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3 results on '"Sacchetti GL"'

1. Articular cartilage engineering with Hyalograft C: 3-year clinical results

Author

Marcacci M, Berruto M, Brocchetta D, Delcogliano A, Ghinelli D, Gobbi A, Kon E, Pederzini L, Sacchetti GL, Stefani G, Zanasi S., ROSA, DONATO, Marcacci, M, Berruto, M, Brocchetta, D, Delcogliano, A, Ghinelli, D, Gobbi, A, Kon, E, Pederzini, L, Rosa, Donato, Sacchetti, Gl, Stefani, G, and Zanasi, S.

Abstract

The use of tissue engineering for cartilage repair has emerged as a potential therapeutic option and has led to the development of Hyalograft C, a tissue-engineered graft composed of autologous chondrocytes grown on a scaffold entirely made of HYAFF 11, an esterified derivative of hyaluronic acid. Here we present the results of an ongoing multicenter clinical study conducted with the primary objective to investigate the subjective symptomatic, functional and health-related quality of life outcomes of patients treated with Hyalograft C. Clinical results on the cohort of 141 patients with followup assessments ranging from 2 to 5 years (average followup time: 38 months), are reported. At followup 91.5% of patients improved according to the International Knee Documentation Committee subjective evaluation; 76% and 88% of patients had no pain and mobility problems respectively assessed by the EuroQol-EQ5D measure. Furthermore, 95.7% of the patients had their treated knee normal or nearly normal as assessed by the surgeon; cartilage repair was graded arthroscopically as normal or nearly normal in 96.4% of the scored knees; the majority of the second-look biopsies of the grafted site histologically were assessed as hyaline-like. Importantly, a very limited complication rate was recorded in this study. The positive clinical results obtained indicate that Hyalograft C is a safe and effective therapeutic option for the treatment of articular cartilage lesions. LEVEL OF EVIDENCE: Therapeutic study, Level III-2 (retrospective cohort study). See the Guidelines for Authors for a complete description of levels of evidence.

Published
2005

2. The distally based posterior interosseous island flap for the coverage of skin loss of the hand.

Author

Landi A, Luchetti R, Soragni O, De Santis G, and Sacchetti GL

Subjects
Adolescent, Adult, Attitude of Health Personnel, Evaluation Studies as Topic, Female, Forearm surgery, Groin surgery, Hand Injuries psychology, Humans, Male, Middle Aged, Patient Satisfaction, Surgical Flaps standards, Surveys and Questionnaires, Forearm blood supply, Hand Injuries surgery, Surgical Flaps methods, Ulna blood supply
Abstract

Eight patients with skin coverage of the hand by the distally based posterior interosseous island flap (DBPIIF) are presented. The first web was reconstructed in 6 and the volar and dorsal aspect of the hand in 2 patients. Primary closure of the donor sites has always been possible. An echo Doppler examination is indicated to verify the presence and size of the vessel and the direction of its flow. The dissection of the vascular pedicle, however, is frequently quite complex and time consuming. To better appreciate the cosmetic aspect of the DBPIIF and its donor site, a random study has been undertaken to compare this flap with the radial forearm and the groin flap and their corresponding donor sites. Females have more often preferred the groin flap, whereas doctors preferred the DBPIIF. Reliability, a good aesthetic result at the donor site, and the preservation of the main vessels of the hand are the specific merits of the DBPIIF.

Published
1991
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3. The use of CT scan in evaluating Volkmann's syndrome in the limbs.

Author

Landi A, De Santis G, Sacchetti GL, Ciuccarelli C, Luchetti R, and Bedeschi P

Subjects
Adolescent, Adult, Arm, Child, Child, Preschool, Compartment Syndromes classification, Compartment Syndromes surgery, Diagnosis, Differential, Female, Humans, Leg, Male, Middle Aged, Preoperative Care, Pronation, Supination, Compartment Syndromes diagnostic imaging, Tomography, X-Ray Computed
Abstract

Between January 1980 and October 1986 26 cases of Volkmann's syndrome were submitted to preoperative CT scan. Thirteen were localised in the upper limb, 11 in the lower limb, and 2 were cases of pseudo-Volkmann's disease. CT scan allowed us to confirm the densitometric features and distribution of muscle infarction in the various muscle planes. Thus, two groups were distinguished, each with different densitometric features: a first group with diffuse hypodensity of the muscular sheaths with unclear borders, and a coefficient of attenuation at approximately 30-40 H.U., which at operation corresponded to diffuse fibrosis; a second group with defined hypodensity of the various muscle groups equal to 10-20 H.U., which at operation gave a macroscopic picture of infarction. CT scan provides a detailed preoperative topographical and morphological evaluation of the infarction area, and therefore a treatment plan based on a more accurate knowledge of the anatomical and pathological lesions.

Published
1989

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