_\mu$ disappearance in the NOvA experiment

Author

Acero, M. A., Adamson, P., Alion, L. Aliaga T., Allakhverdian, V., Antoshkin, N. Anfimov A., Arrieta-Diaz, E., Back, A. Aurisano A., Backhouse, C., Balashov, M. Baird N., Bambah, B. A., Behera, K. Bays B., Bending, S., Bhatnagar, R. Bernstein V., Bhuyan, B., Blackburn, J. Bian T., Blair, J., Bour, A. Bolshakova P., Bromberg, C., Buchanan, J. Brown N., Butkevich, A., Campbell, V. Bychkov M., Carroll, T. J., Cedeno, E. Catano-Mur A., Childress, S., Chowdhury, B. C. Choudhary B., Coan, T. E., Cooper, M. Colo J., Corwin, L., Cronin-Hennessy, L. Cremonesi D., Davies, G. S., De Rijck, J. P. Davies S., Derwent, P. F., Ding, R. Dharmapalan P., Djurcic, Z., Dung, E. C. Dukes P., Duyang, H., Ehrlich, S. Edayath R., Feldman, G. J., Gallagher, M. J. Frank H. R., Gandrajula, R., Germani, F. Gao S., Giri, A., Goodman, R. A. Gomes M. C., Grichine, V., Group, M. Groh R., Grover, D., Habig, B. Guo A., Hakl, F., Hatcher, J. Hartnell R., Hatzikoutelis, A., Himmel, K. Heller A., Holin, A., Huang, B. Howard J., Hylen, J., Judah, F. Jediny M., Kakorin, I., Kaplan, D. Kalra D. M., Keloth, R., Koerner, O. Klimov L. W., Kolupaeva, L., Kourbanis, S. Kotelnikov I., Kreymer, A., Kumar, Ch. Kulenberg A., Kuruppu, C., Lackey, V. Kus T., Lang, K., Lokajicek, S. Lin M., Lozier, J., Maan, S. Luchuk K., Magill, S., Marshak, W. A. Mann M. L., Matveev, V., Messier, D. P. Méndez M. D., Meyer, H., Miller, T. Miao W. H., Mishra, S. R., Mohanta, A. Mislivec R., Moren, A., Muether, L. Mualem M., Mufson, S., Musser, R. Murphy J., Naples, D., Nelson, N. Nayak J. K., Nichol, R., Norman, E. Niner A., Nosek, T., Olshevskiy, Y. Oksuzian A., Olson, T., Patterson, J. Paley R. B., Pawloski, G., Petrova, D. Pershey O., Petti, R., Plunkett, S. Phan-Budd R. K., Potukuchi, B., Psihas, C. Principato F., Radovic, A., Rebel, R. A. Rameika B., Rojas, P., Sachdev, V. Ryabov K., Samoylov, O., Sepulveda-Quiroz, M. C. Sanchez J., Shanahan, P., Singh, A. Sheshukov P., Singh, V., Smolik, E. Smith J., Snopok, P., Song, N. Solomey E., Sousa, A., Strait, K. Soustruznik M., Suter, L., Tas, R. L. Talaga P., Thayyullathil, R. B., Tiras, J. Thomas E., Tognini, S. C., Tripathi, D. Torbunov J., Tsaris, A., Urheim, Y. Torun J., Vahle, P., Vinton, J. Vasel L., Vokac, P., Vrba, A. Vold T., Wang, B., Wetstein, T. K. Warburton M., Whittington, D., Wolcott, S. G. Wojcicki J., Yang, S., Zalesak, S. Yu J., Zamorano, B., and Zwaska, R.

Subjects
High Energy Physics - Experiment
Abstract

We present updated results from the NOvA experiment for $\nu_\mu\rightarrow\nu_\mu$ and $\nu_\mu\rightarrow\nu_e$ oscillations from an exposure of $8.85\times10^{20}$ protons on target, which represents an increase of 46% compared to our previous publication. The results utilize significant improvements in both the simulations and analysis of the data. A joint fit to the data for $\nu_\mu$ disappearance and $\nu_e$ appearance gives the best fit point as normal mass hierarchy, $\Delta m^2_{32} = 2.44\times 10^{-3}{{\rm eV}^2}/c^4$, $\sin^2\theta_{23} = 0.56$, and $\delta_{CP} = 1.21\pi$. The 68.3% confidence intervals in the normal mass hierarchy are $\Delta m^2_{32} \in [2.37,2.52]\times 10^{-3}{{\rm eV}^2}/c^4$, $\sin^2\theta_{23} \in [0.43,0.51] \cup [0.52,0.60]$, and $\delta_{CP} \in [0,0.12\pi] \cup [0.91\pi,2\pi]$. The inverted mass hierarchy is disfavored at the 95% confidence level for all choices of the other oscillation parameters.

