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19 results on '"Sabogal Guaqueta, Angelica"'

3. Mitochondrial transplantation rescues neuronal cells from ferroptosis

Author

Chen, Tingting, Majerníková, Nad'a, Marmolejo-Garza, Alejandro, Trombetta-Lima, Marina, Sabogal-Guáqueta, Angélica María, Zhang, Yuequ, ten Kate, Ruth, Zuidema, Minte, Mulder, Patty P.M.F.A., den Dunnen, Wilfred, Gosens, Reinoud, Verpoorte, Elisabeth, Culmsee, Carsten, Eisel, Ulrich L.M., and Dolga, Amalia M.

Published
2023
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10. Identification and characterization of a small molecule that activates thiosulfate sulfurtransferase and stimulates mitochondrial respiration

Author

Al‐Dahmani, Zeyana M., primary, Hadian, Mojgan, additional, Ruiz‐Moreno, Angel J., additional, Maria, Sabogal‐Guaqueta Angelica, additional, Batista, Fernando A., additional, Zhang, Ran, additional, Luo, Yang, additional, Sadremomtaz, Afsaneh, additional, van der Straat, Robin, additional, Spoor, Mette, additional, Dolga, Amalia M., additional, Dekker, Frank J., additional, S S, Alexander Dömling, additional, van Goor, Harry, additional, and Groves, Matthew R., additional

Published
2023
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14. Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction

Author

Sabogal-Guaqueta, Angelica Maria, primary, Marmolejo-Garza, Alejandro, additional, Lima, Marina Trombetta, additional, Oun, Asmaa, additional, Hunneman, Jasmijn, additional, Chen, Tingting, additional, Koistinaho, Jari, additional, Lehtonen, Sarka, additional, Kortholt, Arjan, additional, Bakker, Barbara M., additional, Eggen, Bart J.L., additional, Boddeke, Erik, additional, and Dolga, Amalia, additional

Published
2023
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16. Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

Author

Goldsteen, Pien, Sabogal Guaqueta, Angelica, Mulder, Patty, Bos, I. Sophie T., Eggens, Manon, van der Koog, Luke, Soeiro, J.T., Halayko, A.J., Mathwig, Klaus, Kistemaker, Loes, Verpoorte, Elisabeth, Dolga, Amalia, Gosens, Reinoud, Molecular Pharmacology, Pharmaceutical Analysis, Medicinal Chemistry and Bioanalysis (MCB), and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
Pharmacology, Pharmacology (medical)
Abstract

Airway cholinergic nerves play a key role in airway physiology and disease. In asthma and other diseases of the respiratory tract, airway cholinergic neurons undergo plasticity and contribute to airway hyperresponsiveness and mucus secretion. We currently lack human in vitro models for airway cholinergic neurons. Here, we aimed to develop a human in vitro model for peripheral cholinergic neurons using human pluripotent stem cell (hPSC) technology. hPSCs were differentiated towards vagal neural crest precursors and subsequently directed towards functional airway cholinergic neurons using the neurotrophin brain-derived neurotrophic factor (BDNF). Cholinergic neurons were characterized by ChAT and VAChT expression, and responded to chemical stimulation with changes in Ca2+ mobilization. To culture these cells, allowing axonal separation from the neuronal cell bodies, a two-compartment PDMS microfluidic chip was subsequently fabricated. The two compartments were connected via microchannels to enable axonal outgrowth. On-chip cell culture did not compromise phenotypical characteristics of the cells compared to standard culture plates. When the hPSC-derived peripheral cholinergic neurons were cultured in the chip, axonal outgrowth was visible, while the somal bodies of the neurons were confined to their compartment. Neurons formed contacts with airway smooth muscle cells cultured in the axonal compartment. The microfluidic chip developed in this study represents a human in vitro platform to model neuro-effector interactions in the airways that may be used for mechanistic studies into neuroplasticity in asthma and other lung diseases.

Published
2022

17. Unraveling molecular signaling in neurodegenerative diseases:focus on a protective mechanism mediated by linalool

Author

Sabogal Guaqueta, Angelica, Sabogal Guaqueta, Angelica, Sabogal Guaqueta, Angelica, and Sabogal Guaqueta, Angelica

Abstract

Neurodegenerative conditions such as Alzheimer`s disease (AD) and stroke are characterized by progressive nervous system dysfunction. The main aim of this work was to propose new therapeutic targets in neurodegeneration and to identify possible phospholipid biomarkers that reflect the progression of the disease. We demonstrated that administration of the terpene, linalool was able to reduce the main pathological markers of AD (extracellular β-amyloidosis, tauopathy) and of ischemic stroke. Linalool treatment in animals improved motor coordination and cognition, along with a reduction of astrogliosis and microgliosis in the hippocampus. Besides, we investigated whether and how linalool exert a neuroprotective effect against glutamate-induced oxidative stress and might affect mitochondrial function. Administration of linalool reduced cell death mediated by glutamate, mitochondrial ROS formation, mitochondrial calcium uptake, lipid peroxidation and mediated a recovery of mitochondrial membrane potential, together with an increase in mitochondrial respiration. In addition, we detected remarkable changes in phospholipids in ischemic stroke, AD and CADASIL in brain samples, CSF and serum. These data could help to unravel novel molecular mechanisms and propose different therapeutic targets to treat transversal pathogenesis. Finally, we showed in a review the role of microglia in neurodegenerative diseases and we present the results of a differentiation protocol of human microglia from iPSC demonstrating the maturity and functionality of these cells. In conclusion, we present various strategies to model and study neurodegeneration and provide answers in the field of inflammation, lipidomics and at the same time we propose a new molecule as a potential therapy against AD and cerebral ischemia.

Published
2020

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