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21 results on '"Saccheri, Fabiana"'

4. Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth

Author

Zagato, Elena, Pozzi, Chiara, Bertocchi, Alice, Schioppa, Tiziana, Saccheri, Fabiana, Guglietta, Silvia, Fosso, Bruno, Melocchi, Laura, Nizzoli, Giulia, Troisi, Jacopo, Marzano, Marinella, Oresta, Bianca, Spadoni, Ilaria, Atarashi, Koji, Carloni, Sara, Arioli, Stefania, Fornasa, Giulia, Asnicar, Francesco, Segata, Nicola, Guglielmetti, Simone, Honda, Kenya, Pesole, Graziano, Vermi, William, Penna, Giuseppe, and Rescigno, Maria

Published
2020
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7. The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

Author

Viaud, Sophie, Saccheri, Fabiana, Mignot, Grégoire, Yamazaki, Takahiro, Daillère, Romain, Hannani, Dalil, Enot, David P., Pfirschke, Christina, Engblom, Camilla, Pittet, Mikael J., Schlitzer, Andreas, Ginhoux, Florent, Apetoh, Lionel, Chachaty, Elisabeth, Woerther, Paul-Louis, Eberl, Gérard, Bérard, Marion, Ecobichon, Chantal, Clermont, Dominique, Bizet, Chantai, Gaboriau-Routhiau, Valérie, Cerf-Bensussan, Nadine, Opolon, Paule, Yessaad, Nadia, Vivier, Eric, Ryffel, Bernhard, Elson, Charles O., Doré, Joël, Kroemer, Guido, Lepage, Patricia, Boneca, Ivo Gomperts, Ghiringhelli, François, and Zitvogel, Laurence

Published
2013
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9. Additional file 3 of Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis

Author

Heffler, Enrico, Saccheri, Fabiana, Bartezaghi, Marta, and Canonica, Giorgio Walter

Abstract

Additional file 3: Figure S3. Efficacy comparison of outcome parameters at baseline and 12 months after omalizumab treatment in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) compared with severe asthma (no chronic rhinosinusitis or nasal polyps). (A) Mean Asthma Control Questionnaire scores, and the change from baseline in ACQ score; (B) Median percent predicted forced expiratory volume in 1 s (FEV1), and change from baseline in percent predicted FEV1; (C) Median number of annual exacerbations in the year prior to initiating omalizumab treatment (baseline) and during 12 months’ treatment with omalizumab, and change from baseline. The p-values within cohorts were calculated using a signed rank test and p-values for comparisons between cohorts were calculated using an ANCOVA model on ranks.

Published
2020
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10. Additional file 1 of Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis

Author

Heffler, Enrico, Saccheri, Fabiana, Bartezaghi, Marta, and Canonica, Giorgio Walter

Abstract

Additional file 1: Figure S1. Efficacy comparison of outcome parameters at baseline and 12 months after omalizumab treatment in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) compared with chronic sinusitis/rhinosinusutis without (CRSsNP). (A) Mean Asthma Control Questionnaire scores, and the change from baseline in ACQ score; (B) Median percent predicted forced expiratory volume in 1 s (FEV1), and change from baseline in percent predicted FEV1; (C) Median number of annual exacerbations in the year prior to initiating omalizumab treatment (baseline) and during 12 months’ treatment with omalizumab, and change from baseline. The p-values within cohorts were calculated using a signed rank test and p-values for comparisons between cohorts were calculated using an ANCOVA model on ranks.