Published
2018
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8. Detection of Trypanosoma cruzi DNA in blood by PCR is associated with Chagas cardiomyopathy and disease severity

Author

Sabino, EC, Ribeiro, AL, Lee, TH, Oliveira, CL, Carneiro‐Proietti, AB, Antunes, AP, Menezes, MM, Ianni, BM, Salemi, VM, Nastari, L, Fernandes, F, Sachdev, V, Carrick, DM, Deng, X, Wright, D, Gonçalez, TT, Murphy, EL, Custer, B, Busch, MP, and Study‐II, International Component for the Chagas Study Group of the NHLBI Retrovirus Epidemiology Donor

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Vector-Borne Diseases, Cardiovascular, Prevention, Heart Disease, Genetics, Clinical Research, Infectious Diseases, Rare Diseases, Good Health and Well Being, Adult, Blood Donors, Case-Control Studies, Chagas Cardiomyopathy, DNA, Protozoan, Female, Humans, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Retrospective Studies, Severity of Illness Index, Trypanosoma cruzi, PCR, cardiomyopathy, Chagas Study Group of the NHLBI Retrovirus Epidemiology Donor Study-II, International Component, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThe significance of detection of Trypanosoma cruzi DNA in blood of antibody-positive patients for risk of development of Chagas heart disease is not well established. The objective of this study was to compare detection of T. cruzi DNA with known clinical and laboratory markers of Chagas cardiomyopathy (CC) severity.MethodsThis is a case-control study nested within a retrospective cohort developed in Brazil to understand the natural history of Chagas disease. The study enrolled 499 T. cruzi seropositive blood donors (SP-BD) and 488 frequency matched seronegative control donors (SN-BD) who had donated between 1996 and 2002, and 101 patients with clinically diagnosed CC. In 2008-2010 all enrolled subjects underwent a health questionnaire, medical examination, electrocardiograms and echocardiograms and polymerase chain reaction (PCR) analyses. A blinded panel of three cardiologists adjudicated the outcome of CC. Trypanosoma cruzi kinetoplast minicircle sequences were amplified by real-time PCR using an assay with a sensitivity of one parasite per 20 mL of blood. All testing was performed on coded samples.ResultsRates of PCR detection of T. cruzi DNA were significantly (P = 0.003) higher in CC patients and SP-BD diagnosed with CC (79/105 [75.2 %]) compared with SP-BD without CC (143/279 [51.3%]). The presence of parasitaemia was significantly associated with known markers of disease progression such as QRS and QT interval duration, lower left ventricular ejection fraction, higher left ventricular index mass, and elevated troponin and NTpro-BNP levels.ConclusionTrypanosoma cruzi PCR positivity is associated with presence and severity of cardiomyopathy, suggesting a direct role of parasite persistence in disease pathogenesis.

Published
2015

17. MA03.05 Hierarchy of Adverse-Prognosis Quality Markers after Curative-Intent Resection of Non-Small Cell Lung Cancer (NSCLC)

Author

Osarogiagbon, R., primary, Lee, Y., additional, Faris, N., additional, Fehnel, C., additional, Akinbobola, O., additional, Ray, M., additional, Jones, C., additional, Meadows-Taylor, M., additional, Saulsberry, A., additional, Patel, H., additional, Eubanks, R., additional, Halal, A., additional, Sachdev, V., additional, Talton, D., additional, Valaulikar, G., additional, Wolf, B., additional, Wiggins, H., additional, Levy, P., additional, Robbins, E., additional, and Smeltzer, M., additional

Published
2021
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30. Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism

Author

Sachdev, V., primary, Leopold, C., additional, Bauer, R., additional, Patankar, J.V., additional, Iqbal, J., additional, Obrowsky, S., additional, Doktorova, M., additional, Scheicher, B., additional, Goeritzer, M., additional, Kolb, D., additional, Turnbull, A.V., additional, Zimmer, A., additional, Hoefler, G., additional, Hussain, M.M., additional, Groen, A.K., additional, and Kratky, D., additional

Published
2018
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33. OA 15.08 Thoroughness of Staging and the Outcomes of Surgical Resection Outcomes in Potentially Curable Non-Small Cell Lung Cancer (NSCLC)

