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Adenoid cystic carcinoma (ACC) is a malignant epithelial tumor of the salivary glands that commonly affects the minor salivary glands, and the palate is the most recurrent site. Treatment is challenging because this tumor tends to recur with distant metastases and poor prognosis. A 50-year-old woman complained of numbness in the upper left hemimaxilla, extended to the labial region, nose wing, and nasolabial sulcus, with clinical intra-oral alterations similar to an endodontic fistula tooth 25 palatal mucosa and discrete periapical rarefaction on radiologic evaluation. Endodontic treatment was provided with laser therapy administered for persistent numbness. After 3 months a palate volume increase and small ulcerated region were noted encompassing the region of teeth 24 to 27. The panoramic and tomographic examination was performed showing extensive bone destruction, and the patient underwent a biopsy followed by microscopic and immunohistochemistry evaluation and diagnosis as ACC. The patient was forwarded to a head and neck surgeon.

This study reported a clinical case about the use of salmon calcitonin in treatment of cherubism. A 12-year-old male melanoderm patient had bilateral expansion of the mandible and maxilla firm by palpation. The sclera below the iris showed the "look to the sky" classic description. The intrabuccal examination showed diastema, crowding, dental absences, and mobility of the lower central incisors. The radiologic examination showed multilocular radiolucent lesions in the maxillary tuberosities, paranasal region, and entire mandible, except the condyle. The treatment consisted of the daily administration of salmon calcitonin 200 UI nasal spray. Biochemical markers of calcium, phosphorus, and parathyroid remain within the reference values, while alkaline phosphatase has been elevated throughout the treatment. After 30 months of therapy, stabilization of the active bone lesion was observed without remission. The child is under periodic clinical and radiographic follow-up to evaluate the long-term therapy.

White sponge nevus (WSN) is a rare autosomal dominant disorder with variable expressivity and high penetrance. Oral mucosa is the most affected region. Usually, this entity occurs at birth or later in childhood or adolescence. A 42-year-old man complained of white, asymptomatic lesions, which were present for more than 3 years. No family history of similar lesions was reported. Intraoral examination revealed nonremovable, symmetric, diffuse white plaques, all over the buccal mucosa, bilaterally, with a corrugated surface. An incisional biopsy was performed and histopathologic analysis revealed stratified squamous epithelium, with hyperparakeratosis, an extensive area with acanthosis and keratotinocytes with perinuclear eosinophilic condensation. Based on clinical and microscopic aspects, the diagnosis made was WSN. Further material was collected for cytopathologic examination in order to confirm the diagnosis. Treatment is not necessary due to the benign nature of WSN. Correct diagnosis is important to exclude other more serious lesions with similar characteristics.