Published
2020
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11. Investigating the role of X chromosome breakpoints in premature ovarian failure

Author

Baronchelli Simona, Villa Nicoletta, Redaelli Serena, Lissoni Sara, Saccheri Fabiana, Panzeri Elena, Conconi Donatella, Bentivegna Angela, Crosti Francesca, Sala Elena, Bertola Francesca, Marozzi Anna, Pedicini Antonio, Ventruto Marialuisa, Police Maria, and Dalprà Leda

Subjects
Breakpoint definition, Premature ovarian failure, X chromosome structural aberrations, Genetics, QH426-470
Abstract

Abstract The importance of the genetic factor in the aetiology of premature ovarian failure (POF) is emphasized by the high percentage of familial cases and X chromosome abnormalities account for 10% of chromosomal aberrations. In this study, we report the detailed analysis of 4 chromosomal abnormalities involving the X chromosome and associated with POF that were detected during a screening of 269 affected women. Conventional and molecular cytogenetics were valuable tools for locating the breakpoint regions and thus the following karyotypes were defined: 46,X,der(X)t(X;19)(p21.1;q13.42)mat, 46,X,t(X;2)(q21.33;q14.3)dn, 46,X,der(X)t(X;Y)(q26.2;q11.223)mat and 46,X,t(X;13)(q13.3;q31)dn. A bioinformatic analysis of the breakpoint regions identified putative candidate genes for ovarian failure near the breakpoint regions on the X chromosome or on autosomes that were involved in the translocation event. HS6ST1, HS6ST2 and MATER genes were identified and their functions and a literature review revealed an interesting connection to the POF phenotype. Moreover, the 19q13.32 locus is associated with the age of onset of the natural menopause. These results support the position effect of the breakpoint on flanking genes, and cytogenetic techniques, in combination with bioinformatic analysis, may help to improve what is known about this puzzling disorder and its diagnostic potential.

Published
2012
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13. Cytogenetics of premature ovarian failure: an investigation on 269 affected women

Author

Baronchelli, Simona, Conconi, Donatella, Panzeri, Elena, Bentivegna, Angela, Redaelli, Serena, Lissoni, Sara, Saccheri, Fabiana, Villa, Nicoletta, Crosti, Francesca, Sala, Elena, Martinoli, Emanuela, Volonte, Marinella, Marozzi, Anna, and Dalpra, Leda

Subjects
Physiological aspects, Research, Genetic aspects, Risk factors, Ovarian diseases -- Genetic aspects -- Research -- Risk factors, Cytogenetics -- Physiological aspects -- Research, X chromosome -- Physiological aspects -- Research
Abstract

1. Introduction The increase of chromosome aneuploidy in human lymphocytes with aging has been described since early 1960s [1, 2]. Numerous reports confirmed the observations of Jacobs and colleagues and [...], The importance of X chromosome in the aetiology of premature ovarian failure (POF) is well-known but in many cases POF still remains idiopathic. Chromosome aneuploidy increase is a physiological phenomenon related to aging, but the role of low- level sex chromosome mosaicism in ovarian function is still undiscovered. Standard cytogenetic analysis was carried out in a total of 269 patients affected by POF: 27 chromosomal abnormalities were identified, including X chromosome and autosomal structural and numerical abnormalities. In 47 patients with 46,XX karyotype we performed interphase FISH using X alpha-satellite probe in order to identify X chromosome mosaicism rate. Aneuploidy rate in the patient group was significantly higher than the general population group. These findings underline the importance of X chromosome in the aetiology of POF and highlight the potential role of low-level sex chromosome mosaicism in ovarian aging that may lead to a premature onset of menopause.

Published
2011
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16. Constitutional de novo deletion of the FBXW7 gene in a patient with focal segmental glomerulosclerosis and multiple primitive tumors

Author

Roversi, Gaia, primary, Picinelli, Chiara, additional, Bestetti, Ilaria, additional, Crippa, Milena, additional, Perotti, Daniela, additional, Ciceri, Sara, additional, Saccheri, Fabiana, additional, Collini, Paola, additional, Poliani, Pietro L., additional, Catania, Serena, additional, Peissel, Bernard, additional, Pagni, Fabio, additional, Russo, Silvia, additional, Peterlongo, Paolo, additional, Manoukian, Siranoush, additional, and Finelli, Palma, additional

Published
2015
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