Author

Smeltzer, M., primary, Lee, Y., additional, Faris, N., additional, Ray, M., additional, Fehnel, C., additional, Houston-Harris, C., additional, Ojeabulu, P., additional, Akinbobola, O., additional, Deese, L., additional, Owen, E., additional, Wolf, B., additional, Wiggins, H., additional, Mutrie, C., additional, Sachdev, V., additional, Levy, P., additional, Signore, R., additional, Robbins, E., additional, and Osarogiagbon, R., additional

Published
2017
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34. P2.16-019 Improving Survival with a Lymph Node (LN) Collection Kit for Non-Small Cell Lung Cancer (NSCLC) Resections

Author

Faris, N., primary, Smeltzer, M., additional, Fehnel, C., additional, Houston-Harris, C., additional, Ojeabulu, P., additional, Akinbobola, O., additional, Ray, M., additional, Lee, Y., additional, Deese, L., additional, Owen, E., additional, Wolf, B., additional, Wiggins, H., additional, Mutrie, C., additional, Sachdev, V., additional, Levy, P., additional, Signore, R., additional, Robbins, E., additional, and Osarogiagbon, R., additional

Published
2017
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36. P2434Echocardiographic findings of Trypanosoma cruzi seropositive blood donors

Author

Salemi, V.M.C., primary, Oliveira, C.D.L., additional, Ribeiro, A.L., additional, Menezes, M.M., additional, Antunes, A.P., additional, Ferreira-Filho, J.C., additional, Sachdev, V., additional, Fernandes, F., additional, Nastari, L., additional, Ianni, B.M., additional, Mady, C., additional, Carneiro-Proietti, A.B., additional, Keating, S.M., additional, Busch, M.P., additional, and Sabino, E.C., additional

Published
2017
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39. Detection of Trypanosoma cruzi DNA in blood by PCR is associated with Chagas cardiomyopathy and disease severity

Author

Sabino, ECE, Ribeiro, ALP, Lee, TH, Oliveira, CL, Carneiro-Proietti, ABF, Antunes, AP, Menezes, MM, Ianni, BMA, Salemi, VMCC, Nastari, L, Fernandes, FS, Sachdev, V, Carrick, DM, Deng, X, Wright, DJ, Gonçalez, TT, Murphy, EL, Custer, BS, and Busch, MP

Subjects
Cardiovascular System & Hematology, parasitic diseases, Cardiorespiratory Medicine and Haematology
Abstract

© 2015 The Authors. European Journal of Heart Failure © 2015 European Society of Cardiology. Background The significance of detection of Trypanosoma cruzi DNA in blood of antibody-positive patients for risk of development of Chagas heart disease is not well established. The objective of this study was to compare detection of T. cruzi DNA with known clinical and laboratory markers of Chagas cardiomyopathy (CC) severity. Methods This is a case-control study nested within a retrospective cohort developed in Brazil to understand the natural history of Chagas disease. The study enrolled 499 T. cruzi seropositive blood donors (SP-BD) and 488 frequency matched seronegative control donors (SN-BD) who had donated between 1996 and 2002, and 101 patients with clinically diagnosed CC. In 2008-2010 all enrolled subjects underwent a health questionnaire, medical examination, electrocardiograms and echocardiograms and polymerase chain reaction (PCR) analyses. A blinded panel of three cardiologists adjudicated the outcome of CC. Trypanosoma cruzi kinetoplast minicircle sequences were amplified by real-time PCR using an assay with a sensitivity of one parasite per 20mL of blood. All testing was performed on coded samples. Results Rates of PCR detection of T. cruzi DNA were significantly (P=0.003) higher in CC patients and SP-BD diagnosed with CC (79/105 [75.2 %]) compared with SP-BD without CC (143/279 [51.3%]). The presence of parasitaemia was significantly associated with known markers of disease progression such as QRS and QT interval duration, lower left ventricular ejection fraction, higher left ventricular index mass, and elevated troponin and NTpro-BNP levels. Conclusion Trypanosoma cruzi PCR positivity is associated with presence and severity of cardiomyopathy, suggesting a direct role of parasite persistence in disease pathogenesis.

Published
2015

40. Study of electrical, dielectric and EMI shielding behavior of copper metal, copper ferrite and PVDF composite.

Author

Sonker, Rakesh K., Sachdev, V. K., Gupta, Vinay, Kamal Halder, Krishna, and Tomar, Monika

Subjects
*ELECTROMAGNETIC compatibility, *IMMUNITY testing (Electronics), *ELECTROMAGNETIC shielding
Abstract

In the present work a comparative study of electrical, dielectric and EMI shielding behaviour of copper metal-PVDF and copper ferrite- PVDF composites has been carried out. The obtained results suggest that copper metal PVDF composite shows better conductivity and dielectric constant in addition to excellent shielding efficiency in the X-band frequency range in comparison to copper ferrite PVDF composite. On the other hand copper ferrite PVDF composite exhibits better crystallinity. A high absorption dominated EMI shielding efficiency (SE) value of 28.75 dB is achieved for the copper metal-PVDF composite, thus making it a potential candidate for shielding application. [ABSTRACT FROM AUTHOR]

Published
2018
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43. Physical and dental manifestations of oral-facial-digital syndrome type I

Author

Tuli, A., Sachdev, V., Singh, A., and Kumar, A.

Subjects
Health
Abstract

Byline: A. Tuli, V. Sachdev, A. Singh, A. Kumar Oral-facial-digital (OFD) syndrome is the collective name of a group of rare inherited syndromes characterized by malformations of the face, oral [...]

Published
2011

44. Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism

Author

Sachdev, V., primary, Leopold, C., additional, Bauer, R., additional, Patankar, J.V., additional, Iqbal, J., additional, Obrowsky, S., additional, Doktorova, M., additional, Goeritzer, M., additional, Scheicher, B., additional, Kolb, D., additional, Hoefler, G., additional, Turnbull, A.V., additional, Zimmer, A., additional, Hussain, M.M., additional, Groen, A.K., additional, and Kratky, D., additional

Published
2016
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48. Ten-Year incidence of chagas cardiomyopathy among asymptomatic trypanosoma cruzi-seropositive former blood donors

Author

Sabino, EC, Ribeiro, AL, Salemi, VMC, Di Lorenzo Oliveira, C, Antunes, AP, Menezes, MM, Ianni, BM, Nastari, L, Fernandes, F, Patavino, GM, Sachdev, V, Capuani, L, De Almeida-Neto, C, Carrick, DM, Wright, D, Kavounis, K, Goncalez, TT, Carneiro-Proietti, AB, Custer, B, Busch, MP, and Murphy, EL

Subjects
parasitic diseases
Abstract

Background-: Very few studies have measured disease penetrance and prognostic factors of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-infected persons. Methods and Results-: We performed a retrospective cohort study among initially healthy blood donors with an index T cruzi-seropositive donation and age-, sex-, and period-matched seronegatives in 1996 to 2002 in the Brazilian cities of São Paulo and Montes Claros. In 2008 to 2010, all subjects underwent medical history, physical examination, ECGs, and echocardiograms. ECG and echocardiogram results were classified by blinded core laboratories, and records with abnormal results were reviewed by a blinded panel of 3 cardiologists who adjudicated the outcome of Chagas cardiomyopathy. Associations with Chagas cardiomyopathy were tested with multivariate logistic regression. Mean follow-up time between index donation and outcome assessment was 10.5 years for the seropositives and 11.1 years for the seronegatives. Among 499 T cruzi seropositives, 120 (24%) had definite Chagas cardiomyopathy, and among 488 T cruzi seronegatives, 24 (5%) had cardiomyopathy, for an incidence difference of 1.85 per 100 person-years attributable to T cruzi infection. Of the 120 seropositives classified as having Chagas cardiomyopathy, only 31 (26%) presented with ejection fraction

Published
2013

49. Electrocardiographic Abnormalities in Trypanosoma cruzi Seropositive and Seronegative Former Blood Donors

Author

Ribeiro, AL, Sabino, EC, Marcolino, MS, Salemi, VMC, Ianni, BM, Fernandes, F, Nastari, L, Antunes, A, Menezes, M, Oliveira, CDL, Sachdev, V, Carrick, DM, Busch, MP, and Murphy, EL

Subjects
cardiovascular system, cardiovascular diseases
Abstract

Background: Blood donor screening leads to large numbers of new diagnoses of Trypanosoma cruzi infection, with most donors in the asymptomatic chronic indeterminate form. Information on electrocardiogram (ECG) findings in infected blood donors is lacking and may help in counseling and recognizing those with more severe disease. Objectives: To assess the frequency of ECG abnormalities in T.cruzi seropositive relative to seronegative blood donors, and to recognize ECG abnormalities associated with left ventricular dysfunction. Methods: The study retrospectively enrolled 499 seropositive blood donors in São Paulo and Montes Claros, Brazil, and 483 seronegative control donors matched by site, gender, age, and year of blood donation. All subjects underwent a health clinical evaluation, ECG, and echocardiogram (Echo). ECG and Echo were reviewed blindly by centralized reading centers. Left ventricular (LV) dysfunction was defined as LV ejection fraction (EF)

Published
2013

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